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Dermaquest Nourishing Peptide Cream
Dermaquest

Dermaquest Nourishing Peptide Cream

Efficacy87/100IrritancyMedium
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Works for

2 of 2 advertised claims delivered

Moisturizing
Cyclotetrapeptide-24 aminocyclohexane carboxylate, Palmitoyl pentapeptide-4 + 25 more
Strong evidence
What the product description says
“Nourishing Peptide Cream”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, imperata cylindrica root extract.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: cyclotetrapeptide-24 aminocyclohexane carboxylate, palmitoyl pentapeptide-4

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.4–0.65%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~5.9–7.2%
Cyclotetrapeptide-24 aminocyclohexane carboxylateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.8–2.2%
EctoinKey activeEffect: HighSoftens the upper layer of the skin and can support skin barrier function~0.2–0.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.1–5%
Glycine soja sterolsKey active· EmollientEffect: HighAn emollient that helps soften the skin~0.25–0.5%
Imperata cylindrica root extractKey active· HumectantEffect: HighA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~0.2–0.4%
Micrococcus lysateKey activeEffect: HighConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"~0.2–0.4%
Palmitoyl pentapeptide-4HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Sodium chondroitin sulfateKey active· HumectantEffect: HighIs naturally present in skin. Helps to attract water to its upper layer~0.45–0.65%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.65–1%
Hydrolyzed vegetable proteinKey activeEffect: Medium~0.55–0.8%
Plankton extractKey activeEffect: MediumCan help attract water to the upper layer of the skin~0.25–0.45%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.5–1.8%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.25–0.45%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.4–2.9%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.45%
Aloe barbadensis leaf juice powderEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.15–0.3%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.25–0.45%
Peg-8· HumectantEffect: LowUsed to create a nice product consistency~0.15–0.3%
AllantoinUnder-dosedEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.15–0.3%
Centella asiatica extractUnder-dosedEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.25–0.5%
Linoleic acidUnder-dosedEffect: HighAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.35–0.65%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.3%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.5%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
Anti-aging
Adenosine triphosphate, Arabidopsis thaliana extract + 10 more
Moderate evidence
What the product description says
“A virtual wellspring for regeneration, peptides encourage cellular growth and collagen production, restoring skin’s youthful luminance.”
Source: Skinstore

This product contains adenosine triphosphate, arabidopsis thaliana extract, cyclotetrapeptide-24 aminocyclohexane carboxylate, palmitoyl pentapeptide-4. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Adenosine triphosphateKey activeEffect: Medium~0.5–0.75%
Arabidopsis thaliana extractKey activeEffect: MediumPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking~0.25–0.45%
Cyclotetrapeptide-24 aminocyclohexane carboxylateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.4%
Palmitoyl pentapeptide-4Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Magnesium aluminum silicateEffect: LowMight be helpful in restoring skin barrier function and, when combined with zinc carbonate and malonic acid, reducing fine lines and wrinkles by stimulating elastin production. Also helps stabilize the product formulation~0.2–0.4%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.4–0.65%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.1–0.15%
Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.3–0.5%
Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.25–0.5%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.3%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.15–0.25%
Anti-oxidation
Not advertised by the brand · Ubiquinone, Imperata cylindrica root extract + 8 more
Strong evidence

This product contains antioxidants (ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - imperata cylindrica root extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.4–0.65%
Imperata cylindrica root extractKey activeEffect: MediumA plat extract that might help neutralize free radicals in skin and attract water to its upper layer~0.2–0.4%
Micrococcus lysateEffect: LowConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"~0.2–0.4%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.3%
ErgothioneineUnder-dosedEffect: HighCan help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking~0.25–0.5%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.1–0.15%
Camellia sinensis leaf extractUnder-dosedEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.25–0.5%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.45–0.65%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.15–0.25%

Can it cause trouble?

Irritancy
2 strong irritants: Retinyl palmitate, Alcohol
Medium risk
We flagged 20 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.3–0.5%est.
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.25–0.45%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.1–0.15%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~5.9–7.2%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~2.1–2.5%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.45–0.65%est.
Imperata cylindrica root extractA plat extract that might help neutralize free radicals in skin and attract water to its upper layerMedium~0.2–0.4%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.25–0.5%est.
Plankton extractCan help attract water to the upper layer of the skinMedium~0.25–0.45%est.
Arabidopsis thaliana extractPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lackingMedium~0.25–0.45%est.
EthoxydiglycolHelps to improve the product consistencyMedium~0.2–0.4%est.
Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.25–0.5%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.45%est.
EthylhexylglycerinA preservativeMedium~0.2–0.4%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.2–0.4%est.
Disodium edtaStabilizes the product formulationMedium~0.2–0.35%est.
Aloe barbadensis leaf juice powderTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.15–0.3%est.
Peg-8Used to create a nice product consistencyMedium~0.15–0.3%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.15–0.25%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05–0.15%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Plankton extractCan help attract water to the upper layer of the skin3/5~0.25–0.45%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.4–2.9%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~2.1–2.5%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Caprylic/capric triglyceride~5.9–7.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Glycerin~4.1–5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetyl
Not recognized
Octane~3.2–3.9%
Formula
Irritation risk
Low
More about Octane
Cetearyl alcohol~2.4–2.9%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Ceteareth-20~2.1–2.5%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Dimethicone~1.8–2.2%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Cetyl alcohol~1.5–1.8%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Ppg-12/smdi copolymer~1.2–1.5%
Formula
Irritation risk
Low

Used to create a nice product finish

More about Ppg-12/smdi copolymer
Hydrolyzed elastin~0.95–1.15%
Formula
Irritation risk
Low
More about Hydrolyzed elastin
Sodium hyaluronate~0.65–1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Hydrolyzed vegetable protein~0.55–0.8%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Hydrolyzed vegetable protein
Adenosine triphosphate~0.5–0.75%
Key active
Irritation risk
Low
Works for
Anti-aging
More about Adenosine triphosphate
Sodium chondroitin sulfate~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Is naturally present in skin. Helps to attract water to its upper layer

More about Sodium chondroitin sulfate
Brassica campestris/aleurites fordi oil copolymer~0.45–0.65%
Formula
Irritation risk
Low
More about Brassica campestris/aleurites fordi oil copolymer
Tocopheryl acetate~0.45–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Ubiquinone~0.4–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Teprenone~0.3–0.6%
Formula
Irritation risk
Low
More about Teprenone
Retinyl palmitate~0.3–0.5%
Under-dosedIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-blemishAnti-agingExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Tocopheryl linoleate/oleate~0.3–0.55%
Formula
Irritation risk
Low
More about Tocopheryl linoleate/oleate
Camellia sinensis leaf extract~0.3–0.55%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAntibacterialAnti-agingAnti-blemishEvens skin toneMoisturizing

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Ergothioneine~0.25–0.5%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidation

Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking

More about Ergothioneine
Imperata cylindrica root extract~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationAnti-inflammatory

A plat extract that might help neutralize free radicals in skin and attract water to its upper layer

More about Imperata cylindrica root extract
Carbomer~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Acrylates/c10-30 alkyl acrylate crosspolymer~0.25–0.5%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Linoleic acid~0.35–0.65%
Under-dosed
Irritation risk
Low
Works for
MoisturizingCleansingAnti-blemish

An excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores

More about Linoleic acid
Glycine soja sterols~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin

More about Glycine soja sterols
Phospholipids~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Plankton extract~0.25–0.45%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Can help attract water to the upper layer of the skin

More about Plankton extract
Lecithin~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Micrococcus lysate~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"

More about Micrococcus lysate
Arabidopsis thaliana extract~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-aging

Plant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking

More about Arabidopsis thaliana extract
Ethoxydiglycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Helps to improve the product consistency

More about Ethoxydiglycol
Sodium polyacrylate~0.25–0.5%
Formula
Irritation risk
Low
Works for
Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate
Butylene glycol~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Polysorbate 20~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Palmitoyl pentapeptide-4~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl pentapeptide-4
Centella asiatica extract~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Reduces irritationReduces rednessMoisturizingAnti-inflammatoryAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract
Darutoside~0.2–0.4%
Formula
Irritation risk
Low
More about Darutoside
Alcohol~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Ectoin~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Softens the upper layer of the skin and can support skin barrier function

More about Ectoin
Cyclotetrapeptide-24 aminocyclohexane carboxylate~0.25–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Cyclotetrapeptide-24 aminocyclohexane carboxylate
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Caprylyl glycol~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Hexylene glycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Xanthan gum~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Magnesium aluminum silicate~0.2–0.4%
Formula
Irritation risk
Low
Works for
Anti-aging

Might be helpful in restoring skin barrier function and, when combined with zinc carbonate and malonic acid, reducing fine lines and wrinkles by stimulating elastin production. Also helps stabilize the product formulation

More about Magnesium aluminum silicate
Disodium edta~0.2–0.35%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Allantoin~0.15–0.3%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Aloe barbadensis leaf juice powder~0.15–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice powder
Peg-8~0.15–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to create a nice product consistency

More about Peg-8
Tocopherol~0.15–0.3%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ascorbyl palmitate~0.15–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Ascorbic acid~0.1–0.15%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Citric acid~0.05–0.15%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Water, Caprylic/capric triglyceride, Glycerin, Unknown, Octane, Cetearyl alcohol, Ceteareth-20, Dimethicone, Cetyl alcohol, Ppg-12/smdi copolymer, Hydrolyzed elastin, Sodium hyaluronate, Hydrolyzed vegetable protein, Adenosine triphosphate, Sodium chondroitin sulfate, Brassica campestris/aleurites fordi oil copolymer, Tocopheryl acetate, Ubiquinone, Teprenone, Retinyl palmitate, Tocopheryl linoleate/oleate, Camellia sinensis leaf extract, Ergothioneine, Imperata cylindrica root extract, Carbomer, Acrylates/c10-30 alkyl acrylate crosspolymer, Linoleic acid, Glycine soja sterols, Phospholipids, Plankton extract, Lecithin, Micrococcus lysate, Arabidopsis thaliana extract, Ethoxydiglycol, Sodium polyacrylate, Butylene glycol, Polysorbate 20, Palmitoyl pentapeptide-4, Centella asiatica extract, Darutoside, Alcohol, Ectoin, Cyclotetrapeptide-24 aminocyclohexane carboxylate, Phenoxyethanol, Caprylyl glycol, Ethylhexylglycerin, Hexylene glycol, Xanthan gum, Magnesium aluminum silicate, Disodium edta, Allantoin, Aloe barbadensis leaf juice powder, Peg-8, Tocopherol, Ascorbyl palmitate, Ascorbic acid, Citric acid

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Amazon USPrice as of 10/24/2026 03:02 GMT
$64.99
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Product summary

"Dermaquest - Nourishing Peptide Cream" has a good moisturizing formula. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (glycerin, imperata cylindrica root extract, sodium chondroitin sulfate, sodium hyaluronate and butylene glycol) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (glycine soja sterols, caprylic/capric triglyceride, dimethicone, cetearyl alcohol and cetyl alcohol) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This product also contains vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.10% - 0.15%) it cannot have a noticeable benefit for the skin.
  • This moisturizer includes a form of retinoids (vitamin A) - retinyl palmitate 0.30% - 0.50%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • This moistruizer also contains peptides (cyclotetrapeptide-24 aminocyclohexane carboxylate 0.25% - 0.40% and palmitoyl pentapeptide-4 0.20% - 0.40%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This moisturizer contains some common irritants, including those without a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails from 76.00$ up to 92.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 24 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
  5. 5
    Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
  6. 6
    Combined effect of sodium chondroitin sulfate and sodium hyaluronate on skin moisturization following single and repeated applicationasianjps.syphu.edu.cn
Dermaquest Nourishing Peptide Cream
DermaquestNourishing Peptide Cream
Buy on Amazon$64.99 · as of 10/24 03:02 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy on Amazon$64.99 · as of 10/24 03:02 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.