Replenix Enriched Nighttime Bio-Therapy
Works for
3 of 3 advertised claims delivered
Anti-agingNiacinamide, Resveratrol + 1 moreStrong evidence
“Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: resveratrol, tetrapeptide-21.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
MoisturizingCeramide np, Niacinamide + 20 moreStrong evidence
“Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, cholesterol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide 2, ceramide ap, ceramide eop, ceramide np, niacinamide, phytosphingosine, tetrapeptide-21
Evens skin toneNiacinamide, ResveratrolStrong evidence
“Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.”
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: resveratrol.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Anti-oxidationNot advertised by the brand · Resveratrol, Caffeine + 1 moreStrong evidence
This product contains antioxidants (resveratrol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Anti-blemishNot advertised by the brand · Niacinamide, PhytosphingosineGood evidence
This product might be able to help reduce blemishes and clogged pores because it contains niacinamide.
Can it cause trouble?
Irritancy11 flagged ingredientsMedium risk
Comedogenic1 ingredient rated 2 or more on the 0–5 pore-clogging scale1 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycerin~4.6–5.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinButylene glycol~3.8–4.7%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolDimethicone~3.1–3.8%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeC12-15 alkyl benzoate~2.3–2.8%
- Irritation risk
- Low
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
More about C12-15 alkyl benzoateHydrogenated polyisobutene~2–2.4%
- Irritation risk
- Low
Used to improve the product consistency and soften the upper layer of the skin
More about Hydrogenated polyisobuteneNiacinamide~1.6–1.9%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideSodium hyaluronate~1.4–1.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateHydrolyzed sodium hyaluronate~1.1–1.4%
- Irritation risk
- Low
Attracts water into the upper layer of the skin
More about Hydrolyzed sodium hyaluronateCetearyl alcohol~1–1.3%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholCetearyl glucoside~0.65–1%
- Irritation risk
- Medium
Helps water and oil in the product mix well together and improves product texture
More about Cetearyl glucosideCeramide np~0.6–0.85%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide npCeramide ap~0.45–0.7%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide apCeramide eop~0.45–0.7%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide eopCeramide 2~0.4–0.65%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide 2Phytosphingosine~0.45–0.65%
- Irritation risk
- Low
A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect
More about PhytosphingosineCholesterol~0.45–0.65%
- Irritation risk
- Low
An emollient that is naturally found in skin
More about CholesterolSodium lauroyl lactylate~0.3–0.6%
- Irritation risk
- Medium
Helps water and oil mix together
More about Sodium lauroyl lactylatePolyacrylamide~0.3–0.55%
- Irritation risk
- Medium
Used to improve product texture and help oil and water mix together
More about PolyacrylamideC13-14 isoparaffin~0.3–0.55%
- Irritation risk
- Low
Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency
More about C13-14 isoparaffinLaureth-7~0.25–0.45%
Tocopheryl acetate~0.25–0.4%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateCamellia sinensis polyphenols~0.2–0.35%
- Irritation risk
- Low
Malus domestica fruit cell culture extract~0.2–0.35%
- Irritation risk
- Low
Peg-40 stearate~0.2–0.4%
Stearyl alcohol~0.25–0.4%
- Irritation risk
- Low
An emollient that helps soften the skin
More about Stearyl alcoholBehenyl alcohol~0.25–0.45%
- Irritation risk
- Low
Non-drying alcohol that helps water and oil mix together. Also serves as an emollient
More about Behenyl alcoholCetyl alcohol~0.25–0.45%
- Irritation risk
- Low
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
More about Cetyl alcoholTetrapeptide-21~0.2–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tetrapeptide-21Resveratrol~0.2–0.4%
- Irritation risk
- Medium
Helps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone
More about ResveratrolCaffeine~0.2–0.35%
- Irritation risk
- Medium
Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes
More about CaffeineLecithin~0.25–0.45%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinGlyceryl stearate~0.25–0.45%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateXanthan gum~0.2–0.35%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumCarbomer~0.15–0.3%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerPhenoxyethanol~0.15–0.25%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolSorbic acid~0.1–0.25%
Caprylyl glycol~0.15–0.3%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolPotassium hydroxide~0.1–0.25%
Titanium dioxide~0.1–0.15%
- Irritation risk
- Low
Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin
More about Titanium dioxideDisodium edta~0.05–0.1%
Ingredient list view
Water, Glycerin, Butylene glycol, Dimethicone, C12-15 alkyl benzoate, Hydrogenated polyisobutene, Niacinamide, Sodium hyaluronate, Hydrolyzed sodium hyaluronate, Cetearyl alcohol, Cetearyl glucoside, Ceramide np, Ceramide ap, Ceramide eop, Ceramide 2, Phytosphingosine, Cholesterol, Sodium lauroyl lactylate, Polyacrylamide, C13-14 isoparaffin, Laureth-7, Tocopheryl acetate, Camellia sinensis polyphenols, Malus domestica fruit cell culture extract, Peg-40 stearate, Stearyl alcohol, Behenyl alcohol, Cetyl alcohol, Tetrapeptide-21, Resveratrol, Caffeine, Lecithin, Glyceryl stearate, Xanthan gum, Carbomer, Phenoxyethanol, Sorbic acid, Caprylyl glycol, Potassium hydroxide, Titanium dioxide, Disodium edta
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| ReplenixEnriched Nighttime Bio-TherapyYOUR PRODUCT | Key SoulcareSKIN TRANSFORMATION CREAM FRAGRANCE FREE | DermaticaNourishing Ceramide + Peptides | AgencyCloud Care Weightless Whipped Moisturizer | |
|---|---|---|---|---|
| Match | — | 85% | 85% | 85% |
| Price | $98.00 | — | $21.32−$76.68 | — |
| Shared key ingredients | — | 9 of 14 | 9 of 14 | 9 of 14 |
| Key difference | — | Bakuchiol | Palmitoyl Tetrapeptide-7 | Panthenol |
| Irritancy | Medium | Low | Low | Low |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
Product summary
"Replenix - Enriched Nighttime Bio-Therapy" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Glycerin, sodium hyaluronate, butylene glycol and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide 2, ceramide eop, ceramide np, phytosphingosine and cholesterol) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- As a plus, this moisturizer also contains ceramides (phytosphingosine 0.45% - 0.65%, ceramide np 0.60% - 0.85%, ceramide eop 0.45% - 0.70%, ceramide ap 0.45% - 0.70% and ceramide 2 0.40% - 0.65%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- This moistruizer also contains peptides (tetrapeptide-21 0.20% - 0.40%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 95.00$ in the United States.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.
- 1
- 2
- 3Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 4
- 5
- 6
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