Perricone MD Neuropeptide Deep Crease Serum
Works for
Anti-agingNiacinamide, Acetyl hexapeptide-8 + 6 moreWorks well
“Target the most visible stubborn lines and creases around your mouth, eyes, lips and forehead with this silky serum for deep wrinkles.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Can it cause trouble?
Irritancy5 strong irritants: Parfum, Citronellol + 3 more — patch-test recommendedHigh risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Niacinamide~4.8–5.8%
- Irritation risk
- Low
Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production
More about NiacinamideCoconut alkanes~4.1–5%
- Irritation risk
- Medium
- Comedogenicity
- 2/5
An emollient that helps soften the skin
More about Coconut alkanesGlycerin~3–3.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinCaprylic/capric triglyceride~2.4–2.9%
- Irritation risk
- Medium
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
More about Caprylic/capric triglycerideIsodecyl neopentanoate~2–2.4%
- Irritation risk
- Low
An emollient that helps soften the skin. It also forms a protective on its surface to reduce water loss.
More about Isodecyl neopentanoateSqualane~1.7–2.1%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneIsononyl isononanoate~1.5–1.9%
- Irritation risk
- Low
Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness
More about Isononyl isononanoateButylene glycol~1.2–1.5%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolLactobacillus/soybean ferment extract~0.95–1.2%
- Irritation risk
- Low
A fermentation product created by bacteria Lactobacillus out of soybean. The fermented product helps to attract water to the upper layer of the skin and has anti-bacterial properties. It might be helpful in calming down inflammation and could be helpful in evening out skin tone, but studies are lacking
More about Lactobacillus/soybean ferment extractPolyglutamic acid~0.7–1.05%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin.
More about Polyglutamic acidPhenoxyethanol~0.6–0.9%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolHydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.55–0.85%
- Irritation risk
- Medium
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerChlorella vulgaris extract~0.5–0.75%
- Irritation risk
- Medium
- Comedogenicity
- 3/5
A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties
More about Chlorella vulgaris extractGlyceryl stearate citrate~0.5–0.8%
- Irritation risk
- Low
Helps oil and water mix together while softening the upper layer of the skin
More about Glyceryl stearate citrateCoco-caprylate/caprate~0.5–0.75%
- Irritation risk
- Low
Helps to soften the upper layer of the skin without creating a greasy texture
More about Coco-caprylate/caprateHydroxyacetophenone~0.45–0.7%
Polyglyceryl-3 stearate~0.45–0.7%
- Irritation risk
- Low
Helps oil and water mix together
More about Polyglyceryl-3 stearateHydrolyzed rice protein~0.35–0.65%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin. Might have some anti-oxidant properties
More about Hydrolyzed rice proteinSodium hyaluronate~0.3–0.6%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronatePropanediol~0.3–0.6%
- Irritation risk
- Low
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
More about PropanediolXanthan gum~0.3–0.55%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumPullulan~0.3–0.55%
- Irritation risk
- High
Creates a thin drying film on the skin resulting in a short-term tightening effect
More about PullulanHydrogenated lecithin~0.3–0.55%
- Irritation risk
- Low
Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.
More about Hydrogenated lecithinParfum~0.25–0.45%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumPolysorbate 60~0.3–0.55%
Citric acid~0.25–0.5%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidSodium phytate~0.25–0.5%
Malus domestica fruit cell culture extract~0.25–0.5%
- Irritation risk
- Low
Sorbitan isostearate~0.3–0.5%
- Irritation risk
- Low
Helps oil and water mix together
More about Sorbitan isostearateGlyceryl stearate~0.3–0.6%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearatePentylene glycol~0.3–0.6%
- Irritation risk
- Medium
Used to preserve products, dissolve other ingredients and create a nice product texture
More about Pentylene glycolCarbomer~0.25–0.5%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerCeteareth-25~0.35–0.65%
Coco-glucoside~0.3–0.6%
- Irritation risk
- High
Used as a cleansing agent (surfactant) in cleansers. Helps water and oil mix together in lotions. Can be irritating
More about Coco-glucosideSodium lactate~0.25–0.5%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateUbiquinone~0.25–0.5%
- Irritation risk
- Low
Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen
More about UbiquinoneLecithin~0.3–0.55%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinSodium benzoate~0.25–0.5%
Potassium sorbate~0.3–0.5%
Caprylyl glycol~0.3–0.55%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolAcetyl hexapeptide-8~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Ceteareth-6~0.3–0.5%
Lactic acid~0.25–0.5%
- Irritation risk
- Medium
An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)
More about Lactic acidPterocarpus marsupium bark extract~0.25–0.5%
- Irritation risk
- Low
Tocopherol~0.25–0.5%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolStearyl alcohol~0.3–0.55%
- Irritation risk
- Low
An emollient that helps soften the skin
More about Stearyl alcoholAcetic acid~0.25–0.45%
- Irritation risk
- Low
Ethylhexylglycerin~0.25–0.4%
Palmitoyl tripeptide-1~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Sodium hydroxide~0.2–0.35%
Palmitoyl tetrapeptide-7~0.2–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1~0.15–0.3%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1Nicotiana benthamiana octapeptide-30 sh-oligopeptide-2~0.15–0.25%
- Irritation risk
- Low
Citronellol~0.15–0.25%
Hydroxycitronellal~0.15–0.25%
- Irritation risk
- High
A fragrance. A likely allergen and can be irritating
More about HydroxycitronellalLimonene~0.1–0.15%
- Irritation risk
- High
A common frangrance that can easily irritate skin, especially if exposed to air, light or heat
More about LimoneneLinalool~0.1–0.15%
Ingredient list view
Water, Niacinamide, Coconut alkanes, Glycerin, Caprylic/capric triglyceride, Isodecyl neopentanoate, Squalane, Isononyl isononanoate, Butylene glycol, Lactobacillus/soybean ferment extract, Polyglutamic acid, Phenoxyethanol, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Chlorella vulgaris extract, Glyceryl stearate citrate, Coco-caprylate/caprate, Hydroxyacetophenone, Polyglyceryl-3 stearate, Hydrolyzed rice protein, Sodium hyaluronate, Propanediol, Xanthan gum, Pullulan, Hydrogenated lecithin, Parfum, Polysorbate 60, Citric acid, Sodium phytate, Malus domestica fruit cell culture extract, Sorbitan isostearate, Glyceryl stearate, Pentylene glycol, Carbomer, Ceteareth-25, Coco-glucoside, Sodium lactate, Ubiquinone, Lecithin, Sodium benzoate, Potassium sorbate, Caprylyl glycol, Acetyl hexapeptide-8, Ceteareth-6, Lactic acid, Pterocarpus marsupium bark extract, Tocopherol, Stearyl alcohol, Acetic acid, Ethylhexylglycerin, Palmitoyl tripeptide-1, Sodium hydroxide, Palmitoyl tetrapeptide-7, Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, Nicotiana benthamiana octapeptide-30 sh-oligopeptide-2, Citronellol, Hydroxycitronellal, Limonene, Linalool
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Perricone MDNeuropeptide Deep Crease SerumYOUR PRODUCT | REMEDY SCIENCEREMEDY for healthy aging | Nooance cosmetiquesMulti-Active Serum | ArenciaDeep Water Surge Serum 30 | |
|---|---|---|---|---|
| Match | — | 88% | 87% | 84% |
| Price | $189.00 | $35.00−$154.00 | — | $15.74−$173.26 |
| Shared key ingredients | — | 11 of 15 | 9 of 15 | 8 of 15 |
| Key difference | — | Retinol | Heptapeptide-15 Palmitate | Copper Tripeptide-1 |
| Irritancy | High | Medium | Medium | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: L'ESSENTIAL Double Serum MiniNIDA Salmon PDRN Peptide Serum
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 17 studies and safety reviews.
- 1
- 2
- 3
- 4
- 5Natural and edible biopolymer poly‐γ‐glutamic acid: synthesis, production, and applicationsonlinelibrary.wiley.com
- 6Safety Assessment of Alkyl Esters as Used in Cosmeticscir-safety.org
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