Peptides (acetyl dipeptide-1 cetyl ester 0.15% - 0.30%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Humectants (arginine pca 0.25% - 0.50%, sodium hyaluronate 0.30% - 0.55% and glycerin 3.10% - 3.70%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails from 39.50£ up to 60.79£ in the United Kingdom, for 64.99$ in the United States and from 59.00CA$ up to 61.00CA$ in Canada.

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What can the product work for?

Anti-aging

What does the product description say?

La Roche-Posay Substiane Serum 30ml is an intensive anti-slackening replenishing corrective serum that acts on the density and volume of facial features.Its formula with PRO-XYLANE?

Source: Cocoon Center

This product contains acetyl dipeptide-1 cetyl ester, serine. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

acetyl dipeptide-1 cetyl ester 0.15% - 0.3%

Irritation risk:

Concentration: Effectiveness: MEDIUM

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

serine 0.25% - 0.4%

Irritation risk:

Concentration: Effectiveness: MEDIUM

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

arginine pca 0.25% - 0.5%

Irritation risk:

Concentration: Effectiveness: LOW

An amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin

Moisturizing

What does the product description say?

A new generation of rich, creamy and melt-in serum texture, developed specifically for mature and sensitive skin which provides a “skin-holding” effect on skin.

Source: La Roche Posay Canada

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine pca, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, dimethiconol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl dipeptide-1 cetyl ester

hydrolyzed linseed extract 0.25% - 0.4%

Irritation risk:

Concentration: Effectiveness: HIGH

Helps soften the upper layer of the skin

hydroxypropyl tetrahydropyrantriol 4.3% - 5.2%

Irritation risk:

Concentration: Effectiveness: HIGH

A sugar-derived compound that helps to attract water to the upper layer of the skin and might be able to stimulate synthesis of skin's own moisturizing factors, but solid research is lacking. It could be irritating

acetyl dipeptide-1 cetyl ester 0.15% - 0.3%

Irritation risk:

Concentration: Effectiveness: HIGH

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

Anti-oxidation

This product contains antioxidants (arginine pca) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

arginine pca 0.25% - 0.5%

Irritation risk:

Concentration: Effectiveness: HIGH

An amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin

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Can it cause trouble?

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Ingredients & concentrations

All ingredients

Key Actives

acetyl dipeptide-1 cetyl ester 0.15% - 0.3%

Irritation risk:

Works for: Anti-inflammatory, Moisturizing, Reduces irritation, Anti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

arginine pca 0.25% - 0.5%

Irritation risk:

Works for: Anti-oxidation, Moisturizing, Anti-aging

An amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin

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Potential irritants

hydroxypropyl tetrahydropyrantriol 4.3% - 5.2%

Irritation risk:

Works for: Moisturizing

alcohol denat. 2.4% - 2.9%

Irritation risk:

Produces temporary toning effect. Can help dissolve other ingredients or preserve products

Comodogenic ingredients

cetearyl alcohol 0.65% - 1%

Irritation risk: Comedogenicity: Medium

Works for: Cleansing, Moisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

All ingredients

water 45% - 55%

Irritation risk:

Plain old water

undecane 7.3% - 8.9%

Irritation risk:

Works for: Moisturizing

Helps create a non-greasy finish on the skin

hydroxypropyl tetrahydropyrantriol 4.3% - 5.2%

Irritation risk:

Works for: Moisturizing

Ingredient list view

Water, Undecane, Hydroxypropyl tetrahydropyrantriol, Glycerin, Alcohol denat., Butylene glycol, Propylene glycol, Sodium tetrahydrojasmonate, Isopropyl lauroyl sarcosinate, Poly c10-30 alkyl acrylate, Dimethicone, Cetearyl alcohol, Tridecane, Dipropylene glycol, Peg-100 stearate, Stearyl alcohol, Glyceryl stearate, Dimethiconol, Cetearyl glucoside, Sodium hyaluronate, Sodium hydroxide, Arginine pca, Serine, Poloxamer 338, Ammonium polyacryloyldimethyl taurate, Disodium edta, Hydrolyzed linseed extract, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Caprylyl glycol, Acetyl dipeptide-1 cetyl ester, Xanthan gum, Acrylates/c10-30 alkyl acrylate crosspolymer, Sodium benzoate, Phenoxyethanol, Parfum

	La Roche-Posay - Substiane Serum	No7 - Laboratories Firming Booster Serum	Triple Hyaluronic Acid - & Lipopeptide Serum	Peter Thomas Roth - FirmX Growth Factor Neuropeptide Serum	CODAGE - Serum No.5 Anti-Aging Serum	mirenesse - Fast Fix Chin Tuck V Shape Lifting Serum	BABOR - LIFTING RX Dual Face Lift Serum	Rilastil - Hydrotenseur serum	Talika - Skintelligence Hydra Hydrating Serum	Natura Bissé - NB Ceutical Intensive Tolerance Booster	Algenist - ELEVATE Firming & Lifting Contouring Serum
Price
WIMJ similarity score		60%	57%	55%	54%	54%	52%	52%	51%	50%	50%
Key ingredients	acetyl dipeptide-1 cetyl ester arginine pca +7 more	Common: acetyl dipeptide-1 cetyl ester glycerin +3 more Other: palmitoyl tripeptide-1 palmitoyl tetrapeptide-7 +2 more	Common: acetyl dipeptide-1 cetyl ester glycerin +1 more Other: anhydroxylitol chondrus crispus extract +5 more	Common: acetyl dipeptide-1 cetyl ester dimethicone +3 more Other: retinyl palmitate urea +11 more	Common: acetyl dipeptide-1 cetyl ester glycerin +2 more Other: acetyl hexapeptide-37 palmitoyl tripeptide-38 +8 more	Common: acetyl dipeptide-1 cetyl ester dimethicone +2 more Other: niacinamide betaine +5 more	Common: acetyl dipeptide-1 cetyl ester glycerin +2 more Other: panthenol panthenol +6 more	Common: acetyl dipeptide-1 cetyl ester sodium hyaluronate +1 more Other: lactobionic acid ceramide np +10 more	Common: acetyl dipeptide-1 cetyl ester glycerin +1 more Other: alpha-glucan oligosaccharide lactobacillus +1 more	Common: acetyl dipeptide-1 cetyl ester serine +1 more Other: tripeptide-1 urea +8 more	Common: acetyl dipeptide-1 cetyl ester glycerin Other: arginine/lysine polypeptide acetyl tetrapeptide-2 +11 more
Irritancy	IRRITANCY MEDIUM	IRRITANCY LOW	IRRITANCY LOW	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM	IRRITANCY MEDIUM
Potential Irritants	parfum Has skin benefit? propylene glycol Has skin benefit? +10 more	t-butyl alcohol Has skin benefit? citric acid Has skin benefit? +7 more	phenethyl alcohol Has skin benefit? sorbic acid Has skin benefit? +7 more	diazolidinyl urea Has skin benefit? propylene glycol Has skin benefit? +7 more	parfum Has skin benefit? trifolium pratense flower extract Has skin benefit? +17 more	jasminum officinale extract Has skin benefit? peucedanum graveolens extract Has skin benefit? +11 more	helichrysum stoechas extract Has skin benefit? helichrysum stoechas extract Has skin benefit? +12 more	parfum Has skin benefit? benzophenone-4 Has skin benefit? +12 more	parfum Has skin benefit? polymnia sonchifolia root juice Has skin benefit? +10 more	ci 19140 Has skin benefit? parfum Has skin benefit? +15 more	parfum Has skin benefit? chlorphenesin Has skin benefit? +15 more
All ingredients	water Has skin benefit? undecane Has skin benefit? +33 more	water Has skin benefit? butylene glycol Has skin benefit? +27 more	water Has skin benefit? methylpropanediol Has skin benefit? +28 more	water Has skin benefit? glycerin Has skin benefit? +53 more	water Has skin benefit? glycerin Has skin benefit? +48 more	water Has skin benefit? glycerin Has skin benefit? +40 more	unknown Has skin benefit? water Has skin benefit? +37 more	water Has skin benefit? glycerin Has skin benefit? +37 more	water Has skin benefit? glycerin Has skin benefit? +24 more	water Has skin benefit? betaine Has skin benefit? +50 more	water Has skin benefit? glycerin Has skin benefit? +46 more

PRODUCT REVIEW

La Roche-Posay Substiane Serum

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Price

What can the product work for?

Works for

Anti-aging

What does the product description say?

Moisturizing

What does the product description say?

Anti-oxidation

Honesty check

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Comodogenic ingredients

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