Sepai De-Puff Eyes Eye Serum

Sepai De-Puff Eyes Eye Serum

Efficacy62/100IrritancyHigh

Works for

Anti-aging
Acetyl tetrapeptide-5, Tripeptide-3 + 3 more
May help
What the product description says
“Achieve a smoother, younger-looking eye contour with the Sepai De-Puff Eyes Eye Serum ; an under-eye elixir powered by the superior brightening and antioxidant properties of a powerful and stable Vitamin C derivative.”
Source: Lookfantastic US

This product contains acetyl tetrapeptide-5, serine, tripeptide-3. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Acetyl tetrapeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.8–1.2%
Tripeptide-3Key activeEffect: Medium~0.45–0.65%
SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.5%
Laminaria digitata extractEffect: Low, below effective doseSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.25–0.45%
Evens skin tone
Albizia julibrissin bark extract, Camellia sinensis leaf extract
Not delivered
What the product description says
“Achieve a smoother, younger-looking eye contour with the Sepai De-Puff Eyes Eye Serum ; an under-eye elixir powered by the superior brightening and antioxidant properties of a powerful and stable Vitamin C derivative.”
Source: Lookfantastic US

This product contains ingredients (albizia julibrissin bark extract) that could help reduce hyperpigmentation (for example, post-acne marks or age spots) in theory, but there is not enough evidence that they actually work.

Albizia julibrissin bark extractEffect: LowA plant extract that might help to neutralize free radicals in skin. Is claimed to help reduce hyperpigmentation but evidence is missing~0.25–0.4%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.5%
Moisturizing
Side benefit · Acetyl tetrapeptide-5, Tripeptide-3 + 9 more
Works well

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin, lactobacillus ferment.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl tetrapeptide-5, panthenol, tripeptide-3

Acetyl tetrapeptide-5Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.8–1.2%
Tripeptide-3HeroEffect: High~0.45–0.65%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.25–0.45%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.4–5.4%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~3–3.6%
Acetyl carnitine hclKey activeEffect: MediumMight be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skin~1.3–1.6%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.8–2.2%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.5%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.45%
Laminaria digitata extractUnder-dosedSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.25–0.45%
Anti-oxidation
Side benefit · Camellia sinensis leaf extract, Lactobacillus ferment + 4 more
May help

This product contains antioxidants (camellia sinensis leaf extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.25–0.5%
Lactobacillus fermentEffect: LowA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~3–3.6%
CaffeineEffect: LowMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes~1.5–1.8%
Albizia julibrissin bark extractEffect: LowA plant extract that might help to neutralize free radicals in skin. Is claimed to help reduce hyperpigmentation but evidence is missing~0.25–0.4%
Laminaria digitata extractEffect: Low, below effective doseSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.25–0.45%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.2–0.4%

Can it cause trouble?

Irritancy
6 strong irritants: Hamamelis virginiana extract, Arnica montana flower extract + 4 more — patch-test recommended
High risk
We flagged 13 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Aesculus hippocastanum extractA plant extract. Benefits of topical application are not confirmedHigh~1.2–1.5%est.
Hedera helix extractA plant extract that has an anti-bacterial effectHigh~0.25–0.5%est.
Hamamelis virginiana extractA plant extract that can help calm down inflammation in skin. Can, however, itself be irritatingHigh~0.35–0.65%est.
Arnica montana flower extractA plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skinHigh~0.25–0.45%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.2–0.4%est.
Citrus limon peel extractA very irritating fragrant ingredientHigh~0.2–0.4%est.
Albizia julibrissin bark extractA plant extract that might help to neutralize free radicals in skin. Is claimed to help reduce hyperpigmentation but evidence is missingHigh~0.25–0.4%est.
PullulanCreates a thin drying film on the skin resulting in a short-term tightening effectHigh~0.25–0.4%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.2%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~1.5–1.8%est.
Vitis vinifera leaf extract—Medium~0.3–0.55%est.
Potassium sorbateA preservativeMedium~0.15–0.3%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Spirulina platensis powder—3/5~0.25–0.45%est.
Laminaria digitata extractSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment3/5~0.25–0.45%est.
Fucus vesiculosus extract—3/5~0.25–0.45%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.4–5.4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Pueraria lobata root extract~3.8–4.7%
Formula
Lactobacillus ferment~3–3.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidationReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Propanediol~2.3–2.8%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Butylene glycol~1.8–2.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Caffeine~1.5–1.8%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Acetyl carnitine hcl~1.3–1.6%
Key active
Irritation risk
Low
Works for
MattifyingMoisturizingAnti-blemish

Might be helpful in decreasing sebum production making the skin less oily. Is claimed to be able to support ceramide production in skin that leads to better hydration, but evidence is lacking. Is able to attract water to the upper layer of the skin

More about Acetyl carnitine hcl
Aesculus hippocastanum extract~1.2–1.5%
Irritant · high
Irritation risk
High

A plant extract. Benefits of topical application are not confirmed

More about Aesculus hippocastanum extract
Acetyl tetrapeptide-5~0.8–1.2%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-5
Ruscus aculeatus root extract~0.45–0.7%
Formula
Decapeptide-2~0.55–0.8%
Formula
Irritation risk
Low
More about Decapeptide-2
Hedera helix extract~0.25–0.5%
Irritant · high
Irritation risk
High
Works for
Antibacterial

A plant extract that has an anti-bacterial effect

More about Hedera helix extract
Tripeptide-3~0.45–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Tripeptide-3
Hamamelis virginiana extract~0.35–0.65%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatory

A plant extract that can help calm down inflammation in skin. Can, however, itself be irritating

More about Hamamelis virginiana extract
Solidago virgaurea extract~0.4–0.6%
Formula
Rhus coriaria leaf/stem extract~0.4–0.6%
Formula
Astragalus membranaceus root extract~0.35–0.65%
Formula
Vitis vinifera leaf extract~0.3–0.55%
Irritant · medium
Darutoside~0.25–0.5%
Formula
Irritation risk
Low
More about Darutoside
Arnica montana flower extract~0.25–0.45%
Irritant · high
Irritation risk
High

A plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skin

More about Arnica montana flower extract
Camellia sinensis leaf extract~0.25–0.5%
Key active
Irritation risk
Low
Works for
Anti-oxidationAntibacterialAnti-agingMoisturizingEvens skin toneAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Rosmarinus officinalis leaf extract~0.2–0.4%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Spirulina platensis powder~0.25–0.45%
Comedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
More about Spirulina platensis powder
Citrus limon peel extract~0.2–0.4%
Irritant · high
Irritation risk
High

A very irritating fragrant ingredient

More about Citrus limon peel extract
Laminaria digitata extract~0.25–0.45%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

Seaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment

More about Laminaria digitata extract
Fucus vesiculosus extract~0.25–0.45%
Comedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
More about Fucus vesiculosus extract
Albizia julibrissin bark extract~0.25–0.4%
Irritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-inflammatory

A plant extract that might help to neutralize free radicals in skin. Is claimed to help reduce hyperpigmentation but evidence is missing

More about Albizia julibrissin bark extract
Citrus aurantium amara peel extract~0.2–0.4%
Irritant · high
Panthenol~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Serine~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Pullulan~0.25–0.4%
Irritant · high
Irritation risk
High
Works for
Mattifying

Creates a thin drying film on the skin resulting in a short-term tightening effect

More about Pullulan
Sclerotium gum~0.2–0.4%
Formula
Irritation risk
Low

Used to create gel-like formulas and stabilize emulsions

More about Sclerotium gum
Xanthan gum~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Silica~0.3–0.55%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Lecithin~0.25–0.45%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Potassium sorbate~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Sodium hydroxide~0.15–0.25%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Sodium benzoate~0.1–0.15%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Parfum~0.1–0.2%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Mica~0.15–0.25%
Formula
Irritation risk
Low

Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light

More about Mica
Titanium dioxide~0.1–0.15%
Formula
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Iron oxides~0.05–0.1%
Formula
Irritation risk
Low
Works for
Sun protection

An umbrella term for the following three colorants: CI 77491, CI 77492, CI 77499. They might be able to offer some protection against visible light, but the degree of the protection is not clear

More about Iron oxides
Ingredient list view

Water, Glycerin, Pueraria lobata root extract, Lactobacillus ferment, Propanediol, Butylene glycol, Caffeine, Acetyl carnitine hcl, Aesculus hippocastanum extract, Acetyl tetrapeptide-5, Ruscus aculeatus root extract, Decapeptide-2, Hedera helix extract, Tripeptide-3, Hamamelis virginiana extract, Solidago virgaurea extract, Rhus coriaria leaf/stem extract, Astragalus membranaceus root extract, Vitis vinifera leaf extract, Darutoside, Arnica montana flower extract, Camellia sinensis leaf extract, Rosmarinus officinalis leaf extract, Spirulina platensis powder, Citrus limon peel extract, Laminaria digitata extract, Fucus vesiculosus extract, Albizia julibrissin bark extract, Citrus aurantium amara peel extract, Panthenol, Serine, Pullulan, Sclerotium gum, Xanthan gum, Silica, Lecithin, Potassium sorbate, Sodium hydroxide, Sodium benzoate, Parfum, Mica, Titanium dioxide, Iron oxides

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
SepaiDe-Puff Eyes Eye SerumYOUR PRODUCTNIODFractionated Eye-Contour Concentrate SerumDerm InstituteYouth Alchemy Eye SerumJS HealthIlluminating Peptide Eye Serum
Match—53%51%51%
Price—$44.58$290.00—
Shared key ingredients—3 of 124 of 124 of 12
Key difference—Decapeptide-22RetinolNiacinamide
Irritancy High Medium Medium Medium
Drying alcohol————
View product Shop Shop Shop

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

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Sepai De-Puff Eyes Eye Serum
SepaiDe-Puff Eyes Eye Serum

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