Replenix Age Restore Bio-Repair Serum

Replenix Age Restore Bio-Repair Serum

Efficacy37/100IrritancyMedium

Works for

Moisturizing
Glycerin, Cyclopentasiloxane + 7 more
Works
What the product description says
“(formerly known as SRS Bio-Repair Therapy) REPLENIX Age Restore Bio-Repair Serum is a scientifically formulated restorative cell therapy treatment serum that combines advanced moisture-binding ingredients with therapeutic medical-grade antioxidants to support skin’s daily replenishment, recovery, and protective process.”
Source: N/A

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, butylene glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: squalane, cyclopentasiloxane.

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–6.5%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~3.6–5.4%
Plankton extractKey activeEffect: MediumCan help attract water to the upper layer of the skin~2–3%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.5–2.2%
Micrococcus lysateKey activeEffect: HighConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"~1–1.5%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.5–1.15%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.1–0.45%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.1–0.4%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.15–0.65%
Evens skin tone
Retinyl palmitate
Not delivered

Effective ingredients missing or their concentration is too low

Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.4–0.95%
Anti-aging
Not advertised by the brand · Arabidopsis thaliana extract, Ascorbyl palmitate + 1 more
May help

This product contains arabidopsis thaliana extract. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Arabidopsis thaliana extractKey activeEffect: MediumPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking~2.8–4.1%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.35–0.85%
Retinyl palmitateUnder-dosedThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.4–0.95%

Can it cause trouble?

Irritancy
1 strong irritant: Retinyl palmitate
Medium risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.4–0.95%est.
Arabidopsis thaliana extractPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lackingMedium~2.8–4.1%est.
Plankton extractCan help attract water to the upper layer of the skinMedium~2–3%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.8–1.25%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.35–0.85%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~0.35–0.8%est.
EthylhexylglycerinA preservativeMedium~0.2–0.75%est.
Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.15–0.65%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.15–0.55%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.1–0.45%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.1–0.3%est.
Disodium edtaStabilizes the product formulationMedium~0.01–0.05%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Plankton extractCan help attract water to the upper layer of the skin3/5~2–3%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.3–6.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cyclopentasiloxane~3.6–5.4%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Arabidopsis thaliana extract~2.8–4.1%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-aging

Plant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking

More about Arabidopsis thaliana extract
Plankton extract~2–3%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Can help attract water to the upper layer of the skin

More about Plankton extract
Evodia rutaecarpa fruit extract~1.6–2.5%
Formula
Squalane~1.5–2.2%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Ergothioneine~1.2–1.8%
Formula
Irritation risk
Low
Works for
Anti-oxidation

Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking

More about Ergothioneine
Micrococcus lysate~1–1.5%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"

More about Micrococcus lysate
Caffeine~0.8–1.25%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Phospholipids~0.5–1.15%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Retinyl palmitate~0.4–0.95%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAnti-agingEvens skin toneExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Ascorbyl palmitate~0.35–0.85%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Tocopheryl acetate~0.35–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Ethylhexylglycerin~0.2–0.75%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Acrylates/c10-30 alkyl acrylate crosspolymer~0.15–0.65%
Irritant · medium
Irritation risk
Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.15–0.55%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Lecithin~0.15–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Butylene glycol~0.1–0.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Pentylene glycol~0.1–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Polysorbate 60~0.1–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Sodium hydroxide~0.05–0.15%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Disodium edta~0.01–0.05%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Ingredient list view

Water, Glycerin, Cyclopentasiloxane, Arabidopsis thaliana extract, Plankton extract, Evodia rutaecarpa fruit extract, Squalane, Ergothioneine, Micrococcus lysate, Caffeine, Phospholipids, Retinyl palmitate, Ascorbyl palmitate, Tocopheryl acetate, Ethylhexylglycerin, Acrylates/c10-30 alkyl acrylate crosspolymer, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Lecithin, Butylene glycol, Pentylene glycol, Polysorbate 60, Phenoxyethanol, Sodium hydroxide, Disodium edta

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Amazon USPrice as of 11/5 15:12 GMT
$90.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ReplenixAge Restore Bio-Repair SerumYOUR PRODUCTCliniqueSmart™ Custom-Repair SerumPhotozymeDNA Youth Recovery Facial SerumThe INKEY List CAQ10 Serum
Match—39%38%38%
Price$90.00—$120.00+$30.00$7.31−$82.69
Shared key ingredients—7 of 84 of 82 of 8
Key difference—Salicylic AcidSodium HyaluronatePalmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
Irritancy Medium Medium Medium Low
Drying alcohol————
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More alternatives: Neocutis Bio Serum Firmeb5 Advanced Repair Peptide Serum

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Product summary

"Replenix - Age Restore Bio-Repair Serum" could be helpful for: Moisturizing and Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • this product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.40% - 0.95%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • Humectants (glycerin 4.30% - 6.50%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails for 101.40$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 4 studies and safety reviews.

  1. 1
  2. 2
  3. 3
  4. 4
Replenix Age Restore Bio-Repair Serum
ReplenixAge Restore Bio-Repair Serum

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As an Amazon Associate, WIMJ earns from qualifying purchases.