Neogenisis Skin Serum

Neogenisis Skin Serum

Efficacy87/100IrritancyMedium

Works for

Anti-aging
Human fibroblast conditioned media, Gluconolactone + 1 more
Works well
What the product description says
“Master hydrators replenish moisture levels, leaving skin plump, radiant, and revitalized.All-in-one serum suitable for all skin types Restores hydration and strengthens the skin barrier Refines texture for a smoother, healthier complexion Softens fine lines and wrinkles while improving elasticity Oncology-approved with a 20% concentration of Stem Cell Media”
Source: Art of skincare

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains gluconolactone, human fibroblast conditioned media.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Human fibroblast conditioned mediaKey activeEffect: HighA cocktail of amino acids that can stimulate skin cell growth and renewal having an anti-aging effect~5.5–6.8%
GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~1.5–1.9%
Human adipose derived stem cell conditioned mediaEffect: LowA stem cell extract. There is no evidence that it is effective when applied topically to the skin~12–14%
Moisturizing
Human adipose derived stem cell conditioned media, Glycerin + 1 more
Works
What the product description says
“Master hydrators replenish moisture levels, leaving skin plump, radiant, and revitalized.All-in-one serum suitable for all skin types Restores hydration and strengthens the skin barrier Refines texture for a smoother, healthier complexion Softens fine lines and wrinkles while improving elasticity Oncology-approved with a 20% concentration of Stem Cell Media”
Source: Art of skincare

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

Human adipose derived stem cell conditioned mediaKey activeEffect: MediumA stem cell extract. There is no evidence that it is effective when applied topically to the skin~12–14%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.3–4.1%
GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~1.5–1.9%
Exfoliation
Not advertised by the brand · Gluconolactone
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: gluconolactone.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~1.5–1.9%
Evens skin tone
Not advertised by the brand · Gluconolactone
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: gluconolactone

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~1.5–1.9%
Anti-oxidation
Not advertised by the brand · Gluconolactone, Human adipose derived stem cell conditioned media
May help

This product contains antioxidants (gluconolactone) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

GluconolactoneKey activeEffect: MediumA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~1.5–1.9%
Human adipose derived stem cell conditioned mediaEffect: LowA stem cell extract. There is no evidence that it is effective when applied topically to the skin~12–14%

Can it cause trouble?

Irritancy
2 flagged ingredients
Medium risk
We flagged 2 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Cassia obtusifolia seed extract—High~0.15–0.25%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~1.5–1.9%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Human adipose derived stem cell conditioned media~12–14%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-agingAnti-oxidation

A stem cell extract. There is no evidence that it is effective when applied topically to the skin

More about Human adipose derived stem cell conditioned media
Human fibroblast conditioned media~5.5–6.8%
Key active
Irritation risk
Low
Works for
Anti-aging

A cocktail of amino acids that can stimulate skin cell growth and renewal having an anti-aging effect

More about Human fibroblast conditioned media
Propanediol~3.9–4.8%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Glycerin~3.3–4.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Potassium citrate~2.5–3%
Formula
Gluconolactone~1.5–1.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingExfoliationEvens skin toneAnti-agingAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Xanthan gum~1.1–1.3%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Sodium benzoate~0.25–0.5%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Glyceryl polyacrylate~0.25–0.5%
Formula
Irritation risk
Low

Helps to create a nice product texture and spread the product more easily on the skin

More about Glyceryl polyacrylate
Chinese senna
Not recognized
Cassia obtusifolia seed extract~0.15–0.25%
Irritant · high
Ingredient list view

Water, Human adipose derived stem cell conditioned media, Human fibroblast conditioned media, Propanediol, Glycerin, Potassium citrate, Gluconolactone, Xanthan gum, Sodium benzoate, Glyceryl polyacrylate, Unknown, Cassia obtusifolia seed extract

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Art of skincare
$149.50
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
NeogenisisSkin SerumYOUR PRODUCTLuzern LaboratoriesLuzern WE3 Triple Action Serum Wrinkle CorrectorBrandHydration Hold Face SerumPSA SkinThe Most: Hyaluronic Super Nutrient Hydration Serum
Match—66%66%66%
Price$149.50———
Shared key ingredients—1 of 32 of 31 of 3
Key difference—NiacinamidePalmitoyl Tripeptide-5Madecassoside
Irritancy Medium Low Low Low
Drying alcohol————
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Product summary

"Neogenisis - Skin Serum" is effective for: Anti-aging, Exfoliation and Evens skin tone

This product could be helpful for: Moisturizing, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • This product contains acids (gluconolactone 1.50% - 1.90%). Their concentration is low, and they will not have a strong exfoliating effect. Instead, they work to support the skin natural acid mantle and to attract water (as humectants). PHAs (gluconolactone) especially are great for improving skin hydration. They might be even able to stimulate the production of skin's natural humectants and support the healthy skin microbiome.
  • Humectants (glycerin 3.30% - 4.10%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 149.50$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 13 studies and safety reviews.

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