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Perricone MD Cold Plasma Plus+ Advanced Hydrating Complex | PerriconeMD
Perricone MD

Perricone MD Cold Plasma Plus+ Advanced Hydrating Complex | PerriconeMD

Efficacy100/100IrritancyMedium
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Works for

3 of 3 advertised claims delivered

Anti-aging
Niacinamide, Centella asiatica leaf extract + 6 more
Strong evidence
What the product description says
“visibly less wrinkles”
Source: Perricone MD

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, centella asiatica leaf extract, copper tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.9–2.3%
Centella asiatica leaf extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.~0.25–0.45%
Copper tripeptide-1Key activeEffect: MediumA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.25–0.5%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.45–0.65%
Lycium barbarum fruit extractEffect: Low, below effective doseA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.15–0.3%
Moisturizing
Niacinamide, Palmitoyl tetrapeptide-7 + 22 more
Strong evidence
What the product description says
“ultra-hydrating moisturizer”
Source: Perricone MD

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: anhydroxylitol, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, copper tripeptide-1, niacinamide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

XylitylglucosideKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrier function~0.25–0.45%
AnhydroxylitolKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and repair the skin barrir function~0.25–0.5%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.5%
IsomaltKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~0.25–0.45%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.9–2.3%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.25–0.45%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.5–1.8%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~1–1.2%
Copper tripeptide-1HeroEffect: HighA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.25–0.5%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~5.4–6.6%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1.7–2.1%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.2–1.5%
Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~2.3–2.8%
Hippophae rhamnoides fruit oilKey activeEffect: MediumA plant oil that might somewhat help to neutralize free radicals. It could be irritating~0.25–0.45%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~3.2–3.9%
GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.2–0.4%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.55–0.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.4–0.6%
Lycium barbarum fruit extractUnder-dosedEffect: MediumA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.15–0.3%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.2–0.4%
Evens skin tone
Niacinamide, Taurine + 1 more
Strong evidence
What the product description says
“helps reduce the look of wrinkles, uneven texture and dullness”
Source: Perricone MD

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.9–2.3%
TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.25–0.45%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.45–0.65%
Anti-blemish
Not advertised by the brand · Niacinamide, Centella asiatica leaf extract + 3 more
Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.9–2.3%
Centella asiatica leaf extractEffect: LowA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.~0.25–0.45%
KaolinEffect: LowA type of clay that consists mainly of aluminum silicate. Helps absorb oil and creates a thicker product consistency. Can be used to add a white color~0.35–0.65%
TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.25–0.45%
Rosmarinus officinalis leaf extractUnder-dosedEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.2–0.4%

Can it cause trouble?

Irritancy
1 strong irritant: Rosmarinus officinalis leaf extract
Medium risk
We flagged 18 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Hippophae rhamnoides fruit oilA plant oil that might somewhat help to neutralize free radicals. It could be irritatingHigh~0.25–0.45%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.2–0.4%est.
Polyglyceryl-3 methylglucose distearateHelps water and oil mix togetherMedium~3.9–4.8%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~1–1.2%est.
Beta vulgaris root extractA plant extract that might have some antioxidant properties, but mostly used in cosmetics for its colorMedium~0.65–1%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.55–0.8%est.
1,2-hexanediolA preservativeMedium~0.45–0.65%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~0.45–0.65%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.35–0.65%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.3–0.6%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.3–0.5%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.25–0.45%est.
TaurineCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectivenessMedium~0.25–0.45%est.
Centella asiatica leaf extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.Medium~0.25–0.45%est.
Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.3–0.5%est.
Potassium sorbateA preservativeMedium~0.25–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.15–0.3%est.
Lycium barbarum fruit extractA plant extract that can help neutralize free radicals in skin and attract water to its upper layerMedium~0.15–0.3%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~3.2–3.9%est.
Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~2.3–2.8%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.2–1.5%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Dimethicone~5.4–6.6%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Polyglyceryl-3 methylglucose distearate~3.9–4.8%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Polyglyceryl-3 methylglucose distearate
Ethylhexyl palmitate~3.2–3.9%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Glyceryl stearate se~2.3–2.8%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se
Niacinamide~1.9–2.3%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Evens skin toneAnti-agingMoisturizingAnti-blemishReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Glycerin~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Squalane~1.5–1.8%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Cetearyl alcohol~1.2–1.5%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Caprylic/capric triglyceride~1–1.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Beta vulgaris root extract~0.65–1%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some antioxidant properties, but mostly used in cosmetics for its color

More about Beta vulgaris root extract
Hydrogenated lecithin~0.6–0.85%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Caprylyl glycol~0.55–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
1,2-hexanediol~0.45–0.65%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Propanediol~0.45–0.7%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Tetrahexyldecyl ascorbate~0.45–0.65%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Butylene glycol~0.4–0.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.35–0.65%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Sucrose palmitate~0.35–0.65%
Formula
Irritation risk
Low
Works for
Cleansing
More about Sucrose palmitate
Acrylates/c10-30 alkyl acrylate crosspolymer~0.3–0.6%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Ammonium acryloyldimethyltaurate/vp copolymer~0.3–0.5%
Formula
Irritation risk
Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer
Copper tripeptide-1~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.

More about Copper tripeptide-1
Hippophae rhamnoides fruit oil~0.25–0.45%
Key activeIrritant · high
Irritation risk
High
Works for
MoisturizingAnti-oxidationAnti-inflammatory

A plant oil that might somewhat help to neutralize free radicals. It could be irritating

More about Hippophae rhamnoides fruit oil
Sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Polysorbate 60~0.3–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Phaseolus angularis seed extract~0.3–0.55%
Formula
Irritation risk
Low
More about Phaseolus angularis seed extract
Carbomer~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Sodium lactate~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Sorbitan isostearate~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Silica~0.4–0.6%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Phenoxyethanol~0.25–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Polysorbate 20~0.3–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Taurine~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Anti-inflammatoryAnti-oxidationAnti-blemishEvens skin tone

Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness

More about Taurine
Isomalt~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Isomalt
Helianthus annuus seed oil~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Centella asiatica leaf extract~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-inflammatoryReduces irritationReduces rednessAnti-agingAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. It can be irritating to sensitive skin. Might be helpful in preventing stretch marks. It could, however, itself be irritating.

More about Centella asiatica leaf extract
Xanthan gum~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Xylitylglucoside~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitylglucoside
Kaolin~0.35–0.65%
Formula
Irritation risk
Low
Works for
MattifyingAnti-blemish

A type of clay that consists mainly of aluminum silicate. Helps absorb oil and creates a thicker product consistency. Can be used to add a white color

More about Kaolin
Anhydroxylitol~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and repair the skin barrir function

More about Anhydroxylitol
Cetearyl glucoside~0.3–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside
Potassium sorbate~0.25–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Xylitol~0.25–0.45%
Formula
Irritation risk
Low

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitol
Acetyl hexapeptide-8~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Rosmarinus officinalis leaf extract~0.2–0.4%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Glucose~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose
Acetic acid~0.2–0.4%
Formula
Irritation risk
Low
More about Acetic acid
Palmitoyl tripeptide-1~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Citric acid~0.15–0.3%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Palmitoyl tetrapeptide-7~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Lecithin~0.2–0.4%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Lycium barbarum fruit extract~0.15–0.3%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

A plant extract that can help neutralize free radicals in skin and attract water to its upper layer

More about Lycium barbarum fruit extract
Ultramarines~0.1–0.2%
Formula
Irritation risk
Low
More about Ultramarines
Titanium dioxide~0.1–0.2%
Formula
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Ingredient list view

Water, Dimethicone, Polyglyceryl-3 methylglucose distearate, Ethylhexyl palmitate, Glyceryl stearate se, Niacinamide, Glycerin, Squalane, Cetearyl alcohol, Caprylic/capric triglyceride, Beta vulgaris root extract, Hydrogenated lecithin, Caprylyl glycol, 1,2-hexanediol, Propanediol, Tetrahexyldecyl ascorbate, Butylene glycol, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Sucrose palmitate, Acrylates/c10-30 alkyl acrylate crosspolymer, Ammonium acryloyldimethyltaurate/vp copolymer, Copper tripeptide-1, Hippophae rhamnoides fruit oil, Sodium hyaluronate, Polysorbate 60, Phaseolus angularis seed extract, Carbomer, Sodium lactate, Sorbitan isostearate, Silica, Phenoxyethanol, Polysorbate 20, Taurine, Isomalt, Helianthus annuus seed oil, Centella asiatica leaf extract, Xanthan gum, Xylitylglucoside, Kaolin, Anhydroxylitol, Cetearyl glucoside, Potassium sorbate, Xylitol, Acetyl hexapeptide-8, Rosmarinus officinalis leaf extract, Glucose, Acetic acid, Palmitoyl tripeptide-1, Citric acid, Palmitoyl tetrapeptide-7, Lecithin, Lycium barbarum fruit extract, Ultramarines, Titanium dioxide

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Amazon USPrice as of 10/22/2026 03:17 GMT
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDCold Plasma Plus+ Advanced Hydrating Complex | PerriconeMDYOUR PRODUCTKeys SoulcareFirm Belief Smoothing Peptide CreamNEOGEN X SUR.MEDICSurmedic 24K Gold Caviar Repair Vital CreamMedicubePDRN Pink Peptide Cream
Match—83%79%77%
Price$94.50$38.71−$55.79$60.00−$34.50$32.67−$61.83
Shared key ingredients—12 of 2011 of 209 of 20
Key difference—Acetyl Tetrapeptide-9Nonapeptide-1Adenosine
Irritancy Medium Medium Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 28 studies and safety reviews.

  1. 1
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  2. 2
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  3. 3
    Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
  4. 4
    Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
  5. 5
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  6. 6
    The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
Perricone MD Cold Plasma Plus+ Advanced Hydrating Complex | PerriconeMD
Perricone MDCold Plasma Plus+ Advanced Hydrating Complex | PerriconeMD
Buy at Perricone MDCheck price$94.50as of 10/22 03:17 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Perricone MDCheck price$94.50as of 10/22 03:17 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.