DERMA FACTORY

DERMA FACTORY Retinal 300ppm Cream

Name: DERMA FACTORY - Retinal 300ppm Cream
Brand: DERMA FACTORY

Efficacy100/100IrritancyMedium

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Works for

3 of 3 advertised claims delivered

Moisturizing

12 ingredients credited for this claim

Strong support

What the product description says

“DERMA FACTORY Retinal 300ppm Cream is an elasticity improvement cream containing vitamin A(Retinal).”

Source: N/A

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, butylene glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, hydrogenated polydecene.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, panthenol

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production2%

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function2%

PolymethylsilsesquioxaneKey activeEffect: HighA silicone that improves product texture and helps dissolve other ingredients. Can form a non-greasy film on the skin to prevent moisture loss~5.4–8.1%

Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~3.9–5.8%

Centella asiatica extractKey activeEffect: HighA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.66.3%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant11%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.55–1.3%

Lecithin· EmollientEffect: LowUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~2.2–3.3%

Caprylyl methiconeEffect: LowA type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin3%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture2%

Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture5%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~23–34%

Evens skin tone

3 ingredients credited for this claim

Strong support

What the product description says

“Niacinamide gives a whitening effect, making the skin clear and bright by relieving pigmentation symptoms.”

Source: N/A

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinal.

In addition, this product contains niacinamide. This ingredient (ingredients) might help reduce hyperpigmentation, but the effect, if any, is likely to be small.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinalHeroEffect: HighOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating0.03%

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production2%

Ascorbic acidUnder-dosedEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.05–0.3%

Anti-aging

5 ingredients credited for this claim

Strong support

What the product description says

“DERMA FACTORY Retinal 300ppm Cream is an elasticity improvement cream containing vitamin A(Retinal).”

Source: N/A

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinal, adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: centella asiatica extract.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.55–1.3%

Centella asiatica extractKey activeEffect: MediumA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.66.3%

Anti-blemish

Not advertised by the brand · 3 ingredients credited for this claim

Strong support

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide, retinal. These ingredients is used for treating acne and can have a noticeable effect.

Centella asiatica extractEffect: LowA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.66.3%

Anti-oxidation

Not advertised by the brand · 3 ingredients credited for this claim

Moderate support

This product contains antioxidants (centella asiatica extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.55–1.3%

Can it cause trouble?

Irritancy

1 strong irritant: Retinal

Medium risk

We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

RetinalOne step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritatingHigh0.03%

Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.05–0.3%est.

Centella asiatica extractA plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.Medium66.3%

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium2%

1,2-hexanediolA preservativeMedium1.7%

Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~3.9–5.8%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~2.7–4%est.

EthylhexylglycerinA preservativeMedium~1.2–1.7%est.

Disodium edtaStabilizes the product formulationMedium~0.35–0.8%est.

T-butyl alcoholUsed to dissolve other ingredients and to improve smell of products. It could be irritatingMedium~0.15–0.6%est.

Comedogenic

Clean of flagged comedogenic ingredients

None flagged

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Ingredients

Filter by role to see what each ingredient is doing.

Centella asiatica extract66.3%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Anti-inflammatoryReduces irritationMoisturizingReduces rednessAnti-agingAnti-oxidationAnti-blemish

A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.

More about Centella asiatica extract

Glycerin11%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Hydrogenated polydecene5%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene

Caprylyl methicone3%

Formula

Irritation risk: Low

Works for

Moisturizing

A type of silicone that helps to soften the upper layer of the skin and create a nice product finish on the skin

More about Caprylyl methicone

Panthenol2%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces rednessReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Pentylene glycol2%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Polyglyceryl-10 behenate/eicosadioate2%

Formula

Irritation risk: Low

Works for

Cleansing

More about Polyglyceryl-10 behenate/eicosadioate

Niacinamide2%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-blemishAnti-agingMoisturizingEvens skin toneReduces irritationReduces rednessAntibacterialAnti-inflammatory

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Water1.9%

Formula

Irritation risk: Low

Plain old water

More about Water

1,2-hexanediol1.7%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Butylene glycol~23–34%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Polymethylsilsesquioxane~5.4–8.1%

Key active

Irritation risk: Low

Works for

Moisturizing

A silicone that improves product texture and helps dissolve other ingredients. Can form a non-greasy film on the skin to prevent moisture loss

More about Polymethylsilsesquioxane

Ammonium acryloyldimethyltaurate/vp copolymer~4.5–6.8%

Formula

Irritation risk: Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer

Caprylic/capric triglyceride~3.9–5.8%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride

Acrylates/c10-30 alkyl acrylate crosspolymer~2.7–4%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Lecithin~2.2–3.3%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin

Tromethamine~1.3–2%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Ethylhexylglycerin~1.2–1.7%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Xanthan gum~0.85–1.25%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Adenosine~0.55–1.3%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Retinal0.03%

Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high

Irritation risk: High

Works for

Anti-agingAnti-blemishEvens skin tone

One step removed from the biologically active in skin form of vitamin A. Once converted to the retinoic acid in the skin, retinal is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. Concentrations of 0.05% and 0.1% are shown to be effective. It can, however, be irritating

More about Retinal

Disodium edta~0.35–0.8%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

T-butyl alcohol~0.15–0.6%

Irritant · medium

Irritation risk: Medium

Used to dissolve other ingredients and to improve smell of products. It could be irritating

More about T-butyl alcohol

Sorbitan isostearate~0.1–0.45%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Sorbitan isostearate

Vincetoxicum atratum extract~0.1–0.4%

Formula

Irritation risk: Low

More about Vincetoxicum atratum extract

Ascorbic acid~0.05–0.3%

Under-dosedIrritant · high

Irritation risk: High

Works for

Evens skin toneAnti-agingAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid

Ingredient list view

Centella asiatica extract, Glycerin, Hydrogenated polydecene, Caprylyl methicone, Panthenol, Pentylene glycol, Polyglyceryl-10 behenate/eicosadioate, Niacinamide, Water, 1,2-hexanediol, Butylene glycol, Polymethylsilsesquioxane, Ammonium acryloyldimethyltaurate/vp copolymer, Caprylic/capric triglyceride, Acrylates/c10-30 alkyl acrylate crosspolymer, Lecithin, Tromethamine, Ethylhexylglycerin, Xanthan gum, Adenosine, Retinal, Disodium edta, T-butyl alcohol, Sorbitan isostearate, Vincetoxicum atratum extract, Ascorbic acid

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Amazon USPrice as of 10/18/2026 15:02 GMT

$12.94

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	DERMA FACTORYRetinal 300ppm CreamYOUR PRODUCT	HSGNRetinally Liposomal Retinal Cream	TOSOWOONGCollagen Lifting Cream	Whitesilk (Derma)Retinal Wrinkle
Match	—	80%	78%	76%
Price	$12.94	$13.20	$18.90+$5.96	$33.05+$20.11
Shared key ingredients	—	6 of 8	7 of 8	5 of 8
Key difference	—	Hexapeptide-9	Copper Tripeptide-1	Bakuchiol
Irritancy	Medium	Medium	High	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"DERMA FACTORY - Retinal 300ppm Cream" is a well-rounded moisturizing product. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Panthenol, glycerin and butylene glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (caprylic/capric triglyceride, hydrogenated polydecene, lecithin and pentylene glycol) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this moisturizer it is used for stabilizing other ingredients in the formulation. In this concentration (0.05% - 0.30%) it cannot have a noticeable benefit for the skin.
This moisturizer contains an effective form of Retinoids (vitamin A): retinal 0.03% (declared). Retinoids are potent multitasking actives. They work to improve and prevent early signs of aging, reduce hyperpigmentation (age spots and post-acne marks), and prevent inflamed blemishes and clogged pores. The downside of Retinoids is that they can be irritating. If you are not already using a Retinoid in your routine, it is best to start slowly and apply the Retinoid product only a few times per week. If your skin tolerates it well, you can gradually increase the frequency to daily. Because of the irritation risk of Retinoids, we recommend to have another, retinoid-free moisturizer in your routine to use on the alternate days or when your skin feels dry.
Adenosine 0.55% - 1.30%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin c

Irritation risk

There are actives in this product that can be irritating. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.