Works for:
based on ingredients and %- Exfoliation
- Evens skin tone
- Moisturizing
- Anti-aging
Can it cause trouble?
- Irritation risk: medium
- Comedogenic risk ingredients: 2
Key actives
Product Summary
"YEOUTH - Day Night Age-Defying Duo: Retinol Serum + Day/Night Cream" is effective for: Anti-blemish, Exfoliation, Evens skin tone, Moisturizing and Anti-aging
Ingredient callouts
- this product contains an effective form of Retinoids (vitamin A): retinol 4.20% - 5.10%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
- Peptides (palmitoyl tripeptide-38 0.05% - 0.15%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Humectants (glycine 0.20% - 0.35%, sodium hyaluronate 0.20% - 0.40%, snail secretion filtrate 0.20% - 0.35%, glycerin 0.35% - 0.65% and sodium hyaluronate 1.70% - 2.10%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 42.90$ in the United States.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
Day Night Age-Defying Duo Retinol Serum + Day/Night Cream
Source: From product name
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: palmitoyl tripeptide-38.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-blemish
This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-oxidation
This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Plant extract that might have some anti-oxidant properties. Can be irritating
A fruit extract that might have some anti-oxidant properties but evidence of effectiveness in skin is lacking
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties
A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating
Evens skin tone
What does the product description say?
This serum is designed to improve the appearance of fine lines, wrinkles, and uneven skin tone.
Source: Yeouth
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Exfoliation
What does the product description say?
oz) , Rejuvenating serum that gently exfoliates the skin to reveal new skin that is visibly smoother, firmer, and less prone to breakouts. Day/Night Cream (4 fl. oz.)
Source: Yeouth
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Moisturizing
What does the product description say?
YEOUTH Day/Night Cream is a rich and luxurious moisturizer that is designed to hydrate and nourish your skin around the clock.
Source: Yeouth
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, glycine.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, oryza sativa bran oil.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-38
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Typically contains hyaluronic acid that helps attract water to the upper layer of the skin. Might contain allantoin that is helpful in calming down inflammation. There is no evidence that it can have any further benefits for the skin, especially when used in skincare products
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Helps soften the upper layer of the skin and might have some anti-oxidant properties
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
Helps to soften the upper layer of the skin without creating a greasy texture
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
Helps attract water to the upper layer of the skin and improves the product texture
Used to stabilize product formulations and help soften the upper layer of the skin
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Helps oil and water mix together and works as an emollient
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Exfoliation | |
| Moisturizing | |
| Evens skin tone |
Total Promises Fulfilled score: 100/100.
We receive a small commission for purchases made through these links at no cost for you. Thank you for your support! Learn more
Potential irritants
Comedogenic ingredients
User reviews (0)
Averages from community submissions.
No reviews yet for this product.
Be the first to share your experience!
Tried this product?
Help capture what the ingredient list can't—texture, finish, pilling, scent, and more. Answer what you can, skip the rest.
Takes ~30 seconds.
Reviews are shown in aggregate. No personal details.
| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 YEOUTH Day Night Age-Defying Duo: Retinol Serum + Day/Night Cream | Current | $42.90 | |
 Dr Dennis Gross Advanced Retinol + Ferulic Triple Correction Serum | 77% | $70.00 | |
 Augustinus Bader Mini The Retinol Serum | 76% | $180.00 | |
 No7 Pure Retinol 1% Night Concentrate | 76% | $37.95 | |
 NourishMax VITAMIN C + B + E + FERULIC & RETINOL SERUM | 76% | $49.00 | |
 PCA SKIN Intensive Age Refining Treatment 0.5 Percent Pure Retinol Night | 75% | $101.00 |
Key Actives
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Helps attract water to the upper layer of the skin and can help improve skin barrier function
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
Typically contains hyaluronic acid that helps attract water to the upper layer of the skin. Might contain allantoin that is helpful in calming down inflammation. There is no evidence that it can have any further benefits for the skin, especially when used in skincare products
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Helps soften the upper layer of the skin and might have some anti-oxidant properties
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Potential irritants
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skin
Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating
Plant extract that might have some anti-oxidant properties. Can be irritating
A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating
Can work as an exfoliant but is typically used to adjust the product pH
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Typically contains hyaluronic acid that helps attract water to the upper layer of the skin. Might contain allantoin that is helpful in calming down inflammation. There is no evidence that it can have any further benefits for the skin, especially when used in skincare products
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
Helps thicken the product formula and create a nice product formulation
Used to improve product texture and help oil and water mix together
Used to stabilize product formulations and help soften the upper layer of the skin
A fruit extract that might have some anti-oxidant properties but evidence of effectiveness in skin is lacking
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Comedogenic ingredients
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps thicken the product formula and create a nice product formulation
All ingredients
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A preservative. It helps prevent bacterial growth in cosmetic products
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Used to thicken product formulations and create gel-like textures
Can work as an exfoliant but is typically used to adjust the product pH
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps to soften the upper layer of the skin without creating a greasy texture
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
A preservative. It helps prevent bacterial growth in cosmetic products
Typically contains hyaluronic acid that helps attract water to the upper layer of the skin. Might contain allantoin that is helpful in calming down inflammation. There is no evidence that it can have any further benefits for the skin, especially when used in skincare products
Helps soften the upper layer of the skin and might have some anti-oxidant properties
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
Helps thicken the product formula and create a nice product formulation
Used to improve product texture and help oil and water mix together
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
Helps attract water to the upper layer of the skin and improves the product texture
Used to stabilize product formulations and help soften the upper layer of the skin
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties
A plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skin
A fruit extract that might have some anti-oxidant properties but evidence of effectiveness in skin is lacking
Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Plant extract that might have some anti-oxidant properties. Can be irritating
A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Ingredient list view
Water, Butylene glycol, Retinol, Polysorbate 20, Phenoxyethanol, Sodium hyaluronate, Hydroxyethylcellulose, Potassium sorbate, Sodium benzoate, Citric acid, Tocopheryl acetate, Aloe barbadensis leaf juice powder, Water, Glycerin, Caprylic/capric triglyceride, Butylene glycol, Cetearyl alcohol, Coco-caprylate/caprate, Glyceryl stearate, Dimethicone, Stearic acid, Phenoxyethanol, Snail secretion filtrate, Cetearyl olivate, Sorbitan olivate, Oryza sativa bran oil, Simmondsia chinensis seed oil, Panthenol, Ethylhexylglycerin, Carbomer, Carrageenan, Sodium hydroxide, Polyacrylamide, Bis(tripeptide-1) copper acetate, C13-14 isoparaffin, Glycine, Sorbitol, Disodium edta, Laureth-7, Hydroxypropyl cyclodextrin, Sodium hyaluronate, Camellia sinensis leaf extract, Avena sativa kernel extract, Arnica montana flower extract, Rubus idaeus fruit extract, Chamomilla recutita flower extract, Centella asiatica extract, Echinacea purpurea extract, Panax ginseng root extract, Palmitoyl tripeptide-38, Glycine soja extract
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Glycerol and the skin: holistic approach to its origin and functions
- Safety Assessment of Alkyl Esters as Used in Cosmetics
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- The Effects of Filtrate of the Secretion of the Cryptomphalus Aspersa on Photoaged Skin
- The Effects of Snail Secretion Filtrate on the damaged skin barrier's recovery of the Atopic dermatitis
- Study on the Composition of Rice Bran Oil and Its Higher Free Fatty Acids Value
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Safety Assessment of Isoparaffins as Used in Cosmetics
- Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiency
- Functional glycine receptor in cultured human keratinocytes
- Effects of Topical Arnica Gel on Post-Laser Treatment Bruises
- Effects of microcurrent application alone or in combination with topical Hypericum perforatum L. and Arnica montana L. on surgically induced wound healing in Wistar rats
- The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.)
- Accelerated resolution of laser‐induced bruising with topical 20% arnica: a rater‐blinded randomized controlled trial
- Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model
- Centella asiatica in cosmetology
- Triterpene Composition and Bioactivities of Centella asiatica
- Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts
- Assessment report on Centella asiatica (L.) Urban, herba
- Contact dermatitis due to Madecassol
- The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
- Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – Part 2: Echinacea purpurea–Lavandula angustifolia
- Ginseng in Dermatology: A Review
- Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin