Works for:
based on ingredients and %- Anti-aging
- Evens skin tone
- Anti-oxidation
- Moisturizing
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 2
Key actives
Product Summary
Judging from the ingredient list, "Osmosis +Beauty - Replenish MD" works well for improving skin hydration
Ingredient callouts
- We love that this moisturizer contains a good concentration of niacinamide 2.60% - 3.90%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.
- This product contains acids (lactic acid 1.40% - 2.00%). Their concentration is low, and they will not have a strong exfoliating effect. Instead, they work to support the skin natural acid mantle and to attract water (as humectants). Lactic acid is particularly good in attracting water to the upper layer of the skin and improving the skin barrier.
- We like that this moisturizer contains peptides (palmitoyl tripeptide-38 0.40% - 0.90%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Panthenol (pro-vitamin B5) at about 0.95% - 1.40% concentration. In this concentration, Panthenol works effectively to improve the skin barrier and reduce inflammation.
Irritation risk
There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Anti-aging
What does the product description say?
It is the most advanced antioxidant serum because of its unique, pharmaceutical-grade delivery system that delivers antioxidants deep below the surface to help address the ravages of aging.
Source: N/A
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: astaxanthin, palmitoyl tripeptide-38, vitis vinifera seed extract.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps neutralize free radicals in skin and might help to calm down inflammation
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-blemish
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-oxidation
This product contains antioxidants (astaxanthin, glutathione, thioctic acid, ubiquinone, vitis vinifera seed extract) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - ginkgo biloba leaf extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
Helps neutralize free radicals in skin and might help to calm down inflammation
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
Might help neutralize free radicals in skin
A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing
Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glutathione, niacinamide
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Moisturizing
This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-38, panthenol
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Used to stabilize product formulations and help soften the upper layer of the skin
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Evens skin tone |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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Key Actives
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
Helps neutralize free radicals in skin and might help to calm down inflammation
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
Potential irritants
Produces temporary toning effect. Can help dissolve other ingredients or preserve products
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
A plant oil with high content of volatile compounds that, especially when exposed to air, can cause allergic reactions and irritate the skin
Used as a fragrance. Can be irritating
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
A preservative. Can be used to mask unpleasant smell. Can be irritating
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
Helps neutralize free radicals in skin and might help to calm down inflammation
A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Used to stabilize product formulations and help soften the upper layer of the skin
Can work as an exfoliant but is typically used to adjust the product pH
Comedogenic ingredients
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
All ingredients
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Produces temporary toning effect. Can help dissolve other ingredients or preserve products
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
Helps attract water to the upper layer of the skin and can help improve skin barrier function
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin
Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking
Helps neutralize free radicals in skin and might help to calm down inflammation
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating
A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation
A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing
A plant oil with high content of volatile compounds that, especially when exposed to air, can cause allergic reactions and irritate the skin
Used as a fragrance. Can be irritating
A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Used to stabilize product formulations and help soften the upper layer of the skin
A preservative. Can be used to mask unpleasant smell. Can be irritating
Can work as an exfoliant but is typically used to adjust the product pH
Ingredient list view
Water, Phosphatidylcholine, Glycerin, Niacinamide, Alcohol denat., Polyglyceryl-4 caprate, Lactic acid, Pyridoxine hcl, Panthenol, Chlorella vulgaris extract, Palmitoyl tripeptide-38, Fulvic acid, Beta-glucan, Thioctic acid, Ubiquinone, Glutathione, Ergothioneine, Astaxanthin, Polygonum cuspidatum extract, Tocopherol, Camellia sinensis leaf extract, Ginkgo biloba leaf extract, Vitis vinifera seed extract, Olea europaea leaf extract, Citrus grandis peel oil, Citrus limon peel oil, Santalum austrocaledonicum wood oil, Glycine soja oil, Lonicera caprifolium flower extract, Lonicera japonica flower extract, Caprylic/capric triglyceride, Xanthan gum, Hydroxypropyl cyclodextrin, Potassium sorbate, Benzyl alcohol, Sodium hydroxide, Citric acid
- Glycerol and the skin: holistic approach to its origin and functions
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- Epidermal and dermal effects of topical lactic acid
- Dual Effects of Alpha-Hydroxy Acids on the Skin
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- β-Glucans: Multi-Functional Modulator of Wound Healing
- Anti-Wrinkle Therapy: Significant New Findings in the Non-Invasive Cosmetic Treatment of Skin Wrinkles with Beta-Glucan
- Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: A Review
- Anticancer properties of low molecular weight oat beta-glucan – An in vitro study
- A critical review on production and industrial applications 2 of beta-glucans
- Improving skin function with CM-glucan, a biological response modifier from yeast
- Preparation, characterization, and biological properties of β-glucans
- Characterization of a new beta(1-3)-glucan branching activity of Aspergillus fumigatus
- Glutathione as a skin whitening agent: Facts, myths, evidence and controversies
- Glutathione for skin lightening: a regnant myth or evidence-based verity?
- Glutathione for skin lightening for dermatologists and cosmetologists
- A comparison of the relative antioxidant potency of L‐ergothioneine and idebenone
- l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study
- Astaxanthin, canthaxanthin and b-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes
- Astaxanthin attenuates the UVA-induced up-regulation of matrixmetalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts
- Protective Effects of Topical Application of a Poorly Soluble Antioxidant Astaxanthin Liposomal Formulation on Ultraviolet-Induced Skin Damage
- Vitamin E in dermatology
- Vitamin E and Skin Health
- Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics
- Cosmeceutical Critique: Ginkgo Biloba
- Safety Assessment of Vitis Vinifera (Grape)-Derived Ingredients as Used in Cosmetics
- The Topical Effect of Grape Seed Extract 2% Cream on Surgery Wound Healing
- Review of the Pharmacological Effects of Vitis vinifera (Grape) and its Bioactive Constituents: An Update
- Wound Repair Potential of Olea europaea L. Leaf Extracts Revealed by In Vivo Experimental Models and Comparative Evaluation of the Extracts' Antioxidant Activity
- VOLATILE CONSTITUENTS FROM THE FLOWERS OF TWO SPECIES OF HONEYSUCKLE ( LONICERA JAPONICA AND LONICERA CAPRIFOLIUM )
- Chemical composition of the essential oils from the flower, leaf and stem of Lonicera japonica