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SKIN 1004. Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot Ampoule
SKIN 1004.

SKIN 1004. Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot Ampoule

Efficacy100/100IrritancyHigh
See all ingredients

Works for

Anti-aging
Retinol, Retinal + 3 more
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, retinol, adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: madecassoside.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1.2–1.9%
RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.7%
AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.6%
MadecassosideKey activeEffect: MediumAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.05–0.15%
Centella asiatica extractUnder-dosedA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.1–0.3%
Exfoliation
Retinol
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1.2–1.9%
Evens skin tone
Retinol, Retinal + 1 more
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal, retinol.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: madecassoside.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1.2–1.9%
RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.7%
MadecassosideEffect: LowAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.05–0.15%
Anti-oxidation
Side benefit · Retinol, Madecassoside + 5 more
Works well

This product contains antioxidants (madecassoside, retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1.2–1.9%
MadecassosideKey activeEffect: HighAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.05–0.15%
Hippophae rhamnoides fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking~0.85–1.25%
AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.6%
Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.1–0.45%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.05–0.25%
Centella asiatica extractUnder-dosedA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.1–0.3%
Moisturizing
Side benefit · Madecassoside, Glycerin + 6 more
Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, squalane.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: madecassoside

MadecassosideHeroEffect: HighAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.05–0.15%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.4–6.6%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~2.1–3.2%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~1.1–1.7%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.55%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.6%
Centella asiatica extractUnder-dosedA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.1–0.3%
PanthenolUnder-dosedHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.05–0.2%
Anti-blemish
Side benefit · Retinol, Retinal + 2 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinal, retinol. These ingredients is used for treating acne and can have a noticeable effect.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~1.2–1.9%
RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating~0.3–0.7%
Centella asiatica extractEffect: Low, below effective doseA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.1–0.3%
Rosmarinus officinalis leaf extractUnder-dosedCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.05–0.25%

Can it cause trouble?

Irritancy
11 flagged ingredients — patch-test recommended
High risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~1.2–1.9%est.
RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh~0.3–0.7%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.05–0.25%est.
1,2-hexanediolA preservativeMedium~1.7–2.6%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~1.1–1.7%est.
Hippophae rhamnoides fruit extractA plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lackingMedium~0.85–1.25%est.
Disodium edtaStabilizes the product formulationMedium~0.1–0.45%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.1–0.45%est.
EthylhexylglycerinA preservativeMedium~0.1–0.3%est.
MadecassosideAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulationsMedium~0.05–0.15%est.
Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.1–0.3%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
Alternatives
Cheaper, or higher on efficacy
SEOUL 1988 Serum : Retinal Liposome 2% + Black Ginseng
K-SECRET SEOUL 1988 Serum : Retinal Liposome 2% + Black Ginseng
Cheaper62% match
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Just retinal
Revox Just retinal
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.4–6.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
1,2-hexanediol~1.7–2.6%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Cetearyl olivate~2.3–3.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
Squalane~2.1–3.2%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Sorbitan olivate~1.7–2.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Carbomer~1.4–2.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Retinol~1.2–1.9%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-blemishMattifyingExfoliationAnti-aging

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Caprylic/capric triglyceride~1.1–1.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Hippophae rhamnoides fruit extract~0.85–1.25%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its effectiveness is lacking

More about Hippophae rhamnoides fruit extract
Tromethamine~0.5–1.15%
Formula
Irritation risk
Low

Helps adjust pH in products

More about Tromethamine
Phaseolus radiatus seed extract~0.4–0.95%
Formula
Irritation risk
Low
More about Phaseolus radiatus seed extract
Hydrogenated lecithin~0.4–0.9%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Inulin lauryl carbamate~0.35–0.85%
Formula
Irritation risk
Low
Works for
Cleansing
More about Inulin lauryl carbamate
Sodium polyacrylate~0.35–0.8%
Formula
Irritation risk
Low
Works for
Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate
Retinal~0.3–0.7%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-agingEvens skin tone

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal
Hydrolyzed sponge~0.2–0.75%
Formula
Irritation risk
Low
More about Hydrolyzed sponge
Adenosine~0.15–0.6%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Sodium hyaluronate~0.15–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Disodium edta~0.1–0.45%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Tocopheryl acetate~0.1–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate~0.1–0.4%
Formula
Irritation risk
Low

Used to increase stability of product formulations

More about Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
Ethylhexylglycerin~0.1–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Rosmarinus officinalis leaf extract~0.05–0.25%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Panthenol~0.05–0.2%
Under-dosed
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Madecassoside~0.05–0.15%
Hero · MoisturizingIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizingAnti-agingEvens skin tone

An antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations

More about Madecassoside
Centella asiatica extract~0.1–0.3%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Reduces irritationAnti-inflammatoryReduces rednessMoisturizingAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract
Ingredient list view

Water, Glycerin, 1,2-hexanediol, Cetearyl olivate, Squalane, Sorbitan olivate, Carbomer, Retinol, Caprylic/capric triglyceride, Hippophae rhamnoides fruit extract, Tromethamine, Phaseolus radiatus seed extract, Hydrogenated lecithin, Inulin lauryl carbamate, Sodium polyacrylate, Retinal, Hydrolyzed sponge, Adenosine, Sodium hyaluronate, Disodium edta, Tocopheryl acetate, Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, Ethylhexylglycerin, Rosmarinus officinalis leaf extract, Panthenol, Madecassoside, Centella asiatica extract

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
SKIN 1004.Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot AmpouleYOUR PRODUCTepiiHPR Pro ShotSome By MiRetinol Intense Reactivating Serum Large Size 50mlMedicubeDeep Vita A Retinol Serum
Match—95%88%86%
Price$12.83$17.49+$4.66$35.08+$22.25$24.05+$11.22
Shared key ingredients—10 of 118 of 119 of 11
Key difference—Hydroxypinacolone RetinoateNiacinamideNiacinamide
Irritancy High High High High
Drying alcohol————
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Product summary

"SKIN 1004. - Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot Ampoule" is effective for: Anti-aging, Exfoliation, Moisturizing, Evens skin tone and Anti-blemish

Ingredient callouts

  • this product contains an effective form of Retinoids (vitamin A): retinal 0.30% - 0.70% and retinol 1.20% - 1.90%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
  • Adenosine 0.15% - 0.60%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).
  • Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - madecassoside 0.05% - 0.15% The Centella Asiatica Actives, even in low concentration, can help reduce inflammation in skin, strengthen the skin barrier and reduce photodamage. They can also help to decrease scarring.
  • Humectants (sodium hyaluronate 0.15% - 0.55% and glycerin 4.40% - 6.60%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

About the brand

According to Cruelty-Free Kitty "SKIN 1004. " is cruelty free and so is its parent company.

Price

The product retails for 12.83$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 29 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
  3. 3
    Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyncbi.nlm.nih.gov
  4. 4
    Improvement of naturally aged skin with vitamin A (retinol)ncbi.nlm.nih.gov
  5. 5
    A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skinonlinelibrary.wiley.com
  6. 6
    Abundance of active ingredients in sea-buckthorn oilncbi.nlm.nih.gov
SKIN 1004. Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot Ampoule
SKIN 1004.Lab in Nature Madagascar Centella Retinol 0.2 Boosting Shot Ampoule
Buy at Yesstyle$12.83Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Yesstyle$12.83Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.