ZO Skin Health Hydrating Creme

ZO Skin Health Hydrating Creme

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
12 ingredients credited for this claim
Strong support
What the product description says
“Hydrating Creme”
Source: Zo Skin Health

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, butylene glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, cetyl alcohol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: colloidal oatmeal, petrolatum, tetrapeptide-21

Colloidal oatmealHero· EmollientEffect: HighHelps to restore skin barrier function, soften the upper layer of the skin and calm down inflammation~1.2–1.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.9–5.8%
PetrolatumHero· Emollient, OcclusiveEffect: HighOne of the most effective and the most studied occlusive ingredients that creates a protective layer on top of the skin preventing moisture loss~3.7–5.6%
Tetrapeptide-21HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.3–0.75%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.3–2%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~1.7–2.5%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.4–2.1%
Isopropyl palmitate· EmollientEffect: LowHelps soften the upper layer of the skin and create a thicker product consistency~2–2.9%
Ophiopogon japonicus root extractEffect: LowPlant extract that might help neutralize free radicals and support skin barrier function, but research on its effectiveness in skin is lacking~0.6–1.4%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.05–0.25%
Dipotassium glycyrrhizateUnder-dosedEffect: HighA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.1–0.45%
Anti-aging
Not advertised by the brand · 5 ingredients credited for this claim
Moderate support

This product contains retinyl palmitate, tetrapeptide-21. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.4–0.95%
Tetrapeptide-21Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.3–0.75%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.3–2%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.4–0.9%
Evens skin tone
Not advertised by the brand · 3 ingredients credited for this claim
Moderate support

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: retinyl palmitate.

Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.4–0.95%
Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.4–0.9%
Dipotassium glycyrrhizateEffect: Low, below effective doseA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.1–0.45%

Can it cause trouble?

Irritancy
1 strong irritant: Retinyl palmitate
Medium risk
We flagged 7 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.4–0.95%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.4–0.9%est.
Benzalkonium chlorideHelps water and oil mix together and works as a cleansing agent (detergent). Also used as a preservative. Can be irritatingHigh~0.05–0.1%est.
Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.05–0.15%est.
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistencyMedium~2–2.9%est.
Ophiopogon japonicus root extractPlant extract that might help neutralize free radicals and support skin barrier function, but research on its effectiveness in skin is lackingMedium~0.6–1.4%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.5–1.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistency3/5~2–2.9%est.
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~1.3–2%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~3.9–5.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Petrolatum~3.7–5.6%
Hero · Moisturizing
Irritation risk
Low
Works for
Moisturizing

One of the most effective and the most studied occlusive ingredients that creates a protective layer on top of the skin preventing moisture loss

More about Petrolatum
Distearyldimonium chloride~2.7–4%
Formula
Isopropyl palmitate~2–2.9%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Helps soften the upper layer of the skin and create a thicker product consistency

More about Isopropyl palmitate
Cyclopentasiloxane~1.7–2.5%
Key active
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Cetyl alcohol~1.4–2.1%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Butyrospermum parkii butter~1.3–2%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Colloidal oatmeal~1.2–1.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationAnti-oxidation

Helps to restore skin barrier function, soften the upper layer of the skin and calm down inflammation

More about Colloidal oatmeal
Ophiopogon japonicus root extract~0.6–1.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizing

Plant extract that might help neutralize free radicals and support skin barrier function, but research on its effectiveness in skin is lacking

More about Ophiopogon japonicus root extract
Tocopheryl acetate~0.5–1.2%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Retinyl palmitate~0.4–0.95%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-agingAnti-blemishEvens skin toneExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Ascorbic acid~0.4–0.9%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Beta-glucan~0.3–0.75%
Key active
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatoryAnti-blemishAnti-oxidationAnti-aging

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan
Tetrapeptide-21~0.2–0.75%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tetrapeptide-21
Myristoyl pentapeptide-11~0.15–0.6%
Formula
Polymethyl methacrylate~0.15–0.6%
Formula
Irritation risk
Low

Is used to enhance product texture and can help to optically mask skin imperfections

More about Polymethyl methacrylate
Dipotassium glycyrrhizate~0.1–0.45%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate
Maltodextrin~0.1–0.35%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Benzalkonium chloride~0.05–0.1%
Irritant · high
Irritation risk
High
Works for
Cleansing

Helps water and oil mix together and works as a cleansing agent (detergent). Also used as a preservative. Can be irritating

More about Benzalkonium chloride
Butylene glycol~0.05–0.25%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Sodium chloride~0.05–0.2%
Formula
Irritation risk
Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride
Benzyl alcohol~0.05–0.15%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Ingredient list view

Water, Glycerin, Petrolatum, Distearyldimonium chloride, Isopropyl palmitate, Cyclopentasiloxane, Cetyl alcohol, Butyrospermum parkii butter, Colloidal oatmeal, Ophiopogon japonicus root extract, Tocopheryl acetate, Retinyl palmitate, Ascorbic acid, Beta-glucan, Tetrapeptide-21, Myristoyl pentapeptide-11, Polymethyl methacrylate, Dipotassium glycyrrhizate, Maltodextrin, Benzalkonium chloride, Butylene glycol, Sodium chloride, Benzyl alcohol

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Amazon USPrice as of 10/13/2026 09:36 GMT
$123.23
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Zo Skin Health
$125.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ZO Skin HealthHydrating CremeYOUR PRODUCTAveenoBaby Soothing Relief Emollient Cream
Match—52%
Price$118.97$5.62−$113.35
Shared key ingredients—3 of 8
Key difference—Oatmeal Extract
Irritancy Medium Low
Drying alcohol——
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Product summary

"ZO Skin Health - Hydrating Creme" is effective for: Anti-inflammatory and Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.40% - 0.90%) it cannot have a noticeable benefit for the skin.
  • This product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.40% - 0.95%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • Peptides (tetrapeptide-21 0.20% - 0.75%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
  • Humectants (glycerin 3.90% - 5.80%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 89.99£ in the United Kingdom and for 125.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 16 studies and safety reviews.

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