Works for
1 of 1 advertised claim delivered
Anti-agingAcetyl hexapeptide-1, Palmitoyl tripeptide-38 + 8 moreModerate evidence
“This powerful 22% multi-Peptide serum helps improve visible signs of aging by stimulating your skin’s response against gradual decrease in collagen and elastin production.”
This product contains acetyl hexapeptide-1, n-prolyl palmitoyl tripeptide-56 acetate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38, sh-oligopeptide-1, sh-polypeptide-11. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
MoisturizingNot advertised by the brand · Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 + 26 moreStrong evidence
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, dimethicone.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, ceramide ng, n-prolyl palmitoyl tripeptide-56 acetate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-38, sh-oligopeptide-1, sh-polypeptide-11
Can it cause trouble?
Irritancy13 flagged ingredientsMedium risk
Comedogenic1 ingredient rated 2 or more on the 0–5 pore-clogging scale1 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Jojoba esters~4.5–5.5%
- Irritation risk
- Medium
An emollient made of jojoba oil. Helps soften the skin and support its barrier function
More about Jojoba estersCaprylic/capric triglyceride~4.3–5.3%
- Irritation risk
- Medium
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
More about Caprylic/capric triglycerideGlycerin~3.1–3.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinMacadamia integrifolia seed oil~2.4–2.9%
- Irritation risk
- Low
A plant oil that helps soften the upper layer of the skin
More about Macadamia integrifolia seed oilHelianthus annuus seed oil~2–2.5%
- Irritation risk
- Low
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
More about Helianthus annuus seed oilEthyl macadamiate~1.6–2%
Propanediol~1.5–1.8%
- Irritation risk
- Low
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
More about PropanediolPolyglyceryl-6 distearate~1.2–1.5%
- Irritation risk
- Medium
Helps oil and water mix together while softening the upper layer of the skin
More about Polyglyceryl-6 distearateMoringa oil/hydrogenated moringa oil esters~0.95–1.15%
- Irritation risk
- Low
Tricaprylin~0.75–1.1%
- Irritation risk
- Low
An emollient that helps soften the skin. Can increase penetration of other ingredients
More about TricaprylinLactococcus ferment lysate~0.55–0.85%
- Irritation risk
- Low
Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin
More about Lactococcus ferment lysateHdi/trimethylol hexyllactone crosspolymer~0.5–0.75%
- Irritation risk
- Low
Used to create a silky product texture and add volume to products
More about Hdi/trimethylol hexyllactone crosspolymerDimethicone~0.55–0.8%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeSh-oligopeptide-1~0.45–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-oligopeptide-1Sh-polypeptide-7 sh-polypeptide-94 sh-polypeptide-95~0.4–0.65%
- Irritation risk
- Low
Sh-polypeptide-11~0.4–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Sh-polypeptide-11Palmitoyl tripeptide-1~0.45–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Palmitoyl tetrapeptide-7~0.35–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Palmitoyl tripeptide-38~0.3–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-38N-prolyl palmitoyl tripeptide-56 acetate~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about N-prolyl palmitoyl tripeptide-56 acetateAcetyl hexapeptide-1~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-1Ceramide ng~0.25–0.5%
- Irritation risk
- Low
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
More about Ceramide ngSodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateBacillus/folic acid ferment filtrate extract~0.25–0.45%
- Irritation risk
- Low
Tocopherol~0.25–0.5%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolMalic acid~0.25–0.45%
Ethylhexylglycerin~0.25–0.45%
Lecithin~0.3–0.55%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinAcetyl glutamine~0.25–0.45%
- Irritation risk
- Low
Xanthan gum~0.25–0.5%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumCarbomer~0.25–0.45%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerCetyl alcohol~0.3–0.55%
- Irritation risk
- Low
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
More about Cetyl alcoholCetearyl alcohol~0.3–0.55%
- Irritation risk
- Low
- Comedogenicity
- 2/5
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
More about Cetearyl alcoholPotassium cetyl phosphate~0.25–0.5%
- Irritation risk
- Medium
Helps oil and water mix together
More about Potassium cetyl phosphateHydroxypropyl cyclodextrin~0.3–0.5%
- Irritation risk
- Medium
Used to stabilize product formulations and help soften the upper layer of the skin
More about Hydroxypropyl cyclodextrinCaprylyl glycol~0.25–0.5%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycol1,2-hexanediol~0.25–0.45%
Pentylene glycol~0.3–0.5%
- Irritation risk
- Medium
Used to preserve products, dissolve other ingredients and create a nice product texture
More about Pentylene glycolSilica~0.35–0.65%
Sodium lactate~0.25–0.45%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateCyclotetrasiloxane~0.25–0.5%
- Irritation risk
- Low
Dimethicone/vinyl dimethicone crosspolymer~0.2–0.4%
- Irritation risk
- Low
Used to stabilize product formulations and create a nice product texture
More about Dimethicone/vinyl dimethicone crosspolymerPhosphoric acid~0.2–0.4%
Butylene glycol~0.2–0.35%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolLactic acid~0.15–0.3%
- Irritation risk
- Medium
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
More about Lactic acidSodium chloride~0.2–0.35%
- Irritation risk
- Low
Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures
More about Sodium chloridePolysorbate 20~0.2–0.35%
Citric acid~0.15–0.25%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidPhenoxyethanol~0.15–0.25%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolSodium benzoate~0.1–0.25%
Ingredient list view
Water, Jojoba esters, Caprylic/capric triglyceride, Glycerin, Macadamia integrifolia seed oil, Helianthus annuus seed oil, Ethyl macadamiate, Propanediol, Polyglyceryl-6 distearate, Moringa oil/hydrogenated moringa oil esters, Tricaprylin, Lactococcus ferment lysate, Hdi/trimethylol hexyllactone crosspolymer, Dimethicone, Sh-oligopeptide-1, Sh-polypeptide-7 sh-polypeptide-94 sh-polypeptide-95, Sh-polypeptide-11, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-38, N-prolyl palmitoyl tripeptide-56 acetate, Acetyl hexapeptide-1, Ceramide ng, Sodium hyaluronate, Bacillus/folic acid ferment filtrate extract, Tocopherol, Malic acid, Ethylhexylglycerin, Lecithin, Acetyl glutamine, Xanthan gum, Carbomer, Cetyl alcohol, Cetearyl alcohol, Potassium cetyl phosphate, Hydroxypropyl cyclodextrin, Caprylyl glycol, 1,2-hexanediol, Pentylene glycol, Silica, Sodium lactate, Cyclotetrasiloxane, Dimethicone/vinyl dimethicone crosspolymer, Phosphoric acid, Butylene glycol, Lactic acid, Sodium chloride, Polysorbate 20, Citric acid, Phenoxyethanol, Sodium benzoate
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Product summary
"Theramid - Derma-Peptides 22%" has a good moisturizing formula. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Glycerin, sodium hyaluronate, sodium lactate, butylene glycol and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide ng, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, jojoba esters and caprylic/capric triglyceride) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- As a plus, this moisturizer also contains Ceramides (ceramide ng 0.25% - 0.50%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- We like that this moisturizer contains peptides (acetyl hexapeptide-1 0.25% - 0.50%, n-prolyl palmitoyl tripeptide-56 acetate 0.25% - 0.50%, palmitoyl tripeptide-38 0.30% - 0.50%, palmitoyl tetrapeptide-7 0.35% - 0.65%, palmitoyl tripeptide-1 0.45% - 0.65%, sh-polypeptide-11 0.40% - 0.65% and sh-oligopeptide-1 0.45% - 0.65%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Irritation risk
This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.
- 1
- 2
- 3
- 4
- 5Effect of topically applied lipids on surfactant-irritated skinonlinelibrary.wiley.com
- 6
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