Works for:
based on ingredients and %- Anti-aging
- Moisturizing
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 5
Key actives
Product Summary
"Perricone MD - Neuropeptide Moisturizer & Night Cream Duo" has a good moisturizing formula. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Acetyl hexapeptide-8, urea, fructose, glycerin and sodium hyaluronate in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Ceramide ng, palmitoyl tetrapeptide-7, dimethicone, squalane and c10-18 triglycerides in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.
Ingredient callouts
- Another benefit is that this moisturizer contain ceramides (ceramide ng 0.25% - 0.50%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
- We like that this moisturizer contains peptides (tetrapeptide-21 0.20% - 0.40%, pentapeptide-18 0.25% - 0.45%, palmitoyl tetrapeptide-7 0.25% - 0.50%, palmitoyl hexapeptide-12 0.25% - 0.45%, dipeptide-2 0.25% - 0.40%, acetyl hexapeptide-8 0.25% - 0.40% and acetyl hexapeptide-8 0.65% - 0.95%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
About the brand
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
Price
The product retails for 349.00$ in the United States.
For a detailed price comparison: click here.
Works for
Anti-aging
What does the product description say?
This ultra-rich wrinkle cream works overnight to nourish skin with essential hydration and smooths the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines.
Source: Perricone MD
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, dipeptide-2, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Moisturizing
What does the product description say?
Neuropeptide Moisturizer & Night Cream Duo
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
fructose, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, squalane.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, ceramide ng, dipeptide-2, palmitoyl hexapeptide-12, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21, urea
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps attract water to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Naturally present in skin and helps to attract water to its upper layer
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A sugar that attracts water to the upper layer of the skin
Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps soften the skin and attract water to its upper layer. Helps create nice product texture
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
Helps preserve products and creates a nice product texture
Helps soften the upper layer of the skin and create a thicker product consistency
Used to create a thicker product consistency and soften the upper layer of the skin
Used to preserve products, dissolve other ingredients and create a nice product texture
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness
Used to create a nice product consistency while softening the upper layer of the skin
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Perricone MD Neuropeptide Moisturizer & Night Cream Duo | Current | $349.00 | |
M-61 Hydraboost Cream | 45% | $68.60 | |
 Peter Thomas Roth PEPTIDE 21 WRINKLE RESIST MOISTURISER - Day care | 44% | $399.00 | |
Dermadoctor Wrinkle Revenge Rescue & Protect Facial Cream | 44% | $45.99 | |
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Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Isopropyl palmitate, Cetearyl alcohol, Taurine, Tyrosine, Glyceryl stearate, Peg-100 stearate, Ceteareth-20, Phosphatidylcholine, Dimethyl mea, Acetyl hexapeptide-8, Sodium hyaluronate, Disodium edta, Dimethicone, Caprylyl glycol, Phenoxyethanol, Sorbic acid, Potassium sorbate, Parfum, Citral, Citronellol, Geraniol, Hydroxycitronellal, Linalool, Water, Glycerin, Isononyl isononanoate, Pentaerythrityl tetraethylhexanoate, Cetearyl alcohol, Butyrospermum parkii butter, C12-20 acid peg-8 ester, Dimethyl isosorbide, C10-18 triglycerides, Isodecyl salicylate, Butylene glycol, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Squalane, C12-15 alkyl benzoate, Dimethicone, Polymethyl methacrylate, Dimethyl mea, Acetyl hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl tetrapeptide-7, Palmitoyl hexapeptide-12, Tyrosine, Tocopheryl acetate, Dipotassium glycyrrhizate, Hesperidin methyl chalcone, Ceramide ng, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium hyaluronate, Citric acid, Sodium hydroxide, Disodium edta, Sodium chloride, Steareth-20, Polysorbate 60, Caprylyl glycol, Tribehenin, Coco-glucoside, Pentylene glycol, Hexylene glycol, Urea, Peg-10 rapeseed sterol, Sodium lactate, Sodium pca, Phenoxyethanol, Potassium sorbate, Parfum, Linalool, Limonene
- Final Report on the Safety Assessment of Isopropyl Isostearate
- Cosmeceuttical Critigue: Taurine
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Annex I: Clinical evidence regarding sensitisation to individual fragrance chemicals and to natural extracts
- Glycerol and the skin: holistic approach to its origin and functions
- Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmetics
- Activity enhancement of ferulic acid with dimethyl isosorbride in cosmetic compositions
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Hesperidin methyl chalcone - a new cosmetic contact allergen
- Benefits of Hesperidin for Cutaneous Functions
- Topical emulsions containing ceramides: Effects on the skin barrier function and anti‐inflammatory properties
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Profile of wound healing process induced by allantoin
- Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Function
- In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response
- Allergen of the Year—Alkyl Glucoside
- Topical urea in skincare: A review