Skinbetter Science InterFuse Treatment Cream FACE & NECK
Works for
2 of 2 advertised claims delivered
MoisturizingDipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine + 13 moreStrong evidence
“Improving the appearance of skin sagging, lines and wrinkles.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, caprylyl glycol.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, dimethicone.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: dipeptide diaminobutyroyl benzylamide diacetate, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-5
Anti-agingDipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine + 3 moreModerate evidence
“Uses proprietary delivery technology that drives a unique messenger peptide blend to help bring the look of firmness back to the skin.”
This product contains dipeptide diaminobutyroyl benzylamide diacetate, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
Can it cause trouble?
Irritancy1 strong irritant: Alcohol denat.Medium risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycerin~4.8–5.9%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinIsododecane~4.2–5.1%
- Irritation risk
- Low
An emollient that helps soften the skin and can decrease moisture loss. Helps create a nice product texture
More about IsododecaneDimethicone~3.1–3.8%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeC12-15 alkyl benzoate~2.3–2.9%
- Irritation risk
- Low
Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth
More about C12-15 alkyl benzoateCyclopentasiloxane~1.9–2.4%
- Irritation risk
- Low
A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin
More about CyclopentasiloxanePeg-16 macadamia glycerides~1.6–2%
Butyrospermum parkii butter~1.5–1.8%
- Irritation risk
- Low
- Comedogenicity
- 3/5
A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals
More about Butyrospermum parkii butterDipeptide diaminobutyroyl benzylamide diacetate~1.1–1.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Dipeptide diaminobutyroyl benzylamide diacetatePalmitoyl tripeptide-5~0.9–1.15%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-5Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~0.65–0.95%
- Irritation risk
- Low
Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.55–0.8%
- Irritation risk
- Low
A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid
More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateOlea europaea fruit extract~0.55–0.8%
- Irritation risk
- Low
An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation
More about Olea europaea fruit extractCetearyl dimethicone crosspolymer~0.45–0.65%
- Irritation risk
- Low
Helps create a nice product texture and soften the upper layer of the skin
More about Cetearyl dimethicone crosspolymerCetyl alcohol~0.45–0.7%
- Irritation risk
- Low
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
More about Cetyl alcoholPolyisobutene~0.45–0.65%
Caprylyl/capryl glucoside~0.45–0.65%
- Irritation risk
- Medium
Helps oil and water mix together. Can be used as a cleansing agent
More about Caprylyl/capryl glucosideGlyceryl stearate~0.4–0.6%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateAlcohol denat.~0.3–0.5%
- Irritation risk
- High
Produces temporary toning effect. Can help dissolve other ingredients or preserve products
More about Alcohol denat.Ammonium acryloyldimethyltaurate/vp copolymer~0.25–0.45%
- Irritation risk
- Low
Increases thickness of a product. Texture enhancer for oil-in-water emulsions
More about Ammonium acryloyldimethyltaurate/vp copolymerSodium acrylate/sodium acryloyldimethyl taurate copolymer~0.2–0.4%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Sodium acrylate/sodium acryloyldimethyl taurate copolymerSorbitan oleate~0.25–0.45%
- Irritation risk
- Medium
- Comedogenicity
- 2/5
Helps oil and water mix together
More about Sorbitan oleateCeteth-20~0.3–0.6%
Steareth-20~0.3–0.5%
Peg-75 stearate~0.2–0.4%
Disodium edta~0.2–0.35%
Magnesium chloride~0.2–0.35%
Citric acid~0.2–0.35%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidSodium hydroxide~0.2–0.35%
Ethylhexylglycerin~0.2–0.35%
Hexylene glycol~0.15–0.3%
- Irritation risk
- Medium
Helps create a more spreadable product texture
More about Hexylene glycolCaprylyl glycol~0.2–0.35%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolPhenoxyethanol~0.15–0.25%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolMica~0.1–0.25%
- Irritation risk
- Low
Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light
More about MicaTitanium dioxide~0.1–0.2%
- Irritation risk
- Low
Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin
More about Titanium dioxideCi 77891~0.1–0.15%
- Irritation risk
- Low
Ingredient list view
Water, Glycerin, Isododecane, Dimethicone, C12-15 alkyl benzoate, Cyclopentasiloxane, Peg-16 macadamia glycerides, Butyrospermum parkii butter, Dipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl tripeptide-5, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Olea europaea fruit extract, Cetearyl dimethicone crosspolymer, Cetyl alcohol, Polyisobutene, Caprylyl/capryl glucoside, Glyceryl stearate, Alcohol denat., Ammonium acryloyldimethyltaurate/vp copolymer, Sodium acrylate/sodium acryloyldimethyl taurate copolymer, Sorbitan oleate, Ceteth-20, Steareth-20, Peg-75 stearate, Disodium edta, Magnesium chloride, Citric acid, Sodium hydroxide, Ethylhexylglycerin, Hexylene glycol, Caprylyl glycol, Phenoxyethanol, Mica, Titanium dioxide, Ci 77891
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Skinbetter ScienceInterFuse Treatment Cream FACE & NECKYOUR PRODUCT | Peter Thomas RothFirm X Collagen Moisturiser | DRMTLGYPeptide Night Cream | HydroPeptideTravel-Size Nimni Cream | |
|---|---|---|---|---|
| Match | — | 60% | 56% | 53% |
| Price | $135.26 | $61.60−$73.66 | $25.23−$110.03 | — |
| Shared key ingredients | — | 5 of 8 | 6 of 8 | 6 of 8 |
| Key difference | — | Hydrolyzed Collagen | Ceramide Ap | Retinol |
| Irritancy | Medium | Low | Medium | Medium |
| Drying alcohol | Contains drying alcohol | — | — | — |
| View product | Shop | Shop | Shop |
Product summary
"Skinbetter Science - InterFuse Treatment Cream FACE & NECK" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Humectants in this product (glycerin and caprylyl glycol) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Emollients in this formulation (butyrospermum parkii butter, dimethicone, c12-15 alkyl benzoate, cetyl alcohol and cyclopentasiloxane) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- This moisturizer also contains Peptides (palmitoyl tripeptide-5 0.90% - 1.15%, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine 0.65% - 0.95% and dipeptide diaminobutyroyl benzylamide diacetate 1.10% - 1.40%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
This moisturizer contains some common irritants, including those without a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 190.00CA$ in Canada.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 5 studies and safety reviews.
- 1
- 2
- 3Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 4
- 5Surfactants and experimental irritant contact dermatitisncbi.nlm.nih.gov
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