Perricone MD High Potency Intensive Smoothing Serum
Works for
Anti-oxidationSide benefit · Ubiquinone, Zinc pca + 3 moreWorks well
This product contains antioxidants (ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
Can it cause trouble?
Irritancy9 flagged ingredientsLow risk
ComedogenicClean of flagged comedogenic ingredientsNone flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Diphenylsiloxy phenyl trimethicone~5.9–7.2%
- Irritation risk
- Low
Help improve the product's texture
More about Diphenylsiloxy phenyl trimethiconeNiacinamide~4.4–5.4%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideDimethicone~3.3–4%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconePolymethylsilsesquioxane~2.4–2.9%
- Irritation risk
- Low
A silicone that improves product texture and helps dissolve other ingredients. Can form a non-greasy film on the skin to prevent moisture loss
More about PolymethylsilsesquioxaneDimethicone/phenyl vinyl dimethicone crosspolymer~1.9–2.4%
- Irritation risk
- Low
Glyceryl stearate~1.7–2.1%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateHydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~1.4–1.7%
- Irritation risk
- Medium
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerGlyceryl ricinoleate~1.2–1.5%
- Irritation risk
- Low
Butylene glycol~0.95–1.15%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolPolysorbate 20~0.7–1.05%
Dimethyl isosorbide~0.55–0.85%
- Irritation risk
- Low
Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin
More about Dimethyl isosorbidePhenoxyethanol~0.5–0.75%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolSqualane~0.5–0.8%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneCaprylyl glycol~0.45–0.7%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolCeramide np~0.45–0.7%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide npGluconolactone~0.35–0.65%
- Irritation risk
- Medium
A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals
More about GluconolactoneZinc pca~0.4–0.6%
- Irritation risk
- Low
A compound that combines zinc with a hydrating ingredient PCA. Might to be helpful against acne and clogged pores. Can help calm down inflammation in skin. Could be helpful in reducing the formation of free radicals in skin. Might help to reduce fine lines in wrinkles, but solid evidence is missing
More about Zinc pcaDimethyl mea~0.3–0.55%
- Irritation risk
- Low
Glycerin~0.3–0.6%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinPolysorbate 60~0.3–0.55%
Sorbitan isostearate~0.25–0.5%
- Irritation risk
- Low
Helps oil and water mix together
More about Sorbitan isostearateSodium hyaluronate crosspolymer~0.25–0.45%
- Irritation risk
- Medium
Attracts water into the upper layer of the skin
More about Sodium hyaluronate crosspolymerOlea europaea leaf extract~0.2–0.4%
- Irritation risk
- Medium
A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing
More about Olea europaea leaf extractSodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateTocopheryl acetate~0.25–0.45%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateSodium acetylated hyaluronate~0.25–0.45%
- Irritation risk
- Low
A type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid
More about Sodium acetylated hyaluronatePropanediol~0.25–0.45%
- Irritation risk
- Low
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
More about PropanediolHyaluronic acid~0.2–0.4%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation
More about Hyaluronic acidHydrolyzed glycosaminoglycans~0.2–0.4%
- Irritation risk
- Low
Long sugars that help attract water to the upper layer of the skin
More about Hydrolyzed glycosaminoglycansHydrolyzed sodium hyaluronate~0.2–0.35%
- Irritation risk
- Low
Attracts water into the upper layer of the skin
More about Hydrolyzed sodium hyaluronate1,2-hexanediol~0.15–0.25%
Ubiquinone~0.15–0.3%
- Irritation risk
- Low
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
More about UbiquinoneHydrolyzed hyaluronic acid~0.15–0.25%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. A version of it is naturally present in skin
More about Hydrolyzed hyaluronic acidAcetyl hexapeptide-38~0.1–0.2%
Heptapeptide-6~0.1–0.15%
- Irritation risk
- Low
Caprylhydroxamic acid~0.05–0.1%
Ingredient list view
Water, Diphenylsiloxy phenyl trimethicone, Niacinamide, Dimethicone, Polymethylsilsesquioxane, Dimethicone/phenyl vinyl dimethicone crosspolymer, Glyceryl stearate, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Glyceryl ricinoleate, Butylene glycol, Polysorbate 20, Dimethyl isosorbide, Phenoxyethanol, Squalane, Caprylyl glycol, Ceramide np, Gluconolactone, Zinc pca, Dimethyl mea, Glycerin, Polysorbate 60, Sorbitan isostearate, Sodium hyaluronate crosspolymer, Olea europaea leaf extract, Sodium hyaluronate, Tocopheryl acetate, Sodium acetylated hyaluronate, Propanediol, Hyaluronic acid, Hydrolyzed glycosaminoglycans, Hydrolyzed sodium hyaluronate, 1,2-hexanediol, Ubiquinone, Hydrolyzed hyaluronic acid, Acetyl hexapeptide-38, Heptapeptide-6, Caprylhydroxamic acid
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Perricone MDHigh Potency Intensive Smoothing SerumYOUR PRODUCT | CollistarAnti-Dark Spot Concentrate Glycolic Acid and Niacinamide | ÉciatKeep Calm Soothing serum | BYOMABrightening Serum | |
|---|---|---|---|---|
| Match | — | 71% | 70% | 66% |
| Price | $135.00 | $42.42−$92.58 | — | $15.99−$119.01 |
| Shared key ingredients | — | 5 of 17 | 8 of 17 | 5 of 17 |
| Key difference | — | Lactobionic Acid | Panthenol | Phytosphingosine |
| Irritancy | Low | Low | Low | Low |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: La Clinica Hydrating & Healing SerumPacifica Beauty Berry Dewy Barrier Support Serum
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.
- 1
- 2
- 3
- 4Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 5
- 6
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