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Mederma PM Intensive Overnight Scar Care Cream
Mederma

Mederma PM Intensive Overnight Scar Care Cream

Efficacy100/100IrritancyHigh
See all ingredients

Works for

Moisturizing
Panthenol, Cetearyl alcohol + 24 more
Works well
What the product description says
“Unique Formula with Triple Benefits plus TriPeptol helps Seal in Moisture, Reduce Redness, Soften and Smooth Texture of Scars while you Sleep.”
Source: Supderdrug

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, aspartic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, hydrolyzed collagen.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: panthenol

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.25–0.45%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~5.2–6.4%
C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~3.1–3.8%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~2–2.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~1.3–1.6%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~0.7–1.1%
Hydrolyzed collagenKey active· Humectant, EmollientEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.3–0.5%
Arginine hclKey activeEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.25–0.45%
GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.25–0.45%
GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.25–0.4%
AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.2–0.4%
Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.2–0.4%
Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.2–0.4%
Lysine hclKey activeEffect: High~0.2–0.35%
Histidine hclKey activeEffect: HighA salt of an amino-acid that helps attract water to the upper layer of the skin. Might be helpful in restoring the skin barrier function~0.15–0.25%
IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.15–0.25%
Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.15–0.25%
TyrosineKey activeEffect: High~0.1–0.15%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~4.4–5.4%
Dicaprylyl carbonate· EmollientEffect: LowHelps products spread more easily and works as an emollient to soften skin~2.3–2.8%
Arachidyl alcohol· EmollientEffect: LowUsed to soften the upper layer of the skin and create a thicker product consistency~1.7–2%
Behenyl alcohol· Emollient, OcclusiveEffect: LowNon-drying alcohol that helps water and oil mix together. Also serves as an emollient~0.65–0.95%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.95–1.15%
CyclohexasiloxaneEffect: Low, below effective doseA silicone that serves as an emollient. Helps create a nice non-greasy feels~0.55–0.8%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%
AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.35–0.65%
Anti-aging
Side benefit · Aspartic acid, Aloe barbadensis leaf juice + 1 more
May help

This product contains aspartic acid. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.2–0.4%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.95–1.15%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%

Can it cause trouble?

Irritancy
3 strong irritants: Alcohol, Allium cepa bulb extract + 1 more — patch-test recommended
High risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~1.4–1.7%est.
Allium cepa bulb extract—High~0.4–0.65%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.35–0.6%est.
Isopropyl alcoholA drying alcohol. Can increase skin's sensitivity and cause dryness and irritationHigh~0.2–0.35%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~4.4–5.4%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.95–1.15%est.
Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.35–0.65%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.3–0.6%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.3–0.55%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.25–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.45%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~5.2–6.4%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Cetearyl alcohol~5.2–6.4%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Pentylene glycol~4.4–5.4%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
C12-15 alkyl benzoate~3.1–3.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate
Dicaprylyl carbonate~2.3–2.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps products spread more easily and works as an emollient to soften skin

More about Dicaprylyl carbonate
Glycerin~2–2.4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Arachidyl alcohol~1.7–2%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to soften the upper layer of the skin and create a thicker product consistency

More about Arachidyl alcohol
Alcohol~1.4–1.7%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Dimethicone~1.3–1.6%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Aloe barbadensis leaf juice~0.95–1.15%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAntibacterialReduces irritationReduces rednessAnti-inflammatoryAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Cyclopentasiloxane~0.7–1.1%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Behenyl alcohol~0.65–0.95%
Formula
Irritation risk
Low
Works for
Moisturizing

Non-drying alcohol that helps water and oil mix together. Also serves as an emollient

More about Behenyl alcohol
Cyclohexasiloxane~0.55–0.8%
Formula
Irritation risk
Low
Works for
Moisturizing

A silicone that serves as an emollient. Helps create a nice non-greasy feels

More about Cyclohexasiloxane
Arachidyl glucoside~0.5–0.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Arachidyl glucoside
Allium cepa bulb extract~0.4–0.65%
Irritant · high
Irritation risk
High
More about Allium cepa bulb extract
Allantoin~0.35–0.65%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Parfum~0.35–0.6%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Cetearyl glucoside~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside
Tocopheryl acetate~0.3–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.3–0.55%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Hydroxyethylcellulose~0.3–0.55%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Glycine~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine
Panthenol~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Hydrolyzed collagen~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Hydrolyzed collagen
Peg-400~0.25–0.45%
Formula
Irritation risk
Low
More about Peg-400
Polysorbate 60~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Sorbitan isostearate~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Citric acid~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Sodium hydroxide~0.25–0.45%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Alanine~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine
Arginine hcl~0.25–0.45%
Key active
Irritation risk
Low
Works for
MoisturizingReduces irritation

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine hcl
Aspartic acid~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid
Glucose~0.25–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose
Glutamic acid~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid
Isopropyl alcohol~0.2–0.35%
Irritant · high
Irritation risk
High

A drying alcohol. Can increase skin's sensitivity and cause dryness and irritation

More about Isopropyl alcohol
Leucine~0.2–0.4%
Formula
Irritation risk
Low
More about Leucine
Lysine hcl~0.2–0.35%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Lysine hcl
Tocopherol~0.2–0.35%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Bis(tripeptide-1) copper acetate~0.15–0.3%
Formula
Irritation risk
Low
More about Bis(tripeptide-1) copper acetate
Histidine hcl~0.15–0.25%
Key active
Irritation risk
Low
Works for
Moisturizing

A salt of an amino-acid that helps attract water to the upper layer of the skin. Might be helpful in restoring the skin barrier function

More about Histidine hcl
Hydrolyzed soy protein~0.15–0.25%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-inflammatoryEvens skin tone

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein
Isoleucine~0.15–0.25%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine
Phenylalanine~0.1–0.2%
Formula
Irritation risk
Low
More about Phenylalanine
Tyrosine~0.1–0.15%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Tyrosine
Ingredient list view

Water, Cetearyl alcohol, Pentylene glycol, C12-15 alkyl benzoate, Dicaprylyl carbonate, Glycerin, Arachidyl alcohol, Alcohol, Dimethicone, Aloe barbadensis leaf juice, Cyclopentasiloxane, Behenyl alcohol, Cyclohexasiloxane, Arachidyl glucoside, Allium cepa bulb extract, Allantoin, Parfum, Cetearyl glucoside, Tocopheryl acetate, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Hydroxyethylcellulose, Glycine, Panthenol, Hydrolyzed collagen, Peg-400, Polysorbate 60, Sorbitan isostearate, Citric acid, Sodium hydroxide, Alanine, Arginine hcl, Aspartic acid, Glucose, Glutamic acid, Isopropyl alcohol, Leucine, Lysine hcl, Tocopherol, Bis(tripeptide-1) copper acetate, Histidine hcl, Hydrolyzed soy protein, Isoleucine, Phenylalanine, Tyrosine

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🇬🇧 Supderdrug (UK)
≈ $26.60 Out of stock
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
MedermaPM Intensive Overnight Scar Care CreamYOUR PRODUCTKlairsDaily Comfort Hand CreamDrunk ElephantSili Body LotionMarudermHyaluronic Acid Moisturizer Face & Body Cream
Match—58%54%54%
Price—$9.08$18.20$21.99
Shared key ingredients—9 of 168 of 165 of 16
Key difference—ArginineCeramide EopNiacinamide
Irritancy High Medium Medium Low
Drying alcohol Contains drying alcohol ———
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 20 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Profile of wound healing process induced by allantoinscielo.br
  5. 5
    Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiencyjamanetwork.com
  6. 6
    Functional glycine receptor in cultured human keratinocytesonlinelibrary.wiley.com
Mederma PM Intensive Overnight Scar Care Cream
MedermaPM Intensive Overnight Scar Care Cream
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As an Amazon Associate, WIMJ earns from qualifying purchases.