Works for
MoisturizingNiacinamide, Palmitoyl tripeptide-1 + 14 moreWorks well
“Lightweight but moisturizing water-based formulation is dermatologically tested.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
arginine, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, hydrolyzed collagen.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, copper tripeptide-1, niacinamide, palmitoyl tripeptide-1
Anti-agingNiacinamide, Adenosine + 4 moreWorks well
“This thin, non-sticky formula infused with 88% of concentrated bifida ferment lysate strengthens the skin barrier for elastic skin, smoothing the appearance of wrinkles.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, copper tripeptide-1, palmitoyl tripeptide-1.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Evens skin toneNiacinamide, Bifida ferment lysate + 1 moreWorks well
“It’s also enriched with Pumpkin Ferment Extract, Soybean Ferment Extract, and Rice Ferment Filtrate to protect skin from external aggressors that can prematurely age skin while brightening and evening skin tone and texture. p H of 6.0 ± 1.0.”
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: bifida ferment lysate, lactobacillus/pumpkin ferment extract.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Anti-blemishSide benefit · Niacinamide, Beta-glucan + 1 moreWorks well
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.
Anti-oxidationSide benefit · Bifida ferment lysate, Scutellaria baicalensis root extract + 6 moreMay help
This product contains antioxidants (bifida ferment lysate) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.
Can it cause trouble?
Irritancy4 strong irritants: Illicium verum fruit extract, Origanum vulgare leaf extract + 2 more — patch-test recommendedHigh risk
ComedogenicClean of flagged comedogenic ingredientsNone flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Bifida ferment lysate~23–34%
- Irritation risk
- Low
Consists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect
More about Bifida ferment lysateLactobacillus/pumpkin ferment extract~4.6–6.8%
- Irritation risk
- Medium
An enzyme-based exfoliant
More about Lactobacillus/pumpkin ferment extractLactobacillus/soybean ferment extract~4.5–6.8%
- Irritation risk
- Low
A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking
More about Lactobacillus/soybean ferment extractLactobacillus/rice ferment filtrate~3.5–5.2%
- Irritation risk
- Low
A fermentation product created by bacteria Lactobacillus out of rice. The fermented product helps attract water to the upper layer of the skin. It has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking
More about Lactobacillus/rice ferment filtratePalmitoyl tripeptide-1~2.8–4.3%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Niacinamide~2–2.9%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideBifida ferment lysate~1.5–2.2%
- Irritation risk
- Low
Consists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect
More about Bifida ferment lysateDipropylene glycol~1.2–1.8%
- Irritation risk
- Low
Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying
More about Dipropylene glycolNiacinamide~1–1.5%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideGlycerin~0.95–1.4%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about Glycerin1,2-hexanediol~0.5–1.2%
Butylene glycol~0.45–1.1%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolIllicium verum fruit extract~0.4–0.95%
- Irritation risk
- High
Anise fruit extract. Used as a fragrance. Can be irritating
More about Illicium verum fruit extractAllantoin panthenol~0.4–0.95%
- Irritation risk
- Low
Water~0.4–0.9%
Scutellaria baicalensis root extract~0.35–0.85%
- Irritation risk
- High
A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties
More about Scutellaria baicalensis root extractArginine~0.35–0.8%
- Irritation risk
- Low
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
More about ArginineCarbomer~0.35–0.8%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerAdenosine~0.3–0.75%
- Irritation risk
- Low
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
More about AdenosineDisodium edta~0.2–0.8%
Lactobacillus/rice ferment filtrate~0.35–0.85%
- Irritation risk
- Low
A fermentation product created by bacteria Lactobacillus out of rice. The fermented product helps attract water to the upper layer of the skin. It has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking
More about Lactobacillus/rice ferment filtrateSodium hyaluronate~0.2–0.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateOriganum vulgare leaf extract~0.2–0.7%
- Irritation risk
- High
A plant extract. Can have an anti-oxidant effect, but can also contain irritants
More about Origanum vulgare leaf extractChamaecyparis obtusa leaf extract~0.2–0.7%
Hydrolyzed collagen~0.4–0.9%
- Irritation risk
- Low
A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin
More about Hydrolyzed collagenSalix alba bark extract~0.2–0.7%
- Irritation risk
- High
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
More about Salix alba bark extractLactobacillus/soybean ferment extract~0.15–0.7%
- Irritation risk
- Low
A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking
More about Lactobacillus/soybean ferment extractLactobacillus/pumpkin ferment extract~0.15–0.65%
- Irritation risk
- Medium
An enzyme-based exfoliant
More about Lactobacillus/pumpkin ferment extractPortulaca oleracea extract~0.15–0.6%
- Irritation risk
- Medium
A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin
More about Portulaca oleracea extractCinnamomum cassia bark extract~0.15–0.55%
Beta-glucan~0.15–0.5%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
More about Beta-glucanAcetyl hexapeptide-8~0.1–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Palmitoyl tripeptide-1~0.15–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Copper tripeptide-1~0.1–0.4%
- Irritation risk
- Low
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
More about Copper tripeptide-1Ingredient list view
Bifida ferment lysate, Lactobacillus/pumpkin ferment extract, Lactobacillus/soybean ferment extract, Lactobacillus/rice ferment filtrate, Palmitoyl tripeptide-1, Niacinamide, Bifida ferment lysate, Dipropylene glycol, Niacinamide, Glycerin, 1,2-hexanediol, Butylene glycol, Illicium verum fruit extract, Allantoin panthenol, Unknown, Water, Scutellaria baicalensis root extract, Arginine, Carbomer, Adenosine, Disodium edta, Lactobacillus/rice ferment filtrate, Sodium hyaluronate, Origanum vulgare leaf extract, Chamaecyparis obtusa leaf extract, Hydrolyzed collagen, Salix alba bark extract, Lactobacillus/soybean ferment extract, Lactobacillus/pumpkin ferment extract, Portulaca oleracea extract, Cinnamomum cassia bark extract, Beta-glucan, Acetyl hexapeptide-8, Palmitoyl tripeptide-1, Copper tripeptide-1
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| ISNTREETW-Real Bifida AmpouleYOUR PRODUCT | ManyoBifida Complex Ampoule | MISSHATime Revolution Night Repair Borabit Ampoule | NATUREKINDBoosting Bifida Ampoule | |
|---|---|---|---|---|
| Match | — | 81% | 78% | 78% |
| Price | $16.32 | $13.71−$2.61 | $29.20+$12.88 | $18.03+$1.71 |
| Shared key ingredients | — | 7 of 12 | 8 of 12 | 6 of 12 |
| Key difference | — | Madecassic Acid | Tripeptide-1 | Polyglutamic Acid |
| Irritancy | High | Medium | Medium | Low |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: Cos De BAHA P M.A Peptide SerumTOSOWOONG Squalane Ampoule
Product summary
"ISNTREE - TW-Real Bifida Ampoule" is effective for: Anti-inflammatory, Moisturizing, Anti-blemish, Anti-aging and Evens skin tone
Ingredient callouts
- A good concentration of Niacinamide (2.00% - 2.90%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
- Peptides (copper tripeptide-1 0.10% - 0.40%, palmitoyl tripeptide-1 0.15% - 0.65%, acetyl hexapeptide-8 0.10% - 0.45% and palmitoyl tripeptide-1 2.80% - 4.30%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Adenosine 0.30% - 0.75%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).
- Humectants (acetyl hexapeptide-8 0.10% - 0.45%, hydrolyzed collagen 0.40% - 0.90%, sodium hyaluronate 0.20% - 0.70%, lactobacillus/rice ferment filtrate 0.35% - 0.85%, arginine 0.35% - 0.80%, glycerin 0.95% - 1.40% and lactobacillus/rice ferment filtrate 3.50% - 5.20%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
About the brand
According to Cruelty-Free Kitty "ISNTREE" is cruelty free and so is its parent company.
Price
The product retails for 24.50A$ in Australia, for 32.09CA$ in Canada and from 16.32$ up to 19.85$ in the United States.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.
- 1Bifidobacterium longumlysate, a new ingredient forreactive skinonlinelibrary.wiley.com
- 2Use of Probiotics for Dermal Applicationsresearchgate.net
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