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skintific 4D Hyaluronic Acid Hydrating Serum
skintific

skintific 4D Hyaluronic Acid Hydrating Serum

Efficacy100/100IrritancyLow
See all ingredients

Works for

Moisturizing
Panthenol, Palmitoyl tetrapeptide-7 + 23 more
Works well
What the product description says
“4D Hyaluronic Acid Hydrating Serum is a lightweight hydrating face serum”
Source: Skintific

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: betaine, carnosine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: cholesterol.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide ap, ceramide as, ceramide eop, ceramide np, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, panthenol

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.45–1.1%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.9%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.85%
Ceramide eopHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.3–0.75%
Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.3–0.7%
Palmitoyl pentapeptide-4HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.7%
Ceramide apHeroEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.15–0.6%
Ceramide asHeroEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.15–0.65%
BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~23–34%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~6.8–10.1%
Hydrolyzed sodium hyaluronateKey activeEffect: HighAttracts water into the upper layer of the skin~3.5–5.3%
Sodium acetylated hyaluronateKey active· HumectantEffect: HighA type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid~2.4–3.6%
Sodium hyaluronate crosspolymerKey active· HumectantEffect: HighAttracts water into the upper layer of the skin~1.7–2.5%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1.2–1.7%
Glyceryl glucosideKey active· HumectantEffect: HighCan help to restore skin barrier function and soften its upper layer~0.9–1.35%
CarnosineKey active· HumectantEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.3–0.7%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.15–0.55%
GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.1–0.35%
Glyceryl acrylate/acrylic acid copolymerKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency~0.1–0.4%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.35–0.8%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.6%
Avena sativa kernel extractUnder-dosedAn effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties~0.3–0.75%
Laminaria digitata extractUnder-dosedSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.15–0.65%
AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.1–0.45%
Sodium pcaUnder-dosedNaturally present in skin and helps to attract water to its upper layer~0.05–0.3%
Anti-oxidation
Side benefit · Creatine, Carnosine + 3 more
Works well

This product contains antioxidants (carnosine) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - creatine also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

CreatineKey activeEffect: MediumCan support skin's ability to neutralize free radicals and produce collagen, though further research is needed to confirm effectiveness~0.6–1.35%
CarnosineKey activeEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.3–0.7%
Avena sativa kernel extractEffect: Low, below effective doseAn effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties~0.3–0.75%
Laminaria digitata extractEffect: Low, below effective doseSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.15–0.65%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.6%
Anti-aging
Side benefit the brand mentions · Creatine, Palmitoyl tetrapeptide-7 + 5 more
May help
What the product description says
“Improves skin elasticity”
Source: Skintific

This product contains carnosine, creatine, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

CreatineKey activeEffect: MediumCan support skin's ability to neutralize free radicals and produce collagen, though further research is needed to confirm effectiveness~0.6–1.35%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.9%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.85%
Palmitoyl pentapeptide-4Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.7%
CarnosineKey activeEffect: MediumA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.3–0.7%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.6%
Laminaria digitata extractEffect: Low, below effective doseSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment~0.15–0.65%

Can it cause trouble?

Irritancy
6 flagged ingredients
Low risk
We flag 6 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.35–0.8%est.
EthylhexylglycerinA preservativeMedium~4.5–6.8%est.
Sodium hyaluronate crosspolymerAttracts water into the upper layer of the skinMedium~1.7–2.5%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.45–1.1%est.
Glyceryl acrylate/acrylic acid copolymerHelps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistencyMedium~0.1–0.4%est.
1,2-hexanediolA preservativeMedium~0.1–0.35%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Laminaria digitata extractSeaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment3/5~0.15–0.65%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Betaine~23–34%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine
Sodium hyaluronate~6.8–10.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Ethylhexylglycerin~4.5–6.8%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Hydrolyzed sodium hyaluronate~3.5–5.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Hydrolyzed sodium hyaluronate
Sodium acetylated hyaluronate~2.4–3.6%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid

More about Sodium acetylated hyaluronate
Sodium hyaluronate crosspolymer~1.7–2.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Sodium hyaluronate crosspolymer
Peg/ppg-17/6 copolymer~1.2–1.8%
Formula
Irritation risk
Low
More about Peg/ppg-17/6 copolymer
Glycerin~1.2–1.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Glyceryl glucoside~0.9–1.35%
Key active
Irritation risk
Low
Works for
Moisturizing

Can help to restore skin barrier function and soften its upper layer

More about Glyceryl glucoside
Creatine~0.6–1.35%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging

Can support skin's ability to neutralize free radicals and produce collagen, though further research is needed to confirm effectiveness

More about Creatine
Panthenol~0.45–1.1%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Acrylates/c10-30 alkyl acrylate crosspolymer~0.45–1.1%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Propylene glycol~0.35–0.8%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Palmitoyl tetrapeptide-7~0.4–0.9%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Palmitoyl pentapeptide-4~0.3–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl pentapeptide-4
Palmitoyl tripeptide-1~0.35–0.85%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Carnosine~0.3–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage

More about Carnosine
Cetyl-pg hydroxyethyl palmitamide~0.2–0.75%
Formula
Irritation risk
Low
More about Cetyl-pg hydroxyethyl palmitamide
Ceramide eop~0.3–0.75%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide eop
Ceramide ns/ceramide ng
Not recognized
Ceramide np~0.3–0.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritation

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np
Ceramide as~0.15–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide as
Ceramide ap~0.15–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide ap
Maris aqua~0.15–0.65%
Formula
Irritation risk
Low

Sea water. Helps dissolve other ingredients in a product

More about Maris aqua
Laminaria digitata extract~0.15–0.65%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

Seaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment

More about Laminaria digitata extract
Avena sativa kernel extract~0.3–0.75%
Under-dosed
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatoryReduces rednessAnti-oxidation

An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties

More about Avena sativa kernel extract
Hydrogenated lecithin~0.15–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Tocopherol~0.15–0.6%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Allantoin~0.1–0.45%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Glyceryl acrylate/acrylic acid copolymer~0.1–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin and provide a longer-lasting hydration. Can create a thicker product consistency

More about Glyceryl acrylate/acrylic acid copolymer
Pvm/ma copolymer~0.15–0.5%
Formula
Irritation risk
Low
More about Pvm/ma copolymer
1,2-hexanediol~0.1–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Sodium pca~0.05–0.3%
Under-dosed
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Glycine~0.1–0.35%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine
Cholesterol~0.15–0.55%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol
Ingredient list view

Betaine, Sodium hyaluronate, Ethylhexylglycerin, Hydrolyzed sodium hyaluronate, Sodium acetylated hyaluronate, Sodium hyaluronate crosspolymer, Peg/ppg-17/6 copolymer, Glycerin, Glyceryl glucoside, Creatine, Panthenol, Acrylates/c10-30 alkyl acrylate crosspolymer, Propylene glycol, Palmitoyl tetrapeptide-7, Palmitoyl pentapeptide-4, Palmitoyl tripeptide-1, Carnosine, Cetyl-pg hydroxyethyl palmitamide, Ceramide eop, Unknown, Ceramide np, Ceramide as, Ceramide ap, Maris aqua, Laminaria digitata extract, Avena sativa kernel extract, Hydrogenated lecithin, Tocopherol, Allantoin, Glyceryl acrylate/acrylic acid copolymer, Pvm/ma copolymer, 1,2-hexanediol, Sodium pca, Glycine, Cholesterol

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
skintific4D Hyaluronic Acid Hydrating SerumYOUR PRODUCTDRMTLGYNeedle-less SerumBalance Active Formula2% HYALURONIC ACID + 3% CERAMIDE COMPLEX BOOSTERPaula's choiceHyaluronic Acid Booster
Match—46%40%39%
Price—$68.75—$30.53
Shared key ingredients—9 of 217 of 217 of 21
Key difference—NiacinamidePhytosphingosinePhytosphingosine
Irritancy Low Low Low Low
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 24 studies and safety reviews.

  1. 1
    Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
  2. 2
    Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
  3. 3
    Acetylated Hyaluronic Acid: Enhanced Bioavailability and Biological Studieshindawi.com
  4. 4
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  5. 5
    Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skinncbi.nlm.nih.gov
  6. 6
    Treatment of Xerosis with a Topical Formulation Containing Glyceryl Glucoside, Natural Moisturizing Factors, and Ceramideeuropepmc.org
skintific 4D Hyaluronic Acid Hydrating Serum
skintific4D Hyaluronic Acid Hydrating Serum
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