Replenix Enriched Nighttime Bio-Therapy
Product summary
"Replenix - Enriched Nighttime Bio-Therapy" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Glycerin, sodium hyaluronate, butylene glycol and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide 2, ceramide eop, ceramide np, phytosphingosine and cholesterol) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- As a plus, this moisturizer also contains ceramides (phytosphingosine 0.45% - 0.65%, ceramide np 0.60% - 0.85%, ceramide eop 0.45% - 0.70%, ceramide ap 0.45% - 0.70% and ceramide 2 0.40% - 0.65%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- This moistruizer also contains peptides (tetrapeptide-21 0.20% - 0.40%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 95.00$ in the United States.
For a detailed price comparison: click here.
Benefits
Promise: Anti-aging
What does the product description say?
Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: resveratrol, tetrapeptide-21.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
| Ingredient | Effectiveness | Concentration | Irritancy |
|---|---|---|---|
| niacinamide | HIGH |  |  |
| resveratrol | MEDIUM | | |
| tetrapeptide-21 | MEDIUM | | |
Promise: Evens skin tone
What does the product description say?
Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: resveratrol.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
| Ingredient | Effectiveness | Concentration | Irritancy |
|---|---|---|---|
| niacinamide | HIGH | | |
| resveratrol | LOW | | |
Promise: Moisturizing
What does the product description say?
Biomimetic Ceramide Complex provides nourishment to help repair the skin barrier, improving elasticity and texturePeptides complement the skin‰Ûªs nightly renewal functions and target wrinklesHyaluronic Acid penetrates skin to deeply moisturize and forms a protective barrier on skin‰Ûªs surface, locking moisture inNiacinamide supports healthy collagen production improving the appearance of fine lines and wrinkles, helps brighten discoloration over time, and promotes healthy texture and even skin toneStem Cells promote softness, firmness and elasticityAntioxidants combat environmental damage and soothe the skinWho is this for?Ideal for dry skin types.
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, cholesterol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide 2, ceramide ap, ceramide eop, ceramide np, niacinamide, phytosphingosine, tetrapeptide-21
| Ingredient | Effectiveness | Concentration | Irritancy |
|---|---|---|---|
| tetrapeptide-21 | HIGH | | |
| ceramide ap | HIGH | | |
| ceramide eop | HIGH | | |
Other benefit: Anti-blemish
This product might be able to help reduce blemishes and clogged pores because it contains niacinamide.
| Ingredient | Effectiveness | Concentration | Irritancy |
|---|---|---|---|
| niacinamide | HIGH | | |
| phytosphingosine | LOW | | |
Other benefit: Anti-oxidation
This product contains antioxidants (resveratrol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
| Ingredient | Effectiveness | Concentration | Irritancy |
|---|---|---|---|
| resveratrol | HIGH | | |
| caffeine | LOW | | |
| tocopheryl acetate | LOW |  | |
Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing | |
| Evens skin tone |
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Potential irritants
| Ingredient | Irritancy | Skin Benefit |
|---|---|---|
| cetearyl glucoside | | |
| sodium lauroyl lactylate | | |
| polyacrylamide | | |
User reviews (0)
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Ingredients & concentrations
- niacinamide
- ceramide np
- ceramide eop
- ceramide 2
- ceramide ap
- tetrapeptide-21
- phytosphingosine
- glycerin
- cholesterol
- dimethicone
- caffeine
- hydrolyzed sodium hyaluronate
- resveratrol
- sodium hyaluronate
- +10 more
| Ingredient | Estimated concentration |
|---|---|
| 45% - 55% | |
| Plain old water | |
| 4.6% - 5.7% | |
| One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant | |
| 3.8% - 4.7% | |
| Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin | |
| 3.1% - 3.8% | |
| A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish | |
| 2.3% - 2.8% | |
| Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth | |
| 2% - 2.4% | |
| Used to improve the product consistency and soften the upper layer of the skin | |
| 1.6% - 1.9% | |
| Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production | |
| 1.4% - 1.7% | |
| One of the best moisturizing ingredients. Attracts water into the upper layer of the skin | |
| 1.1% - 1.4% | |
| Attracts water into the upper layer of the skin | |
| 1% - 1.3% | |
| A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture | |
| 0.65% - 1% | |
| Helps water and oil in the product mix well together and improves product texture | |
| 0.6% - 0.85% | |
| A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin | |
| 0.45% - 0.7% | |
| A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin | |
| 0.45% - 0.7% | |
| A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin | |
| 0.4% - 0.65% | |
| A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin | |
| 0.45% - 0.65% | |
| A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect | |
| 0.45% - 0.65% | |
| An emollient that is naturally found in skin | |
| 0.3% - 0.6% | |
| Helps water and oil mix together | |
| 0.3% - 0.55% | |
| Used to improve product texture and help oil and water mix together | |
| 0.3% - 0.55% | |
| Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency | |
| 0.25% - 0.45% | |
| Helps oil and water mix together | |
| 0.25% - 0.4% | |
| A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients. | |
| 0.2% - 0.35% | |
| 0.2% - 0.35% | |
| 0.2% - 0.4% | |
| Helps oil and water mix together | |
| 0.25% - 0.4% | |
| An emollient that helps soften the skin | |
| 0.25% - 0.45% | |
| Non-drying alcohol that helps water and oil mix together. Also serves as an emollient | |
| 0.25% - 0.45% | |
| A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together | |
| 0.2% - 0.4% | |
| A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles | |
| 0.2% - 0.4% | |
| Helps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone | |
| 0.2% - 0.35% | |
| Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes | |
| 0.25% - 0.45% | |
| Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin | |
| 0.25% - 0.45% | |
| An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together | |
| 0.2% - 0.35% | |
| Used to create a thicker product consistency | |
| 0.15% - 0.3% | |
| Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations | |
| 0.15% - 0.25% | |
| A preservative. It helps prevent bacterial growth in cosmetic products | |
| 0.1% - 0.25% | |
| A preservative | |
| 0.15% - 0.3% | |
| Helps preserve products and creates a nice product texture | |
| 0.1% - 0.25% | |
| Used to adjust the pH level of products | |
| 0.1% - 0.15% | |
| Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin | |
| 0.05% - 0.1% | |
| Stabilizes the product formulation | |
Show more | |
Sources
- Glycerol and the skin: holistic approach to its origin and functions
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmetics
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Topical emulsions containing ceramides: Effects on the skin barrier function and anti‐inflammatory properties
- Safety Assessment of Isoparaffins as Used in Cosmetics
- Skin permeation and antioxidant efficacy of topically applied resveratrol
- Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?
- Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin
- Resveratrol as a Multifunctional Topical Hypopigmenting Agent
- Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation