GRAYMELIN

GRAYMELIN Madecassoside Ampoule

Name: GRAYMELIN - Madecassoside Ampoule
Brand: GRAYMELIN

Efficacy75/100IrritancyHigh

See all ingredients

Works for

Moisturizing

Glycerin, Centella asiatica extract + 13 more

Works

What the product description says

“Contains skin-loving natural ingredients including Green Tea Extract to replenish hydration to skin.”

Source: Yesstyle

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": allantoin, betaine.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.5–5.2%

Centella asiatica extractKey activeEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~2.7–4%

Glycosyl trehaloseKey activeEffect: High~1.8–2.6%

BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~1.4–2.1%

Hydrogenated starch hydrolysateKey active· HumectantEffect: MediumHelps to attract water to the upper layer of the skin. Can add sweet taste to lip products~1.1–1.6%

AllantoinKey active· HumectantEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.85–1.3%

Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.6–1.35%

Dipotassium glycyrrhizateKey active· HumectantEffect: HighA salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening~0.45–1.05%

Madecassic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.4%

Asiatic acidKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.35%

AsiaticosideKey activeEffect: HighAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.4%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~5.2–7.7%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~1.3–2%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.45–1.05%

Scutellaria baicalensis root extract· HumectantEffect: LowA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties~0.3–0.7%

Anti-oxidation

Side benefit · Centella asiatica extract, Asiaticoside + 5 more

Works well

This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - centella asiatica extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Centella asiatica extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~2.7–4%

Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.6–1.35%

Scutellaria baicalensis root extractEffect: LowA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties~0.3–0.7%

Perilla frutescens leaf extractEffect: LowUsed as a fragrance for its mint-like smell~0.2–0.7%

Polygonum cuspidatum root extractEffect: Low, below effective doseA plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the product~0.4–0.9%

Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.2–0.8%

Anti-aging

Side benefit · Centella asiatica extract, Asiaticoside + 1 more

May help

This product contains asiaticoside, centella asiatica extract. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

AsiaticosideKey activeEffect: MediumAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating~0.1–0.4%

Can it cause trouble?

Irritancy

5 strong irritants: Lavandula angustifolia oil, Rosmarinus officinalis leaf extract + 3 more — patch-test recommended

High risk

We flagged 16 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Lavandula angustifolia oilAn essential oil. Potential allergen and can be irritating. It has some anti-bacterial propertiesHigh~0.45–1%est.

Scutellaria baicalensis root extractA plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant propertiesHigh~0.3–0.7%est.

Chamomilla recutita flower extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.35–0.75%est.

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.2–0.8%est.

Commiphora myrrha resin extractUsed as a fragrance. Can be irritatingHigh~0.2–0.7%est.

Perilla frutescens leaf extractUsed as a fragrance for its mint-like smellHigh~0.2–0.7%est.

LinaloolA fragrance. Can be irritatingHigh~0.05–0.25%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~2.7–4%est.

1,2-hexanediolA preservativeMedium~1–1.5%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~1.3–2%est.

EthylhexylglycerinA preservativeMedium~0.5–1.1%est.

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.45–1.05%est.

Polygonum cuspidatum root extractA plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the productMedium~0.4–0.9%est.

AsiaticosideAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.1–0.4%est.

Madecassic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.1–0.4%est.

Asiatic acidAn active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritatingMedium~0.1–0.35%est.

Comedogenic

Clean of flagged comedogenic ingredients

None flagged

Alternatives

Cheaper, or higher on efficacy

TIRTIR Cica Care Serum

Higher efficacy · 100/10069% match

$24.75

ROVECTIN Cica Care Clearing Ampoule

Higher efficacy · 100/10065% match

$17.14

View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Centella asiatica leaf water~22–33%

Formula

Irritation risk: Low

More about Centella asiatica leaf water

Water~12–18%

Formula

Irritation risk: Low

Plain old water

More about Water

Butylene glycol~5.2–7.7%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Glycerin~3.5–5.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Centella asiatica extract~2.7–4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Reduces irritationMoisturizingAnti-inflammatoryReduces rednessAnti-oxidationAnti-agingAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

1,2-hexanediol~1–1.5%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Glycosyl trehalose~1.8–2.6%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Glycosyl trehalose

Betaine~1.4–2.1%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine

Caprylyl glycol~1.3–2%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Hydrogenated starch hydrolysate~1.1–1.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin. Can add sweet taste to lip products

More about Hydrogenated starch hydrolysate

Allantoin~0.85–1.3%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin

Beta-glucan~0.6–1.35%

Key active

Irritation risk: Low

Works for

Anti-inflammatoryReduces irritationMoisturizingAnti-oxidationAnti-agingAnti-blemish

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan

Carbomer~0.55–1.3%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Polyglyceryl-4 caprate~0.55–1.25%

Formula

Irritation risk: Low

Works for

Cleansing

More about Polyglyceryl-4 caprate

Tromethamine~0.5–1.15%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Ethylhexylglycerin~0.5–1.1%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Dipotassium glycyrrhizate~0.45–1.05%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryEvens skin tone

A salt derived from licorice. Works as an emollient to soften the upper layer of the skin and can help calm down inflammation. Might be helpful for skin lightening

More about Dipotassium glycyrrhizate

Lavandula angustifolia oil~0.45–1%

Irritant · high

Irritation risk: High

An essential oil. Potential allergen and can be irritating. It has some anti-bacterial properties

More about Lavandula angustifolia oil

Pentylene glycol~0.45–1.05%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Polygonum cuspidatum root extract~0.4–0.9%

Irritant · medium

Irritation risk: Medium

Works for

Anti-oxidation

A plant extract that can contain resveratrol, an antioxidant that can help neutralize free radicals in skin. The effectiveness depends on the extract quality and concentration in the product

More about Polygonum cuspidatum root extract

Scutellaria baicalensis root extract~0.3–0.7%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatoryAnti-oxidationMoisturizingReduces irritationAntibacterial

A plant extract that might contain a compound baicalin that could be helpful in neutralizing free radicals and reducing inflammation in skin. The baicalin concentration in skincare products is often too low for an effective action. Can be used for its fragrant properties

More about Scutellaria baicalensis root extract

Aspalathus linearis extract~0.35–0.85%

Formula

Irritation risk: Low

More about Aspalathus linearis extract

Chamomilla recutita flower extract~0.35–0.75%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita flower extract

Rosmarinus officinalis leaf extract~0.2–0.8%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Commiphora myrrha resin extract~0.2–0.7%

Irritant · high

Irritation risk: High

Used as a fragrance. Can be irritating

More about Commiphora myrrha resin extract

Perilla frutescens leaf extract~0.2–0.7%

Irritant · high

Irritation risk: High

Works for

Anti-oxidation

Used as a fragrance for its mint-like smell

More about Perilla frutescens leaf extract

Yucca schidigera root extract~0.15–0.5%

Formula

Irritation risk: Low

More about Yucca schidigera root extract

Asiaticoside~0.1–0.4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidationReduces irritationAnti-aging

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiaticoside

Madecassic acid~0.1–0.4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingReduces irritation

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Madecassic acid

Asiatic acid~0.1–0.35%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingReduces irritationAnti-inflammatory

An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating

More about Asiatic acid

Chlorophyllin-copper complex~0.05–0.25%

Formula

Irritation risk: Low

More about Chlorophyllin-copper complex

Linalool~0.05–0.25%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Linalool

Ingredient list view

Centella asiatica leaf water, Water, Butylene glycol, Glycerin, Centella asiatica extract, 1,2-hexanediol, Glycosyl trehalose, Betaine, Caprylyl glycol, Hydrogenated starch hydrolysate, Allantoin, Beta-glucan, Carbomer, Polyglyceryl-4 caprate, Tromethamine, Ethylhexylglycerin, Dipotassium glycyrrhizate, Lavandula angustifolia oil, Pentylene glycol, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, Aspalathus linearis extract, Chamomilla recutita flower extract, Rosmarinus officinalis leaf extract, Commiphora myrrha resin extract, Perilla frutescens leaf extract, Yucca schidigera root extract, Asiaticoside, Madecassic acid, Asiatic acid, Chlorophyllin-copper complex, Linalool

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$16.90

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	GRAYMELINMadecassoside AmpouleYOUR PRODUCT	TIRTIRCica Care Serum	ROVECTINCica Care Clearing Ampoule	APLBCOLLAGEN EFG PEPTIDE SERUM
Match	—	69%	65%	65%
Price	$16.90	$24.75+$7.85	$17.14	$8.80−$8.10
Shared key ingredients	—	9 of 11	8 of 11	7 of 11
Key difference	—	Madecassoside	Madecassoside	Sh-Oligopeptide-1
Irritancy	High	Medium	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"GRAYMELIN - Madecassoside Ampoule" could be helpful for: Moisturizing and Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

Dipotassium Glycyrrhizate in this product (0.45% - 1.05%) can also further help improve the skin barrier. It might be able to calm down inflammation and reduce sensitivity. Dipotassium Glycyrrhizate is an active compound from the licorice root.
In addition, this product contains Allantoin (0.85% - 1.30%). Allantoin is helpful in wound-healing and can help restore the skin barrier faster. It might also be able to improve scars, but the evidence is not very strong for this.
Humectants (betaine 1.40% - 2.10% and glycerin 3.50% - 5.20%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.