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Perricone MD Cold Plasma Plus+ Hand Therapy Duo
Perricone MD

Perricone MD Cold Plasma Plus+ Hand Therapy Duo

Efficacy75/100IrritancyLow
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Works for

2 of 3 advertised claims delivered

Evens skin tone
Hydroxyphenoxy propionic acid
Strong evidence
What the product description says
“This multi-tasking powerhouse strengthens, softens and replenishes the thin, crepey skin on the hands through intense moisturization and diminishes the look of dark spots and discoloration.”
Source: Perricone MD

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: hydroxyethyl urea, hydroxyphenoxy propionic acid

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Hydroxyphenoxy propionic acidKey activeEffect: HighHelps reduce hypepigmentation and even out the skin tone~0.4–0.95%
Moisturizing
Butyrospermum parkii butter, Dimethicone + 10 more
Good evidence
What the product description says
“This multi-tasking powerhouse strengthens, softens and replenishes the thin, crepey skin on the hands through intense moisturization and diminishes the look of dark spots and discoloration.”
Source: Perricone MD

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: hydroxyethyl urea, butylene glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, dimethicone.

Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~3.6–5.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.85–1.3%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.7%
Hydroxyethyl ureaKey active· HumectantEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~4.4–6.6%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~1.5–2.2%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.15–0.65%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1–1.6%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.7–2.5%
Dicaprylyl ether· EmollientEffect: LowHelps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients~2.7–4%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~1.3–2%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.5–1.2%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.3%
Anti-aging
Butyrospermum parkii butter, Tocopherol
Limited evidence
What the product description says
“This silky cream absorbs quickly and visibly firms, tightens and brightens while smoothing the look of fine lines and wrinkles and improving the feel of skin’s elasticity over time.”
Source: Perricone MD

This product does not contain ingredients that are able to reduce fine lines and wrinkles or help with skin elasticity, but it can improve the look of the skin temporarily through moisturization. Well-moisturized skin might also be able to repair the sun damage better.This ingredient - butyrospermum parkii butter - could be helpful for preventing or repairing signs of aging in theory, but there is no evidence that it actually works.

Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~3.6–5.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.3%
Exfoliation
Not advertised by the brand · Hydroxyethyl urea
Strong evidence

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: hydroxyethyl urea.

Hydroxyethyl ureaKey activeEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~4.4–6.6%

Can it cause trouble?

Irritancy
4 flagged ingredients
Low risk
We flag 4 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Aluminum starch octenylsuccinateUsed to thicken the product's consistencyMedium~2.1–3.1%est.
Hydroxyphenoxy propionic acidHelps reduce hypepigmentation and even out the skin toneMedium~0.4–0.95%est.
EthylhexylglycerinA preservativeMedium~0.1–0.35%est.
Sodium acrylates copolymerUsed to create a thicker product consistencyMedium~0.01–0.1%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~3.6–5.4%est.
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~1.5–2.2%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1–1.6%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Hydroxyethyl urea~4.4–6.6%
Key active
Irritation risk
Low
Works for
ExfoliationMoisturizing

A derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients

More about Hydroxyethyl urea
Butyrospermum parkii butter~3.6–5.4%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-agingAnti-oxidation

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Dicaprylyl ether~2.7–4%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients

More about Dicaprylyl ether
Aluminum starch octenylsuccinate~2.1–3.1%
Irritant · medium
Irritation risk
Medium

Used to thicken the product's consistency

More about Aluminum starch octenylsuccinate
Butylene glycol~1.7–2.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Ethylhexyl palmitate~1.5–2.2%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Stearic acid~1.3–2%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Cetearyl alcohol~1–1.6%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Dimethicone~0.85–1.3%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Glyceryl stearate~0.5–1.2%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Hydroxyphenoxy propionic acid~0.4–0.95%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Evens skin tone

Helps reduce hypepigmentation and even out the skin tone

More about Hydroxyphenoxy propionic acid
Palmitoyl glycine~0.35–0.85%
Formula
Irritation risk
Low
More about Palmitoyl glycine
Peg-100 stearate~0.35–0.8%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Helianthus annuus seed oil~0.3–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Phospholipids~0.15–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Xanthan gum~0.1–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Ethylhexylglycerin~0.1–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Tocopherol~0.1–0.3%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Tetrasodium glutamate diacetate~0.05–0.2%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Sodium hydroxide~0.05–0.2%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Sodium acrylates copolymer~0.01–0.1%
Irritant · medium
Irritation risk
Medium

Used to create a thicker product consistency

More about Sodium acrylates copolymer
Ingredient list view

Water, Hydroxyethyl urea, Butyrospermum parkii butter, Dicaprylyl ether, Aluminum starch octenylsuccinate, Butylene glycol, Ethylhexyl palmitate, Stearic acid, Cetearyl alcohol, Dimethicone, Glyceryl stearate, Hydroxyphenoxy propionic acid, Palmitoyl glycine, Peg-100 stearate, Helianthus annuus seed oil, Phospholipids, Xanthan gum, Ethylhexylglycerin, Tocopherol, Tetrasodium glutamate diacetate, Sodium hydroxide, Sodium acrylates copolymer

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 11 studies and safety reviews.

  1. 1
    Safety Assessment of Hydroxyethyl Urea As Used in Cosmeticscir-safety.org
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Efficacy of hydroxyphenoxy propionic acid for age spots and skin tone correctionresearchgate.net
  5. 5
    Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Careonlinelibrary.wiley.com
  6. 6
    Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egyptjournals.lww.com
Perricone MD Cold Plasma Plus+ Hand Therapy Duo
Perricone MDCold Plasma Plus+ Hand Therapy Duo
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