Works for:
based on ingredients and %- Evens skin tone
- Anti-aging
- Anti-oxidation
- Exfoliation
Can it cause trouble?
- Irritation risk: medium
- Comedogenic risk ingredients: 1
Key actives
Product Summary
"Dermedecine - Retinol High Potency Face Cream" is effective for: Evens skin tone, Anti-aging, Exfoliation, Moisturizing and Anti-blemish
Ingredient callouts
- this product contains an effective form of Retinoids (vitamin A): retinol 1.50% - 2.30%. Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily.
- Ceramides (ceramide np 0.10% - 0.30%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
- Humectants (glycerin 0.90% - 1.40% and sodium hyaluronate 2.00% - 3.00%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 85.00$ in the United States.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
Our premium anti aging night cream combines Retinol with natural ingredients to be stimulating and boosting helping your complexion appear more even, youthful and bright while helping to fade the appearance of fine lines and wrinkles, blotchiness and unevenness that becomes more apparent as we age.
Source: Dermdeicine
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: ascorbyl glucoside.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
Anti-blemish
This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
Anti-oxidation
This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - ascorbyl glucoside also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
Evens skin tone
What does the product description say?
Our premium anti aging night cream combines Retinol with natural ingredients to be stimulating and boosting helping your complexion appear more even, youthful and bright while helping to fade the appearance of fine lines and wrinkles, blotchiness and unevenness that becomes more apparent as we age.
Source: Dermdeicine
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: ascorbyl glucoside.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
Exfoliation
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
Moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, cetyl palmitate.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
An emollient that helps soften the skin and is used to improve product texture and stability
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Evens skin tone |
Total Promises Fulfilled score: 100/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Dermedecine Retinol High Potency Face Cream | Current | $85.00 | |
Paula's choice Clinical Ceramide-Enriched Firming Moisturiser | 91% | $47.60 | |
Dermedicine Retinol High Potency Face Serum | 91% | $45.00 | |
 Skincare by Dr V TRIO Blemish PM Gel Moisturiser | 80% | $54.00 | |
 Drunk Elephant A-Passioni Retinol Cream | 80% | $28.00 | |
 SENTÉ Intensive Bio Complete Cream | 80% | $125.00 |
Key Actives
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Potential irritants
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Used to adjust pH of the product and can help improve the product's smell
Comedogenic ingredients
All ingredients
A vitamin C derivative that is more stable but less potent than pure form of vitamin C. Has a potential to boost collagen production, nutralise free radicals and reduce hyperpigmentation, but the required concentration is likely to be much higher than for the pure form of vitamin C, limiting the ingredient's effectiveness in products
A stable derivative of vitamin C. It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate). At the same time, this vitamin C derivative has been shown in studies to be effective in reducing acne, blemishes and clogged pores. It is less irritating then the pure form of vitamin C
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An emollient that helps soften the skin and is used to improve product texture and stability
A preservative. It helps prevent bacterial growth in cosmetic products
Used to adjust pH of the product and can help improve the product's smell
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Ingredient list view
Water, Ascorbyl glucoside, Sodium ascorbyl phosphate, Magnesium ascorbyl phosphate, Sodium hyaluronate, Retinol, Xanthan gum, Caprylic/capric triglyceride, Glycerin, Polysorbate 20, Cetyl palmitate, Laureth-23, Trideceth-6 phosphate, Phenoxyethanol, Triethanolamine, Ceramide np, Ethylhexylglycerin
- The Roles of Vitamin C in Skin Health
- Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives
- Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris
- Sodium ascorbyl phosphate in topical microemulsions
- Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics
- Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate
- Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
- Application of l-ascorbic acid and its derivatives (sodium ascorbyl phosphate and magnesium ascorbyl phosphate) in topical cosmetic formulations: stability studies
- Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial
- Topical L-ascorbic acid: percutaneous absorption studies
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- Improvement of naturally aged skin with vitamin A (retinol)
- A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin
- Glycerol and the skin: holistic approach to its origin and functions
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin