SkinMedica GlyPro Renewal Cream

SkinMedica GlyPro Renewal Cream

Efficacy100/100IrritancyMedium

Works for

Moisturizing
Dipeptide diaminobutyroyl benzylamide diacetate, Urea + 20 more
Works well
What the product description says
“An ultra-rich cream utilizing powerful antioxidants and glycolic acid to help retain moisture and encourage skin renewal and softness. Benefits Suitable for all skin types. Luxurious cream formulation. Encourages cell turnover.”
Source: Skinstore

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: algae extract, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, algae extract.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: dipeptide diaminobutyroyl benzylamide diacetate, urea

Dipeptide diaminobutyroyl benzylamide diacetateHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%
UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.15–0.3%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~4.1–5.1%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.7%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.9–2.3%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~1.2–1.5%
Saccharide isomerateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~0.6–0.95%
Algae extractKey active· Humectant, EmollientEffect: HighPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~0.45–0.65%
Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.2–0.35%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.3%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.15–0.3%
TrehaloseKey active· HumectantEffect: HighA sugar that attracts water to the upper layer of the skin~0.15–0.3%
Dimethicone crosspolymerKey activeEffect: MediumUsed to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface~0.15–0.3%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~1.5–1.8%
CeresinEffect: Low~0.95–1.2%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.4–0.65%
Octyldodecanol· EmollientEffect: LowAn emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation~0.3–0.55%
Polyquaternium-51Effect: LowAn emollient that helps create a nice silky finish on the skin~0.2–0.35%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.35%
CyclohexasiloxaneEffect: Low, below effective doseA silicone that serves as an emollient. Helps create a nice non-greasy feels~0.55–0.8%
Stearic acidEffect: Low, below effective doseHelps oil and water mix together and works as an emollient~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.3%
Anti-oxidation
Side benefit · Superoxide dismutase, Olea europaea leaf extract + 2 more
Works well

This product contains antioxidants (superoxide dismutase) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Superoxide dismutaseKey activeEffect: HighAn antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants~0.2–0.35%
Olea europaea leaf extractEffect: LowA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing~0.15–0.25%
Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.15–0.3%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.15–0.3%
Evens skin tone
Side benefit · Glycolic acid, Magnesium ascorbyl phosphate
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glycolic acid

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~5.2–6.3%
Magnesium ascorbyl phosphateEffect: Low, below effective doseA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high~0.15–0.3%

Can it cause trouble?

Irritancy
14 flagged ingredients
Medium risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~5.2–6.3%est.
TriacetinUsed to dissolve other ingredientsHigh~0.2–0.35%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~1.5–1.8%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~1.2–1.5%est.
Cetearyl glucosideHelps water and oil in the product mix well together and improves product textureMedium~0.45–0.65%est.
Hydrogenated coco-glyceridesHelps oil and water mix together while creating a nice finish on the skinMedium~0.25–0.45%est.
Olea europaea leaf extractA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missingMedium~0.15–0.25%est.
Magnesium ascorbyl phosphateA derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very highMedium~0.15–0.3%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.15–0.3%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.35%est.
Ammonium hydroxideHelps adjust the product pHMedium~0.15–0.3%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.25%est.
EthylhexylglycerinA preservativeMedium~0.15–0.25%est.
Potassium sorbateA preservativeMedium~0.15–0.3%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Algae extractPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet3/5~0.45–0.65%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.9–2.3%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycolic acid~5.2–6.3%
Key activeIrritant · high
Irritation risk
High
Works for
Evens skin toneExfoliationAnti-agingAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid
Cyclopentasiloxane~4.1–5.1%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Glycerin~3–3.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Bis-hydroxyethoxypropyl dimethicone~2.3–2.9%
Formula
Cetearyl alcohol~1.9–2.3%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Stearyl alcohol~1.6–2%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Pentylene glycol~1.5–1.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Caprylic/capric triglyceride~1.2–1.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Ceresin~0.95–1.2%
Formula
Irritation risk
Low
Works for
Moisturizing
More about Ceresin
Saccharide isomerate~0.6–0.95%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Saccharide isomerate
Cyclohexasiloxane~0.55–0.8%
Formula
Irritation risk
Low
Works for
Moisturizing

A silicone that serves as an emollient. Helps create a nice non-greasy feels

More about Cyclohexasiloxane
Cetearyl glucoside~0.45–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil in the product mix well together and improves product texture

More about Cetearyl glucoside
Dipeptide diaminobutyroyl benzylamide diacetate~0.35–0.6%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Dipeptide diaminobutyroyl benzylamide diacetate
Algae extract~0.45–0.65%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-aging

Plant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet

More about Algae extract
Glyceryl stearate~0.4–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Peg-100 stearate~0.45–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Octyldodecanol~0.3–0.55%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation

More about Octyldodecanol
Irvingia gabonensis kernel butter~0.25–0.45%
Formula
Hydrogenated coco-glycerides~0.25–0.45%
Irritant · medium
Irritation risk
Medium

Helps oil and water mix together while creating a nice finish on the skin

More about Hydrogenated coco-glycerides
Magnesium aluminum silicate~0.2–0.4%
Formula
Irritation risk
Low
Works for
Anti-aging

Might be helpful in restoring skin barrier function and, when combined with zinc carbonate and malonic acid, reducing fine lines and wrinkles by stimulating elastin production. Also helps stabilize the product formulation

More about Magnesium aluminum silicate
Polyacrylate-13~0.25–0.4%
Formula
Irritation risk
Low

Used to create a thicker product consistency and stabilize the product formulation

More about Polyacrylate-13
Polyisobutene~0.2–0.35%
Formula
Irritation risk
Low

Used to improve the product consistency

More about Polyisobutene
Polysorbate 20~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Stearic acid~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Sodium pca~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Urea~0.15–0.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Trehalose~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Polyquaternium-51~0.2–0.35%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps create a nice silky finish on the skin

More about Polyquaternium-51
Sodium hyaluronate~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Hydroxyethylcellulose~0.2–0.35%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Dimethicone crosspolymer~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product texture. Helps soften the upper layer of the skin and might be able to prevent moisture loss from its surface

More about Dimethicone crosspolymer
Olea europaea leaf extract~0.15–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing

More about Olea europaea leaf extract
Superoxide dismutase~0.2–0.35%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

An antioxidant enzyme that is naturally present in skin. It can help support skin barrier function and reduce inflammation in skin. It is used in topical medications for inflammatory skin conditions including atopic dermatitis (eczema) and psoriasis. There are three types of natural Superoxide Dismutase in human skin. The compound used in topical treatments and cosmetics are mimics of typically one of these natural variants

More about Superoxide dismutase
Magnesium ascorbyl phosphate~0.15–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Evens skin toneAnti-agingAnti-oxidation

A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high

More about Magnesium ascorbyl phosphate
Tocopherol~0.15–0.3%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Hexylene glycol~0.15–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Caprylyl glycol~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Triacetin~0.2–0.35%
Irritant · high
Irritation risk
High

Used to dissolve other ingredients

More about Triacetin
Aluminum hydroxide~0.2–0.4%
Formula
Irritation risk
Low

Is used to add opaque (non-transparent) appearance to formulations. Can be used to coat other ingredients for even dispersion. This is a different ingredient compared to the ones used in antipersperants (aluminium chloride and aluminium chlorohydrate)

More about Aluminum hydroxide
Ammonium hydroxide~0.15–0.3%
Irritant · medium
Irritation risk
Medium

Helps adjust the product pH

More about Ammonium hydroxide
Disodium edta~0.15–0.25%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Ethylhexylglycerin~0.15–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Potassium sorbate~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Titanium dioxide~0.1–0.2%
Formula
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Ci 77891~0.1–0.15%
Formula
Irritation risk
Low
More about Ci 77891
Ingredient list view

Water, Glycolic acid, Cyclopentasiloxane, Glycerin, Bis-hydroxyethoxypropyl dimethicone, Cetearyl alcohol, Stearyl alcohol, Pentylene glycol, Caprylic/capric triglyceride, Ceresin, Saccharide isomerate, Cyclohexasiloxane, Cetearyl glucoside, Dipeptide diaminobutyroyl benzylamide diacetate, Algae extract, Glyceryl stearate, Peg-100 stearate, Octyldodecanol, Irvingia gabonensis kernel butter, Hydrogenated coco-glycerides, Magnesium aluminum silicate, Polyacrylate-13, Polyisobutene, Polysorbate 20, Stearic acid, Sodium pca, Urea, Trehalose, Polyquaternium-51, Sodium hyaluronate, Hydroxyethylcellulose, Dimethicone crosspolymer, Olea europaea leaf extract, Superoxide dismutase, Magnesium ascorbyl phosphate, Tocopherol, Hexylene glycol, Caprylyl glycol, Triacetin, Aluminum hydroxide, Ammonium hydroxide, Disodium edta, Ethylhexylglycerin, Phenoxyethanol, Potassium sorbate, Titanium dioxide, Ci 77891

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
SkinMedicaGlyPro Renewal CreamYOUR PRODUCTDr. Eve_RyouthSnake Venom + Collagen Wrinkle Filler Night MoisturiserPRIORI SkincarePRIORI Q+ SOD - Moisturizing CreamM-61JetGlow Cream
Match—47%47%46%
Price—$33.05——
Shared key ingredients—6 of 127 of 124 of 12
Key difference—Cera AlbaRetinolPalmitoyl Hexapeptide-19
Irritancy Medium Medium Medium Low
Drying alcohol————
View product Shop Shop Shop

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Product summary

Based on the ingredients included, "SkinMedica - GlyPro Renewal Cream" works well for moisturizing the skin. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Humectants in this product (urea, algae extract, glycerin, saccharide isomerate and sodium hyaluronate) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Algae extract, caprylic/capric triglyceride, cetearyl alcohol, cyclopentasiloxane and caprylyl glycol in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • Exfoliating acids (glycolic acid 5.20% - 6.30%). In this concentration, they will have a noticeable exfoliating effect. They can also have an anti-aging effect and stimulate collagen production in a long-run.
  • This moisturizer also contains Peptides (dipeptide diaminobutyroyl benzylamide diacetate 0.35% - 0.60%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: stearic acid, vitamin e and titanium dioxide

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 84.60$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 24 studies and safety reviews.

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SkinMedica GlyPro Renewal Cream
SkinMedicaGlyPro Renewal Cream

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