PRODUCT REVIEW
Dr. Denese Triple Strength Peptide Super Drops
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Price as of 9/19/2025 4:3 GMT.
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What can the product work for?
Anti-blemish
What does the product description say?
pore size improved by 39 % on average In 100% cases.
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
retinol
1.1% -
1.6%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Anti-aging
What does the product description say?
fine lines improved by 24 % on average In 100% cases.
retinol
1.1% -
1.6%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
palmitoyl tetrapeptide-7
0.55% -
1.25%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
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Evens skin tone
What does the product description say?
skin is more even by 44 % on average.
retinol
1.1% -
1.6%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness: HIGH
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
tetrahexyldecyl ascorbate
2% -
3%
Irritation risk:
Concentration: Insufficient!
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
Exfoliation
retinol
1.1% -
1.6%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Moisturizing
dimethicone
22% -
33%
Irritation risk:
Concentration: Effectiveness: HIGH
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
dimethiconol
4% -
6%
Irritation risk:
Concentration: Effectiveness: HIGH
A silicone that makes products more spreadable and keeps skin smooth. Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time
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Anti-oxidation
retinol
1.1% -
1.6%
Irritation risk:
Concentration: Effectiveness: HIGH
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
melatonin
0.45% -
1%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare
tetrahexyldecyl ascorbate
2% -
3%
Irritation risk:
Concentration: Insufficient!
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
Show more
Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Evens skin tone | |
| Anti-blemish |
Total Promises Fulfilled score:
100/100.
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Can it cause trouble?
- Overall product irritation risk
- Acne & comedogenic risk ingredients: 2
Potential irritants
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Works for:
Anti-aging,
Anti-blemish,
Evens skin tone,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
retinol
1.1% -
1.6%
Irritation risk:
Works for:
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Show more
Comodogenic ingredients
ethylhexyl palmitate
0.15% -
0.6%
Irritation risk: Comedogenicity: High
Works for:
Moisturizing
An emollient that helps soften the skin and create a nice product texture
glycine soja oil
0.15% -
0.55%
Irritation risk: Comedogenicity: Medium
Works for:
Moisturizing
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
User reviews (0)
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HIGH
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MEDIUM
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HIGH
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MEDIUM
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Ingredients & concentrations
All ingredients
Key Actives
retinol
1.1% -
1.6%
Irritation risk:
Works for:
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Works for:
Anti-aging,
Anti-blemish,
Evens skin tone,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
Show more
Potential irritants
hydroxypinacolone retinoate
0.01% -
0.05%
Irritation risk:
Works for:
Anti-aging,
Anti-blemish,
Evens skin tone,
Exfoliation
A derivative of the most potent form of vitamin A, retinoic acid. The ingredient can be sold under name Granactive Retinoid. Note that if a skincare brand discloses the concentration of Granactive Retinoid in a product, the concentration refers to a diluted form of Hydroxypinacolone Retinoate: 1% of Granactive Retinoid corresponds to 0.1% of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate (HPR) is a unique derivative of retinoic acid because it can directly work in the skin and does not require additional conversion steps. According to studies done by the manufacturer on models of human skin (not real people), this derivative is more effective than other cosmetic versions of retinoids (such as retinol, retinaldehyde, and retinyl palmitate), and, at the same time, causes less irritation. It has been also demonstrated to be more stable than retinol which makes formulating with easier and increases the chances that a product with it will maintain its effectiveness after opening. The packaging should still ideally be air-tight. HPR is available over the counter in the EU, UK, Asia, Australia and New Zealand, but is only with a prescription in Canada.
retinol
1.1% -
1.6%
Irritation risk:
Works for:
Mattifying,
Anti-aging,
Anti-oxidation,
Exfoliation,
Anti-blemish,
Evens skin tone
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Show more
Comodogenic ingredients
ethylhexyl palmitate
0.15% -
0.6%
Irritation risk: Comedogenicity: High
Works for:
Moisturizing
An emollient that helps soften the skin and create a nice product texture
glycine soja oil
0.15% -
0.55%
Irritation risk: Comedogenicity: Medium
Works for:
Moisturizing
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
All ingredients
dimethicone
22% -
33%
Irritation risk:
Works for:
Moisturizing,
Mattifying
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
cyclopentasiloxane
5.9% -
8.8%
Irritation risk:
Works for:
Moisturizing,
Mattifying
A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin
caprylyl methicone
4.7% -
7%
Irritation risk:
Works for:
Moisturizing
A type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin
Show more
Ingredient list view
Dimethicone, Cyclopentasiloxane, Caprylyl methicone, Dimethiconol, Dimethicone crosspolymer, Tetrahexyldecyl ascorbate, Hydroxypinacolone retinoate, Unknown, Tocopherol, Retinol, Palmitoyl hexapeptide-14, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Melatonin, C12-15 alkyl benzoate, Polysilicone-11, Ethoxydiglycol, Dimethyl isosorbide, Sorbitan laurate, C18-36 acid glycol ester, C18-36 acid triglyceride, Lecithin, Ethylhexyl palmitate, Glycine soja oil, Phenoxyethanol
Sources
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage
- Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacy
- Antiaging effects of retinoid hydroxypinacolone retinoate on skin models. (2018). Journal of the American Academy of Dermatology, 79(3), AB44. doi:10.1016/j.jaad.2018.05.215
- Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
- Vitamin E in dermatology
- Vitamin E and Skin Health
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- [Melatonin in dermatology. Experimental and clinical aspects]