ADVANCED CLINICALS

ADVANCED CLINICALS Hyaluronic Gel Face Cream

Name: ADVANCED CLINICALS - Hyaluronic Gel Face Cream
Brand: ADVANCED CLINICALS

Efficacy75/100IrritancyHigh

See all ingredients

Works for

Moisturizing

Dimethicone, Glycerin + 9 more

Works

What the product description says

“Hyaluronic Gel Face Cream”

Source: Advanced Clinicals

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: dipotassium glycyrrhizate, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus extract.

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~3.7–5.5%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~2.6–4%

Pyrus malus fruit extractKey activeEffect: MediumCan have some moisturizing properties due to its sugar content~2–3%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~1.4–2.2%

Dipotassium glycyrrhizateKey active· HumectantEffect: HighA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~1–1.5%

Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.4–0.95%

CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.35–0.8%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.85–1.25%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.1–0.35%

Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.3–1.9%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.5%

Can it cause trouble?

Irritancy

3 strong irritants: Rosmarinus officinalis leaf extract, Cymbopogon martini oil + 1 more — patch-test recommended

High risk

We flagged 13 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.4–0.9%est.

Cymbopogon martini oilAromatic plant oil used in cosmetics as a fragrance. A likely irritantHigh~0.35–0.8%est.

Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.15–0.65%est.

Rosa centifolia flower extractContains essential oil. Can be irritatingHigh~0.15–0.55%est.

Pyrus malus fruit extractCan have some moisturizing properties due to its sugar contentMedium~2–3%est.

Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1.3–1.9%est.

Sea saltUsed to thicken the product formulation and might help to add minerals to the surface of the skin. It is used in scrubs as a physical exfoliant. Can increase sensitivity to other ingredients if left on the skin or used in high concentrationMedium~0.3–0.7%est.

CarrageenanHelps thicken the product formula and create a nice product formulationMedium~0.3–0.7%est.

Vaccinium angustifolium fruit extractA plant extract tha can have anti-oxidant properties, but evidence of effectiveness in skin is lackingMedium~0.15–0.65%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.1–0.35%est.

EthylhexylglycerinA preservativeMedium~0.05–0.25%est.

Hexylene glycolHelps create a more spreadable product textureMedium~0.05–0.15%est.

Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.01–0.05%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

CarrageenanHelps thicken the product formula and create a nice product formulation3/5~0.3–0.7%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%

Formula

Irritation risk: Low

Plain old water

More about Water

Propanediol~4.3–6.5%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Dimethicone~3.7–5.5%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Glycerin~2.6–4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Pyrus malus fruit extract~2–3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidation

Can have some moisturizing properties due to its sugar content

More about Pyrus malus fruit extract

Ammonium acryloyldimethyltaurate/vp copolymer~1.7–2.5%

Formula

Irritation risk: Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer

Sodium hyaluronate~1.4–2.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Aloe barbadensis leaf juice~1.3–1.9%

Irritant · medium

Irritation risk: Medium

Works for

MoisturizingAntibacterialReduces irritationReduces rednessAnti-inflammatoryAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice

Dipotassium glycyrrhizate~1–1.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate

Butylene glycol~0.85–1.25%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Caulerpa lentillifera extract~0.55–1.3%

Formula

Irritation risk: Low

More about Caulerpa lentillifera extract

Oryza sativa bran extract~0.45–1%

Formula

Irritation risk: Low

Used to thicken the product consistency

More about Oryza sativa bran extract

Rosmarinus officinalis leaf extract~0.4–0.9%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Helianthus annuus extract~0.4–0.95%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract

Cymbopogon martini oil~0.35–0.8%

Irritant · high

Irritation risk: High

Aromatic plant oil used in cosmetics as a fragrance. A likely irritant

More about Cymbopogon martini oil

Cyanocobalamin~0.35–0.8%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizing

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin

Hydroxyethylcellulose~0.35–0.8%

Formula

Irritation risk: Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose

Sea salt~0.3–0.7%

Irritant · medium

Irritation risk: Medium

Works for

Exfoliation

Used to thicken the product formulation and might help to add minerals to the surface of the skin. It is used in scrubs as a physical exfoliant. Can increase sensitivity to other ingredients if left on the skin or used in high concentration

More about Sea salt

Carrageenan~0.3–0.7%

Comedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Helps thicken the product formula and create a nice product formulation

More about Carrageenan

Vaccinium angustifolium fruit extract~0.15–0.65%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract tha can have anti-oxidant properties, but evidence of effectiveness in skin is lacking

More about Vaccinium angustifolium fruit extract

Ascorbic acid~0.15–0.65%

Irritant · high

Irritation risk: High

Works for

Anti-agingEvens skin toneAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid

Polysorbate 20~0.15–0.65%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Rosa centifolia flower extract~0.15–0.55%

Irritant · high

Irritation risk: High

Contains essential oil. Can be irritating

More about Rosa centifolia flower extract

Phenoxyethanol~0.15–0.5%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Tocopherol~0.1–0.5%

Formula

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Maltodextrin~0.1–0.4%

Formula

Irritation risk: Low

Works for

Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin

Tetrasodium glutamate diacetate~0.1–0.3%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate

Caprylyl glycol~0.1–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Ethylhexylglycerin~0.05–0.25%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Sodium hydroxide~0.05–0.2%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Hexylene glycol~0.05–0.15%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol

Citric acid~0.01–0.05%

Irritant · medium

Irritation risk: Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid

Ingredient list view

Water, Propanediol, Dimethicone, Glycerin, Pyrus malus fruit extract, Ammonium acryloyldimethyltaurate/vp copolymer, Sodium hyaluronate, Aloe barbadensis leaf juice, Dipotassium glycyrrhizate, Butylene glycol, Caulerpa lentillifera extract, Oryza sativa bran extract, Rosmarinus officinalis leaf extract, Helianthus annuus extract, Cymbopogon martini oil, Cyanocobalamin, Hydroxyethylcellulose, Sea salt, Carrageenan, Vaccinium angustifolium fruit extract, Ascorbic acid, Polysorbate 20, Rosa centifolia flower extract, Phenoxyethanol, Tocopherol, Maltodextrin, Tetrasodium glutamate diacetate, Caprylyl glycol, Ethylhexylglycerin, Sodium hydroxide, Hexylene glycol, Citric acid

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$12.99

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	ADVANCED CLINICALSHyaluronic Gel Face CreamYOUR PRODUCT	ElastaliftVegan collagen instant plumping gel	Temple SpaTRUFFLE DE-LIGHT	RéViveHydrogel Moisturizer / Hyaluronic Acid Water Cream
Match	—	46%	43%	43%
Price	$12.99	—	$140.37+$127.38	$136.50+$123.51
Shared key ingredients	—	5 of 7	3 of 7	3 of 7
Key difference	—	Palmitoyl Tripeptide-1	Ceramide Np	Niacinamide
Irritancy	High	High	Medium	Medium
Drying alcohol	—	—	Contains drying alcohol	—
	View product	Shop	Shop	Shop

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 16 studies and safety reviews.

1
Dimethicone as a protective ingredient in topical medicationsjaad.org
2
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
3
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
4
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
5
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
6
Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent modelresearchgate.net
7
Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.ncbi.nlm.nih.gov
8
Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gelpubmed.ncbi.nlm.nih.gov
9
Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmeticsjournals.sagepub.com
10
Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responsesliebertpub.com
11
Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trialpubmed.ncbi.nlm.nih.gov
12
Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasisncbi.nlm.nih.gov
13
Anti-Inflammatory and Neuroactive Properties of Selected Fruit Extractsliebertpub.com
14
https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_073_annex1.pdfec.europa.eu
15
Vitamin E in dermatologyncbi.nlm.nih.gov
16
Vitamin E and Skin Healthlpi.oregonstate.edu

ADVANCED CLINICALSHyaluronic Gel Face Cream

Buy at Advanced Clinicals$12.99 Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Advanced Clinicals$12.99 Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.