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Product summary

"Perricone MD - Neuropeptide Night Cream" is a well-rounded moisturizing product. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Acetyl hexapeptide-8, urea, fructose, glycerin and sodium hyaluronate in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide ng, palmitoyl tetrapeptide-7, butyrospermum parkii butter, dimethicone and squalane) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • Another benefit is that this moisturizer contain ceramides (ceramide ng 0.25% - 0.45%). Ceramides are an important part of our natural skin barrier. The ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • We like that this moisturizer contains peptides (tetrapeptide-21 0.25% - 0.50%, pentapeptide-18 0.30% - 0.55%, palmitoyl tetrapeptide-7 0.30% - 0.55%, palmitoyl hexapeptide-12 0.25% - 0.45%, dipeptide-2 0.25% - 0.45% and acetyl hexapeptide-8 0.30% - 0.60%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.

Irritation risk

There are some common irritants in this product, including ingredients that do not have benefits for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

About the brand

According to Cruelty-Free Kitty "Perricone MD" is cruelty free and so is its parent company.


The product retails for 501.00A$ in Australia, for 240.00$ in the United States and from 199.00£ up to 205.00£ in the United Kingdom.

For a detailed price comparison: click here.