Works for:
based on ingredients and %- Anti-aging
- Moisturizing
Doesn't work for:
based on ingredients and %- Evens skin tone
Can it cause trouble?
- Irritation risk: medium
- Comedogenic risk ingredients: 1
Key actives
Product Summary
"Peter Thomas Roth - Peptide 21 Wrinkle Resist Serum" is effective for: Anti-aging and Moisturizing
Ingredient callouts
- This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.45%) it cannot have a noticeable benefit for the skin.
- This product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.25% - 0.40%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
- Peptides (palmitoyl tripeptide-1 0.30% - 0.55%, trifluoroacetyl tripeptide-2 0.25% - 0.50%, palmitoyl tripeptide-5 0.25% - 0.50%, dipeptide diaminobutyroyl benzylamide diacetate 0.30% - 0.55%, hexapeptide-11 0.30% - 0.55%, palmitoyl tetrapeptide-7 0.45% - 0.65%, tripeptide-1 0.45% - 0.65%, acetyl tetrapeptide-2 0.40% - 0.65%, acetyl tetrapeptide-9 0.40% - 0.65%, palmitoyl oligopeptide 0.55% - 0.85%, acetyl hexapeptide-1 0.50% - 0.75%, acetyl hexapeptide-8 0.55% - 0.80%, acetyl tetrapeptide-11 0.65% - 1.00%, palmitoyl hexapeptide-12 0.95% - 1.15%, acetyl octapeptide-3 1.10% - 1.40% and tripeptide-10 citrulline 1.40% - 1.70%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Humectants (sodium lactate 0.25% - 0.45%, dextran 0.25% - 0.45%, sodium hyaluronate 0.25% - 0.45%, acetyl hexapeptide-8 0.55% - 0.80%, acetyl octapeptide-3 1.10% - 1.40%, mannitol 2.30% - 2.80% and glycerin 4.40% - 5.40%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 125.00$ in the United States, for 134.75A$ in Australia, from 95.00£ up to 103.50£ in the United Kingdom and from 157.50CA$ up to 163.00CA$ in Canada.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
You’ll notice that skin seems smoother with wrinkles appearing finer and less noticeable.
Source: Lookfantastic
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
Moisturizing
What does the product description say?
The anti-ageing serum also boasts impressive hydrating properties thanks to Hyaluronic Acid and Squalane, helping to lock in moisture to combat dry patches and discomfort.
Source: Lookfantastic
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
dextran, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: isopropyl myristate, caprylyl glycol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-12, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
Helps attract water to the most upper layer of the skin. Derived from sugar
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
An emollient that helps soften the skin. Could be comedogenic
Helps to attract water to the upper layer of the skin
Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing
Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
A type of silicone that can help create nice product texture and soften the upper layer of the skin
An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation
Helps preserve products and creates a nice product texture
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
Evens skin tone
What does the product description say?
Two Gamma proteins extracted from Asian Natto Gum complete the blend, working to improve skin tone for a more even finish that glows with natural radiance.
Source: Lookfantastic
Effective ingredients missing or their concentration is too low
Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing
The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing | |
| Evens skin tone |
Total Promises Fulfilled score: 66/100.
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Potential irritants
Comedogenic ingredients
User reviews (1)
Averages from community submissions.
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Peter Thomas Roth Peptide 21 Wrinkle Resist Serum | Current | $-1.00 | |
 RevivSerums TelomErase 6-in-1 Multi-Corrective Serum - NEW & IMPROVED | 49% | $149.00 | |
Maskad Anti aging serum | 47% | $125.00 | |
Thrive Causemetics Timeless Ambition™ Power 10-Peptide Sculpting Serum | 46% | $78.00 | |
PotentLift Advanced Multi Peptide Complex Serum | 42% | $39.00 | |
Formulyst Anti-Wrinkle Peptide Serum | 42% | $-1.00 |
Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Water, Glycerin, Rosa centifolia flower water, Isopropyl myristate, Mannitol, Butylene glycol, Natto gum, Tripeptide-10 citrulline, Acetyl octapeptide-3, Palmitoyl hexapeptide-12, Acetyl tetrapeptide-11, Acetyl hexapeptide-8, Acetyl hexapeptide-1, Palmitoyl oligopeptide, Acetyl tetrapeptide-9, Acetyl tetrapeptide-2, Tripeptide-1, Palmitoyl tetrapeptide-7, Hexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl tripeptide-5, Trifluoroacetyl tripeptide-2, Palmitoyl tripeptide-1, Sodium polyglutamate, Sodium hyaluronate, Tocopheryl acetate, Retinyl palmitate, Ascorbic acid, Hydrolyzed soy protein, Hydrolyzed wheat protein, Lecithin, Pseudoalteromonas ferment extract, Acrylates copolymer, Magnesium chloride, Polysorbate 20, Dimethyl isosorbide, Acrylates/c10-30 alkyl acrylate crosspolymer, Leuconostoc/radish root ferment filtrate, Peg-8 dimethicone, Disodium phosphate, Carbomer, Dextran, Sodium lactate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Xanthan gum, Triethanolamine, Sodium phosphate, Octyldodecanol, Silica, Sodium propoxyhydroxypropyl thiosulfate silica, Sodium hydroxide, Caprylyl glycol, Potassium sorbate, Sodium benzoate, Phenoxyethanol
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