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Peter Thomas Roth Peptide 21 Wrinkle Resist Eye Cream
Peter Thomas Roth

Peter Thomas Roth Peptide 21 Wrinkle Resist Eye Cream

Efficacy83/100IrritancyMedium
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Works for

2 of 3 advertised claims delivered

Anti-aging
Palmitoyl hexapeptide-12, Tripeptide-10 citrulline + 17 more
Strong evidence
What the product description says
“A visibly wrinkle-fighting eye cream with 21 peptides and neuropeptides that visibly reduces the look of crow’s feet, fine lines, and wrinkles.”
Source: Sephora CA

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-19, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Palmitoyl hexapeptide-12Key activeEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Tripeptide-10 citrullineKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Acetyl hexapeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%
Acetyl octapeptide-3Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Acetyl tetrapeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl tetrapeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Acetyl tetrapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Dipeptide diaminobutyroyl benzylamide diacetateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Trifluoroacetyl tripeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: MediumA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.15–0.3%
Tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Hexapeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Palmitoyl hexapeptide-19Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Glycine soja proteinEffect: LowA plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking~0.25–0.45%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.7–1.05%
Moisturizing
Tripeptide-10 citrulline, Trifluoroacetyl tripeptide-2 + 38 more
Strong evidence
What the product description says
“Reforcyl® 3%: Moisturizes and smooths the look of wrinkled skin.”
Source: Sephora CA

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: dextran, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-12, palmitoyl hexapeptide-19, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline

Tripeptide-10 citrullineHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Trifluoroacetyl tripeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl hexapeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%
Acetyl octapeptide-3Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Acetyl tetrapeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl tetrapeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Acetyl tetrapeptide-9HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1–1.2%
Dipeptide diaminobutyroyl benzylamide diacetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.9–4.8%
Hexapeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
MannitolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.2–0.4%
Palmitoyl hexapeptide-12HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Palmitoyl hexapeptide-19HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
PolymethylsilsesquioxaneKey activeEffect: HighA silicone that improves product texture and helps dissolve other ingredients. Can form a non-greasy film on the skin to prevent moisture loss~0.25–0.45%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.15–0.3%
Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.2–0.4%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: HighA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.15–0.3%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.7–1.05%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~2.4–2.9%
DextranKey active· HumectantEffect: HighHelps attract water to the most upper layer of the skin. Derived from sugar~0.15–0.3%
Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%
Dimethicone crosspolymerKey activeEffect: MediumUsed to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface~0.2–0.4%
Glycine soja proteinKey active· Humectant, EmollientEffect: MediumA plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking~0.25–0.45%
Hydrolyzed rice proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-oxidant properties~0.2–0.4%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.6–2%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~1.2–1.5%
Hydrolyzed wheat proteinKey active· HumectantEffect: MediumCan help attract water to the upper layer of the skin. Avoid if sensitive to gluten~0.2–0.35%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~0.25–0.45%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.45%
Isononyl isononanoate· Emollient, OcclusiveEffect: LowForms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness~5.2–6.4%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~2–2.4%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.6–0.85%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~3–3.7%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.45%
Evens skin tone
Glycine soja protein, Hydrolyzed soy protein
Limited evidence
What the product description says
“Gamma proteins harness the power of Asian natto gum to improve the look of elasticity, radiance, uneven skin tone, and texture.”
Source: Sephora CA

This product contains ingredients (glycine soja protein) that could help reduce hyperpigmentation (for example, post-acne marks or age spots) in theory, but there is not enough evidence that they actually work.

Glycine soja proteinEffect: LowA plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking~0.25–0.45%
Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%
Anti-oxidation
Not advertised by the brand · Superoxide dismutase, Butyrospermum parkii butter + 3 more
Strong evidence

This product contains antioxidants (superoxide dismutase) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.2–0.4%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.7–1.05%
Hydrolyzed rice proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-oxidant properties~0.2–0.4%
Glycine soja proteinEffect: LowA plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking~0.25–0.45%
Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%

Can it cause trouble?

Irritancy
14 flagged ingredients
Medium risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Decyl glucosideHelps oil and water mix together. Can be irritatingHigh~0.3–0.55%est.
Phenethyl alcoholA fragrance. Can be irritatingHigh~0.2–0.4%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~2.4–2.9%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~2–2.4%est.
Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.2–0.4%est.
Potassium sorbateA preservativeMedium~0.2–0.4%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.2–0.4%est.
TriethanolamineUsed to adjust pH of the product and can help improve the product's smellMedium~0.25–0.45%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.25–0.45%est.
Acrylates copolymerUsed to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistencyMedium~0.2–0.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.45%est.
Hydrolyzed wheat proteinCan help attract water to the upper layer of the skin. Avoid if sensitive to glutenMedium~0.2–0.35%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.15–0.3%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.1–0.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.7–1.05%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.6–2%est.
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Alternatives
Cheaper, or higher on efficacy
Peptine Biome Eye Cream
SWANICOCO Peptine Biome Eye Cream
CheaperHigher efficacy · 100/10050% match
$18.00
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Isononyl isononanoate~5.2–6.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness

More about Isononyl isononanoate
Glycerin~3.9–4.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Butylene glycol~3–3.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Caprylic/capric triglyceride~2.4–2.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Pentylene glycol~2–2.4%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Cetearyl alcohol~1.6–2%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Sorbitan stearate~1.4–1.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sorbitan stearate
Cyclopentasiloxane~1.2–1.5%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Dimethicone~1–1.2%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Butyrospermum parkii butter~0.7–1.05%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Glyceryl stearate~0.6–0.85%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Peg-100 stearate~0.55–0.85%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Palmitoyl tripeptide-5~0.4–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Tripeptide-10 citrulline~0.35–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tripeptide-10 citrulline
Acetyl tetrapeptide-11~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-11
Acetyl hexapeptide-1~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-1
Acetyl hexapeptide-8~0.3–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Palmitoyl hexapeptide-12~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl hexapeptide-12
Acetyl tetrapeptide-9~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-9
Acetyl tetrapeptide-2~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-2
Palmitoyl hexapeptide-19~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl hexapeptide-19
Palmitoyl tetrapeptide-7~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Trifluoroacetyl tripeptide-2~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Trifluoroacetyl tripeptide-2
Acetyl octapeptide-3~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl octapeptide-3
Tripeptide-1~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tripeptide-1
Palmitoyl tripeptide-1~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Hexapeptide-11~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-11
Dipeptide diaminobutyroyl benzylamide diacetate~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Dipeptide diaminobutyroyl benzylamide diacetate
Leuconostoc/radish root ferment filtrate~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate
Hydrolyzed soy protein~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryEvens skin toneAnti-oxidation

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein
Natto gum~0.25–0.45%
Formula
Irritation risk
Low
More about Natto gum
Glycine soja protein~0.25–0.45%
Key active
Irritation risk
Low
Works for
CleansingMoisturizingAnti-agingEvens skin toneAnti-oxidation

A plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking

More about Glycine soja protein
Superoxide dismutase~0.2–0.4%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingAnti-oxidation

An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants

More about Superoxide dismutase
Potassium sorbate~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Pseudoalteromonas ferment extract~0.2–0.4%
Formula
Irritation risk
Low
More about Pseudoalteromonas ferment extract
Citric acid~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Cistus incanus flower/leaf/stem extract~0.2–0.4%
Formula
Irritation risk
Low
More about Cistus incanus flower/leaf/stem extract
Gynostemma pentaphyllum leaf/stem extract~0.25–0.45%
Formula
Irritation risk
Low
More about Gynostemma pentaphyllum leaf/stem extract
Sodium polyglutamate~0.2–0.35%
Formula
Irritation risk
Low
More about Sodium polyglutamate
Polymethylsilsesquioxane~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

A silicone that improves product texture and helps dissolve other ingredients. Can form a non-greasy film on the skin to prevent moisture loss

More about Polymethylsilsesquioxane
Phenoxyethanol~0.25–0.4%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Hydrolyzed rice protein~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

Helps attract water to the upper layer of the skin. Might have some anti-oxidant properties

More about Hydrolyzed rice protein
Xanthan gum~0.25–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Polysilicone-11~0.25–0.45%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Dimethicone crosspolymer~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface

More about Dimethicone crosspolymer
Triethanolamine~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to adjust pH of the product and can help improve the product's smell

More about Triethanolamine
Carbomer~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Hydroxyethylcellulose~0.25–0.45%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Sodium phytate~0.2–0.4%
Formula
Irritation risk
Low

Used to stabilize product formulations

More about Sodium phytate
Mannitol~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin

More about Mannitol
Polysorbate 20~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Dimethyl isosorbide~0.2–0.4%
Formula
Irritation risk
Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide
Glutamine~0.2–0.4%
Formula
Irritation risk
Low
More about Glutamine
Decyl glucoside~0.3–0.55%
Irritant · high
Irritation risk
High
Works for
Cleansing

Helps oil and water mix together. Can be irritating

More about Decyl glucoside
Phenethyl alcohol~0.2–0.4%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Phenethyl alcohol
Acrylates/c10-30 alkyl acrylate crosspolymer~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Sodium hydroxide~0.2–0.4%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Acrylates copolymer~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Used to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistency

More about Acrylates copolymer
Sodium benzoate~0.2–0.4%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Silica~0.3–0.55%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Caprylyl glycol~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Hydrolyzed wheat protein~0.2–0.35%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten

More about Hydrolyzed wheat protein
Magnesium chloride~0.2–0.35%
Formula
Irritation risk
Low

Helps thicken the product formulation

More about Magnesium chloride
Disodium phosphate~0.2–0.35%
Formula
Irritation risk
Low

Helps adjust the product pH and stabilize the formulation

More about Disodium phosphate
Lecithin~0.25–0.45%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Sodium dextran sulfate~0.2–0.35%
Formula
Irritation risk
Low
More about Sodium dextran sulfate
Dextran~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the most upper layer of the skin. Derived from sugar

More about Dextran
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.15–0.3%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid

More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate
Sodium lactate~0.15–0.3%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Sodium phosphate~0.15–0.3%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Sodium phosphate
Polysorbate 60~0.1–0.2%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Mica~0.1–0.2%
Formula
Irritation risk
Low

Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light

More about Mica
Ingredient list view

Water, Isononyl isononanoate, Glycerin, Butylene glycol, Caprylic/capric triglyceride, Pentylene glycol, Cetearyl alcohol, Sorbitan stearate, Cyclopentasiloxane, Dimethicone, Butyrospermum parkii butter, Glyceryl stearate, Peg-100 stearate, Palmitoyl tripeptide-5, Tripeptide-10 citrulline, Acetyl tetrapeptide-11, Acetyl hexapeptide-1, Acetyl hexapeptide-8, Palmitoyl hexapeptide-12, Acetyl tetrapeptide-9, Acetyl tetrapeptide-2, Palmitoyl hexapeptide-19, Palmitoyl tetrapeptide-7, Trifluoroacetyl tripeptide-2, Acetyl octapeptide-3, Tripeptide-1, Palmitoyl tripeptide-1, Hexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate, Leuconostoc/radish root ferment filtrate, Hydrolyzed soy protein, Natto gum, Glycine soja protein, Superoxide dismutase, Potassium sorbate, Pseudoalteromonas ferment extract, Citric acid, Cistus incanus flower/leaf/stem extract, Gynostemma pentaphyllum leaf/stem extract, Sodium polyglutamate, Polymethylsilsesquioxane, Phenoxyethanol, Hydrolyzed rice protein, Xanthan gum, Polysilicone-11, Dimethicone crosspolymer, Triethanolamine, Carbomer, Hydroxyethylcellulose, Sodium phytate, Mannitol, Polysorbate 20, Dimethyl isosorbide, Glutamine, Decyl glucoside, Phenethyl alcohol, Acrylates/c10-30 alkyl acrylate crosspolymer, Sodium hydroxide, Acrylates copolymer, Sodium benzoate, Silica, Caprylyl glycol, Hydrolyzed wheat protein, Magnesium chloride, Disodium phosphate, Lecithin, Sodium dextran sulfate, Dextran, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Sodium lactate, Sodium phosphate, Polysorbate 60, Mica

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Peter Thomas RothPeptide 21 Wrinkle Resist Eye CreamYOUR PRODUCTSWANICOCOPeptine Biome Eye Cream
Match—50%
Price$69.77$18.00−$51.77
Shared key ingredients—14 of 28
Key difference—Acetyl Dipeptide-1 Cetyl Ester
Irritancy Medium Medium
Drying alcohol——
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Product summary

Judging from the ingredient list, "Peter Thomas Roth - Peptide 21 Wrinkle Resist Eye Cream" works well for improving skin hydration The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Acetyl hexapeptide-8, acetyl octapeptide-3, dextran, glycerin and mannitol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, tripeptide-1, caprylic/capric triglyceride and dimethicone) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This moistruizer also contains peptides (tripeptide-10 citrulline 0.35% - 0.60%, tripeptide-1 0.25% - 0.45%, trifluoroacetyl tripeptide-2 0.20% - 0.40%, palmitoyl tetrapeptide-7 0.20% - 0.40%, palmitoyl hexapeptide-19 0.20% - 0.35%, palmitoyl hexapeptide-12 0.25% - 0.50%, acetyl tetrapeptide-9 0.25% - 0.45%, acetyl tetrapeptide-2 0.20% - 0.40%, acetyl tetrapeptide-11 0.30% - 0.60%, acetyl octapeptide-3 0.20% - 0.40%, acetyl hexapeptide-8 0.30% - 0.50%, palmitoyl tripeptide-5 0.40% - 0.60%, palmitoyl tripeptide-1 0.25% - 0.45%, dipeptide diaminobutyroyl benzylamide diacetate 0.20% - 0.40%, hexapeptide-11 0.20% - 0.40% and acetyl hexapeptide-1 0.30% - 0.60%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

There are some common irritants in this product, including ingredients that do not have benefits for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 75.00$ in the United States, from 94.50CA$ up to 98.00CA$ in Canada, for 110.95A$ in Australia and from 34.75£ up to 57.75£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activityonlinelibrary.wiley.com
  5. 5
    Dermatological and cosmeceutical benefits of Glycine max (soybean) and its active componentsncbi.nlm.nih.gov
  6. 6
    Safety Assessment of Soy Peptides as Used in Cosmeticscir-safety.org
Peter Thomas Roth Peptide 21 Wrinkle Resist Eye Cream
Peter Thomas RothPeptide 21 Wrinkle Resist Eye Cream
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