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Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer
Peter Thomas Roth

Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer

Efficacy66/100IrritancyMedium
See all ingredients In 2 routines
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Works for

2 of 3 advertised claims delivered

Moisturizing
Palmitoyl hexapeptide-19, Palmitoyl oligopeptide + 39 more
Strong evidence
What the product description says
“Packed with 21 Peptides and Neuropeptides and 2 Gamma Proteins, this lightweight moisturizer delivers intense hydration and leaves skin feeling bouncy, firm, lifted and younger-looking.”
Source: Beautylish

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: dextran, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, simmondsia chinensis seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-12, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline

Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.15–0.3%
Palmitoyl hexapeptide-19HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.65%
PhytosterolsKey active· EmollientEffect: HighLipids that work as an emollient and can be helpful in repairing skin barrier function~0.3–0.55%
Acetyl hexapeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl octapeptide-3Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl tetrapeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%
Acetyl tetrapeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl tetrapeptide-9HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
DextranKey active· HumectantEffect: HighHelps attract water to the most upper layer of the skin. Derived from sugar~0.2–0.35%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~4.2–5.1%
Dipeptide diaminobutyroyl benzylamide diacetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.5–0.75%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.7–5.7%
Hexapeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.55–0.8%
MannitolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.25–0.45%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.7–1.1%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%
Palmitoyl hexapeptide-12HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~2–2.4%
SqualeneKey active· Emollient, OcclusiveEffect: HighAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~0.3–0.5%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: HighA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.15–0.3%
TrehaloseKey active· HumectantEffect: HighA sugar that attracts water to the upper layer of the skin~0.25–0.45%
Trifluoroacetyl tripeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Tripeptide-10 citrullineHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.3–0.55%
Hydrolyzed wheat proteinKey active· HumectantEffect: MediumCan help attract water to the upper layer of the skin. Avoid if sensitive to gluten~0.2–0.4%
Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~1.2–1.5%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.3–0.55%
Batyl alcohol· EmollientEffect: LowNon-drying alcohol. Used to stabilize other ingredients and is an emollient~1–1.2%
Behenyl alcohol· Emollient, OcclusiveEffect: LowNon-drying alcohol that helps water and oil mix together. Also serves as an emollient~1.5–1.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.6–1.9%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.3–0.55%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Anti-aging
Palmitoyl hexapeptide-12, Acetyl hexapeptide-1 + 17 more
Strong evidence
What the product description says
“Packed with 21 Peptides and Neuropeptides and 2 Gamma Proteins, this lightweight moisturizer delivers intense hydration and leaves skin feeling bouncy, firm, lifted and younger-looking.”
Source: Beautylish

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Palmitoyl hexapeptide-12Key activeEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Acetyl hexapeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Acetyl octapeptide-3Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl tetrapeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%
Acetyl tetrapeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl tetrapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Dipeptide diaminobutyroyl benzylamide diacetateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.5–0.75%
Hexapeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.55–0.8%
Palmitoyl hexapeptide-19Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.5%
Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.65%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: MediumA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.15–0.3%
Tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.5%
Tripeptide-10 citrullineKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.6%
Trifluoroacetyl tripeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Evens skin tone
Hydrolyzed soy protein
Weak evidence
What the product description says
“Gamma Proteins harness the power of Asian natto gum, a breakthrough ingredient that helps improve the look of elasticity, radiance, uneven skin tone and texture.”
Source: Beautylish

Effective ingredients missing or their concentration is too low

Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%
Anti-oxidation
Not advertised by the brand · Squalene, Cereus grandiflorus flower extract + 2 more
Moderate evidence

This product contains antioxidants (cereus grandiflorus flower extract, squalene) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

SqualeneKey activeEffect: MediumAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~0.3–0.5%
Cereus grandiflorus flower extractKey activeEffect: MediumA cactus extract that can help neutralize free radicals because it contains a chemical compound called betacyanins and flavonolglycosides. Can help make the surface of the skin dryer helping make pores look smaller for a very short period of time. The concentrations usually used in cosmetics are too small to have any effect~0.25–0.45%
Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.4%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%

Can it cause trouble?

Irritancy
15 flagged ingredients
Medium risk
We flagged 15 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.7–1.1%est.
Sorbic acidA preservativeMedium~0.25–0.45%est.
Cereus grandiflorus flower extractA cactus extract that can help neutralize free radicals because it contains a chemical compound called betacyanins and flavonolglycosides. Can help make the surface of the skin dryer helping make pores look smaller for a very short period of time. The concentrations usually used in cosmetics are too small to have any effectMedium~0.25–0.45%est.
Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.25–0.45%est.
PhytosterolsLipids that work as an emollient and can be helpful in repairing skin barrier functionMedium~0.3–0.55%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.25–0.5%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.3–0.55%est.
Potassium sorbateA preservativeMedium~0.25–0.45%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
Laureth-12Helps water and oil mix togetherMedium~0.25–0.5%est.
Hydrolyzed wheat proteinCan help attract water to the upper layer of the skin. Avoid if sensitive to glutenMedium~0.2–0.4%est.
EthylhexylglycerinA preservativeMedium~0.2–0.35%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.15–0.3%est.
TriethanolamineUsed to adjust pH of the product and can help improve the product's smellMedium~0.1–0.15%est.
Acrylates copolymerUsed to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistencyMedium~0.1–0.15%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
SqualeneAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast2/5~0.3–0.5%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.7–5.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Dimethicone~4.2–5.1%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Olive oil decyl esters~3.1–3.7%
Formula
Irritation risk
Low
More about Olive oil decyl esters
Glycereth-26~2.3–2.8%
Formula
Irritation risk
Low

Helps create a thicker product consistency

More about Glycereth-26
Squalane~2–2.4%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Butylene glycol~1.6–1.9%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Behenyl alcohol~1.5–1.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Non-drying alcohol that helps water and oil mix together. Also serves as an emollient

More about Behenyl alcohol
Polysilicone-11~1.2–1.5%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Batyl alcohol~1–1.2%
Formula
Irritation risk
Low
Works for
AntibacterialMoisturizing

Non-drying alcohol. Used to stabilize other ingredients and is an emollient

More about Batyl alcohol
Simmondsia chinensis seed oil~0.7–1.1%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Hexapeptide-11~0.55–0.8%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-11
Dipeptide diaminobutyroyl benzylamide diacetate~0.5–0.75%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Dipeptide diaminobutyroyl benzylamide diacetate
Palmitoyl tripeptide-5~0.45–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Tripeptide-10 citrulline~0.4–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tripeptide-10 citrulline
Acetyl hexapeptide-1~0.4–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-1
Acetyl tetrapeptide-11~0.35–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-11
Acetyl hexapeptide-8~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Palmitoyl hexapeptide-12~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl hexapeptide-12
Acetyl tetrapeptide-9~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-9
Palmitoyl tetrapeptide-7~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Acetyl tetrapeptide-2~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-2
Acetyl octapeptide-3~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl octapeptide-3
Palmitoyl hexapeptide-19~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl hexapeptide-19
Trifluoroacetyl tripeptide-2~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Trifluoroacetyl tripeptide-2
Tripeptide-1~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Tripeptide-1
Palmitoyl oligopeptide~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
CleansingMoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide
Palmitoyl tripeptide-1~0.3–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Potassium hydrolyzed polygamma-glutamate~0.25–0.45%
Formula
Irritation risk
Low
More about Potassium hydrolyzed polygamma-glutamate
Sodium polyglutamate~0.25–0.4%
Formula
Irritation risk
Low
More about Sodium polyglutamate
Squalene~0.3–0.5%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
MoisturizingAnti-oxidation

An oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast

More about Squalene
Mica~0.3–0.5%
Formula
Irritation risk
Low

Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light

More about Mica
Sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Sorbic acid~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Sorbic acid
Tocopherol~0.25–0.45%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingMoisturizingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Cereus grandiflorus flower extract~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A cactus extract that can help neutralize free radicals because it contains a chemical compound called betacyanins and flavonolglycosides. Can help make the surface of the skin dryer helping make pores look smaller for a very short period of time. The concentrations usually used in cosmetics are too small to have any effect

More about Cereus grandiflorus flower extract
Pseudoalteromonas ferment extract~0.25–0.45%
Formula
Irritation risk
Low
More about Pseudoalteromonas ferment extract
Leuconostoc/radish root ferment filtrate~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate
Magnesium chloride~0.25–0.45%
Formula
Irritation risk
Low

Helps thicken the product formulation

More about Magnesium chloride
Phenoxyethanol~0.25–0.45%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Cetyl alcohol~0.3–0.55%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Stearyl alcohol~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Trehalose~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Glyceryl stearate~0.3–0.55%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Silanetriol trehalose ether~0.25–0.5%
Formula
Irritation risk
Low
More about Silanetriol trehalose ether
Mannitol~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin

More about Mannitol
Phytosterols~0.3–0.55%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Lipids that work as an emollient and can be helpful in repairing skin barrier function

More about Phytosterols
Acrylates/c10-30 alkyl acrylate crosspolymer~0.25–0.5%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Caprylic/capric triglyceride~0.3–0.55%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Hydrogenated lecithin~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Polyglyceryl-10 myristate~0.25–0.45%
Formula
Irritation risk
Low
More about Polyglyceryl-10 myristate
Polysorbate 20~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Dimethyl isosorbide~0.25–0.45%
Formula
Irritation risk
Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide
Sodium benzoate~0.25–0.45%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Sodium hydroxide~0.25–0.45%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Laureth-12~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Laureth-12
Hydrolyzed wheat protein~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten

More about Hydrolyzed wheat protein
Lecithin~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Disodium phosphate~0.2–0.4%
Formula
Irritation risk
Low

Helps adjust the product pH and stabilize the formulation

More about Disodium phosphate
Hydrolyzed soy protein~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin toneAnti-oxidationAnti-inflammatory

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein
Carbomer~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Dextran~0.2–0.35%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the most upper layer of the skin. Derived from sugar

More about Dextran
Ethylhexylglycerin~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Sodium lactate~0.15–0.3%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.15–0.3%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid

More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate
Sodium phosphate~0.15–0.3%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Sodium phosphate
Xanthan gum~0.15–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Triethanolamine~0.1–0.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to adjust pH of the product and can help improve the product's smell

More about Triethanolamine
Acrylates copolymer~0.1–0.15%
Irritant · medium
Irritation risk
Medium

Used to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistency

More about Acrylates copolymer
Ingredient list view

Water, Glycerin, Dimethicone, Olive oil decyl esters, Glycereth-26, Squalane, Butylene glycol, Behenyl alcohol, Polysilicone-11, Batyl alcohol, Simmondsia chinensis seed oil, Hexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl tripeptide-5, Tripeptide-10 citrulline, Acetyl hexapeptide-1, Acetyl tetrapeptide-11, Acetyl hexapeptide-8, Palmitoyl hexapeptide-12, Acetyl tetrapeptide-9, Palmitoyl tetrapeptide-7, Acetyl tetrapeptide-2, Acetyl octapeptide-3, Palmitoyl hexapeptide-19, Trifluoroacetyl tripeptide-2, Tripeptide-1, Palmitoyl oligopeptide, Palmitoyl tripeptide-1, Potassium hydrolyzed polygamma-glutamate, Sodium polyglutamate, Squalene, Mica, Sodium hyaluronate, Sorbic acid, Tocopherol, Cereus grandiflorus flower extract, Pseudoalteromonas ferment extract, Leuconostoc/radish root ferment filtrate, Magnesium chloride, Phenoxyethanol, Cetyl alcohol, Stearyl alcohol, Trehalose, Glyceryl stearate, Silanetriol trehalose ether, Mannitol, Phytosterols, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylic/capric triglyceride, Hydrogenated lecithin, Polyglyceryl-10 myristate, Polysorbate 20, Dimethyl isosorbide, Sodium benzoate, Potassium sorbate, Caprylyl glycol, Sodium hydroxide, Laureth-12, Hydrolyzed wheat protein, Lecithin, Disodium phosphate, Hydrolyzed soy protein, Carbomer, Dextran, Ethylhexylglycerin, Sodium lactate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Sodium phosphate, Xanthan gum, Triethanolamine, Acrylates copolymer

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Product summary

"Peter Thomas Roth - Peptide 21 Lift & Firm Moisturizer" is a well-rounded moisturizing product. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Acetyl hexapeptide-8, acetyl octapeptide-3, dextran, glycerin and mannitol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, tripeptide-1, phytosterols and dimethicone) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • This moistruizer also contains peptides (trifluoroacetyl tripeptide-2 0.25% - 0.45%, palmitoyl tripeptide-5 0.45% - 0.65%, palmitoyl tripeptide-1 0.30% - 0.50%, palmitoyl tetrapeptide-7 0.30% - 0.55%, palmitoyl oligopeptide 0.30% - 0.60%, palmitoyl hexapeptide-19 0.25% - 0.45%, palmitoyl hexapeptide-12 0.30% - 0.55%, tripeptide-10 citrulline 0.40% - 0.60%, tripeptide-1 0.25% - 0.50%, hexapeptide-11 0.55% - 0.80%, dipeptide diaminobutyroyl benzylamide diacetate 0.50% - 0.75%, acetyl tetrapeptide-9 0.25% - 0.50%, acetyl tetrapeptide-2 0.25% - 0.45%, acetyl tetrapeptide-11 0.35% - 0.65%, acetyl octapeptide-3 0.25% - 0.45%, acetyl hexapeptide-8 0.30% - 0.60% and acetyl hexapeptide-1 0.40% - 0.60%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails from 95.00$ up to 103.00$ in the United States, for 172.97A$ in Australia, from 56.40£ up to 117.50£ in the United Kingdom and from 119.70CA$ up to 124.00CA$ in Canada.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Safety Assessment of Glycerin Ethoxylates as Used in Cosmeticscir-safety.org
  5. 5
    Squalene and its potential clinical useseuropepmc.org
  6. 6
    Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology mdpi.com
Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer
Peter Thomas RothPeptide 21 Lift & Firm Moisturizer
Buy at Sephora$56.00Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Sephora$56.00Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.