Perricone MD Neuropeptide Moisturizer & Night Cream Duo
Works for
2 of 3 advertised claims delivered
Anti-agingPalmitoyl hexapeptide-12, Dipeptide-2 + 5 moreStrong evidence
“This ultra-rich wrinkle cream works overnight to nourish skin with essential hydration and smooths the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, dipeptide-2, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
MoisturizingAcetyl hexapeptide-8, Dipeptide-2 + 30 moreStrong evidence
“A luxurious, ultra-powerful formula provides essential, all-day hydration and helps dramatically and visibly firm thin and sagging skin on face.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
fructose, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, squalane.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, ceramide ng, dipeptide-2, palmitoyl hexapeptide-12, palmitoyl tetrapeptide-7, pentapeptide-18, tetrapeptide-21, urea
Evens skin toneTaurine, Dipotassium glycyrrhizateWeak evidence
“Improved appearance of skin resilience, tone and texture.”
Effective ingredients missing or their concentration is too low
Can it cause trouble?
Irritancy7 strong irritants: Parfum, Citral + 5 more — patch-test recommendedHigh risk
Comedogenic5 ingredients rated 2 or more on the 0–5 pore-clogging scale5 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Isopropyl palmitate~5.4–6.7%
- Irritation risk
- Medium
- Comedogenicity
- 3/5
Helps soften the upper layer of the skin and create a thicker product consistency
More about Isopropyl palmitateCetearyl alcohol~4.2–5.2%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholTaurine~3.5–4.3%
- Irritation risk
- Medium
Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness
More about TaurineTyrosine~2.6–3.2%
Glyceryl stearate~2.2–2.7%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearatePeg-100 stearate~1.9–2.3%
- Irritation risk
- Low
Helps oil and water mix togehter and creates a nice product texture
More about Peg-100 stearateCeteareth-20~1.6–1.9%
- Irritation risk
- Medium
- Comedogenicity
- 2/5
Helps oil and water mix together. Has some emollient properties
More about Ceteareth-20Phosphatidylcholine~1.2–1.5%
- Irritation risk
- Medium
Used to enhance the delivery of other ingredients
More about PhosphatidylcholineDimethyl mea~0.95–1.15%
- Irritation risk
- Low
Acetyl hexapeptide-8~0.65–0.95%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Sodium hyaluronate~0.55–0.8%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateDisodium edta~0.5–0.7%
Dimethicone~0.5–0.75%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeCaprylyl glycol~0.45–0.65%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolPhenoxyethanol~0.4–0.6%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolSorbic acid~0.35–0.6%
Potassium sorbate~0.3–0.6%
Parfum~0.25–0.5%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumCitral~0.25–0.45%
Citronellol~0.25–0.45%
Geraniol~0.25–0.45%
Hydroxycitronellal~0.2–0.4%
- Irritation risk
- High
A fragrance. A likely allergen and can be irritating
More about HydroxycitronellalLinalool~0.2–0.4%
Water~0.25–0.45%
Glycerin~0.25–0.5%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinIsononyl isononanoate~0.25–0.5%
- Irritation risk
- Low
Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness
More about Isononyl isononanoatePentaerythrityl tetraethylhexanoate~0.3–0.5%
- Irritation risk
- Low
Used to create a nice product consistency while softening the upper layer of the skin
More about Pentaerythrityl tetraethylhexanoateCetearyl alcohol~0.3–0.5%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholButyrospermum parkii butter~0.25–0.5%
- Irritation risk
- Low
- Comedogenicity
- 3/5
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
More about Butyrospermum parkii butterC12-20 acid peg-8 ester~0.25–0.45%
- Irritation risk
- Medium
Helps oil and water mix together
More about C12-20 acid peg-8 esterDimethyl isosorbide~0.25–0.45%
- Irritation risk
- Low
Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin
More about Dimethyl isosorbideC10-18 triglycerides~0.25–0.5%
- Irritation risk
- Low
Helps soften the skin and attract water to its upper layer. Helps create nice product texture
More about C10-18 triglyceridesIsodecyl salicylate~0.25–0.4%
- Irritation risk
- Low
Butylene glycol~0.25–0.45%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolHydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.25–0.45%
- Irritation risk
- Medium
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerSqualane~0.3–0.5%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneC12-15 alkyl benzoate~0.25–0.5%
- Irritation risk
- Low
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
More about C12-15 alkyl benzoateDimethicone~0.3–0.55%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconePolymethyl methacrylate~0.25–0.5%
- Irritation risk
- Low
Is used to enhance product texture and can help to optically mask skin imperfections
More about Polymethyl methacrylateDimethyl mea~0.25–0.45%
- Irritation risk
- Low
Acetyl hexapeptide-8~0.25–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Pentapeptide-18~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Pentapeptide-18Tetrapeptide-21~0.2–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tetrapeptide-21Dipeptide-2~0.25–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Dipeptide-2Palmitoyl tetrapeptide-7~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Palmitoyl hexapeptide-12~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl hexapeptide-12Tyrosine~0.2–0.4%
Tocopheryl acetate~0.25–0.45%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateDipotassium glycyrrhizate~0.25–0.4%
- Irritation risk
- Low
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
More about Dipotassium glycyrrhizateHesperidin methyl chalcone~0.25–0.45%
- Irritation risk
- High
Might help neutralize free radicals in skin. Is claimed to be able to improve the appearance of undereye darkness but evidence is missing. Can be an allergen and cause irritation
More about Hesperidin methyl chalconeCeramide ng~0.25–0.5%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide ngFructose~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin
More about FructoseAllantoin~0.25–0.4%
- Irritation risk
- Low
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
More about AllantoinTrehalose~0.25–0.45%
- Irritation risk
- Low
A sugar that attracts water to the upper layer of the skin
More about TrehaloseMaltose~0.25–0.4%
- Irritation risk
- Low
Glucose~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function
More about GlucoseSodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateCitric acid~0.25–0.45%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidSodium hydroxide~0.25–0.45%
Disodium edta~0.25–0.45%
Sodium chloride~0.25–0.45%
- Irritation risk
- Low
Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures
More about Sodium chlorideSteareth-20~0.3–0.6%
Polysorbate 60~0.25–0.5%
Caprylyl glycol~0.25–0.5%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolTribehenin~0.25–0.5%
- Irritation risk
- Low
Used to create a thicker product consistency and soften the upper layer of the skin
More about TribeheninCoco-glucoside~0.3–0.5%
- Irritation risk
- High
Used as a cleansing agent (surfactant) in cleansers. Helps water and oil mix together in lotions. Can be irritating
More about Coco-glucosidePentylene glycol~0.3–0.55%
- Irritation risk
- Medium
Used to preserve products, dissolve other ingredients and create a nice product texture
More about Pentylene glycolHexylene glycol~0.25–0.45%
- Irritation risk
- Medium
Helps create a more spreadable product texture
More about Hexylene glycolUrea~0.25–0.45%
- Irritation risk
- Low
Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations
More about UreaPeg-10 rapeseed sterol~0.35–0.65%
Sodium lactate~0.25–0.4%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateSodium pca~0.2–0.35%
- Irritation risk
- Low
Naturally present in skin and helps to attract water to its upper layer
More about Sodium pcaPhenoxyethanol~0.15–0.3%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolPotassium sorbate~0.2–0.35%
Parfum~0.15–0.25%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumLinalool~0.1–0.15%
Limonene~0.1–0.15%
- Irritation risk
- High
A common frangrance that can easily irritate skin, especially if exposed to air, light or heat
More about LimoneneIngredient list view
Water, Isopropyl palmitate, Cetearyl alcohol, Taurine, Tyrosine, Glyceryl stearate, Peg-100 stearate, Ceteareth-20, Phosphatidylcholine, Dimethyl mea, Acetyl hexapeptide-8, Sodium hyaluronate, Disodium edta, Dimethicone, Caprylyl glycol, Phenoxyethanol, Sorbic acid, Potassium sorbate, Parfum, Citral, Citronellol, Geraniol, Hydroxycitronellal, Linalool, Water, Glycerin, Isononyl isononanoate, Pentaerythrityl tetraethylhexanoate, Cetearyl alcohol, Butyrospermum parkii butter, C12-20 acid peg-8 ester, Dimethyl isosorbide, C10-18 triglycerides, Isodecyl salicylate, Butylene glycol, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Squalane, C12-15 alkyl benzoate, Dimethicone, Polymethyl methacrylate, Dimethyl mea, Acetyl hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl tetrapeptide-7, Palmitoyl hexapeptide-12, Tyrosine, Tocopheryl acetate, Dipotassium glycyrrhizate, Hesperidin methyl chalcone, Ceramide ng, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium hyaluronate, Citric acid, Sodium hydroxide, Disodium edta, Sodium chloride, Steareth-20, Polysorbate 60, Caprylyl glycol, Tribehenin, Coco-glucoside, Pentylene glycol, Hexylene glycol, Urea, Peg-10 rapeseed sterol, Sodium lactate, Sodium pca, Phenoxyethanol, Potassium sorbate, Parfum, Linalool, Limonene
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Product summary
"Perricone MD - Neuropeptide Moisturizer & Night Cream Duo" has a good moisturizing formula. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Acetyl hexapeptide-8, urea, fructose, glycerin and sodium hyaluronate in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Ceramide ng, palmitoyl tetrapeptide-7, dimethicone, squalane and c10-18 triglycerides in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.
Ingredient callouts
- Another benefit is that this moisturizer contain ceramides (ceramide ng 0.25% - 0.50%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
- We like that this moisturizer contains peptides (tetrapeptide-21 0.20% - 0.40%, pentapeptide-18 0.25% - 0.45%, palmitoyl tetrapeptide-7 0.25% - 0.50%, palmitoyl hexapeptide-12 0.25% - 0.45%, dipeptide-2 0.25% - 0.40%, acetyl hexapeptide-8 0.25% - 0.40% and acetyl hexapeptide-8 0.65% - 0.95%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
About the brand
According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.
Price
The product retails for 349.00$ in the United States.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.
- 1Final Report on the Safety Assessment of Isopropyl Isostearatejournals.sagepub.com
- 2Cosmeceuttical Critigue: Taurinemdedge.com
- 3Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
- 4
- 5
- 6Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
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