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Synergie Skin DermaCalm
Synergie Skin

Synergie Skin DermaCalm

Efficacy87/100IrritancyMedium
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Works for

Moisturizing
Acetyl hexapeptide-49, Squalane + 14 more
Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, hydrolyzed algin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, simmondsia chinensis seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-49

Acetyl hexapeptide-49HeroEffect: High~0.55–0.85%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~5.4–6.6%
SqualeneKey active· Emollient, OcclusiveEffect: HighAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~4.4–5.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.1–3.8%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~2.4–2.9%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~2.1–2.5%
Macadamia integrifolia seed oilKey active· EmollientEffect: MediumA plant oil that helps soften the upper layer of the skin~1.7–2.1%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.95–1.2%
Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.5–0.75%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.45–0.7%
Hydrolyzed alginKey active· HumectantEffect: MediumDerived from brown algae. Helps attract water to the upper layer of the skin~0.15–0.3%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.2–1.5%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.55–0.85%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.65–1%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.8%
AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.15–0.3%
Anti-aging
Acetyl hexapeptide-49, Beta-glucan + 2 more
May help
What the product description says
“Acetyl tetrapeptide 40 A revoluntionary new peptide that decreases the appearance of facial redness and visible fine blood vessels, whilst also providing protection against UV induced cell damage and inflammation.Acetyl hexpeptide 49 A peptide that reduces the activity of inflammatory markers in skin cells, reducing the sensation of itch and the discomfort of heat.Hydrolysed algin Rebuilds the epidermal skin by stimulating the activity of epidermal stem cells to rapidly restore and recontruct skin tissue.Squalane Promotes barrier repair, exhibits superior moisturisation and emollience, and enhances the penetration of active ingredients.”
Source: N/A

This product contains acetyl hexapeptide-49. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Acetyl hexapeptide-49Key activeEffect: Medium~0.55–0.85%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.5–0.75%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.65–1%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.8%
Anti-oxidation
Side benefit · Squalene, Epilobium angustifolium flower/leaf/stem extract + 5 more
May help

This product contains antioxidants (epilobium angustifolium flower/leaf/stem extract, squalene) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

SqualeneKey activeEffect: MediumAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~4.4–5.4%
Epilobium angustifolium flower/leaf/stem extractKey activeEffect: MediumA plant extract that might contain antioxidants~0.15–0.25%
BisabololEffect: LowAn active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties~1–1.2%
Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.5–0.75%
Hippophae rhamnoides fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking~0.45–0.7%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.05–0.15%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.8%

Can it cause trouble?

Irritancy
1 strong irritant: Rosmarinus officinalis leaf extract
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Epilobium angustifolium flower/leaf/stem extractA plant extract that might contain antioxidantsHigh~0.15–0.25%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.05–0.15%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~2.1–2.5%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.65–1%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.55–0.85%est.
Hippophae rhamnoides fruit extractA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lackingMedium~0.45–0.7%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~0.45–0.65%est.
Potassium sorbateA preservativeMedium~0.3–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.1–0.2%est.
Comedogenic
4 ingredients rated 2 or more on the 0–5 pore-clogging scale
4 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Hydrolyzed alginDerived from brown algae. Helps attract water to the upper layer of the skin3/5~0.15–0.3%est.
SqualeneAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast2/5~4.4–5.4%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.95–1.2%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~0.45–0.65%est.
Alternatives
The closest match we found
Emulsion Gel Sensible S.R
Biologique Recherche Emulsion Gel Sensible S.R
Closest match50% match
$195.88
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Squalane~5.4–6.6%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Squalene~4.4–5.4%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
MoisturizingAnti-oxidation

An oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast

More about Squalene
Glycerin~3.1–3.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetyl alcohol~2.4–2.9%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Simmondsia chinensis seed oil~2.1–2.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Macadamia integrifolia seed oil~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

A plant oil that helps soften the upper layer of the skin

More about Macadamia integrifolia seed oil
Hydrolyzed tomato skin~1.5–1.8%
Formula
Irritation risk
Low
More about Hydrolyzed tomato skin
Butylene glycol~1.2–1.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Bisabolol~1–1.2%
Formula
Irritation risk
Low
Works for
Anti-inflammatoryReduces irritationAnti-oxidation

An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties

More about Bisabolol
Cetearyl alcohol~0.95–1.2%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Aloe barbadensis leaf juice~0.65–1%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAntibacterialAnti-inflammatoryReduces rednessReduces irritationAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Acetyl tetrapeptide-40~0.6–0.9%
Formula
Irritation risk
Low
More about Acetyl tetrapeptide-40
Acetyl hexapeptide-49~0.55–0.85%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Acetyl hexapeptide-49
Tocopherol~0.55–0.8%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingMoisturizingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Caprylyl glycol~0.55–0.85%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Beta-glucan~0.5–0.75%
Key active
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatoryAnti-blemishAnti-oxidationAnti-aging

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan
Hippophae rhamnoides fruit extract~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking

More about Hippophae rhamnoides fruit extract
Helianthus annuus seed oil~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Ceteareth-20~0.45–0.65%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Potassium sorbate~0.3–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Avena sativa kernel meal~0.35–0.6%
Formula
Irritation risk
Low
More about Avena sativa kernel meal
Xanthan gum~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Allantoin~0.15–0.3%
Under-dosed
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Hydrolyzed algin~0.15–0.3%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

Derived from brown algae. Helps attract water to the upper layer of the skin

More about Hydrolyzed algin
Epilobium angustifolium flower/leaf/stem extract~0.15–0.25%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-oxidation

A plant extract that might contain antioxidants

More about Epilobium angustifolium flower/leaf/stem extract
Citric acid~0.1–0.2%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Rosmarinus officinalis leaf extract~0.05–0.15%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Sodium benzoate~0.1–0.15%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Ingredient list view

Water, Squalane, Squalene, Glycerin, Cetyl alcohol, Simmondsia chinensis seed oil, Macadamia integrifolia seed oil, Hydrolyzed tomato skin, Butylene glycol, Bisabolol, Cetearyl alcohol, Aloe barbadensis leaf juice, Acetyl tetrapeptide-40, Acetyl hexapeptide-49, Tocopherol, Caprylyl glycol, Beta-glucan, Hippophae rhamnoides fruit extract, Helianthus annuus seed oil, Ceteareth-20, Potassium sorbate, Avena sativa kernel meal, Xanthan gum, Allantoin, Hydrolyzed algin, Epilobium angustifolium flower/leaf/stem extract, Citric acid, Rosmarinus officinalis leaf extract, Sodium benzoate

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Synergie SkinDermaCalmYOUR PRODUCTBiologique RechercheEmulsion Gel Sensible S.RAmazon BeleiUltra Sensitive Clarifying TonerSarah Chapman LondonSerum & Treatment Skinesis Ultra Recovery Booster
Match—50%49%47%
Price—$195.88——
Shared key ingredients—4 of 112 of 113 of 11
Key difference—Alteromonas Ferment ExtractPanthenolAlpha-Glucan Oligosaccharide
Irritancy Medium Medium Low Medium
Drying alcohol————
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Product summary

"Synergie Skin - DermaCalm" is effective for: Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (acetyl hexapeptide-49 0.55% - 0.85%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
  • Humectants (glycerin 3.10% - 3.80%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 27 studies and safety reviews.

  1. 1
    Squalene and its potential clinical useseuropepmc.org
  2. 2
    Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology mdpi.com
  3. 3
    Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxidesonlinelibrary.wiley.com
  4. 4
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  5. 5
    Fatty acids profile of oil from nine varieties of Macadamia nuttandfonline.com
  6. 6
    α-(-)-Bisabolol Reduces Pro-Inflammatory Cytokine Production and Ameliorates Skin Inflammationresearchgate.net
Synergie Skin DermaCalm
Synergie SkinDermaCalm
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As an Amazon Associate, WIMJ earns from qualifying purchases.