MediFlower

MediFlower Collagen Wrinkle Ampoule

Name: MediFlower - Collagen Wrinkle Ampoule
Brand: MediFlower

Efficacy87/100IrritancyMedium

See all ingredients

Works for

Anti-aging

Adenosine, Beta-glucan + 1 more

Works well

What the product description says

“Mediflower Collagen Wrinkle Ampoule helps to restore skin resilience and fight wrinkles.”

Source: Lila Beauty

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.05–0.25%

Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.05–0.2%

Centella asiatica extractUnder-dosedA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.1–0.3%

Moisturizing

Glycerin, Macadamia ternifolia seed oil + 16 more

Works

What the product description says

“Contains 8 types of hyaluronic acids to strengthen moisture barrier.”

Source: Lila Beauty

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: betaine, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, hydrolyzed collagen.

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.1–6.2%

Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~2.7–4.1%

BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~2–3%

DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.3–1.9%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.45–1%

Hydrolyzed collagenKey active· Humectant, EmollientEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.15–0.7%

Glycosyl trehaloseKey activeEffect: High~0.15–0.7%

Hydrogenated starch hydrolysateKey active· HumectantEffect: MediumHelps to attract water to the upper layer of the skin. Can add sweet taste to lip products~0.15–0.55%

Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.05–0.2%

Glyceryl acrylate/acrylic acid copolymerKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency~0.05–0.3%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.05–0.25%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~3.4–5.1%

Cetyl ethylhexanoate· EmollientEffect: LowAn emollient that helps soften the skin and creates a thicker product texture~1.7–2.5%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~0.45–1.05%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.75%

Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.1–0.4%

AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.15–0.6%

Can it cause trouble?

Irritancy

2 strong irritants: Illicium verum fruit extract, Parfum

Medium risk

We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Illicium verum fruit extractAnise fruit extract. Used as a fragrance. Can be irritatingHigh~0.1–0.4%est.

Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.1–0.4%est.

Morus alba bark extractA plant extract that might have anti-oxidant properties and help even out skin tone, but solid evidence is lackingHigh~0.05–0.25%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.01–0.05%est.

Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~2.7–4.1%est.

Cetyl ethylhexanoateAn emollient that helps soften the skin and creates a thicker product textureMedium~1.7–2.5%est.

ChlorphenesinA preservativeMedium~0.16–0.32%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.75%est.

Disodium edtaStabilizes the product formulationMedium~0.05–0.25%est.

Glyceryl acrylate/acrylic acid copolymerHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistencyMedium~0.05–0.3%est.

Glycyrrhiza glabra root extractA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicalsMedium~0.05–0.25%est.

Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.05–0.3%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.1–0.3%est.

1,2-hexanediolA preservativeMedium~0.01–0.1%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.45–1%est.

Alternatives

Cheaper, or higher on efficacy

AMPLE:N Ceramide Shot Ampoule

Higher efficacy · 100/10062% match

$26.59

Kiehl's Retinol Fast Release Wrinkle-Reducing Night Serum

Higher efficacy · 100/10060% match

$60.23

View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.1–6.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Butylene glycol~3.4–5.1%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Macadamia ternifolia seed oil~2.7–4.1%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

More about Macadamia ternifolia seed oil

Betaine~2–3%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine

Cetyl ethylhexanoate~1.7–2.5%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

An emollient that helps soften the skin and creates a thicker product texture

More about Cetyl ethylhexanoate

Sodium acrylate/sodium acryloyldimethyl taurate copolymer~1.3–1.9%

Formula

Irritation risk: Low

Used to create a thicker product consistency

More about Sodium acrylate/sodium acryloyldimethyl taurate copolymer

Dimethicone~1.3–1.9%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone

Peg-400~1–1.45%

Formula

Irritation risk: Low

More about Peg-400

Polysorbate 20~0.6–1.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Hydrogenated polydecene~0.45–1.05%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Cetearyl alcohol~0.45–1%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Chlorphenesin~0.16–0.32%

Irritant · medium

Irritation risk: Medium

A preservative

More about Chlorphenesin

Caprylyl glycol~0.2–0.75%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Glycosyl trehalose~0.15–0.7%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Glycosyl trehalose

Allantoin~0.15–0.6%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryAnti-blemishReduces irritationReduces rednessExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin

Hydrolyzed collagen~0.15–0.7%

Key active

Irritation risk: Low

Works for

Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Hydrolyzed collagen

Hydrogenated starch hydrolysate~0.15–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin. Can add sweet taste to lip products

More about Hydrogenated starch hydrolysate

Illicium verum fruit extract~0.1–0.4%

Irritant · high

Irritation risk: High

Anise fruit extract. Used as a fragrance. Can be irritating

More about Illicium verum fruit extract

Ammonium acryloyldimethyltaurate/vp copolymer~0.1–0.45%

Formula

Irritation risk: Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer

Propylene glycol~0.1–0.4%

Irritant · high

Irritation risk: High

Works for

Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol

Xanthan gum~0.1–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Adenosine~0.05–0.25%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Laureth-8~0.1–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

More about Laureth-8

Disodium edta~0.05–0.25%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Glyceryl acrylate/acrylic acid copolymer~0.05–0.3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency

More about Glyceryl acrylate/acrylic acid copolymer

Glycyrrhiza glabra root extract~0.05–0.25%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationAnti-inflammatoryReduces rednessEvens skin toneAntibacterial

A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals

More about Glycyrrhiza glabra root extract

Tocopheryl acetate~0.05–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate

Morus alba bark extract~0.05–0.25%

Irritant · high

Irritation risk: High

Works for

Anti-oxidationEvens skin tone

A plant extract that might have anti-oxidant properties and help even out skin tone, but solid evidence is lacking

More about Morus alba bark extract

Lilium candidum bulb extract~0.05–0.2%

Formula

Irritation risk: Low

More about Lilium candidum bulb extract

Beta-glucan~0.05–0.2%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryReduces irritationMoisturizingAnti-oxidationAnti-agingAnti-blemish

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan

Centella asiatica extract~0.1–0.3%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Reduces irritationAnti-inflammatoryReduces rednessMoisturizingAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

1,2-hexanediol~0.01–0.1%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Parfum~0.01–0.05%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Ingredient list view

Water, Glycerin, Butylene glycol, Macadamia ternifolia seed oil, Betaine, Cetyl ethylhexanoate, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Dimethicone, Peg-400, Polysorbate 20, Hydrogenated polydecene, Cetearyl alcohol, Chlorphenesin, Caprylyl glycol, Glycosyl trehalose, Allantoin, Hydrolyzed collagen, Hydrogenated starch hydrolysate, Illicium verum fruit extract, Ammonium acryloyldimethyltaurate/vp copolymer, Propylene glycol, Xanthan gum, Adenosine, Laureth-8, Disodium edta, Glyceryl acrylate/acrylic acid copolymer, Glycyrrhiza glabra root extract, Tocopheryl acetate, Morus alba bark extract, Lilium candidum bulb extract, Beta-glucan, Centella asiatica extract, 1,2-hexanediol, Parfum

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	MediFlowerCollagen Wrinkle AmpouleYOUR PRODUCT	AMPLE:NCeramide Shot Ampoule	Cos De BAHAES EGF Peptide Serum	ONE THINGCica B5 Serum
Match	—	62%	60%	60%
Price	$9.78	$26.59+$16.81	$15.42+$5.64	$14.60+$4.82
Shared key ingredients	—	5 of 10	5 of 10	4 of 10
Key difference	—	Niacinamide	Madecassoside	Madecassic Acid
Irritancy	Medium	Low	Low	Low
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

More alternatives: Coreana Lab Ample:N Peptide Shot Ampoule Kiehl's Retinol Fast Release Wrinkle-Reducing Night Serum

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Product summary

"MediFlower - Collagen Wrinkle Ampoule" could be helpful for: Moisturizing, but its actives are not the most effective or are not well-studied.

Ingredient callouts

Humectants (glyceryl acrylate/acrylic acid copolymer 0.05% - 0.30%, hydrolyzed collagen 0.15% - 0.70%, betaine 2.00% - 3.00% and glycerin 4.10% - 6.20%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 17.95A$ in Australia and for 11.20$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 29 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Fatty acids profile of oil from nine varieties of Macadamia nuttandfonline.com
3
Dimethicone as a protective ingredient in topical medicationsjaad.org
4
Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
5
Safety Assessment of Polyene Group as Used in Cosmeticscir-safety.org
6
Profile of wound healing process induced by allantoinscielo.br
7
Safety assessment of hydrogenated starch hydrolysatesncbi.nlm.nih.gov
8
Surfactants and experimental irritant contact dermatitisncbi.nlm.nih.gov
9
Propylene Glycolpubmed.ncbi.nlm.nih.gov
10
Skin-sensitizing and irritant properties of propylene glycolonlinelibrary.wiley.com
11
Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS techniquencbi.nlm.nih.gov
12
Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesisjstage.jst.go.jp
13
Morus alba L. nature's functional tonicsciencedirect.com
14
β-Glucans: Multi-Functional Modulator of Wound Healingncbi.nlm.nih.gov
15
Anti-Wrinkle Therapy: Significant New Findings in the Non-Invasive Cosmetic Treatment of Skin Wrinkles with Beta-Glucanonlinelibrary.wiley.com
16
Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: A Reviewonlinelibrary.wiley.com
17
Anticancer properties of low molecular weight oat beta-glucan – An in vitro studysciencedirect.com
18
A critical review on production and industrial applications 2 of beta-glucanssciencedirect.com
19
Improving skin function with CM-glucan, a biological response modifier from yeastonlinelibrary.wiley.com
20
Preparation, characterization, and biological properties of β-glucansncbi.nlm.nih.gov
21
Characterization of a new beta(1-3)-glucan branching activity of Aspergillus fumigatusncbi.nlm.nih.gov
22
Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Modelmdpi.com
23
Centella asiatica in cosmetologyncbi.nlm.nih.gov
24
Triterpene Composition and Bioactivities of Centella asiatica mdpi.com
25
Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblastsonlinelibrary.wiley.com
26
Assessment report on Centella asiatica (L.) Urban, herbaema.europa.eu
27
Contact dermatitis due to Madecassolonlinelibrary.wiley.com
28
The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trialliebertpub.com
29
The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov

MediFlowerCollagen Wrinkle Ampoule

Buy at Yesstyle$9.78 Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Yesstyle$9.78 Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.