Perricone MD High Potency Hyaluronic Intensive Hydrating Serum

Perricone MD High Potency Hyaluronic Intensive Hydrating Serum

Efficacy100/100IrritancyMedium

Works for

Evens skin tone
Niacinamide, Acetyl glucosamine
Works well
What the product description says
“Niacinamide: Vitamin B3 helps reduce the look of uneven skin tone and texture while supporting the moisture barrier and providing antioxidant support.”
Source: Perricone MD

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: acetyl glucosamine, niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Acetyl glucosamineKey activeEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~2.1–3.1%
Anti-aging
Niacinamide, Acetyl glucosamine + 3 more
Works well
What the product description says
“As it targets dehydration, loss of radiance and loss of volume, this fast-absorbing, hydrating serum helps increase the feel of skin cushion and reduce the appearance of fine lines and wrinkles.”
Source: Perricone MD

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains acetyl glucosamine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl tetrapeptide-11, acetyl tetrapeptide-9.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Acetyl glucosamineKey activeEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~2.1–3.1%
Acetyl tetrapeptide-11Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.25%
Acetyl tetrapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.2%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.05–0.25%
Moisturizing
Niacinamide, Acetyl glucosamine + 14 more
Works well
What the product description says
“High Potency Hyaluronic Intensive Hydrating Serum”
Source: Perricone MD

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, hyaluronic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, squalane.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl glucosamine, acetyl tetrapeptide-11, acetyl tetrapeptide-9, ceramide np, niacinamide, phytosphingosine

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
Acetyl glucosamineHero· HumectantEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~2.1–3.1%
PhytosphingosineHero· EmollientEffect: HighA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.1–0.35%
Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.1–0.45%
Acetyl tetrapeptide-11HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.25%
Acetyl tetrapeptide-9HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.2%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~4.7–7%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.8–2.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.05–0.25%
Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.05–0.25%
Sodium acetylated hyaluronateKey active· HumectantEffect: HighA type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid~0.05–0.2%
Sodium hyaluronate crosspolymerKey active· HumectantEffect: HighAttracts water into the upper layer of the skin~0.05–0.25%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.05–0.2%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~3.4–5.1%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~1.3–1.9%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.1–0.5%
Anti-blemish
Side benefit · Niacinamide, Phytosphingosine
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.7–4%
PhytosphingosineEffect: LowA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.1–0.35%

Can it cause trouble?

Irritancy
8 flagged ingredients
Medium risk
We flagged 8 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
1,2-hexanediolA preservativeMedium~0.1–0.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.1–0.5%est.
HydroxyacetophenoneUsed to increase effectiveness of preservativesMedium~0.1–0.45%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.1–0.45%est.
Caprylyl/capryl glucosideHelps oil and water mix together. Can be used as a cleansing agentMedium~0.1–0.45%est.
Sorbitan oleateHelps oil and water mix togetherMedium~0.1–0.35%est.
Sodium hyaluronate crosspolymerAttracts water into the upper layer of the skinMedium~0.05–0.25%est.
EthylhexylglycerinA preservativeMedium~0.05–0.25%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Sorbitan oleateHelps oil and water mix together2/5~0.1–0.35%est.

User reviews

Would you recommend?
No community reviews yet.

Be the first — your take helps the next person decide.

Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Dimethicone~4.7–7%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Butylene glycol~3.4–5.1%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Niacinamide~2.7–4%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAntibacterialAnti-inflammatoryReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Acetyl glucosamine~2.1–3.1%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingEvens skin toneAnti-agingExfoliation

An effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin

More about Acetyl glucosamine
Squalane~1.8–2.7%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Sodium acrylate/sodium acryloyldimethyl taurate copolymer~1.3–2%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Sodium acrylate/sodium acryloyldimethyl taurate copolymer
Polysilicone-11~1.3–1.9%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Cetearyl olivate~0.95–1.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
Hdi/trimethylol hexyllactone crosspolymer~0.55–1.25%
Formula
Irritation risk
Low

Used to create a silky product texture and add volume to products

More about Hdi/trimethylol hexyllactone crosspolymer
Polyisobutene~0.45–1%
Formula
Irritation risk
Low

Used to improve the product consistency

More about Polyisobutene
Sorbitan olivate~0.3–0.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Dimethyl isosorbide~0.15–0.55%
Formula
Irritation risk
Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide
Polysorbate 20~0.15–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
1,2-hexanediol~0.1–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Caprylyl glycol~0.1–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Dimethyl mea~0.1–0.45%
Formula
Irritation risk
Low
More about Dimethyl mea
Hydroxyacetophenone~0.1–0.45%
Irritant · medium
Irritation risk
Medium

Used to increase effectiveness of preservatives

More about Hydroxyacetophenone
Citric acid~0.1–0.45%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ceramide np~0.1–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np
Caprylyl/capryl glucoside~0.1–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together. Can be used as a cleansing agent

More about Caprylyl/capryl glucoside
Sorbitan oleate~0.1–0.35%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan oleate
Sodium gluconate~0.05–0.2%
Formula
Irritation risk
Low

Helps stabilize product formulations

More about Sodium gluconate
Spermidine~0.05–0.25%
Formula
Irritation risk
Low
More about Spermidine
Silica~0.1–0.5%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Sodium acetylated hyaluronate~0.05–0.2%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid

More about Sodium acetylated hyaluronate
Sodium hyaluronate~0.05–0.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Phytosphingosine~0.1–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-blemish

A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect

More about Phytosphingosine
Sodium hyaluronate crosspolymer~0.05–0.25%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Sodium hyaluronate crosspolymer
Hyaluronic acid~0.05–0.25%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Ethylhexylglycerin~0.05–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Acetyl tetrapeptide-11~0.05–0.25%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-11
Acetyl tetrapeptide-9~0.05–0.2%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-9
Glycerin~0.05–0.25%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Disodium acetyl glucosamine phosphate~0.05–0.1%
Formula
Sodium glucuronate~0.01–0.05%
Formula
Magnesium sulfate~0.01–0.05%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Magnesium sulfate
Ingredient list view

Water, Dimethicone, Butylene glycol, Niacinamide, Acetyl glucosamine, Squalane, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Polysilicone-11, Cetearyl olivate, Hdi/trimethylol hexyllactone crosspolymer, Polyisobutene, Sorbitan olivate, Dimethyl isosorbide, Polysorbate 20, 1,2-hexanediol, Caprylyl glycol, Dimethyl mea, Hydroxyacetophenone, Citric acid, Ceramide np, Caprylyl/capryl glucoside, Sorbitan oleate, Sodium gluconate, Spermidine, Silica, Sodium acetylated hyaluronate, Sodium hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium hyaluronate crosspolymer, Hyaluronic acid, Ethylhexylglycerin, Acetyl tetrapeptide-11, Acetyl tetrapeptide-9, Glycerin, Disodium acetyl glucosamine phosphate, Sodium glucuronate, Magnesium sulfate

Compare prices

Retailers ranked by price — lowest first.

Amazon USPrice as of 11/14 12:05 GMT
$135.00
Buy
Perricone MD
$135.00
Buy

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDHigh Potency Hyaluronic Intensive Hydrating SerumYOUR PRODUCTDaughters of MalayPost-Breakout Recovery SerumÉciatKeep Calm Soothing serumBYOMABrightening Serum
Match—82%80%79%
Price$135.00——$15.99−$119.01
Shared key ingredients—5 of 147 of 146 of 14
Key difference—Alpha-ArbutinPanthenolCaprylic/Capric Triglyceride
Irritancy Medium Low Low Low
Drying alcohol————
View product Shop Shop Shop

More alternatives: kilig Probiotics & Niacinamide face seruminnisfree Retinol Cica Moisture Recovery Serum

Cheaper alternatives? See how this stacks up against similar formulas.
We compare ingredient profiles across our catalog — pick the closest match for your budget.
Open dupe finder

Product summary

"Perricone MD - High Potency Hyaluronic Intensive Hydrating Serum" is effective for: Evens skin tone, Moisturizing, Anti-blemish and Anti-aging

Ingredient callouts

  • A good concentration of Niacinamide (2.70% - 4.00%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
  • Ceramides (phytosphingosine 0.10% - 0.35% and ceramide np 0.10% - 0.45%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • Peptides (acetyl tetrapeptide-9 0.05% - 0.20% and acetyl tetrapeptide-11 0.05% - 0.25%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Humectants (sodium hyaluronate 0.05% - 0.20%, sodium acetylated hyaluronate 0.05% - 0.20%, glycerin 0.05% - 0.25% and acetyl glucosamine 2.10% - 3.10%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.

Price

The product retails from 59.25£ up to 1798.00£ in the United Kingdom and from 87.00$ up to 129.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 23 studies and safety reviews.

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
Perricone MD High Potency Hyaluronic Intensive Hydrating Serum
Perricone MDHigh Potency Hyaluronic Intensive Hydrating Serum

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.