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Dr. Denese Med MD 33 Clinical Neck Treatment
Dr. Denese

Dr. Denese Med MD 33 Clinical Neck Treatment

Efficacy100/100IrritancyHigh
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Works for

1 of 1 advertised claim delivered

Anti-aging
Heptapeptide-15 palmitate, Palmitoyl tripeptide-38 + 9 more
Strong evidence
What the product description says
“Anyone who wants the appearance of a youthful-looking evenness and luminosity to the neck and decollete.”
Source: Dr. Denese

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains heptapeptide-15 palmitate.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: copper heptapeptide-14 pantothenate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Heptapeptide-15 palmitateKey activeEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Palmitoyl tripeptide-38Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Copper heptapeptide-14 pantothenateKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.7%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.65%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.2–0.4%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~5.8–7.1%
Centella asiatica extractUnder-dosedEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.25–0.5%
Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.35%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.2–0.4%
Moisturizing
Not advertised by the brand · Palmitoyl tripeptide-38, Isosorbide dicaprylate + 39 more
Strong evidence

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: dextran, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: beeswax, butyrospermum parkii butter.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: copper heptapeptide-14 pantothenate, heptapeptide-15 palmitate, isosorbide dicaprylate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38, urea

Palmitoyl tripeptide-38HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Isosorbide dicaprylateHero· EmollientEffect: HighHelps soften the upper layer of the skin. Early studies suggest that it can help strengthen the skin barrier~1.2–1.4%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.65%
Linolenic acidKey active· EmollientEffect: HighAn emollient that helps soften the skin and calm down inflammation~0.3–0.55%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.45–0.7%
Theobroma cacao seed butterKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~2–2.4%
UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.2–0.4%
BeeswaxKey active· Emollient, OcclusiveEffect: HighForms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen~0.25–0.5%
Copper heptapeptide-14 pantothenateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.6%
DextranKey active· HumectantEffect: HighHelps attract water to the most upper layer of the skin. Derived from sugar~0.15–0.3%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~2.5–3.1%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.3–0.5%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–5.2%
Soluble collagenKey active· HumectantEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.9–1.15%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–0.7%
Heptapeptide-15 palmitateHero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.2–0.4%
Triticum vulgare germ oilKey active· EmollientEffect: HighA good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).~0.25–0.5%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~5.8–7.1%
Pantothenic acidKey activeEffect: HighHelps attract water to the upper layer of the skin and may help reduce inflammation in skin~0.2–0.4%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.25–0.4%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.4–1.8%
Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~0.2–0.4%
Hydrolyzed alginKey active· HumectantEffect: MediumDerived from brown algae. Helps attract water to the upper layer of the skin~0.2–0.4%
Hydrolyzed wheat proteinKey active· HumectantEffect: MediumCan help attract water to the upper layer of the skin. Avoid if sensitive to gluten~0.2–0.4%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.6–0.85%
Sorbitol· HumectantEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.2–0.4%
Di-c12-15 alkyl fumarate· EmollientEffect: LowUsed to soften the upper layer of the skin and create a nice product texture~1.7–2%
Pentaerythrityl tetraethylhexanoate· EmollientEffect: LowUsed to create a nice product consistency while softening the upper layer of the skin~3.2–3.9%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.35%
Isohexadecane· EmollientEffect: LowImproves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent~0.3–0.6%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.2–0.35%
Hydroxypropyl cyclodextrin· EmollientEffect: LowUsed to stabilize product formulations and help soften the upper layer of the skin~0.2–0.35%
Glyceryl polymethacrylate· Humectant, EmollientEffect: LowUsed to create a nice product texture~0.25–0.45%
Linoleic acidUnder-dosedEffect: HighAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.35–0.6%
PanthenolUnder-dosedEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.2–0.4%
AllantoinUnder-dosedEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.2–0.35%
Simmondsia chinensis seed oilUnder-dosedEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.3–0.5%
Centella asiatica extractUnder-dosedEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.45%
Aloe barbadensis leaf extractEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.25–0.5%

Can it cause trouble?

Irritancy
6 strong irritants: Humulus lupulus extract, Melissa officinalis leaf extract + 4 more — patch-test recommended
High risk
We flagged 26 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Humulus lupulus extractHops extract. Can contain common irritants and allergens geraniol, limonene, linaloolHigh~0.25–0.4%est.
Melissa officinalis leaf extractA plant extract that is added for its fragrance. Can be irritatingHigh~0.2–0.4%est.
Chamomilla recutita flower extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.2–0.4%est.
Achillea millefolium extractPlant extract that can help neutralize free radicals in skin. Can be used as a fragrance. Can be irritatingHigh~0.25–0.45%est.
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.2–0.4%est.
Equisetum arvense extractA plant extract that might have anti-oxidant properties. Can be irritatingHigh~0.25–0.45%est.
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.35%est.
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.2–0.4%est.
Di-c12-15 alkyl fumarateUsed to soften the upper layer of the skin and create a nice product textureMedium~1.7–2%est.
Viscum album leaf extractA plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lackingMedium~0.2–0.35%est.
Aloe barbadensis leaf extractTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.25–0.5%est.
Hydrolyzed wheat proteinCan help attract water to the upper layer of the skin. Avoid if sensitive to glutenMedium~0.2–0.4%est.
Phytic acidAn alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmeticsMedium~0.25–0.45%est.
Linolenic acidAn emollient that helps soften the skin and calm down inflammationMedium~0.3–0.55%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.3–0.5%est.
Ascorbyl methylsilanol pectinateA stable derivative of pectin and vitamin C. It might help neutralize free radicals in skin, but evidence of effectiveness is lacking. Helps create a thicker product consistency and stabilize the product formulationMedium~0.2–0.4%est.
Cucumis sativus extract—Medium~0.2–0.4%est.
Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium~0.25–0.5%est.
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~0.2–0.4%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.2–0.4%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.25–0.45%est.
Sodium stearoyl glutamateHelps oil and water mix togetherMedium~0.3–0.5%est.
Polyvinyl alcoholHelps improve the product textureMedium~0.25–0.45%est.
Hydroxypropyl cyclodextrinUsed to stabilize product formulations and help soften the upper layer of the skinMedium~0.2–0.35%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.25%est.
EthylhexylglycerinA preservativeMedium~0.1–0.15%est.
Comedogenic
6 ingredients rated 2 or more on the 0–5 pore-clogging scale
6 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~5.8–7.1%est.
Theobroma cacao seed butterHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect3/5~2–2.4%est.
Triticum vulgare germ oilA good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).3/5~0.25–0.5%est.
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~0.2–0.4%est.
Hydrolyzed alginDerived from brown algae. Helps attract water to the upper layer of the skin3/5~0.2–0.4%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.4–1.8%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Butyrospermum parkii butter~5.8–7.1%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Glycerin~4.3–5.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Pentaerythrityl tetraethylhexanoate~3.2–3.9%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product consistency while softening the upper layer of the skin

More about Pentaerythrityl tetraethylhexanoate
Squalane~2.5–3.1%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Theobroma cacao seed butter~2–2.4%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-dandruff

Helps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect

More about Theobroma cacao seed butter
Di-c12-15 alkyl fumarate~1.7–2%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to soften the upper layer of the skin and create a nice product texture

More about Di-c12-15 alkyl fumarate
Cetearyl alcohol~1.4–1.8%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Isosorbide dicaprylate~1.2–1.4%
Hero · Moisturizing
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin. Early studies suggest that it can help strengthen the skin barrier

More about Isosorbide dicaprylate
Soluble collagen~0.9–1.15%
Key active
Irritation risk
Low
Works for
Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Soluble collagen
Peg-100 stearate~0.7–1.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Glyceryl stearate~0.6–0.85%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Sodium hyaluronate~0.45–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Palmitoyl tetrapeptide-7~0.45–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Palmitoyl tripeptide-1~0.45–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Heptapeptide-15 palmitate~0.35–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Heptapeptide-15 palmitate
Copper heptapeptide-14 pantothenate~0.3–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Copper heptapeptide-14 pantothenate
Palmitoyl tripeptide-38~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-38
Globularia cordifolia callus culture extract~0.25–0.5%
Formula
Irritation risk
Low
Works for
Anti-inflammatory

An extract from plant stem cells that might help calm down inflammation in skin

More about Globularia cordifolia callus culture extract
Foeniculum vulgare fruit extract~0.25–0.5%
Formula
Irritation risk
Low
More about Foeniculum vulgare fruit extract
Humulus lupulus extract~0.25–0.4%
Irritant · high
Irritation risk
High

Hops extract. Can contain common irritants and allergens geraniol, limonene, linalool

More about Humulus lupulus extract
Melissa officinalis leaf extract~0.2–0.4%
Irritant · high
Irritation risk
High

A plant extract that is added for its fragrance. Can be irritating

More about Melissa officinalis leaf extract
Viscum album leaf extract~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAntibacterialAnti-inflammatory

A plant extract that has anti-inflammatory and anti-bacterial properties and might help neutralize free radicals in skin, but solid research is lacking

More about Viscum album leaf extract
Chamomilla recutita flower extract~0.2–0.4%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita flower extract
Achillea millefolium extract~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Anti-oxidation

Plant extract that can help neutralize free radicals in skin. Can be used as a fragrance. Can be irritating

More about Achillea millefolium extract
Urea~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Allantoin~0.2–0.35%
Under-dosed
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Aloe barbadensis leaf extract~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf extract
Acetamide mea~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing
More about Acetamide mea
Panthenol~0.2–0.4%
Under-dosed
Irritation risk
Low
Works for
MoisturizingReduces rednessReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Hydrolyzed wheat protein~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten

More about Hydrolyzed wheat protein
Hyaluronic acid~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Phytic acid~0.25–0.45%
Irritant · medium
Irritation risk
Medium

An alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmetics

More about Phytic acid
Triticum vulgare germ oil~0.25–0.5%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidation

A good emoillient. Contains vitamin E which can help neutralise free radicals, however the oil is unstable. Avoid if you have gluten or wheat sensitivity (including food allergies).

More about Triticum vulgare germ oil
Linoleic acid~0.35–0.6%
Under-dosed
Irritation risk
Low
Works for
MoisturizingCleansingAnti-blemish

An excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores

More about Linoleic acid
Linolenic acid~0.3–0.55%
Key activeIrritant · medium
Irritation risk
Medium
Works for
CleansingMoisturizingAnti-inflammatoryReduces irritation

An emollient that helps soften the skin and calm down inflammation

More about Linolenic acid
Simmondsia chinensis seed oil~0.3–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Propylene glycol~0.2–0.4%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Sorbitol~0.2–0.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol
Tocopherol~0.25–0.45%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ascorbyl methylsilanol pectinate~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A stable derivative of pectin and vitamin C. It might help neutralize free radicals in skin, but evidence of effectiveness is lacking. Helps create a thicker product consistency and stabilize the product formulation

More about Ascorbyl methylsilanol pectinate
Urtica dioica extract~0.2–0.4%
Formula
Irritation risk
Low
More about Urtica dioica extract
Equisetum arvense extract~0.25–0.45%
Irritant · high
Irritation risk
High

A plant extract that might have anti-oxidant properties. Can be irritating

More about Equisetum arvense extract
Cucumis sativus extract~0.2–0.4%
Irritant · medium
Irritation risk
Medium
More about Cucumis sativus extract
Centella asiatica extract~0.25–0.5%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Reduces irritationReduces rednessMoisturizingAnti-inflammatoryAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract
Chamomile matricaria extract
Not recognized
Chlorella vulgaris extract~0.2–0.4%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-inflammatory

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract
Hydrolyzed algin~0.2–0.4%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

Derived from brown algae. Helps attract water to the upper layer of the skin

More about Hydrolyzed algin
Phospholipids~0.25–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Retinyl palmitate~0.2–0.35%
Under-dosedIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-blemishAnti-agingExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Pantothenic acid~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-blemishReduces redness

Helps attract water to the upper layer of the skin and may help reduce inflammation in skin

More about Pantothenic acid
Ascorbyl palmitate~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-agingAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Tocopheryl acetate~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Dimethicone~0.3–0.5%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Sodium stearoyl glutamate~0.3–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Sodium stearoyl glutamate
Sodium acrylate/sodium acryloyldimethyl taurate copolymer~0.2–0.4%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Sodium acrylate/sodium acryloyldimethyl taurate copolymer
Isohexadecane~0.3–0.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Improves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent

More about Isohexadecane
Polysorbate 20~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Polysorbate 80~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Polysorbate 80
Beeswax~0.25–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen

More about Beeswax
Lactic acid/glycolic acid copolymer~0.25–0.4%
Formula
Irritation risk
Low
More about Lactic acid/glycolic acid copolymer
Glyceryl polymethacrylate~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture

More about Glyceryl polymethacrylate
Polyvinyl alcohol~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Helps improve the product texture

More about Polyvinyl alcohol
Alcohol~0.2–0.4%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Butylene glycol~0.2–0.35%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Propylene glycol~0.2–0.35%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Dextran~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the most upper layer of the skin. Derived from sugar

More about Dextran
Hydroxypropyl cyclodextrin~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to stabilize product formulations and help soften the upper layer of the skin

More about Hydroxypropyl cyclodextrin
Disodium edta~0.15–0.25%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Xanthan gum~0.15–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Phenoxyethanol~0.15–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ethylhexylglycerin~0.1–0.15%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Ingredient list view

Water, Butyrospermum parkii butter, Glycerin, Pentaerythrityl tetraethylhexanoate, Squalane, Theobroma cacao seed butter, Di-c12-15 alkyl fumarate, Cetearyl alcohol, Isosorbide dicaprylate, Soluble collagen, Peg-100 stearate, Glyceryl stearate, Sodium hyaluronate, Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Heptapeptide-15 palmitate, Copper heptapeptide-14 pantothenate, Palmitoyl tripeptide-38, Globularia cordifolia callus culture extract, Foeniculum vulgare fruit extract, Humulus lupulus extract, Melissa officinalis leaf extract, Viscum album leaf extract, Chamomilla recutita flower extract, Achillea millefolium extract, Urea, Allantoin, Aloe barbadensis leaf extract, Acetamide mea, Panthenol, Hydrolyzed wheat protein, Hyaluronic acid, Phytic acid, Triticum vulgare germ oil, Linoleic acid, Linolenic acid, Simmondsia chinensis seed oil, Propylene glycol, Sorbitol, Tocopherol, Ascorbyl methylsilanol pectinate, Urtica dioica extract, Equisetum arvense extract, Cucumis sativus extract, Centella asiatica extract, Unknown, Chlorella vulgaris extract, Hydrolyzed algin, Phospholipids, Retinyl palmitate, Pantothenic acid, Ascorbyl palmitate, Tocopheryl acetate, Dimethicone, Sodium stearoyl glutamate, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Isohexadecane, Polysorbate 20, Polysorbate 80, Beeswax, Lactic acid/glycolic acid copolymer, Glyceryl polymethacrylate, Polyvinyl alcohol, Alcohol, Butylene glycol, Propylene glycol, Dextran, Hydroxypropyl cyclodextrin, Disodium edta, Xanthan gum, Phenoxyethanol, Ethylhexylglycerin

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Product summary

Judging from the ingredient list, "Dr. Denese - Med MD 33 Clinical Neck Treatment" works well for improving skin hydration The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (heptapeptide-15 palmitate, urea, dextran, glycerin and hyaluronic acid) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (isosorbide dicaprylate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, linolenic acid and theobroma cacao seed butter) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • this moisturizer includes a form of Retinoids (vitamin A) - retinyl palmitate 0.20% - 0.35%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • This moisturizer also contains Peptides (palmitoyl tripeptide-38 0.30% - 0.55%, copper heptapeptide-14 pantothenate 0.30% - 0.60%, heptapeptide-15 palmitate 0.35% - 0.60%, palmitoyl tripeptide-1 0.45% - 0.65% and palmitoyl tetrapeptide-7 0.45% - 0.70%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: centella asiatica extract, vitamin e, jojoba oil and allantoin

Irritation risk

There are quite a few common irritants in this product, including ingredients without particular skin benefits. We would not recommend it for sensitive skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 34 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmeticsjournals.sagepub.com
  3. 3
    Cocoa polyphenols and their influence on parameters involved in ex vivo skin restructuringncbi.nlm.nih.gov
  4. 4
    Improvement of hydration and epidermal barrier function in human skin by a novel compound isosorbide dicaprylatepubmed.ncbi.nlm.nih.gov
  5. 5
    Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
  6. 6
    Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
Dr. Denese Med MD 33 Clinical Neck Treatment
Dr. DeneseMed MD 33 Clinical Neck Treatment
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