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Perricone MD Treatments Essential Fx Deep Crease Serum
Perricone MD

Perricone MD Treatments Essential Fx Deep Crease Serum

Efficacy87/100IrritancyHigh·100% recommend (1 review)
See all ingredients

Works for

Moisturizing
Palmitoyl tripeptide-5, Acetyl hexapeptide-8 + 22 more
Works well
What the product description says
“This intensely hydrating deep wrinkle serum is formulated with Acyl-Glutathione to help reduce the look of deep wrinkles and creases by protecting and replenishing skin.”
Source: Allbeauty

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: anhydroxylitol, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-5

Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.65–0.95%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–0.9%
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineHeroEffect: High~0.3–0.6%
SqualeneKey active· Emollient, OcclusiveEffect: HighAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~4.1–5%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~2–2.5%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1.7–2.1%
Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~1.5–1.9%
XylitylglucosideKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrier function~1.2–1.5%
AnhydroxylitolKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrir function~0.6–0.85%
Salvia hispanica seed oilKey active· EmollientEffect: HighChia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier~0.45–0.7%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.35–0.65%
Magnesium aspartateKey activeEffect: MediumMight be helpful in restoring skin barrier function and calm down inflammation in skin~0.35–0.6%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.3–0.6%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: HighA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.3–0.6%
GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.3–0.6%
Hydrogenated polyisobutene· Emollient, OcclusiveEffect: LowUsed to improve the product consistency and soften the upper layer of the skin~3.2–3.9%
Linum usitatissimum seed oilEffect: Low~0.45–0.7%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–0.65%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.55–0.8%
Caprylic/capric triglycerideUnder-dosedA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.35–0.6%
Copper gluconateUnder-dosedTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.6%
Zinc gluconateUnder-dosedTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.6%
Alaria esculenta extractUnder-dosedWorks as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.~0.3–0.6%
Anti-aging
Palmitoyl tripeptide-5, Acetyl hexapeptide-8 + 8 more
May help
What the product description says
“This intensely hydrating deep wrinkle serum is formulated with Acyl-Glutathione to help reduce the look of deep wrinkles and creases by protecting and replenishing skin.”
Source: Allbeauty

This product contains acetyl hexapeptide-8, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.65–0.95%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.6–0.9%
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonineKey activeEffect: Medium~0.3–0.6%
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateKey activeEffect: MediumA peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid~0.3–0.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–0.65%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.6%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.6%
Alaria esculenta extractEffect: Low, below effective doseWorks as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.~0.3–0.6%
Tetrahexyldecyl ascorbateUnder-dosedBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~1–1.3%
Lactic acidUnder-dosedAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.55–0.8%
Anti-oxidation
Side benefit · Squalene, Rosmarinus officinalis leaf extract + 5 more
May help

This product contains antioxidants (squalene) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

SqualeneKey activeEffect: MediumAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast~4.1–5%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.3–0.55%
Zinc gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin~0.3–0.6%
Alaria esculenta extractEffect: Low, below effective doseWorks as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.~0.3–0.6%
Copper gluconateEffect: Low, below effective doseTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing~0.3–0.6%
Tetrahexyldecyl ascorbateUnder-dosedBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~1–1.3%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.45–0.65%

Can it cause trouble?

Irritancy
5 strong irritants: Rosmarinus officinalis leaf extract, Parfum + 3 more — patch-test recommended
High risk
We flagged 16 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.3–0.55%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.25%est.
HydroxycitronellalA fragrance. A likely allergen and can be irritatingHigh~0.15–0.25%est.
LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.1–0.15%est.
LinaloolA fragrance. Can be irritatingHigh~0.1–0.15%est.
Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~1.5–1.9%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~1–1.3%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.55–0.8%est.
EthylhexylglycerinA preservativeMedium~0.4–0.6%est.
Zinc gluconateTypically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skinMedium~0.3–0.6%est.
Copper gluconateTypically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missingMedium~0.3–0.6%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.35–0.6%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.3–0.5%est.
Caprylyl/capryl glucosideHelps oil and water mix together. Can be used as a cleansing agentMedium~0.4–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
Potassium sorbateA preservativeMedium~0.2–0.35%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
SqualeneAn oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast2/5~4.1–5%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Propanediol~4.2–5.2%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Squalene~4.1–5%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
MoisturizingAnti-oxidation

An oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast

More about Squalene
Hydrogenated polyisobutene~3.2–3.9%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene
S-palmitoylglutathione~2.3–2.8%
Formula
Irritation risk
Low
More about S-palmitoylglutathione
Dimethicone~2–2.5%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Glycerin~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Macadamia ternifolia seed oil~1.5–1.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil
Xylitylglucoside~1.2–1.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitylglucoside
Tetrahexyldecyl ascorbate~1–1.3%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Dimethyl mea~0.75–1.15%
Formula
Irritation risk
Low
More about Dimethyl mea
Palmitoyl tripeptide-5~0.65–0.95%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Acetyl hexapeptide-8~0.6–0.9%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Anhydroxylitol~0.6–0.85%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrir function

More about Anhydroxylitol
Lactic acid~0.55–0.8%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Xylitol~0.55–0.8%
Formula
Irritation risk
Low

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitol
Xanthan gum~0.55–0.8%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Linum usitatissimum seed oil~0.45–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing
More about Linum usitatissimum seed oil
Salvia hispanica seed oil~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Chia seed oil. Helps to soften the upper layer of the skin and might be helpful in repairing skin barrier

More about Salvia hispanica seed oil
Tocopherol~0.45–0.65%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ethylhexylglycerin~0.4–0.6%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Magnesium aspartate~0.35–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

Might be helpful in restoring skin barrier function and calm down inflammation in skin

More about Magnesium aspartate
Zinc gluconate~0.3–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-blemishAnti-agingAnti-oxidationEvens skin toneAnti-inflammatoryExfoliation

Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin

More about Zinc gluconate
Alaria esculenta extract~0.3–0.6%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

Works as a humectant helping to attract water to the upper layer of the skin and might be effective as an anti-oxidant.

More about Alaria esculenta extract
Glucose~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose
Sodium hyaluronate~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Copper gluconate~0.3–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-agingEvens skin toneAnti-blemishExfoliationAnti-oxidation

Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing

More about Copper gluconate
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.3–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid

More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate
Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine
Helianthus annuus seed oil~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Rosmarinus officinalis leaf extract~0.3–0.55%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Tetrasodium glutamate diacetate~0.3–0.55%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Magnesium chloride~0.3–0.55%
Formula
Irritation risk
Low

Helps thicken the product formulation

More about Magnesium chloride
Caprylic/capric triglyceride~0.35–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Acrylates/c10-30 alkyl acrylate crosspolymer~0.3–0.5%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Caprylyl/capryl glucoside~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together. Can be used as a cleansing agent

More about Caprylyl/capryl glucoside
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Potassium sorbate~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Parfum~0.15–0.25%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Hydroxycitronellal~0.15–0.25%
Irritant · high
Irritation risk
High

A fragrance. A likely allergen and can be irritating

More about Hydroxycitronellal
Limonene~0.1–0.15%
Irritant · high
Irritation risk
High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene
Linalool~0.1–0.15%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Ingredient list view

Water, Propanediol, Squalene, Hydrogenated polyisobutene, S-palmitoylglutathione, Dimethicone, Glycerin, Macadamia ternifolia seed oil, Xylitylglucoside, Tetrahexyldecyl ascorbate, Dimethyl mea, Palmitoyl tripeptide-5, Acetyl hexapeptide-8, Anhydroxylitol, Lactic acid, Xylitol, Xanthan gum, Linum usitatissimum seed oil, Salvia hispanica seed oil, Tocopherol, Ethylhexylglycerin, Magnesium aspartate, Zinc gluconate, Alaria esculenta extract, Glucose, Sodium hyaluronate, Copper gluconate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Helianthus annuus seed oil, Rosmarinus officinalis leaf extract, Tetrasodium glutamate diacetate, Magnesium chloride, Caprylic/capric triglyceride, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylyl/capryl glucoside, Caprylyl glycol, Potassium sorbate, Phenoxyethanol, Parfum, Hydroxycitronellal, Limonene, Linalool

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDTreatments Essential Fx Deep Crease SerumYOUR PRODUCTBlissYouth Got This SerumGenabellePDRN Dual Glow Serum MistMEDIHEALBaobab Soothing Moisture Serum
Match—48%47%47%
Price—$32.00$20.65—
Shared key ingredients—8 of 209 of 206 of 20
Key difference—RetinolCopper Tripeptide-1Copper Tripeptide-1
Irritancy High Medium Medium Medium
Drying alcohol————
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More alternatives: NEOGEN X SUR.MEDIC AGECURE ONE MINUTE WRINKLE PERFECTIONcolibri skincare Polypeptide Booster

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Product summary

"Perricone MD - Treatments Essential Fx Deep Crease Serum" is effective for: Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine 0.30% - 0.60%, acetyl hexapeptide-8 0.60% - 0.90% and palmitoyl tripeptide-5 0.65% - 0.95%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Humectants (sodium hyaluronate 0.30% - 0.60%, anhydroxylitol 0.60% - 0.85%, acetyl hexapeptide-8 0.60% - 0.90%, xylitylglucoside 1.20% - 1.50% and glycerin 1.70% - 2.10%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails from 114.00£ up to 3157.00£ in the United Kingdom.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 31 studies and safety reviews.

  1. 1
    Squalene and its potential clinical useseuropepmc.org
  2. 2
    Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology mdpi.com
  3. 3
    Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxidesonlinelibrary.wiley.com
  4. 4
    Final report of the cosmetic ingredient review expert panel on the safety assessment of Polyisobutene and Hydrogenated Polyisobutene as used in cosmeticssemanticscholar.org
  5. 5
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  6. 6
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
Perricone MD Treatments Essential Fx Deep Crease Serum
Perricone MDTreatments Essential Fx Deep Crease Serum
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