Osmosis +Beauty

Osmosis +Beauty Replenish MD

Name: Osmosis +Beauty - Replenish MD
Brand: Osmosis +Beauty

Efficacy100/100IrritancyHigh

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Works for

2 of 2 advertised claims delivered

Anti-aging

10 ingredients credited for this claim

Strong support

What the product description says

“It is the most advanced antioxidant serum because of its unique, pharmaceutical-grade delivery system that delivers antioxidants deep below the surface to help address the ravages of aging.”

Source: N/A

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: astaxanthin, palmitoyl tripeptide-38, vitis vinifera seed extract.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.6–3.9%

Vitis vinifera seed extractKey activeEffect: MediumA plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation~0.1–0.35%

Palmitoyl tripeptide-38Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.9%

AstaxanthinKey activeEffect: MediumHelps neutralize free radicals in skin and might help to calm down inflammation~0.1–0.5%

Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.15–0.55%

UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.15–0.5%

Thioctic acidEffect: Low~0.15–0.5%

Lactic acidUnder-dosedEffect: MediumAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~1.4–2%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.45%

Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.1–0.4%

Evens skin tone

4 ingredients credited for this claim

Strong support

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glutathione, niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

GlutathioneKey activeEffect: HighA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin~0.1–0.5%

Lactic acidUnder-dosedEffect: HighAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~1.4–2%

Anti-oxidation

Not advertised by the brand · 15 ingredients credited for this claim

Strong support

This product contains antioxidants (astaxanthin, glutathione, thioctic acid, ubiquinone, vitis vinifera seed extract) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - ginkgo biloba leaf extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Thioctic acidKey activeEffect: High~0.15–0.5%

AstaxanthinKey activeEffect: HighHelps neutralize free radicals in skin and might help to calm down inflammation~0.1–0.5%

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.15–0.5%

Vitis vinifera seed extractKey activeEffect: HighA plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation~0.1–0.35%

Ginkgo biloba leaf extractKey activeEffect: MediumA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.1–0.35%

Lonicera japonica flower extractEffect: LowA plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating~0.05–0.25%

Chlorella vulgaris extractEffect: LowA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.5–1.2%

Lonicera caprifolium flower extractEffect: LowA plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating~0.05–0.2%

Pyridoxine hclEffect: LowMight help neutralize free radicals in skin~1.1–1.7%

Olea europaea leaf extractEffect: LowA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing~0.05–0.25%

ErgothioneineUnder-dosedEffect: HighCan help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking~0.1–0.5%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.45%

Camellia sinensis leaf extractUnder-dosedEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.1–0.4%

Moisturizing

Not advertised by the brand · 14 ingredients credited for this claim

Strong support

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, palmitoyl tripeptide-38, panthenol

Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.15–0.55%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.1–4.7%

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.6–3.9%

Palmitoyl tripeptide-38HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.9%

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.95–1.4%

Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.5–1.2%

Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.1–0.35%

Glycine soja oilUnder-dosedEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.05–0.25%

Hydroxypropyl cyclodextrinEffect: Low, below effective doseUsed to stabilize product formulations and help soften the upper layer of the skin~0.05–0.25%

Anti-blemish

Not advertised by the brand · 4 ingredients credited for this claim

Strong support

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

Ginkgo biloba leaf extractEffect: LowA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating~0.1–0.35%

Can it cause trouble?

Irritancy

4 strong irritants: Alcohol denat., Citrus grandis peel oil + 2 more — patch-test recommended

High risk

We flagged 20 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Alcohol denat.Produces temporary toning effect. Can help dissolve other ingredients or preserve productsHigh~2–3%est.

Ginkgo biloba leaf extractA plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritatingHigh~0.1–0.35%est.

Citrus grandis peel oilA plant oil with high content of volatile compounds that, especially when exposed to air, can cause allergic reactions and irritate the skinHigh~0.05–0.2%est.

Citrus limon peel oilA highly irritating fragranceHigh~0.05–0.2%est.

Santalum austrocaledonicum wood oilUsed as a fragrance. Can be irritatingHigh~0.05–0.2%est.

Lonicera caprifolium flower extractA plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritatingHigh~0.05–0.2%est.

Lonicera japonica flower extractA plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritatingHigh~0.05–0.25%est.

Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.01–0.05%est.

PhosphatidylcholineUsed to enhance the delivery of other ingredientsMedium~3.5–5.3%est.

Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~1.4–2%est.

Pyridoxine hclMight help neutralize free radicals in skinMedium~1.1–1.7%est.

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~0.5–1.2%est.

GlutathioneA peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skinMedium~0.1–0.5%est.

AstaxanthinHelps neutralize free radicals in skin and might help to calm down inflammationMedium~0.1–0.5%est.

Olea europaea leaf extractA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missingMedium~0.05–0.25%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.05–0.25%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.1–0.35%est.

Hydroxypropyl cyclodextrinUsed to stabilize product formulations and help soften the upper layer of the skinMedium~0.05–0.25%est.

Potassium sorbateA preservativeMedium~0.05–0.15%est.

Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.01–0.1%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~0.5–1.2%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.05–0.25%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%

Formula

Irritation risk: Low

Plain old water

More about Water

Phosphatidylcholine~3.5–5.3%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Used to enhance the delivery of other ingredients

More about Phosphatidylcholine

Glycerin~3.1–4.7%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Niacinamide~2.6–3.9%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Evens skin toneAnti-blemishAnti-agingMoisturizingReduces irritationAntibacterialReduces rednessAnti-inflammatory

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Alcohol denat.~2–3%

Irritant · high

Irritation risk: High

Produces temporary toning effect. Can help dissolve other ingredients or preserve products

More about Alcohol denat.

Polyglyceryl-4 caprate~1.7–2.5%

Formula

Irritation risk: Low

Works for

Cleansing

More about Polyglyceryl-4 caprate

Lactic acid~1.4–2%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid

Pyridoxine hcl~1.1–1.7%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

Might help neutralize free radicals in skin

More about Pyridoxine hcl

Panthenol~0.95–1.4%

Hero · Moisturizing

Irritation risk: Low

Works for

Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Chlorella vulgaris extract~0.5–1.2%

Key activeComedogenic 3/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-inflammatory

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract

Palmitoyl tripeptide-38~0.4–0.9%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-38

Fulvic acid~0.2–0.8%

Formula

Irritation risk: Low

More about Fulvic acid

Beta-glucan~0.15–0.55%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryReduces irritationMoisturizingAnti-oxidationAnti-agingAnti-blemish

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan

Thioctic acid~0.15–0.5%

Key active

Irritation risk: Low

Works for

Anti-oxidationAnti-aging

More about Thioctic acid

Ubiquinone~0.15–0.5%

Key active

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone

Glutathione~0.1–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingEvens skin toneAnti-oxidation

A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation. It can also help attract moisture to the upper layer of the skin

More about Glutathione

Ergothioneine~0.1–0.5%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidation

Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking

More about Ergothioneine

Astaxanthin~0.1–0.5%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-inflammatoryAnti-aging

Helps neutralize free radicals in skin and might help to calm down inflammation

More about Astaxanthin

Polygonum cuspidatum extract~0.1–0.5%

Formula

Irritation risk: Low

More about Polygonum cuspidatum extract

Tocopherol~0.1–0.45%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Camellia sinensis leaf extract~0.1–0.4%

Under-dosed

Irritation risk: Low

Works for

AntibacterialAnti-oxidationAnti-agingAnti-blemishEvens skin toneMoisturizing

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract

Ginkgo biloba leaf extract~0.1–0.35%

Key activeIrritant · high

Irritation risk: High

Works for

Anti-oxidationAnti-blemishAntibacterialAnti-inflammatory

A plant extract that might help neutralize free radicals and reduce inflammation in skin. It can be irritating

More about Ginkgo biloba leaf extract

Vitis vinifera seed extract~0.1–0.35%

Key active

Irritation risk: Low

Works for

Anti-oxidationAnti-inflammatoryAnti-agingAntibacterial

A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation

More about Vitis vinifera seed extract

Olea europaea leaf extract~0.05–0.25%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing

More about Olea europaea leaf extract

Citrus grandis peel oil~0.05–0.2%

Irritant · high

Irritation risk: High

A plant oil with high content of volatile compounds that, especially when exposed to air, can cause allergic reactions and irritate the skin

More about Citrus grandis peel oil

Citrus limon peel oil~0.05–0.2%

Irritant · high

Irritation risk: High

A highly irritating fragrance

More about Citrus limon peel oil

Santalum austrocaledonicum wood oil~0.05–0.2%

Irritant · high

Irritation risk: High

Used as a fragrance. Can be irritating

More about Santalum austrocaledonicum wood oil

Glycine soja oil~0.05–0.25%

Under-dosedComedogenic 2/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 2/5

Works for

Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil

Lonicera caprifolium flower extract~0.05–0.2%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating

More about Lonicera caprifolium flower extract

Lonicera japonica flower extract~0.05–0.25%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract that might help neutralize free radicals in skin. Can contain volalite oils and be irritating

More about Lonicera japonica flower extract

Caprylic/capric triglyceride~0.1–0.35%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Xanthan gum~0.05–0.2%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Hydroxypropyl cyclodextrin~0.05–0.25%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to stabilize product formulations and help soften the upper layer of the skin

More about Hydroxypropyl cyclodextrin

Potassium sorbate~0.05–0.15%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Benzyl alcohol~0.01–0.05%

Irritant · high

Irritation risk: High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol

Sodium hydroxide~0.01–0.05%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Citric acid~0.01–0.1%

Irritant · medium

Irritation risk: Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid

Ingredient list view

Water, Phosphatidylcholine, Glycerin, Niacinamide, Alcohol denat., Polyglyceryl-4 caprate, Lactic acid, Pyridoxine hcl, Panthenol, Chlorella vulgaris extract, Palmitoyl tripeptide-38, Fulvic acid, Beta-glucan, Thioctic acid, Ubiquinone, Glutathione, Ergothioneine, Astaxanthin, Polygonum cuspidatum extract, Tocopherol, Camellia sinensis leaf extract, Ginkgo biloba leaf extract, Vitis vinifera seed extract, Olea europaea leaf extract, Citrus grandis peel oil, Citrus limon peel oil, Santalum austrocaledonicum wood oil, Glycine soja oil, Lonicera caprifolium flower extract, Lonicera japonica flower extract, Caprylic/capric triglyceride, Xanthan gum, Hydroxypropyl cyclodextrin, Potassium sorbate, Benzyl alcohol, Sodium hydroxide, Citric acid

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	Osmosis +BeautyReplenish MDYOUR PRODUCT	January LabsRetexturizing Night Cream	AbibGlutathiosome Creme Vita Tube 75ml	SUNDOReal Moisturizing Light Cream
Match	—	75%	74%	74%
Price	—	$86.00	$26.37	$17.60
Shared key ingredients	—	5 of 14	5 of 14	5 of 14
Key difference	—	Palmitoyl Tripeptide-5	Madecassoside	Adenosine
Irritancy	High	Medium	Medium	Medium
Drying alcohol	Contains drying alcohol	—	—	—
	View product	Shop	Shop	Shop

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Product summary

Judging from the ingredient list, "Osmosis +Beauty - Replenish MD" works well for improving skin hydration

Ingredient callouts

We love that this moisturizer contains a good concentration of niacinamide 2.60% - 3.90%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.
This product contains acids (lactic acid 1.40% - 2.00%). Their concentration is low, and they will not have a strong exfoliating effect. Instead, they work to support the skin natural acid mantle and to attract water (as humectants). Lactic acid is particularly good in attracting water to the upper layer of the skin and improving the skin barrier.
We like that this moisturizer contains peptides (palmitoyl tripeptide-38 0.40% - 0.90%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Panthenol (pro-vitamin B5) at about 0.95% - 1.40% concentration. In this concentration, Panthenol works effectively to improve the skin barrier and reduce inflammation.

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: caprylic/capric triglyceride, vitamin e, ergothioneine and lactic acid

Irritation risk

There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.