PRODUCT REVIEW
Perricone MD Neuropeptide Necolletage
Works for:
based on ingredients and %- Anti-aging
- Moisturizing
- Anti-oxidation
- Evens skin tone
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Can it cause trouble?
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Cheaper alternatives
What can the product work for?
Works for
Anti-aging
What does the product description say?
Harnessing Dr Perricone’s patented technologies based upon years of scientific research and experience, the advanced formula seeks to address loss of elasticity and alleviate the look of wrinkles with a blend of Neuropeptides and DMAE.
tetrahexyldecyl ascorbate
8.2% -
10%
Irritation risk:
Concentration: Effectiveness: HIGH
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
carnosine
0.45% -
0.7%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage
acetyl hexapeptide-8
0.1% -
0.15%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
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Moisturizing
What does the product description say?
Lightweight and quickly absorbed, the non-greasy cream leaves skin feeling hydrated and refreshed, with the appearance of typical crisscross lines and that leathery texture substantially alleviated.
palmitoyl oligopeptide
0.35% -
0.6%
Irritation risk:
Concentration: Effectiveness: HIGH
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
carnosine
0.45% -
0.7%
Irritation risk:
Concentration: Effectiveness: HIGH
A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage
Show more
Evens skin tone
tetrahexyldecyl ascorbate
8.2% -
10%
Irritation risk:
Concentration: Effectiveness: HIGH
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
glycyrrhetinic acid
0.55% -
0.8%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
Active compound of licorice root. Works to calm down inflammation, as an anti-oxidant, and might be helpful in lightening the skin and reducing hyperpigmentation
ferulic acid
0.45% -
0.65%
Irritation risk:
Concentration: Effectiveness:
MEDIUM
A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%
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Anti-oxidation
tetrahexyldecyl ascorbate
8.2% -
10%
Irritation risk:
Concentration: Effectiveness: HIGH
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
carnosine
0.45% -
0.7%
Irritation risk:
Concentration: Effectiveness: HIGH
A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage
ferulic acid
0.45% -
0.65%
Irritation risk:
Concentration: Effectiveness: HIGH
A potent anti-oxidant that has been shown to be effective in neutralizing free radicals in skin. There seem to have a synergetic effect of ferulic acid, vitamin E and C, meaning that when the ingredients are used together, they enhance each other's ability protect the skin against free radicals. Ferulic acid also helps to stabilize other ingredients - including vitamins C and E. It can help to even out the skin tone. Ferulic acid is approved for use as a sunscreen ingredient in Japan in concentrations up to 10%
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Honesty check
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing |
Total Promises Fulfilled score:
100/100.
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Can it cause trouble?
- Overall product irritation risk
- Acne & comedogenic risk ingredients: 0
Potential irritants
benzyl alcohol
0.65% -
0.95%
Irritation risk:
A preservative. Can be used to mask unpleasant smell. Can be irritating
parfum
0.45% -
0.7%
Irritation risk:
An aromatic blend of unspecified and possibly irritating ingredients
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Comodogenic ingredients
No comodogenic ingredients detected
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30%
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27%
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26%
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| Irritancy | IRRITANCY
MEDIUM
| IRRITANCY
LOW
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LOW
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LOW
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LOW
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LOW
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MEDIUM
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MEDIUM
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LOW
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LOW
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Ingredients & concentrations
All ingredients
Key Actives
zinc gluconate
0.35% -
0.65%
Irritation risk:
Works for:
Moisturizing,
Exfoliation,
Anti-blemish,
Anti-aging,
Anti-inflammatory,
Anti-oxidation,
Evens skin tone
Typically used to stabilize the product formulations. It is a salt of a polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing. Due to the zinc content, might help calm down inflammation in skin
copper gluconate
0.2% -
0.4%
Irritation risk:
Works for:
Moisturizing,
Anti-oxidation,
Evens skin tone,
Anti-blemish,
Exfoliation,
Anti-aging
Typically used to stabilize the product formulations. It is a salt of polyhydroxy acid (PHA) and in larger concentrations, can help shed the dead cells from the skin surface revealing smoother skin. It can help attract water to the upper layer of the skin. Might to be helpful against acne and clogged pores. Could be helpful in neutralizing free radicals, but solid research is missing
Show more
Potential irritants
benzyl alcohol
0.65% -
0.95%
Irritation risk:
A preservative. Can be used to mask unpleasant smell. Can be irritating
parfum
0.45% -
0.7%
Irritation risk:
An aromatic blend of unspecified and possibly irritating ingredients
Show more
Comodogenic ingredients
We couldn't find any comodogenic ingredients in this product
All ingredients
tetrahexyldecyl ascorbate
8.2% -
10%
Irritation risk:
Works for:
Anti-aging,
Evens skin tone,
Anti-oxidation
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
glycerin
4.2% -
5.1%
Irritation risk:
Works for:
Moisturizing
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
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Ingredient list view
Water, Tetrahexyldecyl ascorbate, Glycerin, Taurine, Peg-12, Carbomer, Tyrosine, Hydroxylated lecithin, Butylene glycol, Dimethyl mea, Acetyl carnosine, Benzyl alcohol, Phosphatidylcholine, Magnesium ascorbyl phosphate, Sodium fumarate, Phytic acid, Pantethine, Glycyrrhetinic acid, Parfum, Ascorbyl palmitate, Carnosine, Ferulic acid, Docosahexaenoic acid, Zinc gluconate, Magnesium aspartate, Polysorbate 20, Palmitoyl oligopeptide, Copper gluconate, Elaeis guineensis extract, Tetrapeptide-3, Acetyl hexapeptide-8
Sources
- Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage
- Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacy
- Glycerol and the skin: holistic approach to its origin and functions
- Cosmeceuttical Critigue: Taurine
- Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives
- Topical L-ascorbic acid: percutaneous absorption studies
- Cosmetic and dermatologic use of alpha hydroxy acids
- Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma
- Topical use of dexpanthenol in skin disorders
- Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
- Effects of topical application of B‐Resorcinol and Glycyrrhetinic acid monotherapy and in combination with fractional CO2 laser treatment for benign hand hyperpigmentation treatment
- 18β-Glycyrrhetinic Acid and Glabridin Prevent Oxidative DNA Fragmentation in UVB-irradiated Human Keratinocyte Cultures
- Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products
- Ferulic Acid: Therapeutic Potential Through Its Antioxidant Property
- Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin
- Antioxidant Properties of Ferulic Acid and Its Possible Application
- Zinc salts in dermatology
- An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders
- Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins
- Evaluation of the effects of topical zinc gluconate in wound healing
- A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
- Applications of hydroxy acids: classification, mechanisms, and photoactivity