Perricone MD Treatments Neuropeptide Night Cream
Works for
2 of 3 advertised claims delivered
MoisturizingTetrapeptide-21, Dipeptide-2 + 28 moreStrong evidence
“Hydrating, nourishing and soothing.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
fructose, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, dimethicone.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, ceramide 2, dipeptide-2, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21, urea
Anti-agingDipeptide-2, Palmitoyl oligopeptide + 5 moreModerate evidence
“Benefits. . Minimises the appearance of fine line and wrinkles. . Develops radiant, younger and brighter looking skin. .”
This product contains acetyl hexapeptide-8, dipeptide-2, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
Evens skin toneDipotassium glycyrrhizateWeak evidence
“This unique complex is released upon contact with the skin to maximise hydration, minimise the appearance of lines, uneven skin tone, and to increase radiance and glow.”
Effective ingredients missing or their concentration is too low
Can it cause trouble?
Irritancy1 strong irritant: ParfumMedium risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycerin~4.6–5.6%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinIsononyl isononanoate~4.1–5%
- Irritation risk
- Low
Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness
More about Isononyl isononanoatePentaerythrityl tetraethylhexanoate~3.1–3.8%
- Irritation risk
- Low
Used to create a nice product consistency while softening the upper layer of the skin
More about Pentaerythrityl tetraethylhexanoateCetearyl alcohol~2.3–2.8%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholButyrospermum parkii butter~2–2.4%
- Irritation risk
- Low
- Comedogenicity
- 3/5
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
More about Butyrospermum parkii butterC12-20 acid peg-8 ester~1.6–2%
- Irritation risk
- Medium
Helps oil and water mix together
More about C12-20 acid peg-8 esterDimethyl isosorbide~1.4–1.7%
- Irritation risk
- Low
Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin
More about Dimethyl isosorbideC10-18 triglycerides~1.2–1.5%
- Irritation risk
- Low
Helps soften the skin and attract water to its upper layer. Helps create nice product texture
More about C10-18 triglyceridesIsodecyl salicylate~0.9–1.1%
- Irritation risk
- Low
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.65–1%
- Irritation risk
- Medium
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerButylene glycol~0.55–0.85%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolSqualane~0.55–0.85%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneC12-15 alkyl benzoate~0.5–0.7%
- Irritation risk
- Low
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
More about C12-15 alkyl benzoateDimethicone~0.5–0.75%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconePolymethyl methacrylate~0.45–0.7%
- Irritation risk
- Low
Is used to enhance product texture and can help to optically mask skin imperfections
More about Polymethyl methacrylateDimethyl mea~0.4–0.6%
- Irritation risk
- Low
Citric acid~0.3–0.6%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidPhenoxyethanol~0.3–0.6%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolParfum~0.25–0.5%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumCaprylyl glycol~0.3–0.55%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolTribehenin~0.3–0.5%
- Irritation risk
- Low
Used to create a thicker product consistency and soften the upper layer of the skin
More about TribeheninCoco-glucoside~0.3–0.5%
- Irritation risk
- High
Used as a cleansing agent (surfactant) in cleansers. Helps water and oil mix together in lotions. Can be irritating
More about Coco-glucosidePolysorbate 60~0.25–0.45%
Tyrosine~0.2–0.4%
Pentylene glycol~0.25–0.5%
- Irritation risk
- Medium
Used to preserve products, dissolve other ingredients and create a nice product texture
More about Pentylene glycolPotassium sorbate~0.25–0.45%
Tocopheryl acetate~0.25–0.45%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateDipotassium glycyrrhizate~0.2–0.4%
- Irritation risk
- Low
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
More about Dipotassium glycyrrhizateHesperidin methyl chalcone~0.25–0.4%
- Irritation risk
- High
Might help neutralize free radicals in skin. Is claimed to be able to improve the appearance of undereye darkness but evidence is missing. Can be an allergen and cause irritation
More about Hesperidin methyl chalconeHexylene glycol~0.2–0.4%
- Irritation risk
- Medium
Helps create a more spreadable product texture
More about Hexylene glycolCeramide 2~0.25–0.45%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide 2Sodium hydroxide~0.25–0.4%
Urea~0.2–0.4%
- Irritation risk
- Low
Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations
More about UreaFructose~0.25–0.4%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin
More about FructosePeg-10 rapeseed sterol~0.3–0.55%
Disodium edta~0.2–0.4%
Steareth-20~0.3–0.55%
Allantoin~0.2–0.4%
- Irritation risk
- Low
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
More about AllantoinTrehalose~0.2–0.4%
- Irritation risk
- Low
A sugar that attracts water to the upper layer of the skin
More about TrehaloseSodium lactate~0.2–0.4%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateSodium chloride~0.25–0.45%
- Irritation risk
- Low
Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures
More about Sodium chlorideSodium pca~0.2–0.35%
- Irritation risk
- Low
Naturally present in skin and helps to attract water to its upper layer
More about Sodium pcaMaltose~0.2–0.35%
- Irritation risk
- Low
Acetyl hexapeptide-8~0.2–0.35%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Pentapeptide-18~0.2–0.35%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Pentapeptide-18Tetrapeptide-21~0.15–0.3%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tetrapeptide-21Glucose~0.15–0.25%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function
More about GlucoseSodium hyaluronate~0.15–0.3%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateDipeptide-2~0.15–0.25%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Dipeptide-2Palmitoyl tetrapeptide-7~0.15–0.25%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Palmitoyl oligopeptide~0.2–0.35%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl oligopeptideIngredient list view
Water, Glycerin, Isononyl isononanoate, Pentaerythrityl tetraethylhexanoate, Cetearyl alcohol, Butyrospermum parkii butter, C12-20 acid peg-8 ester, Dimethyl isosorbide, C10-18 triglycerides, Isodecyl salicylate, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Butylene glycol, Squalane, C12-15 alkyl benzoate, Dimethicone, Polymethyl methacrylate, Dimethyl mea, Citric acid, Phenoxyethanol, Parfum, Caprylyl glycol, Tribehenin, Coco-glucoside, Polysorbate 60, Tyrosine, Pentylene glycol, Potassium sorbate, Tocopheryl acetate, Dipotassium glycyrrhizate, Hesperidin methyl chalcone, Hexylene glycol, Ceramide 2, Sodium hydroxide, Urea, Fructose, Peg-10 rapeseed sterol, Disodium edta, Steareth-20, Allantoin, Trehalose, Sodium lactate, Sodium chloride, Sodium pca, Maltose, Acetyl hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Glucose, Sodium hyaluronate, Dipeptide-2, Palmitoyl tetrapeptide-7, Palmitoyl oligopeptide
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Product summary
Based on the ingredients included, "Perricone MD - Treatments Neuropeptide Night Cream" works well for moisturizing the skin. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (acetyl hexapeptide-8, urea, fructose, glycerin and sodium hyaluronate) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (ceramide 2, palmitoyl tetrapeptide-7, butyrospermum parkii butter, dimethicone and squalane) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- Another benefit is that this moisturizer contain ceramides (ceramide 2 0.25% - 0.45%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
- This moistruizer also contains peptides (palmitoyl oligopeptide 0.20% - 0.35%, palmitoyl tetrapeptide-7 0.15% - 0.25%, dipeptide-2 0.15% - 0.25%, tetrapeptide-21 0.15% - 0.30%, pentapeptide-18 0.20% - 0.35% and acetyl hexapeptide-8 0.20% - 0.35%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
There are some common irritants in this product, including ingredients that do not have benefits for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
About the brand
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 17 studies and safety reviews.
- 1
- 2Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmeticsjournals.sagepub.com
- 3
- 4
- 5Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 6
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