Replenix

Replenix AE Facial Firming Therapy

Name: Replenix - AE Facial Firming Therapy
Brand: Replenix

Efficacy75/100IrritancyHigh

See all ingredients

Works for

Anti-aging

Palmitoyl pentapeptide-4, Camellia sinensis leaf extract + 3 more

May help

What the product description says

“Replenix AE Dermal Restructuring Therapy is a luxurious serum designed to relax fine lines and wrinkles while stimulating collagen production for a firmer skin texture.”

Source: Dermstore

This product contains palmitoyl pentapeptide-4. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl pentapeptide-4Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–0.9%

Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.55–0.8%

UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.35%

Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.2–0.4%

Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.35%

Anti-oxidation

Not advertised by the brand · Disodium lauriminodipropionate tocopheryl phosphates, Camellia sinensis leaf extract + 7 more

Works well

This product contains antioxidants (disodium lauriminodipropionate tocopheryl phosphates, superoxide dismutase, ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - camellia sinensis leaf extract, rubus idaeus seed oil also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Disodium lauriminodipropionate tocopheryl phosphatesKey activeEffect: HighA form of Vitamin E. In concentrations 1-3%, it can help neutralize free radicals in skin and support photodamage repair~1.4–1.7%

Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.55–0.8%

Rubus idaeus seed oilKey activeEffect: MediumA plant oil that might be able to help neutralize free radicals in skin~0.4–0.6%

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.2–0.35%

Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.2–0.35%

Sea whip extractEffect: LowMight help neutrlize free radicals, calm down inflammation, and attract water to the upper layer of the skin~0.3–0.5%

BisabololEffect: Low, below effective doseAn active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties~0.3–0.6%

Tocopheryl acetateEffect: Low, below effective doseA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~0.25–0.45%

Moisturizing

Side benefit the brand mentions · Palmitoyl pentapeptide-4, Ceramide 2 + 18 more

Works well

What the product description says

“Macrocystis Pyrifera Extract extracted from Giant Sea Kelp provides immediate tightening and toning action while Hyaluronic Acid offers powerful moisture replenishment, leaving skin taut, firm and hydrated.”

Source: Skinstore

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, saccharomyces lysate extract.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, squalane.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide 2, palmitoyl pentapeptide-4

Palmitoyl pentapeptide-4HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–0.9%

Ceramide 2Hero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.25–0.4%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.7–5.8%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~3.6–4.4%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~2.3–2.9%

Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.9–2.3%

Padina pavonica extractKey activeEffect: HighAn algae extract. Helps attract water to the upper layer of the skin~1.5–1.9%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.5–0.8%

EctoinKey activeEffect: HighSoftens the upper layer of the skin and can support skin barrier function~0.4–0.6%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.35–0.6%

Sea whip extractKey activeEffect: HighMight help neutrlize free radicals, calm down inflammation, and attract water to the upper layer of the skin~0.3–0.5%

Saccharomyces lysate extractKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Can have some anti-inflammatory effect~0.25–0.45%

PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.25–0.5%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.4%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~0.2–0.35%

LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.45%

Caprylic/capric triglycerideUnder-dosedA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.25–0.5%

Can it cause trouble?

Irritancy

3 strong irritants: Retinyl palmitate, Imidazolidinyl urea + 1 more — patch-test recommended

High risk

We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.35%est.

Imidazolidinyl ureaA preservative. Is more irritating than many other preservatives availableHigh~0.1–0.15%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.1%est.

Rubus idaeus seed oilA plant oil that might be able to help neutralize free radicals in skinMedium~0.4–0.6%est.

Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.2–0.4%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.45%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.25–0.5%est.

TriethanolamineUsed to adjust pH of the product and can help improve the product's smellMedium~0.2–0.35%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.15–0.3%est.

Disodium edtaStabilizes the product formulationMedium~0.05%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~3.6–4.4%est.

Alternatives

Cheaper, or higher on efficacy

Elizabeth Grant Suprême Cell Vitality Renewal Night Serum

Cheaper57% match

$44.00

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.7–5.8%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Cetearyl alcohol~3.6–4.4%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Ppg-2 myristyl ether propionate~2.8–3.4%

Formula

Irritation risk: Low

More about Ppg-2 myristyl ether propionate

Squalane~2.3–2.9%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Cetyl alcohol~1.9–2.3%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol

Padina pavonica extract~1.5–1.9%

Key active

Irritation risk: Low

Works for

Moisturizing

An algae extract. Helps attract water to the upper layer of the skin

More about Padina pavonica extract

Disodium lauriminodipropionate tocopheryl phosphates~1.4–1.7%

Key active

Irritation risk: Low

Works for

Anti-oxidationCleansing

A form of Vitamin E. In concentrations 1-3%, it can help neutralize free radicals in skin and support photodamage repair

More about Disodium lauriminodipropionate tocopheryl phosphates

Phyllanthus emblica extract~1.1–1.3%

Formula

Irritation risk: Low

More about Phyllanthus emblica extract

Camellia sinensis polyphenols~0.95–1.15%

Formula

Irritation risk: Low

More about Camellia sinensis polyphenols

Palmitoyl pentapeptide-4~0.6–0.9%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl pentapeptide-4

Camellia sinensis leaf extract~0.55–0.8%

Key active

Irritation risk: Low

Works for

AntibacterialAnti-oxidationAnti-agingAnti-blemishEvens skin toneMoisturizing

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract

Dimethicone~0.5–0.8%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Ectoin~0.4–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Softens the upper layer of the skin and can support skin barrier function

More about Ectoin

Bisabolol~0.3–0.6%

Formula

Irritation risk: Low

Works for

Anti-inflammatoryReduces irritationAnti-oxidation

An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties

More about Bisabolol

Sodium hyaluronate~0.35–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Rubus idaeus seed oil~0.4–0.6%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant oil that might be able to help neutralize free radicals in skin

More about Rubus idaeus seed oil

Sea whip extract~0.3–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-inflammatory

Might help neutrlize free radicals, calm down inflammation, and attract water to the upper layer of the skin

More about Sea whip extract

Phospholipids~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids

Saccharomyces lysate extract~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Can have some anti-inflammatory effect

More about Saccharomyces lysate extract

Ascorbyl palmitate~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate

Tocopheryl acetate~0.25–0.45%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Retinyl palmitate~0.2–0.35%

Under-dosedIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-blemishAnti-agingExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate

Caprylic/capric triglyceride~0.25–0.5%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Butylene glycol~0.2–0.4%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Polysorbate 20~0.25–0.45%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Ceramide 2~0.25–0.4%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide 2

Carbomer~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Hydrogenated polydecene~0.2–0.35%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Trideceth-6~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Trideceth-6

Sodium polyacrylate~0.25–0.45%

Formula

Irritation risk: Low

Works for

Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate

Superoxide dismutase~0.2–0.35%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryMoisturizingAnti-oxidation

An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants

More about Superoxide dismutase

Ubiquinone~0.2–0.35%

Key active

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone

Lecithin~0.25–0.45%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin

Triethanolamine~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Used to adjust pH of the product and can help improve the product's smell

More about Triethanolamine

Polysorbate 60~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Methylparaben~0.1–0.15%

Formula

Irritation risk: Low

A preservative

More about Methylparaben

Propylparaben~0.1–0.2%

Formula

Irritation risk: Low

A preservative

More about Propylparaben

Imidazolidinyl urea~0.1–0.15%

Irritant · high

Irritation risk: High

A preservative. Is more irritating than many other preservatives available

More about Imidazolidinyl urea

Disodium edta~0.05%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Parfum~0.05–0.1%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Ingredient list view

Water, Glycerin, Cetearyl alcohol, Ppg-2 myristyl ether propionate, Squalane, Cetyl alcohol, Padina pavonica extract, Disodium lauriminodipropionate tocopheryl phosphates, Phyllanthus emblica extract, Camellia sinensis polyphenols, Palmitoyl pentapeptide-4, Camellia sinensis leaf extract, Dimethicone, Ectoin, Bisabolol, Sodium hyaluronate, Rubus idaeus seed oil, Sea whip extract, Phospholipids, Saccharomyces lysate extract, Ascorbyl palmitate, Tocopheryl acetate, Retinyl palmitate, Caprylic/capric triglyceride, Butylene glycol, Polysorbate 20, Ceramide 2, Carbomer, Hydrogenated polydecene, Trideceth-6, Sodium polyacrylate, Superoxide dismutase, Ubiquinone, Lecithin, Triethanolamine, Polysorbate 60, Methylparaben, Propylparaben, Imidazolidinyl urea, Disodium edta, Parfum

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Dermstore1 fl. oz

$140.00 Out of stock

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	ReplenixAE Facial Firming TherapyYOUR PRODUCT	Jan MariniAge Intervention Regeneration Booster	Elizabeth GrantSuprême Cell Vitality Renewal Night Serum	MEDI-PEELDerma Maison Time Wrinkle Perfect Serum
Match	—	57%	57%	48%
Price	—	$235.00	$44.00	$44.30
Shared key ingredients	—	6 of 19	7 of 19	6 of 19
Key difference	—	Myristoyl Pentapeptide-8	Niacinamide	Anhydroxylitol
Irritancy	High	Low	Medium	Medium
Drying alcohol	—	—	Contains drying alcohol	—
	View product	Shop	Shop	Shop

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Product summary

"Replenix - AE Facial Firming Therapy" is a well-rounded moisturizing product.

Ingredient callouts

This moistruizer also contains peptides (palmitoyl tripeptide-38 0.95% - 1.40%, acetyl hexapeptide-8 6.80% - 10.10% and acetyl dipeptide-1 cetyl ester 1.20% - 1.70%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

There are actives in this product that can be irritating. We assess the overall irritancy of this moisturizer to be low. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.