Dr.Different 131 Moisturizer

Dr.Different 131 Moisturizer

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
25 ingredients credited for this claim
Strong support
What the product description says
“131 Moisturizer”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, niacinamide, phytosphingosine

PhytosphingosineHero· EmollientEffect: HighA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.15–0.25%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.2–0.35%
AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.25%
Carthamus tinctorius seed oilKey active· EmollientEffect: HighAn emollient that helps soften the skin and might help calm down inflammation~0.3–0.55%
Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.2–0.4%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.35–0.65%
Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.15–0.25%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.6–5.6%
GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.15–0.3%
GlycosphingolipidsKey active· EmollientEffect: HighA type of lipids naturally present in skin. They can be converted to ceramides in skin~0.2–0.35%
Hydroxypropyl bispalmitamide meaKey active· EmollientEffect: High~0.45–0.7%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~2.4–2.9%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.35–0.65%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3–3.7%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.45–0.7%
Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~1.6–1.9%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.4%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
Oleic acid· EmollientEffect: LowHelps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin dryness~0.25–0.5%
Palmitic acid· EmollientEffect: LowAn emollient that is naturally present in skin and helps soften it~0.25–0.5%
Myristyl alcohol· EmollientEffect: LowHelps to stabilize the product formulation while softening the upper layer of the skin. Can be irritating~0.25–0.45%
Linoleic acidUnder-dosedEffect: HighAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.3–0.55%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%
Stearic acidEffect: Low, below effective doseHelps oil and water mix together and works as an emollient~0.6–0.9%
Anti-aging
Not advertised by the brand · 3 ingredients credited for this claim
Strong support

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: serine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3–3.7%
SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.4%
Evens skin tone
Not advertised by the brand · 2 ingredients credited for this claim
Strong support

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3–3.7%
AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.25%
Anti-blemish
Not advertised by the brand · 3 ingredients credited for this claim
Strong support

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~3–3.7%
PhytosphingosineEffect: LowA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.15–0.25%
Linoleic acidUnder-dosedEffect: MediumAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.3–0.55%

Can it cause trouble?

Irritancy
1 strong irritant: Sorbitan sesquioleate
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Sorbitan sesquioleateUsed to help oil and water mix together. Can be irritatingHigh~0.9–1.1%est.
Myristyl alcoholHelps to stabilize the product formulation while softening the upper layer of the skin. Can be irritatingHigh~0.25–0.45%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~2.4–2.9%est.
1,2-hexanediolA preservativeMedium~0.6–0.95%est.
EthylhexylglycerinA preservativeMedium~0.3–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
Oleic acidHelps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin drynessMedium~0.25–0.5%est.
Hydrogenated phosphatidylcholineHelps oil and water mix togetherMedium~0.25–0.4%est.
Rosa canina fruit extractA plant extract that might have some anti-oxidant properties, but evidence is lackingMedium~0.2–0.35%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~1.6–1.9%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.6–5.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Propanediol~3.9–4.8%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Niacinamide~3–3.7%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Anti-blemishEvens skin toneAnti-agingMoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterial

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Caprylic/capric triglyceride~2.4–2.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
1,2-hexanediol~0.6–0.95%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Glyceryl stearate se~1.6–1.9%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se
Cetearyl olivate~1.4–1.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
C18-21 alkane~1.1–1.4%
Formula
Irritation risk
Low
More about C18-21 alkane
Sorbitan sesquioleate~0.9–1.1%
Irritant · high
Irritation risk
High
Works for
Cleansing

Used to help oil and water mix together. Can be irritating

More about Sorbitan sesquioleate
Sorbitan olivate~0.65–1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Carbomer~0.55–0.8%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Stearic acid~0.6–0.9%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Stearyl alcohol~0.55–0.8%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Arginine~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Hydroxypropyl bispalmitamide mea~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Hydroxypropyl bispalmitamide mea
Cetyl alcohol~0.45–0.7%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Ethylhexylglycerin~0.3–0.6%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Cholesterol~0.35–0.65%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol
Carthamus tinctorius seed oil~0.3–0.55%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the skin and might help calm down inflammation

More about Carthamus tinctorius seed oil
Isomerized linoleic acid~0.25–0.45%
Formula
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Decylene glycol~0.2–0.4%
Formula
Irritation risk
Low

Used to creat a nice product texture and support penetration of other ingredients

More about Decylene glycol
Xanthan gum~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Oleic acid~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
CleansingAnti-inflammatoryMoisturizing

Helps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin dryness

More about Oleic acid
Myristyl alcohol~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps to stabilize the product formulation while softening the upper layer of the skin. Can be irritating

More about Myristyl alcohol
Butylene glycol~0.2–0.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Palmitic acid~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally present in skin and helps soften it

More about Palmitic acid
Tocopherol~0.2–0.4%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Lauryl alcohol~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing
More about Lauryl alcohol
Hydrogenated phosphatidylcholine~0.25–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Hydrogenated phosphatidylcholine
Linoleic acid~0.3–0.55%
Under-dosed
Irritation risk
Low
Works for
MoisturizingCleansingAnti-blemish

An excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores

More about Linoleic acid
Sodium pca~0.2–0.35%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Serine~0.2–0.35%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Rosa canina fruit extract~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant properties, but evidence is lacking

More about Rosa canina fruit extract
Glycine~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine
Tremella fuciformis polysaccharide~0.2–0.35%
Formula
Ceramide np~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np
Alanine~0.15–0.25%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine
Glutamic acid~0.15–0.25%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid
Cholesteryl macadamiate~0.2–0.35%
Formula
Glycosphingolipids~0.2–0.35%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of lipids naturally present in skin. They can be converted to ceramides in skin

More about Glycosphingolipids
Phytosphingosine~0.15–0.25%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-blemish

A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect

More about Phytosphingosine
Sucrose stearate~0.15–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sucrose stearate
Ingredient list view

Water, Glycerin, Propanediol, Niacinamide, Caprylic/capric triglyceride, 1,2-hexanediol, Glyceryl stearate se, Cetearyl olivate, C18-21 alkane, Sorbitan sesquioleate, Sorbitan olivate, Carbomer, Stearic acid, Stearyl alcohol, Arginine, Hydroxypropyl bispalmitamide mea, Cetyl alcohol, Ethylhexylglycerin, Cholesterol, Carthamus tinctorius seed oil, Isomerized linoleic acid, Caprylyl glycol, Decylene glycol, Xanthan gum, Oleic acid, Myristyl alcohol, Butylene glycol, Palmitic acid, Tocopherol, Lauryl alcohol, Hydrogenated phosphatidylcholine, Linoleic acid, Sodium pca, Serine, Rosa canina fruit extract, Glycine, Tremella fuciformis polysaccharide, Ceramide np, Alanine, Glutamic acid, Cholesteryl macadamiate, Glycosphingolipids, Phytosphingosine, Sucrose stearate

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Amazon USPrice as of 10/9/2026 21:06 GMT
$22.49
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$31.32
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Dr.Different131 MoisturizerYOUR PRODUCTFaceGymSupreme Restructure Firming Moisturisere.l.f. CosmeticsPure Skin MoisturizerBYOMAMoisturising Gel Cream
Match—86%86%84%
Price$22.49$125.59+$103.10$11.81−$10.68$13.99−$8.50
Shared key ingredients—13 of 176 of 176 of 17
Key difference—Hexapeptide-9Ceramide EopLactic Acid
Irritancy Medium Medium Low Low
Drying alcohol————
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Product summary

"Dr. Different - 131 Moisturizer" is a well-rounded moisturizing product. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Alanine, arginine, glutamic acid, glycerin and glycine in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Ceramide np, phytosphingosine, carthamus tinctorius seed oil, cholesterol and glycosphingolipids in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • We particularly like that there is a good concentration of Niacinamide (3.00% - 3.70%) in this moisturizer. Niacinamide is a well-studied multi-tasking active. It is a great ingredient to have in a moisturizer. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and help improve the skin tone, reducing pigmentation marks.
  • As a plus, this moisturizer also contains Ceramides (phytosphingosine 0.15% - 0.25% and ceramide np 0.20% - 0.40%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e and stearic acid

Irritation risk

This moisturizer contains some common irritants, including those without a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 31.32$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 20 studies and safety reviews.

  1. 1
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  6. 6

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As an Amazon Associate, WIMJ earns from qualifying purchases.