MAXCLINIC

MAXCLINIC Cica Biome Cream

Name: MAXCLINIC - Cica Biome Cream
Brand: MAXCLINIC

Efficacy100/100IrritancyHigh

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Works for

1 of 1 advertised claim delivered

Moisturizing

Ceramide np, Niacinamide + 34 more

Strong evidence

What the product description says

“Cica Biome Cream”

From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, c12-15 alkyl benzoate.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, niacinamide, phytosphingosine

TriethylhexanoinKey activeEffect: HighHelps soften the upper layer of the skin~0.3–0.6%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.15–0.3%

Asiatic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.15–0.25%

AsiaticosideKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.2%

Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.15–0.3%

BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~1.5–1.8%

Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.2–0.4%

ErythritolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.45–0.7%

Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.15–0.3%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~0.15–0.3%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.15–0.3%

HistidineKey active· HumectantEffect: High~0.15–0.3%

IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.15–0.3%

Lactobacillus ferment filtrateKey activeEffect: HighHelps attract water to the upper layer of the skin and might support the healthy skin microbiome~0.15–0.25%

Madecassic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.15–0.25%

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.1–3.8%

OrnithineKey activeEffect: HighAn amino-acid. Helps attract water to the upper layer of the skin~0.15–0.3%

PhytosphingosineHero· EmollientEffect: HighA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.2–0.4%

Polyglutamic acidKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin.~0.15–0.25%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.15–0.3%

AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.3%

Olea europaea fruit oilKey active· EmollientEffect: MediumAn emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation~0.15–0.3%

C12-15 alkyl benzoateKey active· EmollientEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~0.2–0.35%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

Lactobacillus/soybean ferment extractKey activeEffect: MediumA fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking~0.15–0.3%

Moringa oleifera seed extractKey activeEffect: MediumHelps soften the upper layer of the skin and might have some antioxidant effect~0.15–0.25%

Macadamia ternifolia seed oilKey active· EmollientEffect: MediumPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients~0.2–0.4%

ProlineKey activeEffect: Medium~0.2–0.35%

Scutellaria baicalensis root extract· HumectantEffect: LowA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties~0.1–0.2%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~2.3–2.8%

Portulaca oleracea extract· HumectantEffect: LowA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin~0.15–0.3%

Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.2–0.4%

Centella asiatica extractUnder-dosedEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

PanthenolUnder-dosedEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.25–0.5%

Dipotassium glycyrrhizateUnder-dosedEffect: HighA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.15–0.3%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.25%

Anti-oxidation

Not advertised by the brand · Asiaticoside, Camellia sinensis extract + 11 more

Strong evidence

This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - camellia sinensis extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Camellia sinensis extractKey activeEffect: MediumTea extract. Might be helpful in neutralizing free radicals in skin~0.1–0.2%

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.15–0.3%

Portulaca oleracea extractEffect: LowA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin~0.15–0.3%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

Scutellaria baicalensis root extractEffect: LowA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties~0.1–0.2%

Moringa oleifera seed extractEffect: LowHelps soften the upper layer of the skin and might have some antioxidant effect~0.15–0.25%

Origanum vulgare leaf extractEffect: LowA plant extract. Can have an anti-oxidant effect, but can also contain irritants~0.15–0.3%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.25%

Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.1–0.2%

Polygonum cuspidatum root extractEffect: Low, below effective doseA plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the product~0.15–0.3%

Salix alba bark extractEffect: Low, below effective doseA plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect~0.15–0.25%

Anti-aging

Not advertised by the brand · Adenosine, Niacinamide + 5 more

Strong evidence

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: asiaticoside, aspartic acid, serine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3.1–3.8%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.15–0.3%

AsiaticosideKey activeEffect: MediumAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.2%

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.15–0.3%

Anti-blemish

Not advertised by the brand · Niacinamide, Taurine + 4 more

Strong evidence

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.15–0.3%

PhytosphingosineEffect: LowA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.2–0.4%

Rosmarinus officinalis leaf extractUnder-dosedEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.1–0.2%

Centella asiatica extractEffect: Low, below effective doseA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.3–0.55%

Evens skin tone

Not advertised by the brand · Niacinamide, Alanine + 2 more

Strong evidence

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.3%

TaurineEffect: LowCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness~0.15–0.3%

Dipotassium glycyrrhizateEffect: Low, below effective doseA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.15–0.3%

Can it cause trouble?

Irritancy

7 strong irritants: Rosmarinus officinalis leaf extract, Citrus aurantium dulcis flower extract + 5 more — patch-test recommended

High risk

We flagged 26 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Scutellaria baicalensis root extractA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant propertiesHigh~0.1–0.2%est.

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.1–0.2%est.

Chamomilla recutita flower extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.15–0.25%est.

Citrus aurantium dulcis flower extract—High~0.15–0.25%est.

Origanum vulgare leaf extractA plant extract. Can have an anti-oxidant effect, but can also contain irritantsHigh~0.15–0.3%est.

Chamaecyparis obtusa leaf extractUsed as a fragranceHigh~0.15–0.3%est.

Salix alba bark extractA plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effectHigh~0.15–0.25%est.

Cinnamomum cassia bark extractUsed as a fragrance. Can be irritatingHigh~0.2–0.35%est.

ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.1%est.

Hexyl cinnamalA fragrance with jasmine smell. A likely irritantHigh~0.05–0.1%est.

1,2-hexanediolA preservativeMedium~0.65–0.95%est.

TriethylhexanoinHelps soften the upper layer of the skinMedium~0.3–0.6%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.3–0.55%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.3–0.55%est.

EthylhexylglycerinA preservativeMedium~0.2–0.4%est.

Disodium edtaStabilizes the product formulationMedium~0.15–0.25%est.

Moringa oleifera seed extractHelps soften the upper layer of the skin and might have some antioxidant effectMedium~0.15–0.25%est.

AsiaticosideAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.1–0.2%est.

Madecassic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.15–0.25%est.

Asiatic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.15–0.25%est.

Polygonum cuspidatum root extractA plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the productMedium~0.15–0.3%est.

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.2–0.4%est.

Olea europaea fruit oilAn emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammationMedium~0.15–0.3%est.

Macadamia ternifolia seed oilPlant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredientsMedium~0.2–0.4%est.

Portulaca oleracea extractA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skinMedium~0.15–0.3%est.

TaurineCould be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectivenessMedium~0.15–0.3%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Fucus vesiculosus extract—3/5~0.15–0.3%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Dipropylene glycol~6.4–7.8%

Formula

Irritation risk: Low

Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying

More about Dipropylene glycol

Propanediol~4–4.9%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Niacinamide~3.1–3.8%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-blemishEvens skin toneAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Butylene glycol~2.3–2.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

1,2-hexanediol~0.65–0.95%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Betaine~1.5–1.8%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine

Isopentyldiol~1.3–1.6%

Formula

Irritation risk: Low

Helps dissolve other ingredients in a formulation

More about Isopentyldiol

C12-14 pareth-12~1.1–1.3%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about C12-14 pareth-12

C12-14 pareth-7~0.75–1.1%

Formula

Irritation risk: Low

Works for

Cleansing

More about C12-14 pareth-7

Diphenyl dimethicone~0.6–0.9%

Formula

Irritation risk: Low

Works for

Cleansing

More about Diphenyl dimethicone

Erythritol~0.45–0.7%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin

More about Erythritol

Triethylhexanoin~0.3–0.6%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Triethylhexanoin

Tromethamine~0.3–0.6%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Acrylates/c10-30 alkyl acrylate crosspolymer~0.3–0.55%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Carbomer~0.3–0.55%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Panthenol~0.25–0.5%

Under-dosed

Irritation risk: Low

Works for

Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Centella asiatica extract~0.3–0.55%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Reduces irritationAnti-inflammatoryReduces rednessMoisturizingAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

Ethylhexylglycerin~0.2–0.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Cellulose gum~0.2–0.4%

Formula

Irritation risk: Low

Used to create thicker product consistency and stabilize emulsions

More about Cellulose gum

Adenosine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Dipotassium glycyrrhizate~0.15–0.3%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate

Lactobacillus ferment filtrate~0.15–0.25%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and might support the healthy skin microbiome

More about Lactobacillus ferment filtrate

Disodium edta~0.15–0.25%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Glycerin~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Moringa oleifera seed extract~0.15–0.25%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidation

Helps soften the upper layer of the skin and might have some antioxidant effect

More about Moringa oleifera seed extract

Polyglutamic acid~0.15–0.25%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin.

More about Polyglutamic acid

Asiaticoside~0.1–0.2%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-oxidationMoisturizingAnti-agingReduces irritation

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiaticoside

Madecassic acid~0.15–0.25%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingReduces irritation

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Madecassic acid

Asiatic acid~0.15–0.25%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-inflammatoryReduces irritationMoisturizing

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiatic acid

Scutellaria baicalensis root extract~0.1–0.2%

Irritant · high

Irritation risk: High

Works for

AntibacterialAnti-oxidationMoisturizingReduces irritationAnti-inflammatory

A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties

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Polygonum cuspidatum root extract~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the product

More about Polygonum cuspidatum root extract

Camellia sinensis extract~0.1–0.2%

Key active

Irritation risk: Low

Works for

Anti-oxidation

Tea extract. Might be helpful in neutralizing free radicals in skin

More about Camellia sinensis extract

Rosmarinus officinalis leaf extract~0.1–0.2%

Under-dosedIrritant · high

Irritation risk: High

Works for

Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Chamomilla recutita flower extract~0.15–0.25%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita flower extract

Prunella vulgaris extract~0.15–0.3%

Formula

Irritation risk: Low

More about Prunella vulgaris extract

Fucus vesiculosus extract~0.15–0.3%

Comedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

More about Fucus vesiculosus extract

Melissa officinalis extract~0.1–0.25%

Formula

Irritation risk: Low

More about Melissa officinalis extract

Chaenomeles sinensis fruit extract~0.15–0.3%

Formula

Irritation risk: Low

More about Chaenomeles sinensis fruit extract

Citrus aurantium dulcis flower extract~0.15–0.25%

Irritant · high

Irritation risk: High

More about Citrus aurantium dulcis flower extract

Lactobacillus/milk ferment filtrate~0.15–0.25%

Formula

Irritation risk: Low

More about Lactobacillus/milk ferment filtrate

Caprylic/capric triglyceride~0.2–0.4%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Candida bombicola/glucose/methyl rapeseedate ferment~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps water and oil mix together and preserve the product formulation

More about Candida bombicola/glucose/methyl rapeseedate ferment

Olea europaea fruit oil~0.15–0.3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation

More about Olea europaea fruit oil

Origanum vulgare leaf extract~0.15–0.3%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

A plant extract. Can have an anti-oxidant effect, but can also contain irritants

More about Origanum vulgare leaf extract

Chamaecyparis obtusa leaf extract~0.15–0.3%

Irritant · high

Irritation risk: High

Used as a fragrance

More about Chamaecyparis obtusa leaf extract

Salix alba bark extract~0.15–0.25%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatoryAnti-oxidationAnti-blemishExfoliation

A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect

More about Salix alba bark extract

Macadamia ternifolia seed oil~0.2–0.4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Plant oil from nuts that helps soften the upper layer of the skin. Contains a high concentration of oleic acid that can weaken skin's barrier function and increase water-loss while enhancing penetration of other ingredients

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Lactobacillus/soybean ferment extract~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking

More about Lactobacillus/soybean ferment extract

Portulaca oleracea extract~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidationMoisturizing

A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin

More about Portulaca oleracea extract

Cinnamomum cassia bark extract~0.2–0.35%

Irritant · high

Irritation risk: High

Used as a fragrance. Can be irritating

More about Cinnamomum cassia bark extract

C12-15 alkyl benzoate~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate

Ceramide np~0.2–0.4%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np

Phytosphingosine~0.2–0.4%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryAnti-blemish

A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect

More about Phytosphingosine

Hydrogenated lecithin~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

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Glycine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Glutamic acid~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid

Leucine~0.15–0.3%

Formula

Irritation risk: Low

More about Leucine

Methionine~0.15–0.3%

Formula

Irritation risk: Low

More about Methionine

Valine~0.15–0.3%

Formula

Irritation risk: Low

More about Valine

Serine~0.15–0.3%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Aspartic acid~0.15–0.3%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid

Isoleucine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine

Alanine~0.15–0.3%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Arginine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Ornithine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid. Helps attract water to the upper layer of the skin

More about Ornithine

Taurine~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Anti-inflammatoryAnti-oxidationAnti-blemishEvens skin tone

Could be helpful in reducing inflammation in skin, evening out the skin tone and neutralizing free radicals, but more research is needed to confirm its effectiveness

More about Taurine

Phenylalanine~0.15–0.3%

Formula

Irritation risk: Low

More about Phenylalanine

Proline~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Histidine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Histidine

Glycol~0.15–0.3%

Formula

Irritation risk: Low

More about Glycol

Sodium surfactin~0.25–0.45%

Formula

Irritation risk: Low

Works for

Cleansing

More about Sodium surfactin

Tocopherol~0.15–0.25%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Centella asiatica oil~0.15–0.25%

Formula

Irritation risk: Low

More about Centella asiatica oil

Parfum~0.05–0.1%

Irritant · high

Irritation risk: High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum

Hexyl cinnamal~0.05–0.1%

Irritant · high

Irritation risk: High

A fragrance with jasmine smell. A likely irritant

More about Hexyl cinnamal

Ingredient list view

Water, Dipropylene glycol, Propanediol, Niacinamide, Butylene glycol, 1,2-hexanediol, Betaine, Isopentyldiol, C12-14 pareth-12, C12-14 pareth-7, Diphenyl dimethicone, Erythritol, Triethylhexanoin, Tromethamine, Acrylates/c10-30 alkyl acrylate crosspolymer, Carbomer, Panthenol, Centella asiatica extract, Ethylhexylglycerin, Cellulose gum, Adenosine, Dipotassium glycyrrhizate, Lactobacillus ferment filtrate, Disodium edta, Glycerin, Moringa oleifera seed extract, Polyglutamic acid, Asiaticoside, Madecassic acid, Asiatic acid, Scutellaria baicalensis root extract, Polygonum cuspidatum root extract, Camellia sinensis extract, Rosmarinus officinalis leaf extract, Chamomilla recutita flower extract, Prunella vulgaris extract, Fucus vesiculosus extract, Melissa officinalis extract, Chaenomeles sinensis fruit extract, Citrus aurantium dulcis flower extract, Lactobacillus/milk ferment filtrate, Caprylic/capric triglyceride, Candida bombicola/glucose/methyl rapeseedate ferment, Olea europaea fruit oil, Origanum vulgare leaf extract, Chamaecyparis obtusa leaf extract, Salix alba bark extract, Macadamia ternifolia seed oil, Lactobacillus/soybean ferment extract, Portulaca oleracea extract, Cinnamomum cassia bark extract, C12-15 alkyl benzoate, Ceramide np, Phytosphingosine, Hydrogenated lecithin, Glycine, Glutamic acid, Leucine, Methionine, Valine, Serine, Aspartic acid, Isoleucine, Alanine, Arginine, Ornithine, Taurine, Phenylalanine, Proline, Histidine, Glycol, Sodium surfactin, Tocopherol, Centella asiatica oil, Parfum, Hexyl cinnamal

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	MAXCLINICCica Biome CreamYOUR PRODUCT	TIRTIRMatcha Calming Cream 50ml	mixsoonCica Hyal Deep Soothing Cream 50ml	Centellian24Madeca Cream Time Reverse
Match	—	87%	87%	86%
Price	$17.10	$23.14+$6.04	$14.01−$3.09	$12.36−$4.74
Shared key ingredients	—	14 of 27	11 of 27	15 of 27
Key difference	—	Dipeptide-2	Bacillus Ferment	Madecassoside
Irritancy	High	Medium	Medium	High
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"MAXCLINIC - Cica Biome Cream" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Alanine, arginine, aspartic acid, betaine and erythritol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide np, phytosphingosine, arginine, c12-15 alkyl benzoate and macadamia ternifolia seed oil) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

We particularly like that there is a good concentration of Niacinamide (3.10% - 3.80%) in this moisturizer. Niacinamide is a well-studied multi-tasking active. It is a great ingredient to have in a moisturizer. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and help improve the skin tone, reducing pigmentation marks.
As a plus, this moisturizer also contains Ceramides (phytosphingosine 0.20% - 0.40% and ceramide np 0.20% - 0.40%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
Adenosine 0.15% - 0.30%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - asiatic acid 0.15% - 0.25%, madecassic acid 0.15% - 0.25% and asiaticoside 0.10% - 0.20% The Centella Asiatica Actives help strengthen and restore the skin barrier, decrease inflammation in skin and neutralize free radicals. They also can help to reduce scarring. The good news is that these actives work even in low concentrations.

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e, caprylic/capric triglyceride and dipotassium glycyrrhizate

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.