Peter Thomas Roth Peptide 21 Wrinkle Resist Serum
Works for
Anti-agingTripeptide-10 citrulline, Acetyl octapeptide-3 + 17 moreWorks well
“Packed with a cutting-edge complex of 21 peptides and neuropeptides, this revolutionary wrinkle-fighting serum helps to visibly reduce the look of fine lines and wrinkles.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
MoisturizingTripeptide-10 citrulline, Acetyl octapeptide-3 + 29 moreWorks well
“For boosted hydration, hyaluronic acid and squalane work together to lock in lasting moisture, while reducing the look and feel of dryness.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
dextran, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: squalane, isopropyl myristate.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-12, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline
Evens skin toneAscorbic acid ~0.25–0.45% + 1 moreUnder-dosed
“Peter Thomas Roth Peptide 21 Wrinkle Resist Serum harnesses the power of Asian natto gum, a breakthrough ingredient that helps improve the look of elasticity and skin tone and texture, plus squalane, hyaluronic acid, and vitamins A, C, and E.”
Effective ingredients missing or their concentration is too low
Can it cause trouble?
Irritancy2 strong irritants: Rosa centifolia flower water, Retinyl palmitateMedium risk
Comedogenic1 ingredient rated 2 or more on the 0–5 pore-clogging scale1 flagged
User reviews
1 of 1 community members would buy it again.
Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycerin~5–6.1%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinRosa centifolia flower water~4.2–5.1%
- Irritation risk
- High
Isopropyl myristate~3.1–3.8%
- Irritation risk
- Low
- Comedogenicity
- 3/5
An emollient that helps soften the skin. Could be comedogenic
More about Isopropyl myristateSqualane~2.4–2.9%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneMannitol~1.8–2.2%
- Irritation risk
- Low
Helps to attract water to the upper layer of the skin
More about MannitolButylene glycol~1.6–1.9%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolNatto gum~1.4–1.8%
- Irritation risk
- Low
Tripeptide-10 citrulline~1.1–1.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tripeptide-10 citrullineAcetyl octapeptide-3~0.9–1.1%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl octapeptide-3Palmitoyl hexapeptide-12~0.65–1%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl hexapeptide-12Acetyl tetrapeptide-11~0.55–0.8%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-11Acetyl hexapeptide-8~0.5–0.75%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Acetyl hexapeptide-1~0.45–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-1Palmitoyl oligopeptide~0.5–0.8%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl oligopeptideAcetyl tetrapeptide-9~0.4–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-9Acetyl tetrapeptide-2~0.4–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-2Tripeptide-1~0.4–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tripeptide-1Palmitoyl tetrapeptide-7~0.35–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Hexapeptide-11~0.3–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Hexapeptide-11Dipeptide diaminobutyroyl benzylamide diacetate~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Dipeptide diaminobutyroyl benzylamide diacetatePalmitoyl tripeptide-5~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-5Trifluoroacetyl tripeptide-2~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Trifluoroacetyl tripeptide-2Palmitoyl tripeptide-1~0.3–0.55%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Sodium polyglutamate~0.25–0.45%
- Irritation risk
- Low
Sodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateTocopheryl acetate~0.25–0.5%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateRetinyl palmitate~0.2–0.4%
- Irritation risk
- High
Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect
More about Retinyl palmitateAscorbic acid~0.25–0.45%
- Irritation risk
- High
The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging
More about Ascorbic acidHydrolyzed soy protein~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing
More about Hydrolyzed soy proteinHydrolyzed wheat protein~0.25–0.45%
- Irritation risk
- Medium
Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten
More about Hydrolyzed wheat proteinLecithin~0.3–0.55%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinPseudoalteromonas ferment extract~0.25–0.45%
- Irritation risk
- Low
Acrylates copolymer~0.25–0.5%
- Irritation risk
- Medium
Used to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistency
More about Acrylates copolymerMagnesium chloride~0.25–0.45%
Polysorbate 20~0.25–0.5%
Dimethyl isosorbide~0.25–0.45%
- Irritation risk
- Low
Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin
More about Dimethyl isosorbideAcrylates/c10-30 alkyl acrylate crosspolymer~0.25–0.5%
- Irritation risk
- Medium
Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together
More about Acrylates/c10-30 alkyl acrylate crosspolymerLeuconostoc/radish root ferment filtrate~0.25–0.45%
- Irritation risk
- Medium
A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine
More about Leuconostoc/radish root ferment filtratePeg-8 dimethicone~0.25–0.45%
- Irritation risk
- Low
A type of silicone that can help create nice product texture and soften the upper layer of the skin
More about Peg-8 dimethiconeDisodium phosphate~0.25–0.45%
- Irritation risk
- Low
Helps adjust the product pH and stabilize the formulation
More about Disodium phosphateCarbomer~0.25–0.45%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerDextran~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the most upper layer of the skin. Derived from sugar
More about DextranSodium lactate~0.25–0.45%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateTetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.2–0.4%
- Irritation risk
- Low
A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid
More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateXanthan gum~0.25–0.45%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumTriethanolamine~0.2–0.4%
- Irritation risk
- Medium
Used to adjust pH of the product and can help improve the product's smell
More about TriethanolamineSodium phosphate~0.2–0.35%
Octyldodecanol~0.2–0.4%
- Irritation risk
- Low
An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation
More about OctyldodecanolSilica~0.3–0.55%
Sodium propoxyhydroxypropyl thiosulfate silica~0.15–0.3%
- Irritation risk
- Low
Sodium hydroxide~0.15–0.25%
Caprylyl glycol~0.15–0.3%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolPotassium sorbate~0.15–0.25%
Sodium benzoate~0.1–0.2%
Phenoxyethanol~0.1–0.2%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolIngredient list view
Water, Glycerin, Rosa centifolia flower water, Isopropyl myristate, Squalane, Mannitol, Butylene glycol, Natto gum, Tripeptide-10 citrulline, Acetyl octapeptide-3, Palmitoyl hexapeptide-12, Acetyl tetrapeptide-11, Acetyl hexapeptide-8, Acetyl hexapeptide-1, Palmitoyl oligopeptide, Acetyl tetrapeptide-9, Acetyl tetrapeptide-2, Tripeptide-1, Palmitoyl tetrapeptide-7, Hexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl tripeptide-5, Trifluoroacetyl tripeptide-2, Palmitoyl tripeptide-1, Sodium polyglutamate, Sodium hyaluronate, Tocopheryl acetate, Retinyl palmitate, Ascorbic acid, Hydrolyzed soy protein, Hydrolyzed wheat protein, Lecithin, Pseudoalteromonas ferment extract, Acrylates copolymer, Magnesium chloride, Polysorbate 20, Dimethyl isosorbide, Acrylates/c10-30 alkyl acrylate crosspolymer, Leuconostoc/radish root ferment filtrate, Peg-8 dimethicone, Disodium phosphate, Carbomer, Dextran, Sodium lactate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Xanthan gum, Triethanolamine, Sodium phosphate, Octyldodecanol, Silica, Sodium propoxyhydroxypropyl thiosulfate silica, Sodium hydroxide, Caprylyl glycol, Potassium sorbate, Sodium benzoate, Phenoxyethanol
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Peter Thomas RothPeptide 21 Wrinkle Resist SerumYOUR PRODUCT | RevivSerumsTelomErase 6-in-1 Multi-Corrective Serum - NEW & IMPROVED | MaskadAnti aging serum | USOLABBio Brightening Bleaching Ampoule | |
|---|---|---|---|---|
| Match | — | 48% | 47% | 44% |
| Price | $125.00 | — | $35.00−$90.00 | — |
| Shared key ingredients | — | 18 of 25 | 9 of 25 | 12 of 25 |
| Key difference | — | Pentapeptide-18 | Copper Tripeptide-1 | Copper Tripeptide-1 |
| Irritancy | Medium | High | Low | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: Loving Immortal -Skin Longevity & DNA Stabilizing Well-Aging SerumColorescience PEP UP Collagen Boost Face and Neck Treatment
Product summary
"Peter Thomas Roth - Peptide 21 Wrinkle Resist Serum" is effective for: Anti-aging and Moisturizing
Ingredient callouts
- This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.25% - 0.45%) it cannot have a noticeable benefit for the skin.
- This product includes a form of Retinoids (vitamin A) - retinyl palmitate 0.25% - 0.40%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
- Peptides (palmitoyl tripeptide-1 0.30% - 0.55%, trifluoroacetyl tripeptide-2 0.25% - 0.50%, palmitoyl tripeptide-5 0.25% - 0.50%, dipeptide diaminobutyroyl benzylamide diacetate 0.30% - 0.55%, hexapeptide-11 0.30% - 0.55%, palmitoyl tetrapeptide-7 0.45% - 0.65%, tripeptide-1 0.45% - 0.65%, acetyl tetrapeptide-2 0.40% - 0.65%, acetyl tetrapeptide-9 0.40% - 0.65%, palmitoyl oligopeptide 0.55% - 0.85%, acetyl hexapeptide-1 0.50% - 0.75%, acetyl hexapeptide-8 0.55% - 0.80%, acetyl tetrapeptide-11 0.65% - 1.00%, palmitoyl hexapeptide-12 0.95% - 1.15%, acetyl octapeptide-3 1.10% - 1.40% and tripeptide-10 citrulline 1.40% - 1.70%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
- Humectants (sodium lactate 0.25% - 0.45%, dextran 0.25% - 0.45%, sodium hyaluronate 0.25% - 0.45%, acetyl hexapeptide-8 0.55% - 0.80%, acetyl octapeptide-3 1.10% - 1.40%, mannitol 2.30% - 2.80% and glycerin 4.40% - 5.40%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 125.00$ in the United States, for 134.75A$ in Australia, from 95.00£ up to 103.50£ in the United Kingdom and from 157.50CA$ up to 163.00CA$ in Canada.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 10 studies and safety reviews.
- 1
- 2Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
- 3
- 4Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activityonlinelibrary.wiley.com
- 5
- 6Safety Assessment of Soy Peptides as Used in Cosmeticscir-safety.org
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