La Roche-Posay Substiane Rich

La Roche-Posay Substiane Rich

Efficacy75/100IrritancyMedium

Works for

Anti-aging
Acetyl dipeptide-1 cetyl ester, Serine + 2 more
May help
What the product description says
“Substiane Rich Fundamental replenishing anti-ageing care.”
Source: La Roche Posay Canada

This product contains acetyl dipeptide-1 cetyl ester, serine. There is some human evidence that these ingredients help reduce and prevent fine lines and wrinkles and improve skin elasticity and firmness, though it is smaller or less consistent than the evidence for the best anti-aging ingredients.

Acetyl dipeptide-1 cetyl esterKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~4.2–5.1%
Arginine pcaEffect: LowAn amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin~0.25–0.45%
Moisturizing
Side benefit · Acetyl dipeptide-1 cetyl ester, Glycerin + 18 more
Works well

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine pca, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: beeswax, butyrospermum parkii butter.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl dipeptide-1 cetyl ester

Acetyl dipeptide-1 cetyl esterHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–5.2%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~4.2–5.1%
Prunus armeniaca kernel oilKey active· EmollientEffect: HighAn emollient that helps soften the skin~2.4–2.9%
Hydroxypropyl tetrahydropyrantriolKey activeEffect: HighPro-Xylane, a sugar-derived molecule developed by L'Oréal. In lab and skin-model studies it prompts skin cells to make more glycosaminoglycans, the water-holding molecules of the dermis. Evidence in people comes almost only from L'Oréal's own multi-ingredient products.~0.95–1.15%
Cera albaKey active· Emollient, OcclusiveEffect: HighForms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen~0.95–1.15%
BeeswaxKey active· Emollient, OcclusiveEffect: HighForms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen~0.65–0.95%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.55–0.8%
DimethiconolKey active· Emollient, OcclusiveEffect: HighA silicone that makes products more spreadable and keeps skin smooth. Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time~0.3–0.55%
Arginine pcaKey active· HumectantEffect: HighAn amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin~0.25–0.45%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.4%
Hydrolyzed linseed extractKey activeEffect: HighHelps soften the upper layer of the skin~0.2–0.4%
Cyclohexasiloxane· EmollientEffect: LowA silicone that serves as an emollient. Helps create a nice non-greasy feels~3.1–3.8%
Pentaerythrityl tetraethylhexanoate· EmollientEffect: LowUsed to create a nice product consistency while softening the upper layer of the skin~2–2.4%
Isohexadecane· EmollientEffect: LowImproves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent~1.7–2.1%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.5–0.7%
Palmitic acid· EmollientEffect: LowAn emollient that is naturally present in skin and helps soften it~0.5–0.75%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.35–0.6%
Bis-peg-18 methyl ether dimethyl silane· Humectant, EmollientEffect: LowA type of silicone that helps soften the upper layer of the skin and create a nice product texture~0.3–0.55%
Stearic acidEffect: Low, below effective doseHelps oil and water mix together and works as an emollient~0.65–0.95%
Anti-oxidation
Side benefit · Arginine pca, Butyrospermum parkii butter + 1 more
Works well

This product contains antioxidants (arginine pca) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Arginine pcaKey activeEffect: HighAn amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin~0.25–0.45%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~4.2–5.1%
Prunus armeniaca kernel oilEffect: LowAn emollient that helps soften the skin~2.4–2.9%

Can it cause trouble?

Irritancy
1 strong irritant: Parfum
Medium risk
We flagged 7 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.35–0.6%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05%est.
Prunus armeniaca kernel oilAn emollient that helps soften the skinMedium~2.4–2.9%est.
Zea mays starchUsed to thicken the product's consistencyMedium~1.4–1.8%est.
Cera albaForms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergenMedium~0.95–1.15%est.
Disodium edtaStabilizes the product formulationMedium~0.2–0.4%est.
Benzoic acidA preservativeMedium~0.1–0.2%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~4.2–5.1%est.
Zea mays starchUsed to thicken the product's consistency3/5~1.4–1.8%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.3–5.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Butyrospermum parkii butter~4.2–5.1%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Cyclohexasiloxane~3.1–3.8%
Formula
Irritation risk
Low
Works for
Moisturizing

A silicone that serves as an emollient. Helps create a nice non-greasy feels

More about Cyclohexasiloxane
Prunus armeniaca kernel oil~2.4–2.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the skin

More about Prunus armeniaca kernel oil
Pentaerythrityl tetraethylhexanoate~2–2.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product consistency while softening the upper layer of the skin

More about Pentaerythrityl tetraethylhexanoate
Isohexadecane~1.7–2.1%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Improves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent

More about Isohexadecane
Zea mays starch~1.4–1.8%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Mattifying

Used to thicken the product's consistency

More about Zea mays starch
Silica~1.5–1.8%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Hydroxypropyl tetrahydropyrantriol~0.95–1.15%
Key active
Irritation risk
Low
Works for
Moisturizing

Pro-Xylane, a sugar-derived molecule developed by L'Oréal. In lab and skin-model studies it prompts skin cells to make more glycosaminoglycans, the water-holding molecules of the dermis. Evidence in people comes almost only from L'Oréal's own multi-ingredient products.

More about Hydroxypropyl tetrahydropyrantriol
Cera alba~0.95–1.15%
Key activeIrritant · medium
Irritation risk
Medium
Works for
CleansingMoisturizing

Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen

More about Cera alba
Beeswax~0.65–0.95%
Key active
Irritation risk
Low
Works for
Moisturizing

Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen

More about Beeswax
Stearic acid~0.65–0.95%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Dimethicone~0.55–0.8%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Palmitic acid~0.5–0.75%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally present in skin and helps soften it

More about Palmitic acid
Peg-100 stearate~0.55–0.8%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Glyceryl stearate~0.5–0.7%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Propylene glycol~0.35–0.6%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Peg-20 stearate~0.35–0.6%
Formula
Irritation risk
Low
Works for
Cleansing
More about Peg-20 stearate
Bis-peg-18 methyl ether dimethyl silane~0.3–0.55%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

A type of silicone that helps soften the upper layer of the skin and create a nice product texture

More about Bis-peg-18 methyl ether dimethyl silane
Stearyl alcohol~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Dimethiconol~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

A silicone that makes products more spreadable and keeps skin smooth. Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time

More about Dimethiconol
Arginine pca~0.25–0.45%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-aging

An amino-acid. Helps attract water to the upper layer of the skin and can help neutralize free radicals in skin

More about Arginine pca
Serine~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Disodium edta~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Hydrolyzed linseed extract~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Hydrolyzed linseed extract
Acetyl dipeptide-1 cetyl ester~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingReduces irritationAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl dipeptide-1 cetyl ester
Polysorbate 80~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Polysorbate 80
Acrylamide/sodium acryloyldimethyltaurate copolymer~0.15–0.25%
Formula
Irritation risk
Low

Helps water and oil mix together and create gel-like textures

More about Acrylamide/sodium acryloyldimethyltaurate copolymer
Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate~0.15–0.3%
Formula
Irritation risk
Low

Used to increase stability of product formulations

More about Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
Sodium benzoate~0.1–0.2%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Phenoxyethanol~0.1–0.2%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Benzoic acid~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Benzoic acid
Parfum~0.05%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Ingredient list view

Water, Glycerin, Butyrospermum parkii butter, Cyclohexasiloxane, Prunus armeniaca kernel oil, Pentaerythrityl tetraethylhexanoate, Isohexadecane, Zea mays starch, Silica, Hydroxypropyl tetrahydropyrantriol, Cera alba, Beeswax, Stearic acid, Dimethicone, Palmitic acid, Peg-100 stearate, Glyceryl stearate, Propylene glycol, Peg-20 stearate, Bis-peg-18 methyl ether dimethyl silane, Stearyl alcohol, Dimethiconol, Arginine pca, Serine, Disodium edta, Hydrolyzed linseed extract, Acetyl dipeptide-1 cetyl ester, Polysorbate 80, Acrylamide/sodium acryloyldimethyltaurate copolymer, Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, Sodium benzoate, Phenoxyethanol, Benzoic acid, Parfum

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
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Match—51%51%50%
Price—$23.11——
Shared key ingredients—4 of 124 of 126 of 12
Key difference—Palmitoyl Tripeptide-1CyclopentasiloxaneNiacinamide
Irritancy Medium Low Low Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 15 studies and safety reviews.

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La Roche-Posay Substiane Rich
La Roche-PosaySubstiane Rich

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