PRODUCT REVIEW
Perricone MD The Advanced Soothing Regimen
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Product summary
What can the product work for?
Anti-aging
What does the product description say?
It visibly reduces the appearance of lines, wrinkles, uneven texture, uneven tone, redness and enlarged pores, but goes further by soothing and calming skin.
glycolic acid
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness: HIGH
An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid
copper tripeptide-1
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
acetyl hexapeptide-8
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
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Evens skin tone
What does the product description say?
It visibly reduces the appearance of lines, wrinkles, uneven texture, uneven tone, redness and enlarged pores, but goes further by soothing and calming skin.
glycolic acid
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness: HIGH
An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid
tetrahexyldecyl ascorbate
0.25% -
0.4%
Irritation risk:
Concentration: Insufficient!
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
retinyl palmitate
0.2% -
0.35%
Irritation risk:
Concentration: Insufficient!
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
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Moisturizing
What does the product description say?
It is an ultra-gentle cream designed to calm and smooth skin's appearance without irritating even the most sensitive skin.
glycine soja oil
0.2% -
0.4%
Irritation risk: Comedogenicity: Medium
Concentration: Effectiveness: HIGH
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
grifola frondosa fruiting body extract
0.25% -
0.45%
Irritation risk:
Concentration: Effectiveness: HIGH
Mushroom extract that helps attract water to the upper layer of the skin and might be able to stimulate sebum production in skin
helianthus annuus seed oil
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness: HIGH
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
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Exfoliation
glycolic acid
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness: HIGH
An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid
zinc gluconate
0.2% -
0.4%
Irritation risk:
Concentration: Insufficient!
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
retinyl palmitate
0.2% -
0.35%
Irritation risk:
Concentration: Insufficient!
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
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Anti-oxidation
tocotrienols
0.2% -
0.35%
Irritation risk:
Concentration: Effectiveness: HIGH
A type of vitamin E that is more powerful in neutralizing free radicals compared to its other forms
annona cherimola fruit extract
0.2% -
0.4%
Irritation risk:
Concentration: Effectiveness:
LOW
A fruit extract that might have an anti-oxidant effect in skin
Irritation risk:
Concentration: Effectiveness:
LOW
CBD. Can bind to skin cell receptors and can reduce inflammation, itching, and help support skin barrier function
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Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing | |
| Evens skin tone |
Total Promises Fulfilled score:
100/100.
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Can it cause trouble?
- Overall product irritation risk
- Acne & comedogenic risk ingredients: 6
Potential irritants
calendula officinalis flower extract
0.5% -
0.7%
Irritation risk:
Works for:
Anti-oxidation
A plant extract that has some anti-oxidant and anti-bacterial properties. Can be irritating
phenylpropanol
0.2% -
0.4%
Irritation risk:
Helps mask the smell of other ingredients and helps preserve the product formulation
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Comodogenic ingredients
cetearyl alcohol
2.3% -
2.8%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
glycine soja oil
0.2% -
0.4%
Irritation risk: Comedogenicity: Medium
Works for:
Moisturizing
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
Show more
User reviews (0)
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| Irritancy | IRRITANCY
HIGH
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MEDIUM
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MEDIUM
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MEDIUM
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HIGH
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HIGH
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HIGH
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HIGH
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MEDIUM
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HIGH
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Ingredients & concentrations
All ingredients
Key Actives
zinc gluconate
0.2% -
0.4%
Irritation risk:
Works for:
Moisturizing,
Anti-oxidation,
Exfoliation,
Evens skin tone,
Anti-blemish,
Anti-aging,
Anti-inflammatory
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
allantoin
0.25% -
0.5%
Irritation risk:
Works for:
Moisturizing,
Anti-inflammatory,
Reduces irritation,
Reduces redness,
Anti-blemish,
Exfoliation
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
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Potential irritants
calendula officinalis flower extract
0.5% -
0.7%
Irritation risk:
Works for:
Anti-oxidation
A plant extract that has some anti-oxidant and anti-bacterial properties. Can be irritating
phenylpropanol
0.2% -
0.4%
Irritation risk:
Helps mask the smell of other ingredients and helps preserve the product formulation
Show more
Comodogenic ingredients
cetearyl alcohol
2.3% -
2.8%
Irritation risk: Comedogenicity: Medium
Works for:
Cleansing,
Moisturizing
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
glycine soja oil
0.2% -
0.4%
Irritation risk: Comedogenicity: Medium
Works for:
Moisturizing
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
Show more
All ingredients
glycerin
4.8% -
5.9%
Irritation risk:
Works for:
Moisturizing
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
glyceryl stearate
3.3% -
4%
Irritation risk:
Works for:
Cleansing,
Moisturizing
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Show more
Ingredient list view
Water, Glycerin, Glyceryl stearate, Aluminum starch octenylsuccinate, Cetearyl alcohol, Bis-diglyceryl polyacyladipate-2, Cetyl alcohol, Vitis vinifera seed oil, Dicaprylyl ether, Hydrogenated palm kernel glycerides, Squalane, Calendula officinalis flower extract, Unknown, Cannabidiol - derived from extract or tincture or resin of cannabis, Glyceryl caprylate, Bisabolol, Ectoin, Citrullus lanatus fruit extract, Allantoin, Dipotassium glycyrrhizate, Xanthan gum, Pyrus malus fruit extract, Hydrogenated palm glycerides, Tocotrienols, Tocopherol, Glycine soja oil, Caprylhydroxamic acid, Ceteareth-20, 1,2-hexanediol, Sodium polyacrylate, Lens esculenta fruit extract, Sodium lactate, Elaeis guineensis oil, Sodium pca, Potassium sorbate, Unknown, Water, 1,2-hexanediol, Sodium pca, Triethyl citrate, Propanediol, Capryloyl glycine, Glycerin, Annona cherimola fruit extract, Cannabidiol - derived from extract or tincture or resin of cannabis, Ganoderma lucidum stem extract, Grifola frondosa fruiting body extract, Sodium bicarbonate, Caprylhydroxamic acid, Sodium hydroxide, Citric acid, Cannabis sativa seed oil glycereth-8 esters, Acrylates/c10-30 alkyl acrylate crosspolymer, Sodium citrate, Lentinus edodes mycelium extract, Sodium dehydroacetate, Phenylpropanol, Water, Isopropyl palmitate, Glycerin, Cetearyl alcohol, Glyceryl stearate, Peg-100 stearate, Butylene glycol, Phosphatidylcholine, Tetrahexyldecyl ascorbate, Dimethyl mea, Acetyl hexapeptide-8, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Tyrosine, Cannabidiol - derived from extract or tincture or resin of cannabis, Echium plantagineum seed oil, Glycolic acid, Hydrolyzed myrtus communis leaf extract, Copper tripeptide-1, Magnesium aspartate, Zinc gluconate, Copper gluconate, Ethylhexylglycerin, Rosmarinus officinalis leaf extract, Sodium hyaluronate, Retinyl palmitate, Helianthus annuus seed oil, Disodium edta, Carbomer, Ceteareth-20, Hydrogenated vegetable glycerides, Dimethicone, Caprylyl glycol, Polysorbate 20, Phenoxyethanol, Sorbic acid, Potassium sorbate
Sources
- Glycerol and the skin: holistic approach to its origin and functions
- Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics
- Topical application of Calendula officinalis (L.): Formulation and evaluation of hydrophilic cream with antioxidant activity
- The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.)
- Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis
- Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – part 1: Achillea millefolium–Curcuma longa
- α-(-)-Bisabolol Reduces Pro-Inflammatory Cytokine Production and Ameliorates Skin Inflammation
- Analyzing Lycopene Content in Fruits
- Profile of wound healing process induced by allantoin
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics
- Tocotrienol‐rich fraction attenuates UV‐induced inflammaging: A bench to bedside study
- Tocotrienols: Vitamin E beyond tocopherols
- Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)
- Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics
- Vitamin E in dermatology
- Vitamin E and Skin Health
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Genetic Architecture of Palm Oil Fatty Acid Composition in Cultivated Oil Palm (Elaeis guineensis Jacq.) Compared to Its Wild Relative E. oleifera (H.B.K) Cortés
- Nutrient composition of Nigerian palm kernel from the dura and tenera varieties of the oil palm (Elaeis guineensis)
- Citric Acid, Inorganic Citrate Salts and Alkyl Citrate Esters As Used in Cosmetics
- Annona cherimola Miller Fruit as a Promising Candidate against Diabetic Complications: An In Vitro Study and Preliminary Clinical Results
- Assessment of the antioxidant, cytotoxic, and genotoxic potential of the Annona muricata leaves and their influence on genomic stability
- 4 Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid
- Final Report on the Safety Assessment of Isopropyl Isostearate
- Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage
- Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacy
- Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids
- Photoprotective and antiinflammatory effects of topical glycolic acid
- Glycolic acid peel therapy – a current review
- Dual Effects of Alpha-Hydroxy Acids on the Skin
- Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review
- Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L.
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
- Topical Peptide Treatments with Effective Anti-Aging Results
- Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study
- Selected Biomarkers Revealed Potential Skin Toxicity Caused by Certain Copper Compounds
- Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines
- Zinc salts in dermatology
- An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders
- Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins
- Evaluation of the effects of topical zinc gluconate in wound healing
- A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
- Applications of hydroxy acids: classification, mechanisms, and photoactivity
- Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gel
- Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics
- Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
- Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egypt
- Effect of topically applied lipids on surfactant-irritated skin
- Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries
- Dimethicone as a protective ingredient in topical medications