Perricone MD Neuropeptide Corrective Brightening Under-Eye Cream

Perricone MD Neuropeptide Corrective Brightening Under-Eye Cream

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Anti-aging
7 ingredients credited for this claim
Strong support
What the product description says
“Smooths the appearance of crow’s feet & deep lines around the eyes”
Source: Perricone MD

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, acetyl tetrapeptide-5, nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%
Acetyl tetrapeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.3%
UbiquinoneEffect: LowCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.5%
Moisturizing
Not advertised by the brand · 23 ingredients credited for this claim
Strong support

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, lactobacillus ferment.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, acetyl tetrapeptide-5, niacinamide, nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, panthenol

Acetyl tetrapeptide-5Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.5–0.75%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.6–5.6%
NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%
Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.3%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.4%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.35%
PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.25–0.5%
CyanocobalaminKey activeEffect: HighCan support skin barrier function and reduce inflammation in skin~0.2–0.4%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.25–0.45%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~1.2–1.5%
UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.5%
Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
IsododecaneKey active· Emollient, OcclusiveEffect: MediumAn emollient that helps soften the skin and can decrease moisture loss. Helps create a nice product texture~4.2–5.2%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.5–3.1%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~0.65–0.95%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.35–0.6%
Hydrogenated polyisobutene· Emollient, OcclusiveEffect: LowUsed to improve the product consistency and soften the upper layer of the skin~0.75–1.1%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~1.7–2%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.45–0.65%
Caprylic/capric triglycerideUnder-dosedEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~0.3–0.6%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.3–0.6%
Anti-oxidation
Not advertised by the brand · 3 ingredients credited for this claim
Strong support

This product contains antioxidants (ubiquinone) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

UbiquinoneKey activeEffect: HighCoenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen~0.25–0.5%
CaffeineEffect: LowMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes~0.95–1.2%
Lactobacillus fermentEffect: LowA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.5–0.75%
Evens skin tone
Not advertised by the brand · 1 ingredient credited for this claim
Strong support

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%

Can it cause trouble?

Irritancy
11 flagged ingredients
Medium risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Candelilla/jojoba/rice bran polyglyceryl-3 estersHelp oil and water mix togetherMedium~1.5–1.8%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.95–1.2%est.
Sodium stearoyl lactylateHelps oil and water mix togetherMedium~0.5–0.75%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.45–0.7%est.
1,2-hexanediolA preservativeMedium~0.3–0.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.35–0.6%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.25–0.45%est.
Ceteareth-25Helps oil and water mix togetherMedium~0.35–0.65%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~0.3–0.6%est.
Potassium sorbateA preservativeMedium~0.25–0.5%est.
EthylhexylglycerinA preservativeMedium~0.15–0.3%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.5–3.1%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.6–5.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Isododecane~4.2–5.2%
Key active
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin and can decrease moisture loss. Helps create a nice product texture

More about Isododecane
Cetearyl alcohol~2.5–3.1%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Niacinamide~2.3–2.8%
Hero · Moisturizing
Irritation risk
Low
Works for
Anti-agingEvens skin toneAnti-blemishMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Illite~2–2.5%
Formula
Irritation risk
Low
More about Illite
Glyceryl stearate~1.7–2%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Candelilla/jojoba/rice bran polyglyceryl-3 esters~1.5–1.8%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Help oil and water mix together

More about Candelilla/jojoba/rice bran polyglyceryl-3 esters
Sodium pca~1.2–1.5%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Caffeine~0.95–1.2%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Hydrogenated polyisobutene~0.75–1.1%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to improve the product consistency and soften the upper layer of the skin

More about Hydrogenated polyisobutene
Polysilicone-11~0.65–0.95%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Lactobacillus ferment~0.5–0.75%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidationReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Sodium stearoyl lactylate~0.5–0.75%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Sodium stearoyl lactylate
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.45–0.7%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Butylene glycol~0.45–0.65%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Polyacrylate crosspolymer-6~0.45–0.65%
Formula
Synthetic fluorphlogopite~0.4–0.65%
Formula
Irritation risk
Low

A mineral that is used as an optical filter (makes the skin looks nicer through light reflection) and to improve the texture of cosmetic products

More about Synthetic fluorphlogopite
1,2-hexanediol~0.3–0.6%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Caprylyl glycol~0.35–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Lecithin~0.3–0.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Panthenol~0.25–0.5%
Hero · Moisturizing
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Tetrasodium glutamate diacetate~0.25–0.45%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Sorbitan isostearate~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Malus domestica fruit cell culture extract~0.25–0.45%
Formula
Phenoxyethanol~0.25–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Carbomer~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Sodium lactate~0.25–0.45%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Ceteareth-25~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Ceteareth-25
Polysorbate 20~0.3–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Caprylic/capric triglyceride~0.3–0.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Ubiquinone~0.25–0.5%
Key active
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-aging

Coenzyme Q10. It helps neutralize free radicals in skin, improves skin hydration and might be helpful agains fine lines and wrinkles. It can be an allergen

More about Ubiquinone
Sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Potassium sorbate~0.25–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Xanthan gum~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Acetic acid~0.25–0.45%
Formula
Irritation risk
Low
More about Acetic acid
Acetyl hexapeptide-8~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Acetyl tetrapeptide-5~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-5
Ceteareth-6~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing
More about Ceteareth-6
Pterocarpus marsupium bark extract~0.2–0.4%
Formula
Cyanocobalamin~0.2–0.4%
Key active
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizing

Can support skin barrier function and reduce inflammation in skin

More about Cyanocobalamin
Stearyl alcohol~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Ethylhexylglycerin~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Palmitoyl tripeptide-1~0.2–0.35%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Palmitoyl tetrapeptide-7~0.2–0.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1~0.15–0.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1
Nicotiana benthamiana octapeptide-30 sh-oligopeptide-2~0.1–0.2%
Formula
Titanium dioxide~0.1–0.2%
Formula
Irritation risk
Low
Works for
Sun protection

Works as a UV filter when used in high concentrations. It is photostable and is effective mostly against the UVB light, with some protection in the UVA range. In small concentrations, used for its ability to improve the color of cosmetic products. Is usually well tolerated by the skin

More about Titanium dioxide
Ingredient list view

Water, Glycerin, Isododecane, Cetearyl alcohol, Niacinamide, Illite, Glyceryl stearate, Candelilla/jojoba/rice bran polyglyceryl-3 esters, Sodium pca, Caffeine, Hydrogenated polyisobutene, Polysilicone-11, Lactobacillus ferment, Sodium stearoyl lactylate, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Butylene glycol, Polyacrylate crosspolymer-6, Synthetic fluorphlogopite, 1,2-hexanediol, Caprylyl glycol, Lecithin, Panthenol, Tetrasodium glutamate diacetate, Sorbitan isostearate, Malus domestica fruit cell culture extract, Phenoxyethanol, Carbomer, Sodium lactate, Ceteareth-25, Polysorbate 20, Caprylic/capric triglyceride, Ubiquinone, Sodium hyaluronate, Potassium sorbate, Xanthan gum, Acetic acid, Acetyl hexapeptide-8, Acetyl tetrapeptide-5, Ceteareth-6, Pterocarpus marsupium bark extract, Cyanocobalamin, Stearyl alcohol, Ethylhexylglycerin, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Nicotiana benthamiana hexapeptide-40 sh-oligopeptide-1, Nicotiana benthamiana octapeptide-30 sh-oligopeptide-2, Titanium dioxide

Compare prices

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Amazon USPrice as of 10/18/2026 15:11 GMT
$129.00
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Perricone MD
$129.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDNeuropeptide Corrective Brightening Under-Eye CreamYOUR PRODUCTNEOGEN X SUR.MEDICV.Biome Advanced Eye CreamCeraVeSkin Renewing Eye CreamHanskinCollagen Peptide Eye Cream
Match—82%82%81%
Price$129.00$25.16−$103.84$15.12−$113.88$20.80−$108.20
Shared key ingredients—9 of 178 of 179 of 17
Key difference—Copper Tripeptide-1PetrolatumOligopeptide-32
Irritancy Medium Medium Low Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 15 studies and safety reviews.

  1. 1
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  5. 5
  6. 6
Perricone MD Neuropeptide Corrective Brightening Under-Eye Cream
Perricone MDNeuropeptide Corrective Brightening Under-Eye Cream

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As an Amazon Associate, WIMJ earns from qualifying purchases.