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Clinique Smart Night™ Clinical MD Multi-Dimensional Repair Treatment Retinol
Clinique

Clinique Smart Night™ Clinical MD Multi-Dimensional Repair Treatment Retinol

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Anti-aging
Retinol, Niacinamide + 4 more
Works well
What the product description says
“With high-grade retinol, this creamy formula sinks in to help support skin's natural surface cell turnover to help improve the look of fine lines and wrinkles.”
Source: Clinique

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2–2.4%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Algae extractEffect: LowPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~1.3–1.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.5%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.35–0.65%
Evens skin tone
Retinol, Niacinamide + 1 more
Works well
What the product description says
“Skin tone looks improved, more radiant.”
Source: Clinique

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

In addition, this product contains hydroxyethyl urea, niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2–2.4%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.35–0.65%
Moisturizing
Niacinamide, Linoleic acid + 24 more
Works well
What the product description says
“Delivers nourishing hydration, which helps comfort skin and offset dryness sometimes associated with retinol.*”
Source: Clinique

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: algae extract, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, linoleic acid, niacinamide, urea

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2–2.4%
Linoleic acidHero· EmollientEffect: HighAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.45–0.65%
UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.3–0.6%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~5.7–7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~2.5–3%
Phenyl trimethiconeKey active· OcclusiveEffect: HighA type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture~1.8–2.1%
Algae extractKey active· Humectant, EmollientEffect: HighPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~1.3–1.6%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.1–1.3%
Hydroxyethyl ureaKey active· HumectantEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~0.7–1.05%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.7–1.05%
Mangifera indica seed butterKey activeEffect: HighHelps to soften the upper layer of the skin and might have some anti-oxidant effect~0.45–0.7%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.65%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~0.35–0.65%
TrehaloseKey active· HumectantEffect: HighA sugar that attracts water to the upper layer of the skin~0.3–0.5%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.25–0.5%
Ppg-15 stearyl ether· EmollientEffect: LowHelp soften the upper layer of the skin and create a nice product consistency~4.5–5.5%
Caprylic/capric/myristic/stearic triglyceride· EmollientEffect: LowHelps to soften the upper layer of the skin~1.5–1.8%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.35–0.6%
Behenyl alcohol· Emollient, OcclusiveEffect: LowNon-drying alcohol that helps water and oil mix together. Also serves as an emollient~0.35–0.6%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.3–0.55%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
Sorbitol· HumectantEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.25–0.5%
Polyquaternium-51Effect: LowAn emollient that helps create a nice silky finish on the skin~0.25–0.45%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.5%
Triticum vulgare germ extractUnder-dosedPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance~0.3–0.55%
Anti-oxidation
Not advertised by the brand · Retinol, Coffea arabica seed oil + 7 more
Works well

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
Coffea arabica seed oilEffect: LowMight be helpful in neutralizing free radicals in skin~0.45–0.7%
Mangifera indica seed butterEffect: LowHelps to soften the upper layer of the skin and might have some anti-oxidant effect~0.45–0.7%
CaffeineEffect: LowMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes~0.4–0.6%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.3–0.55%
Hordeum vulgare extractEffect: Low, below effective doseA plant extract that might have some anti-oxidant properties. Avoid if you are sensitive to gluten~0.3–0.55%
Triticum vulgare germ extractEffect: Low, below effective dosePlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance~0.3–0.55%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.35–0.65%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.5%
Exfoliation
Not advertised by the brand · Hydroxyethyl urea, Retinol + 1 more
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: hydroxyethyl urea, retinol.

Hydroxyethyl ureaKey activeEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~0.7–1.05%
RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
UreaKey activeEffect: MediumNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.3–0.6%
Anti-blemish
Not advertised by the brand · Niacinamide, Retinol + 1 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinol. These ingredients is used for treating acne and can have a noticeable effect.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: linoleic acid

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2–2.4%
RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.5–0.75%
Linoleic acidKey activeEffect: MediumAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.45–0.65%

Can it cause trouble?

Irritancy
1 strong irritant: Retinol
Medium risk
We flagged 19 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.5–0.75%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.35–0.65%est.
TriacetinUsed to dissolve other ingredientsHigh~0.25–0.45%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~5.7–7%est.
C12-20 acid peg-8 esterHelps oil and water mix togetherMedium~2.8–3.5%est.
Sigesbeckia orientalis extractA plant extract that can contain an anti-inflammatory compoundMedium~0.45–0.7%est.
Coffea arabica seed oilMight be helpful in neutralizing free radicals in skinMedium~0.45–0.7%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.4–0.6%est.
Triticum vulgare germ extractPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intoleranceMedium~0.3–0.55%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.3–0.55%est.
Hordeum vulgare extractA plant extract that might have some anti-oxidant properties. Avoid if you are sensitive to glutenMedium~0.3–0.55%est.
Potassium cetyl phosphateHelps oil and water mix togetherMedium~0.3–0.55%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.3–0.55%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
BhtA preservativeMedium~0.15–0.3%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.3%est.
Sodium metabisulfiteA preservativeMedium~0.1–0.2%est.
ChlorphenesinA preservativeMedium~0.15–0.3%est.
Potassium sorbateA preservativeMedium~0.15–0.3%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Algae extractPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet3/5~1.3–1.6%est.
Triticum vulgare germ extractPlant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance3/5~0.3–0.55%est.
Alternatives
Cheaper, or higher on efficacy
Youth Radiant Renewal Retinol Serum
The Purest Solutions Youth Radiant Renewal Retinol Serum
Cheaper73% match
$6.63
Pure Retinol 1% Night Concentrate
No7 Pure Retinol 1% Night Concentrate
Cheaper71% match
$42.99
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Caprylic/capric triglyceride~5.7–7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Ppg-15 stearyl ether~4.5–5.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Help soften the upper layer of the skin and create a nice product consistency

More about Ppg-15 stearyl ether
C12-20 acid peg-8 ester~2.8–3.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about C12-20 acid peg-8 ester
Glycerin~2.5–3%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Niacinamide~2–2.4%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Evens skin toneAnti-agingMoisturizingAnti-blemishReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Phenyl trimethicone~1.8–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture

More about Phenyl trimethicone
Caprylic/capric/myristic/stearic triglyceride~1.5–1.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin

More about Caprylic/capric/myristic/stearic triglyceride
Algae extract~1.3–1.6%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-aging

Plant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet

More about Algae extract
Dimethicone~1.1–1.3%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Hydroxyethyl urea~0.7–1.05%
Key active
Irritation risk
Low
Works for
ExfoliationMoisturizing

A derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients

More about Hydroxyethyl urea
Cetyl alcohol~0.7–1.05%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Retinol~0.5–0.75%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishMattifyingExfoliationAnti-oxidation

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Sigesbeckia orientalis extract~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-inflammatory

A plant extract that can contain an anti-inflammatory compound

More about Sigesbeckia orientalis extract
Mangifera indica seed butter~0.45–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

Helps to soften the upper layer of the skin and might have some anti-oxidant effect

More about Mangifera indica seed butter
Coffea arabica seed oil~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

Might be helpful in neutralizing free radicals in skin

More about Coffea arabica seed oil
Sodium hyaluronate~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Caffeine~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Ascorbic acid~0.35–0.65%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationAnti-agingEvens skin tone

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Urea~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Butylene glycol~0.3–0.55%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Squalane~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Trehalose~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Triticum vulgare germ extract~0.3–0.55%
Under-dosedComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidation

Plant extract that might have moisturizing properties. Avoid if you suffer from wheat or gluten intolerance

More about Triticum vulgare germ extract
Tocopheryl acetate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Peg-100 stearate~0.4–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Linoleic acid~0.45–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
CleansingMoisturizingAnti-blemish

An excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores

More about Linoleic acid
Glyceryl stearate~0.35–0.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Hordeum vulgare extract~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant properties. Avoid if you are sensitive to gluten

More about Hordeum vulgare extract
Acetyl hexapeptide-8~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Sorbitol~0.25–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol
Potassium cetyl phosphate~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Potassium cetyl phosphate
Acrylates/c10-30 alkyl acrylate crosspolymer~0.3–0.55%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Tocopherol~0.3–0.5%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ammonium acryloyldimethyltaurate/vp copolymer~0.25–0.5%
Formula
Irritation risk
Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer
Behenyl alcohol~0.35–0.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Non-drying alcohol that helps water and oil mix together. Also serves as an emollient

More about Behenyl alcohol
Sodium pca~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Sodium hydroxide~0.25–0.45%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Carbomer~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Triacetin~0.25–0.45%
Irritant · high
Irritation risk
High

Used to dissolve other ingredients

More about Triacetin
Polyquaternium-51~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps create a nice silky finish on the skin

More about Polyquaternium-51
Xanthan gum~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Bht~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Bht
Disodium edta~0.15–0.3%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Sodium metabisulfite~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Sodium metabisulfite
Chlorphenesin~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Chlorphenesin
Potassium sorbate~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Water, Caprylic/capric triglyceride, Ppg-15 stearyl ether, C12-20 acid peg-8 ester, Glycerin, Niacinamide, Phenyl trimethicone, Caprylic/capric/myristic/stearic triglyceride, Algae extract, Dimethicone, Hydroxyethyl urea, Cetyl alcohol, Retinol, Sigesbeckia orientalis extract, Mangifera indica seed butter, Coffea arabica seed oil, Sodium hyaluronate, Caffeine, Ascorbic acid, Urea, Butylene glycol, Squalane, Trehalose, Triticum vulgare germ extract, Tocopheryl acetate, Peg-100 stearate, Linoleic acid, Glyceryl stearate, Hordeum vulgare extract, Acetyl hexapeptide-8, Sorbitol, Potassium cetyl phosphate, Acrylates/c10-30 alkyl acrylate crosspolymer, Tocopherol, Ammonium acryloyldimethyltaurate/vp copolymer, Behenyl alcohol, Sodium pca, Sodium hydroxide, Caprylyl glycol, Carbomer, Triacetin, Polyquaternium-51, Xanthan gum, Bht, Disodium edta, Sodium metabisulfite, Chlorphenesin, Potassium sorbate, Phenoxyethanol

Compare prices

Retailers ranked by price — lowest first.

Sephora
$73.00
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Bluemercury
$79.00
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Amazon US
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
CliniqueSmart Night™ Clinical MD Multi-Dimensional Repair Treatment RetinolYOUR PRODUCTThe Purest SolutionsYouth Radiant Renewal Retinol SerumNo7Pure Retinol 1% Night ConcentrateREMEDY SCIENCEREMEDY for healthy aging
Match—73%71%70%
Price$73.00$6.63−$66.37$42.99−$30.01$35.00−$38.00
Shared key ingredients—8 of 195 of 198 of 19
Key difference—3-O-Ethyl Ascorbic AcidAcetyl Dipeptide-1 Cetyl EsterRetinal
Irritancy Medium Medium Medium Medium
Drying alcohol— Contains drying alcohol ——
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  • matches yours
  • differs
  • cheaper

More alternatives: SKIN&LAB Vitamin C Brightening SerumKiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide

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Product summary

"Clinique - Smart Night™ Clinical MD Multi-Dimensional Repair Treatment Retinol" is effective for: Anti-aging, Moisturizing, Anti-blemish, Evens skin tone and Exfoliation

Ingredient callouts

  • A good concentration of Niacinamide (2.00% - 2.40%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.35% - 0.65%) it cannot have a noticeable benefit for the skin.
  • This product contains an effective form of Retinoids (vitamin A): retinol 0.50% - 0.75%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
  • Peptides (acetyl hexapeptide-8 0.25% - 0.50%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
  • Humectants (hydroxyethyl urea 0.70% - 1.05%, urea 0.30% - 0.60%, trehalose 0.30% - 0.50%, sodium pca 0.25% - 0.50%, sodium hyaluronate 0.45% - 0.65%, glycerin 2.50% - 3.00%, algae extract 1.30% - 1.60% and acetyl hexapeptide-8 0.25% - 0.50%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails from 73.00$ up to 79.00$ in the United States and for 90.00CA$ in Canada.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.

  1. 1
    Final report on the safety assessment of PPG-11 and PPG-15 stearyl ethersncbi.nlm.nih.gov
  2. 2
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  3. 3
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  4. 4
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  5. 5
    Amended Safety Assessment of Triglycerides as Used in Cosmeticir-safety.org
  6. 6
    Dimethicone as a protective ingredient in topical medicationsjaad.org
Clinique Smart Night™ Clinical MD Multi-Dimensional Repair Treatment Retinol
CliniqueSmart Night™ Clinical MD Multi-Dimensional Repair Treatment Retinol
Buy at Sephora$73.00Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Sephora$73.00Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.