Protocol Hyaluronic Acid & Niacinamide Hydration Cream

Protocol Hyaluronic Acid & Niacinamide Hydration Cream

Efficacy100/100IrritancyMedium

Works for

Anti-aging
Niacinamide, Hyaluronic acid + 2 more
Works well
What the product description says
“Provides deep, long term moisture to create springy, youthful skin.”
Source: Protocol Skincare

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.4–3.6%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~1.5–2.2%
TocopherolEffect: LowPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.7%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1–1.5%
Moisturizing
Niacinamide, Panthenol + 8 more
Works well
What the product description says
“Provides deep, long term moisture to create springy, youthful skin.”
Source: Protocol Skincare

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, hyaluronic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: cocos nucifera oil, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: niacinamide, panthenol

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.4–3.6%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.45–1.05%
Cocos nucifera oilKey active· Emollient, OcclusiveEffect: HighAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic~4.6–6.9%
Rosa canina seed oilKey activeEffect: HighA plant oil that helps soften the upper layer of the skin. It might have anti-oxidant properties. Might help reduce inflammation in skin and help against blemishes~4.3–6.5%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–4.5%
Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~1.5–2.2%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.7%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~2–3%
TocopherolEffect: LowPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.7%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1–1.5%
Evens skin tone
Side benefit · Niacinamide
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.4–3.6%
Anti-blemish
Side benefit · Niacinamide, Rosmarinus officinalis leaf extract + 1 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: rosmarinus officinalis leaf extract

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.4–3.6%
Rosmarinus officinalis leaf extractKey activeEffect: MediumCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.8–1.2%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1–1.5%
Anti-oxidation
Side benefit · Tocopherol, Rosa canina seed oil + 1 more
Works well

This product contains antioxidants (tocopherol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

TocopherolKey activeEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~1.1–1.7%
Rosa canina seed oilEffect: LowA plant oil that helps soften the upper layer of the skin. It might have anti-oxidant properties. Might help reduce inflammation in skin and help against blemishes~4.3–6.5%
Rosmarinus officinalis leaf extractEffect: LowCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.8–1.2%

Can it cause trouble?

Irritancy
2 strong irritants: Rosmarinus officinalis leaf extract, Alcohol
Medium risk
We flagged 4 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.8–1.2%est.
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.1–0.35%est.
Rosa canina seed oilA plant oil that helps soften the upper layer of the skin. It might have anti-oxidant properties. Might help reduce inflammation in skin and help against blemishesMedium~4.3–6.5%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1–1.5%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cocos nucifera oilAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic3/5~4.6–6.9%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Cocos nucifera oil~4.6–6.9%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic

More about Cocos nucifera oil
Rosa canina seed oil~4.3–6.5%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

A plant oil that helps soften the upper layer of the skin. It might have anti-oxidant properties. Might help reduce inflammation in skin and help against blemishes

More about Rosa canina seed oil
Glycerin~3–4.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Niacinamide~2.4–3.6%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Evens skin toneAnti-agingMoisturizingAnti-blemishReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Stearic acid~2–3%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Emulsifying wax
Not recognized
Hyaluronic acid~1.5–2.2%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Tocopherol~1.1–1.7%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-agingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Aloe barbadensis leaf juice~1–1.5%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAntibacterialAnti-inflammatoryReduces rednessReduces irritationAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Hibiscus flower extract
Not recognized
Rosmarinus officinalis leaf extract~0.8–1.2%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Azadirachta indica seed oil~0.5–1.15%
Formula
Panthenol~0.45–1.05%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Unspecified form of vitamin c~0.45–1%
Formula
Beta-carotene~0.35–0.8%
Formula
Irritation risk
Low

A colorant adding orange or bright yellow color

More about Beta-carotene
Helianthus annuus seed oil~0.3–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Propanediol~0.15–0.55%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Alcohol~0.1–0.35%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Xanthan gum~0.05–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Tetrasodium glutamate diacetate~0.05–0.2%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Water, Cocos nucifera oil, Rosa canina seed oil, Glycerin, Niacinamide, Stearic acid, Unknown, Hyaluronic acid, Tocopherol, Aloe barbadensis leaf juice, Unknown, Rosmarinus officinalis leaf extract, Azadirachta indica seed oil, Panthenol, Unspecified form of vitamin c, Beta-carotene, Helianthus annuus seed oil, Propanediol, Alcohol, Xanthan gum, Tetrasodium glutamate diacetate, Phenoxyethanol

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ProtocolHyaluronic Acid & Niacinamide Hydration CreamYOUR PRODUCTRilastilAcnestil Attiva CreamCetaphilHydrating Night Cream12 GRABSOlibetaine Rich Hyaluron Moist Cream
Match—92%89%89%
Price$54.00$15.61−$38.39$1.33−$52.67$19.80−$34.20
Shared key ingredients—5 of 95 of 95 of 9
Key difference—Potassium Azeloyl DiglycinatePetrolatumAdenosine
Irritancy Medium Low Low Low
Drying alcohol Contains drying alcohol ———
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Product summary

Based on the ingredient list, "Protocol - Hyaluronic Acid & Niacinamide Hydration Cream" can work well for skin moisturization. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. Protocol - Hyaluronic Acid & Niacinamide Hydration Cream ticks this box. Humectants in this product (glycerin, hyaluronic acid and aloe barbadensis leaf juice) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Helianthus annuus extract, helianthus annuus seed oil, cetyl alcohol and stearic acid in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • We love that this moisturizer contains a good concentration of niacinamide 4.40% - 6.60%. Niacinamide is a perfect active in a moistruizer because it helps calm down inflamation in skin and support the skin barrier. More than that, it is helpful for most common skin concerns: it helps regulat oil production, help reduce acne and clogged pores, improve skin tone and prevent pigmentation marks. It also helps fight photodamage.

Irritation risk

This moisturizer contains some common irritants, including those without a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 19 studies and safety reviews.

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Protocol Hyaluronic Acid & Niacinamide Hydration Cream
ProtocolHyaluronic Acid & Niacinamide Hydration Cream

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.