Works for:
based on ingredients and %- Moisturizing
- Anti-oxidation
- Anti-aging
- Anti-blemish
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 1
Key actives
Product Summary
"MAXCLINIC - Cica Biome Cream" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Alanine, arginine, aspartic acid, betaine and erythritol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide np, phytosphingosine, arginine, c12-15 alkyl benzoate and macadamia ternifolia seed oil) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- We particularly like that there is a good concentration of Niacinamide (3.10% - 3.80%) in this moisturizer. Niacinamide is a well-studied multi-tasking active. It is a great ingredient to have in a moisturizer. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and help improve the skin tone, reducing pigmentation marks.
- As a plus, this moisturizer also contains Ceramides (phytosphingosine 0.20% - 0.40% and ceramide np 0.20% - 0.40%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- Adenosine 0.15% - 0.30%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
- Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - asiatic acid 0.15% - 0.25%, madecassic acid 0.15% - 0.25% and asiaticoside 0.10% - 0.20% The Centella Asiatica Actives help strengthen and restore the skin barrier, decrease inflammation in skin and neutralize free radicals. They also can help to reduce scarring. The good news is that these actives work even in low concentrations.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails from 17.10$ up to 23.50$ in the United States.
For a detailed price comparison: click here.
Anti-aging
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: asiaticoside, aspartic acid, serine.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
Anti-blemish
This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness
A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect
Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
Anti-oxidation
This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - camellia sinensis extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Tea extract. Might be helpful in neutralizing free radicals in skin
Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness
A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties
Helps soften the upper layer of the skin and might have some antioxidant effect
A plant extract. Can have an anti-oxidant effect, but can also contain irritants
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating
A plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the product
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
Evens skin tone
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Moisturizing
What does the product description say?
Cica Biome Cream
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
alanine, arginine.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, c12-15 alkyl benzoate.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, niacinamide, phytosphingosine
Helps soften the upper layer of the skin
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
Helps attract water to the upper layer of the skin and improves the product texture
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Helps to attract water to the upper layer of the skin
An amino-acid that helps attract water to the upper layer of the skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function
Helps attract water to the upper layer of the skin and might support the healthy skin microbiome
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
An amino-acid. Helps attract water to the upper layer of the skin
A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect
Helps attract water to the upper layer of the skin.
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking
Helps soften the upper layer of the skin and might have some antioxidant effect
Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients
A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Helps attract water to the upper layer of the skin and can help improve skin barrier function
A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Moisturizing |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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|---|---|---|---|
 MAXCLINIC Cica Biome Cream | Current | $17.10 | |
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Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Dipropylene glycol, Propanediol, Niacinamide, Butylene glycol, 1,2-hexanediol, Betaine, Isopentyldiol, C12-14 pareth-12, C12-14 pareth-7, Diphenyl dimethicone, Erythritol, Triethylhexanoin, Tromethamine, Acrylates/c10-30 alkyl acrylate crosspolymer, Carbomer, Panthenol, Centella asiatica extract, Ethylhexylglycerin, Cellulose gum, Adenosine, Dipotassium glycyrrhizate, Lactobacillus ferment filtrate, Disodium edta, Glycerin, Moringa oleifera seed extract, Polyglutamic acid, Asiaticoside, Madecassic acid, Asiatic acid, Scutellaria baicalensis root extract, Polygonum cuspidatum root extract, Camellia sinensis extract, Rosmarinus officinalis leaf extract, Chamomilla recutita flower extract, Prunella vulgaris extract, Fucus vesiculosus extract, Melissa officinalis extract, Chaenomeles sinensis fruit extract, Citrus aurantium dulcis flower extract, Lactobacillus/milk ferment filtrate, Caprylic/capric triglyceride, Candida bombicola/glucose/methyl rapeseedate ferment, Olea europaea fruit oil, Origanum vulgare leaf extract, Chamaecyparis obtusa leaf extract, Salix alba bark extract, Macadamia ternifolia seed oil, Lactobacillus/soybean ferment extract, Portulaca oleracea extract, Cinnamomum cassia bark extract, C12-15 alkyl benzoate, Ceramide np, Phytosphingosine, Hydrogenated lecithin, Glycine, Glutamic acid, Leucine, Methionine, Valine, Serine, Aspartic acid, Isoleucine, Alanine, Arginine, Ornithine, Taurine, Phenylalanine, Proline, Histidine, Glycol, Sodium surfactin, Tocopherol, Centella asiatica oil, Parfum, Hexyl cinnamal
- Niacinamide - mechanisms of action and its topical use in dermatology
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Amended Safety Assessment of Triglycerides as Used in Cosmetics
- Safety Assessment of Tromethamine as Used in Cosmetics
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model
- Centella asiatica in cosmetology
- Triterpene Composition and Bioactivities of Centella asiatica
- Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts
- Assessment report on Centella asiatica (L.) Urban, herba
- Contact dermatitis due to Madecassol
- The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
- Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique
- Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
- Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
- Glycerol and the skin: holistic approach to its origin and functions
- Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health
- γ‐Polyglutamic Acid Produced by Bacillus Subtilis (Natto): Structural Characteristics, Chemical Properties and Biological Functionalities
- Natural and edible biopolymer poly‐γ‐glutamic acid: synthesis, production, and applications
- Contact dermatitis due to Madecassol
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- Contact dermatitis due to Madecassol
- Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants
- Flavonoids in Treating Psoriasis
- Improvement of skin barrier dysfunction by Scutellaria baicalensis GEOGI extracts through lactic acid fermentation
- Safety Assessment of Scutellaria baicalensis-Derived Ingredients as Used in Cosmetics
- Nuclear Factor Kappa B Inhibition as a Therapeutic Target of Nutraceuticals in Arthritis, Osteoarthritis, and Related Inflammation
- Resveratrol as an active ingredient for cosmetic and dermatological applications: a review
- Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gel
- Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics
- Rosmarinus officinalis Extract Suppresses Propionibacterium acnes–Induced Inflammatory Responses
- Use of “natural” oils for moisturization: Review of olive, coconut, and sunflower seed oil
- Efficacy and Safety of White Willow Bark (Salix alba) Extract
- An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
- Fatty acids profile of oil from nine varieties of Macadamia nut
- Portulaca oleracea (purslane)
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiency
- Functional glycine receptor in cultured human keratinocytes
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
- Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof
- In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmness
- Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trial
- Combination of amino acids reduces pigmentation in B16F0 melanoma cells
- Cosmeceuttical Critigue: Taurine
- Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseases
- Safety Assessment of α-Amino Acids as Used in Cosmetics
- Vitamin E in dermatology
- Vitamin E and Skin Health