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skincode-Swiss Cellular Night Refine & Repair
skincode-Swiss

skincode-Swiss Cellular Night Refine & Repair

Efficacy75/100IrritancyHigh
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Works for

3 of 4 advertised claims delivered

Moisturizing
Hexanoyl dipeptide-3 norleucine acetate, Urea + 16 more
Strong evidence
What the product description says
“-Refines, repairs, and deeply moisturizes the skin.”
Source: Skincode

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: hexanoyl dipeptide-3 norleucine acetate, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, urea

Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.3–0.5%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.55%
Hexanoyl dipeptide-3 norleucine acetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Peg/ppg-18/18 dimethiconeKey activeEffect: HighA silicone that mixes with water creating nice light-weight product texture~1–1.2%
Saccharum officinarum extractKey activeEffect: HighSugar extract that helps attract water to the upper layer of the skin~0.35–0.6%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.65%
UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~2.7–3.4%
Phenyl trimethiconeKey active· OcclusiveEffect: HighA type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture~1.6–2%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~6.7–8.2%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.4–0.6%
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineHeroEffect: High~0.7–1.05%
C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~1.9–2.3%
Coco-caprylate/caprateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin without creating a greasy texture~2.3–2.9%
Tribehenin· EmollientEffect: LowUsed to create a thicker product consistency and soften the upper layer of the skin~3.7–4.5%
Butyrospermum parkii butterUnder-dosedEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.55–0.85%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.3–0.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–0.65%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.35–0.65%
Evens skin tone
Retinyl palmitate
Moderate evidence
What the product description says
“-Stimulates cellular regeneration and helps reduce pigmentation marks.”
Source: Skincode

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: retinyl palmitate.

Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.25–0.5%
Anti-aging
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Retinyl palmitate + 3 more
Moderate evidence
What the product description says
“-Powered by anti-aging ingredients that help restore youthful appearance.”
Source: Skincode

This product contains hexanoyl dipeptide-3 norleucine acetate, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, retinyl palmitate. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineKey activeEffect: Medium~0.7–1.05%
Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.25–0.5%
Hexanoyl dipeptide-3 norleucine acetateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Butyrospermum parkii butterEffect: Low, below effective doseA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.55–0.85%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–0.65%
Exfoliation
Urea, Retinyl palmitate
Limited evidence
What the product description says
“-Gently exfoliates and resurfaces the skin overnight.”
Source: Skincode

This product might help exfoliate the skin with urea, retinyl palmitate, but These ingredients is not the most effective.

UreaKey activeEffect: MediumNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~2.7–3.4%
Retinyl palmitateEffect: LowThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.25–0.5%

Can it cause trouble?

Irritancy
5 strong irritants: Retinyl palmitate, Citrus aurantium dulcis fruit extract + 3 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.25–0.5%est.
Citrus aurantium dulcis fruit extractA plant extract that is used as a fragrance. Can be irritating and lead to photosensitivityHigh~0.25–0.5%est.
Citrus limon fruit extractUsed as a fragrance. Can be irritating and cause photosensitivityHigh~0.25–0.5%est.
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.25–0.45%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.2%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.5–0.7%est.
Vaccinium myrtillus fruit extractA plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lackingMedium~0.4–0.6%est.
Acer saccharum extractA plant extract that contains small percentage of AHAs. Is unlikely to have any skin benefit due the small concentration of the active compoundsMedium~0.3–0.5%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.3–0.5%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.3–0.6%est.
Potassium sorbateA preservativeMedium~0.15–0.25%est.
Disodium edtaStabilizes the product formulationMedium~0.05–0.1%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.55–0.85%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.3–0.5%est.
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Alternatives
Cheaper, or higher on efficacy
Hydro-Dynamic Ultimate Moisture Moisturiser
Murad Hydro-Dynamic Ultimate Moisture Moisturiser
Higher efficacy · 87/10051% match
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Dimethicone~6.7–8.2%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
C12-13 alkyl lactate~5.2–6.3%
Formula
Irritation risk
Low
More about C12-13 alkyl lactate
Tribehenin~3.7–4.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product consistency and soften the upper layer of the skin

More about Tribehenin
Urea~2.7–3.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Coco-caprylate/caprate~2.3–2.9%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin without creating a greasy texture

More about Coco-caprylate/caprate
C12-15 alkyl benzoate~1.9–2.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate
Phenyl trimethicone~1.6–2%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture

More about Phenyl trimethicone
Sodium chloride~1.4–1.7%
Formula
Irritation risk
Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride
Peg/ppg-18/18 dimethicone~1–1.2%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A silicone that mixes with water creating nice light-weight product texture

More about Peg/ppg-18/18 dimethicone
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~0.7–1.05%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine
Palmitoyl dipeptide-5 diaminohydroxybutyrate~0.55–0.85%
Formula
Irritation risk
Low
More about Palmitoyl dipeptide-5 diaminohydroxybutyrate
Butyrospermum parkii butter~0.55–0.85%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-agingAnti-oxidation

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Tocopheryl acetate~0.5–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Tocopherol~0.45–0.65%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Sodium hyaluronate~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Vaccinium myrtillus fruit extract~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking

More about Vaccinium myrtillus fruit extract
Saccharum officinarum extract~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Sugar extract that helps attract water to the upper layer of the skin

More about Saccharum officinarum extract
Glycerin~0.4–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Lecithin~0.35–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Retinyl palmitate~0.25–0.5%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Acer saccharum extract~0.3–0.5%
Irritant · medium
Irritation risk
Medium

A plant extract that contains small percentage of AHAs. Is unlikely to have any skin benefit due the small concentration of the active compounds

More about Acer saccharum extract
Helianthus annuus seed oil~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Hexanoyl dipeptide-3 norleucine acetate~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexanoyl dipeptide-3 norleucine acetate
Citrus aurantium dulcis fruit extract~0.25–0.5%
Irritant · high
Irritation risk
High

A plant extract that is used as a fragrance. Can be irritating and lead to photosensitivity

More about Citrus aurantium dulcis fruit extract
Citrus limon fruit extract~0.25–0.5%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating and cause photosensitivity

More about Citrus limon fruit extract
Glycine soja oil~0.3–0.5%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Caprylic/capric triglyceride~0.3–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Alcohol~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Polysorbate 80~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Polysorbate 80
Soy isoflavones~0.2–0.35%
Formula
Irritation risk
Low
More about Soy isoflavones
Sodium benzoate~0.15–0.3%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Parfum~0.1–0.2%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Potassium sorbate~0.15–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Disodium edta~0.05–0.1%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Ingredient list view

Water, Dimethicone, C12-13 alkyl lactate, Tribehenin, Urea, Coco-caprylate/caprate, C12-15 alkyl benzoate, Phenyl trimethicone, Sodium chloride, Peg/ppg-18/18 dimethicone, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Palmitoyl dipeptide-5 diaminohydroxybutyrate, Butyrospermum parkii butter, Tocopheryl acetate, Tocopherol, Sodium hyaluronate, Vaccinium myrtillus fruit extract, Saccharum officinarum extract, Glycerin, Lecithin, Retinyl palmitate, Acer saccharum extract, Helianthus annuus seed oil, Hexanoyl dipeptide-3 norleucine acetate, Citrus aurantium dulcis fruit extract, Citrus limon fruit extract, Glycine soja oil, Caprylic/capric triglyceride, Phenoxyethanol, Alcohol, Polysorbate 80, Soy isoflavones, Sodium benzoate, Parfum, Potassium sorbate, Disodium edta

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Skincode
≈ $161.33
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
skincode-SwissCellular Night Refine & RepairYOUR PRODUCTMuradHydro-Dynamic Ultimate Moisture Moisturiser
Match—51%
Price$162.55—
Shared key ingredients—8 of 15
Key difference—Anhydroxylitol
Irritancy High Medium
Drying alcohol Contains drying alcohol —
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.

  1. 1
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  2. 2
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  3. 3
    Topical urea in skincare: A reviewpubmed.ncbi.nlm.nih.gov
  4. 4
    Safety Assessment of Alkyl Esters as Used in Cosmeticscir-safety.org
  5. 5
    Vitamin E in dermatologyncbi.nlm.nih.gov
  6. 6
    Vitamin E and Skin Healthlpi.oregonstate.edu
skincode-Swiss Cellular Night Refine & Repair
skincode-SwissCellular Night Refine & Repair
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