Paula's choice CellularYouth™ Age-Disrupting Longevity Serum

Paula's choice CellularYouth™ Age-Disrupting Longevity Serum

Efficacy58/100IrritancyMedium

Works for

Moisturizing
Acetyl tetrapeptide-2, Glycerin + 13 more
Works well
What the product description says
“- Sunflower Sprout Extract: Nourishes by fueling natural NAD+ pathways—key to cellular energy.”
Source: Sephora CA

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, isomalt.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, simmondsia chinensis seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl tetrapeptide-2

Acetyl tetrapeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.5–0.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4–4.9%
TriheptanoinKey activeEffect: HighA synthetic triglyceride. Helps soften the upper layer of the skin~3.2–3.9%
Methyl gluceth-20Key active· HumectantEffect: MediumHelps attract water to the upper layer of the skin and soften it~2.5–3%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~2.2–2.7%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1–1.3%
Bacillus fermentKey activeEffect: HighA product of bacterial fermentation. Can help attract water to the upper layer of the skin~0.6–0.9%
Helianthus annuus sprout extractKey activeEffect: HighHelps soften the upper layer of the skin and can help support the skin barrier~0.5–0.75%
IsomaltKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~0.5–0.7%
Lycium barbarum fruit extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.5–0.75%
Coco-caprylate/caprateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin without creating a greasy texture~0.45–0.7%
CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.15–0.25%
Tridecyl trimellitate· EmollientEffect: LowUsed to create a thicker product consistency and soften the upper layer of the skin~1.7–2.1%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.2–0.35%
Anti-aging
Acetyl tetrapeptide-2, Lycium barbarum fruit extract
May help
What the product description says
“Clinically proven to improve the appearance of skin sagging, tone & fine lines & wrinkles**”
Source: Paula's Choice AUS

This product contains acetyl tetrapeptide-2. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Acetyl tetrapeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.5–0.7%
Lycium barbarum fruit extractEffect: LowA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.5–0.75%
Evens skin tone
Taurine
Not delivered
What the product description says
“Clinically proven to improve the appearance of skin sagging, tone & fine lines & wrinkles**”
Source: Paula's Choice AUS

Effective ingredients missing or their concentration is too low

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.7–1.05%
Anti-oxidation
Not advertised by the brand · Lycium barbarum fruit extract, Taurine
May help

This product contains antioxidants (lycium barbarum fruit extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Lycium barbarum fruit extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.5–0.75%
TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.7–1.05%

Can it cause trouble?

Irritancy
13 flagged ingredients
Medium risk
We flagged 13 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~2.2–2.7%est.
Tridecyl trimellitateUsed to create a thicker product consistency and soften the upper layer of the skinMedium~1.7–2.1%est.
1,2-hexanediolA preservativeMedium~0.75–1.1%est.
TaurineCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectivenessMedium~0.7–1.05%est.
Lycium barbarum fruit extractA plant extract that can help neutralize free radicals in skin and attract water to its upper layerMedium~0.5–0.75%est.
HydroxyacetophenoneUsed to increase effectiveness of preservativesMedium~0.4–0.65%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.4–0.6%est.
Glyceryl behenateUsed to create a thicker product consistency and help soften the upper layer of the skinMedium~0.45–0.65%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.35–0.6%est.
Acacia senegal gumHelps mask the small of other ingredients and improve the product textureMedium~0.3–0.6%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.3–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.2–0.4%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Propanediol~5.3–6.4%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Glycerin~4–4.9%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Triheptanoin~3.2–3.9%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A synthetic triglyceride. Helps soften the upper layer of the skin

More about Triheptanoin
Methyl gluceth-20~2.5–3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and soften it

More about Methyl gluceth-20
Simmondsia chinensis seed oil~2.2–2.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Tridecyl trimellitate~1.7–2.1%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to create a thicker product consistency and soften the upper layer of the skin

More about Tridecyl trimellitate
Maltodextrin~1.5–1.8%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
1,2-hexanediol~0.75–1.1%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Dimethicone~1–1.3%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Taurine~0.7–1.05%
Irritant · medium
Irritation risk
Medium
Works for
Anti-blemishAnti-oxidationAnti-inflammatoryEvens skin tone

Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness

More about Taurine
Bacillus ferment~0.6–0.9%
Key active
Irritation risk
Low
Works for
Moisturizing

A product of bacterial fermentation. Can help attract water to the upper layer of the skin

More about Bacillus ferment
Ganoderma lucidum stem extract~0.55–0.85%
Formula
Helianthus annuus sprout extract~0.5–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin and can help support the skin barrier

More about Helianthus annuus sprout extract
Lycium barbarum fruit extract~0.5–0.75%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

A plant extract that can help neutralize free radicals in skin and attract water to its upper layer

More about Lycium barbarum fruit extract
Acetyl tetrapeptide-2~0.5–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-2
Isomalt~0.5–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Isomalt
Coco-caprylate/caprate~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin without creating a greasy texture

More about Coco-caprylate/caprate
Hydroxyacetophenone~0.4–0.65%
Irritant · medium
Irritation risk
Medium

Used to increase effectiveness of preservatives

More about Hydroxyacetophenone
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.4–0.6%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
C9-12 alkane~0.35–0.65%
Formula
Irritation risk
Low

Helps dissolve other ingredients in a formulation

More about C9-12 alkane
Dilinoleic acid/butanediol copolymer~0.4–0.6%
Formula
Glyceryl behenate~0.45–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to create a thicker product consistency and help soften the upper layer of the skin

More about Glyceryl behenate
Polyglyceryl-6 octastearate~0.35–0.65%
Formula
Irritation risk
Low
Works for
Cleansing
More about Polyglyceryl-6 octastearate
Sodium phytate~0.3–0.6%
Formula
Irritation risk
Low

Used to stabilize product formulations

More about Sodium phytate
Acrylates/c10-30 alkyl acrylate crosspolymer~0.35–0.6%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Potassium chloride~0.35–0.6%
Formula
Acacia senegal gum~0.3–0.6%
Irritant · medium
Irritation risk
Medium

Helps mask the small of other ingredients and improve the product texture

More about Acacia senegal gum
Xanthan gum~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Polysorbate 60~0.3–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Sorbitan isostearate~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Synthetic fluorphlogopite~0.3–0.5%
Formula
Irritation risk
Low

A mineral that is used as an optical filter (makes the skin looks nicer through light reflection) and to improve the texture of cosmetic products

More about Synthetic fluorphlogopite
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Citric acid~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Castor oil/ipdi copolymer~0.2–0.35%
Formula
Irritation risk
Low

Helps improve the product texture

More about Castor oil/ipdi copolymer
Lecithin~0.2–0.35%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Cyanocobalamin~0.15–0.25%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatory

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin
Tin oxide~0.2–0.35%
Formula
Irritation risk
Low

A colorant that can add a pearl-like appearance to the formulation

More about Tin oxide
Iron oxides~0.05–0.15%
Formula
Irritation risk
Low
Works for
Sun protection

An umbrella term for the following three colorants: CI 77491, CI 77492, CI 77499. They might be able to offer some protection against visible light, but the degree of the protection is not clear

More about Iron oxides
Titanium dioxide~0.1–0.2%
Formula
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Ingredient list view

Water, Propanediol, Glycerin, Triheptanoin, Methyl gluceth-20, Simmondsia chinensis seed oil, Tridecyl trimellitate, Maltodextrin, 1,2-hexanediol, Dimethicone, Taurine, Bacillus ferment, Ganoderma lucidum stem extract, Helianthus annuus sprout extract, Lycium barbarum fruit extract, Acetyl tetrapeptide-2, Isomalt, Coco-caprylate/caprate, Hydroxyacetophenone, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, C9-12 alkane, Dilinoleic acid/butanediol copolymer, Glyceryl behenate, Polyglyceryl-6 octastearate, Sodium phytate, Acrylates/c10-30 alkyl acrylate crosspolymer, Potassium chloride, Acacia senegal gum, Xanthan gum, Polysorbate 60, Sorbitan isostearate, Synthetic fluorphlogopite, Caprylyl glycol, Citric acid, Castor oil/ipdi copolymer, Lecithin, Cyanocobalamin, Tin oxide, Iron oxides, Titanium dioxide

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Dermstore30 ml
$72.00
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Sephora
$72.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Paula's choiceCellularYouth™ Age-Disrupting Longevity SerumYOUR PRODUCTPeter Thomas RothFirm X Collagen SerumTheramidAZIDThe OrdinaryMulti-Antioxidant Radiance Serum
Match—55%55%53%
Price$72.00$69.30−$2.70$39.23−$32.77$14.00−$58.00
Shared key ingredients—3 of 102 of 102 of 10
Key difference—Palmitoyl Dipeptide-5 Diaminobutyroyl HydroxythreonineAzelaic AcidAscorbyl Glucoside
Irritancy Medium Low Low Low
Drying alcohol————
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Product summary

"Paula's choice - CellularYouth™ Age-Disrupting Longevity Serum" is effective for: Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (acetyl tetrapeptide-2 0.50% - 0.70%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
  • Humectants (isomalt 0.50% - 0.70% and glycerin 4.00% - 4.90%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Paula's choice CellularYouth™ Age-Disrupting Longevity Serum
Paula's choiceCellularYouth™ Age-Disrupting Longevity Serum

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