NEOSTRATA

NEOSTRATA Dermal Replenishment

Name: NEOSTRATA - Dermal Replenishment
Brand: NEOSTRATA

Efficacy100/100IrritancyMedium

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Works for

3 of 3 advertised claims delivered

Evens skin tone

3 ingredients credited for this claim

Strong support

What the product description says

“*91% brown spots are less apparent *91% skin has better clarity and radiance *Percentage of participants noting improvement after use of a antiaging regimen.”

Source: Neostrata

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: acetyl glucosamine, maltobionic acid

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Maltobionic acidKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4–4.9%

Acetyl glucosamineKey activeEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~3–3.7%

AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.3%

Anti-aging

10 ingredients credited for this claim

Strong support

What the product description says

“Proprietary AMINOFIL ® works together with Maltobionic Acid and NEOGLUCOSAMINE ® technology to help provide a firmer appearance and reduce the look of wrinkles.”

Source: Neostrata

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains acetyl glucosamine, acetyl tyrosinamide, maltobionic acid.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: lysine, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, serine, threonine, vitis vinifera seed extract.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Acetyl tyrosinamideKey activeEffect: HighAn amino acid derivative. A manufacturer's study shows that it can help somewhat reduce wrinkles when used in combination with a low concentration of glycolic acid. No independent human in-vivo studies of this compound are available~0.35–0.6%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%

LysineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Vitis vinifera seed extractKey activeEffect: MediumA plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation~0.25–0.5%

ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.5–1.8%

Moisturizing

29 ingredients credited for this claim

Strong support

What the product description says

“This deeply hydrating face cream contains skin's amino acid building blocks and natural sugars called Natural Moisturizing Factor (NMF) to attract water and help strengthen the skin's moisture barrier.”

Source: Neostrata

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, butyrospermum parkii butter.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl glucosamine, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Sodium pcaKey activeEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.2–0.4%

Glutamic acidKey activeEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.2–0.35%

GlycerinKey activeEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.9–6%

GlycineKey activeEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.2–0.35%

Isopropyl myristateKey activeEffect: HighAn emollient that helps soften the skin. Could be comedogenic~0.2–0.4%

LysineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.2–0.35%

Octyldodecyl neopentanoateKey activeEffect: HighAn emollient that helps soften the skin. Often used to stabilize other ingredients, for example, sunscreen~2.3–2.8%

Palmitoyl tetrapeptide-7HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%

Palmitoyl tripeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.6%

Saccharide isomerateKey activeEffect: HighHelps attract water to the upper layer of the skin~0.3–0.6%

Acetyl glucosamineHeroEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~3–3.7%

AlanineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.3%

ArginineKey activeEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.15–0.3%

BetaineKey activeEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~0.15–0.3%

Butyrospermum parkii butterKey activeEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~1.5–1.8%

Cetyl alcoholKey activeEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~0.25–0.45%

C12-15 alkyl benzoateKey activeEffect: MediumEnhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth~1.6–2%

CyclopentasiloxaneKey activeEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~0.45–0.7%

ProlineKey activeEffect: Medium~0.2–0.35%

Caprylyl glycolEffect: LowHelps preserve products and creates a nice product texture~0.2–0.35%

OctyldodecanolEffect: LowAn emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation~1.1–1.4%

Propylene glycolEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~0.15–0.3%

Butylene glycolEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.35%

SorbitolEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.2–0.35%

CyclohexasiloxaneEffect: Low, below effective doseA silicone that serves as an emollient. Helps create a nice non-greasy feels~0.35–0.65%

Exfoliation

Not advertised by the brand · 2 ingredients credited for this claim

Strong support

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: maltobionic acid.

Acetyl glucosamineKey activeEffect: MediumAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~3–3.7%

Anti-oxidation

Not advertised by the brand · 4 ingredients credited for this claim

Strong support

This product contains antioxidants (vitis vinifera seed extract) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - acetyl tyrosinamide also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Vitis vinifera seed extractKey activeEffect: HighA plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation~0.25–0.5%

Acetyl tyrosinamideKey activeEffect: MediumAn amino acid derivative. A manufacturer's study shows that it can help somewhat reduce wrinkles when used in combination with a low concentration of glycolic acid. No independent human in-vivo studies of this compound are available~0.35–0.6%

Maltobionic acidEffect: LowA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~4–4.9%

Can it cause trouble?

Irritancy

17 flagged ingredients

Medium risk

We flagged 17 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~0.15–0.3%est.

Sodium bisulfiteA preservativeHigh~0.1–0.2%est.

MethyldihydrojasmonateUsed as a fragrance. Smells similar to jasmineHigh~0.1–0.15%est.

Ethylene brassylateA fragrance. Can be irritatingHigh~0.1–0.2%est.

Methyl decenolUsed to mask the smell of other ingredients in the formulationHigh~0.1–0.2%est.

Ci 19140A yellow dyeHigh~0.05–0.1%est.

Maltobionic acidA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~4–4.9%est.

Steareth-2Helps oil and water mix togetherMedium~1.8–2.3%est.

Steareth-20Helps oil and water mix togetherMedium~0.9–1.1%est.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.6–0.9%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.2–0.4%est.

Ammonium hydroxideHelps adjust the product pHMedium~0.15–0.3%est.

Disodium edtaStabilizes the product formulationMedium~0.15–0.3%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.35%est.

ChlorphenesinA preservativeMedium~0.1–0.15%est.

Isobutyl methyl tetrahydropyranolHelps improve the product textureMedium~0.1–0.15%est.

Ci 14700A colorantMedium~0.05–0.15%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~1.5–1.8%est.

Isopropyl myristateAn emollient that helps soften the skin. Could be comedogenic3/5~0.2–0.4%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.9–6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Maltobionic acid~4–4.9%

Key activeIrritant · medium

Irritation risk: Medium

Works for

ExfoliationEvens skin toneMoisturizingAnti-agingAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is genter than AHAs. In addition, it helps attract water to the upper layer of the skin. It has been shown to be helpful against acne and clogged pores. Might help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Maltobionic acid

Acetyl glucosamine~3–3.7%

Hero · Moisturizing

Irritation risk: Low

Works for

Anti-agingEvens skin toneMoisturizingExfoliation

An effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin

More about Acetyl glucosamine

Octyldodecyl neopentanoate~2.3–2.8%

Key active

Irritation risk: Low

Works for

Moisturizing

An emollient that helps soften the skin. Often used to stabilize other ingredients, for example, sunscreen

More about Octyldodecyl neopentanoate

Steareth-2~1.8–2.3%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Steareth-2

C12-15 alkyl benzoate~1.6–2%

Key active

Irritation risk: Low

Works for

Moisturizing

Enhances the product texture and makes it more spreadable. Helps reduce water loss from the outer layer of skin. Extands the shelf life by preventing bacteria growth

More about C12-15 alkyl benzoate

Butyrospermum parkii butter~1.5–1.8%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter

Octyldodecanol~1.1–1.4%

Formula

Irritation risk: Low

Works for

Moisturizing

An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation

More about Octyldodecanol

Steareth-20~0.9–1.1%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Steareth-20

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.6–0.9%

Irritant · medium

Irritation risk: Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

Isostearic acid~0.55–0.85%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a nice product texture

More about Isostearic acid

Cyclopentasiloxane~0.45–0.7%

Key active

Irritation risk: Low

Works for

MoisturizingMattifying

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane

Acetyl tyrosinamide~0.35–0.6%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

An amino acid derivative. A manufacturer's study shows that it can help somewhat reduce wrinkles when used in combination with a low concentration of glycolic acid. No independent human in-vivo studies of this compound are available

More about Acetyl tyrosinamide

Saccharide isomerate~0.3–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin

More about Saccharide isomerate

Cyclohexasiloxane~0.35–0.65%

Formula

Irritation risk: Low

Works for

Moisturizing

A silicone that serves as an emollient. Helps create a nice non-greasy feels

More about Cyclohexasiloxane

Palmitoyl tripeptide-1~0.35–0.6%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1

Palmitoyl tetrapeptide-7~0.3–0.55%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7

Vitis vinifera seed extract~0.25–0.5%

Key active

Irritation risk: Low

Works for

Anti-oxidationAnti-inflammatoryAnti-agingAntibacterial

A plant extract that contains resveratrol and other anti-oxidant compounds that can help neutralize free radicals, reduce inflammation in skin and even out its tone. Can be also used to stabilize the product formulation

More about Vitis vinifera seed extract

Sodium pca~0.2–0.4%

Key active

Irritation risk: Low

Works for

Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca

Serine~0.2–0.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Glycine~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Alanine~0.15–0.3%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Lysine~0.2–0.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Lysine

Arginine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Threonine~0.2–0.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine

Proline~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Cetyl alcohol~0.25–0.45%

Key active

Irritation risk: Low

Works for

CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol

Propylene glycol~0.15–0.3%

Irritant · high

Irritation risk: High

Works for

Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol

Betaine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine

Sorbitol~0.2–0.35%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol

Isopropyl myristate~0.2–0.4%

Key activeComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

Moisturizing

An emollient that helps soften the skin. Could be comedogenic

More about Isopropyl myristate

Glutamic acid~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid

Butylene glycol~0.2–0.35%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Polysorbate 60~0.2–0.4%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Sorbitan isostearate~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Sorbitan isostearate

Carbomer~0.2–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Polysorbate 20~0.2–0.4%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Ammonium hydroxide~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Helps adjust the product pH

More about Ammonium hydroxide

Disodium edta~0.15–0.3%

Irritant · medium

Irritation risk: Medium

Stabilizes the product formulation

More about Disodium edta

Caprylyl glycol~0.2–0.35%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Sodium bisulfite~0.1–0.2%

Irritant · high

Irritation risk: High

A preservative

More about Sodium bisulfite

Xanthan gum~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Phenoxyethanol~0.15–0.25%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Chlorphenesin~0.1–0.15%

Irritant · medium

Irritation risk: Medium

A preservative

More about Chlorphenesin

Methyldihydrojasmonate~0.1–0.15%

Irritant · high

Irritation risk: High

Used as a fragrance. Smells similar to jasmine

More about Methyldihydrojasmonate

Isobutyl methyl tetrahydropyranol~0.1–0.15%

Irritant · medium

Irritation risk: Medium

Helps improve the product texture

More about Isobutyl methyl tetrahydropyranol

Ethylene brassylate~0.1–0.2%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Ethylene brassylate

Methyl decenol~0.1–0.2%

Irritant · high

Irritation risk: High

Used to mask the smell of other ingredients in the formulation

More about Methyl decenol

Ci 14700~0.05–0.15%

Irritant · medium

Irritation risk: Medium

A colorant

More about Ci 14700

Ci 19140~0.05–0.1%

Irritant · high

Irritation risk: High

A yellow dye

More about Ci 19140

Ingredient list view

Water, Glycerin, Maltobionic acid, Acetyl glucosamine, Octyldodecyl neopentanoate, Steareth-2, C12-15 alkyl benzoate, Butyrospermum parkii butter, Octyldodecanol, Steareth-20, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Isostearic acid, Cyclopentasiloxane, Acetyl tyrosinamide, Saccharide isomerate, Cyclohexasiloxane, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Vitis vinifera seed extract, Sodium pca, Serine, Glycine, Alanine, Lysine, Arginine, Threonine, Proline, Cetyl alcohol, Propylene glycol, Betaine, Sorbitol, Isopropyl myristate, Glutamic acid, Butylene glycol, Polysorbate 60, Sorbitan isostearate, Carbomer, Polysorbate 20, Ammonium hydroxide, Disodium edta, Caprylyl glycol, Sodium bisulfite, Xanthan gum, Phenoxyethanol, Chlorphenesin, Methyldihydrojasmonate, Isobutyl methyl tetrahydropyranol, Ethylene brassylate, Methyl decenol, Ci 14700, Ci 19140

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	NEOSTRATADermal ReplenishmentYOUR PRODUCT	ExuvianceAge Reverse Hydrafirm Hyaluronic Acid Antiaging Moisturizer
Match	—	63%
Price	$123.35	$68.80−$54.55
Shared key ingredients	—	19 of 21
Key difference	—	Sodium Hyaluronate
Irritancy	Medium	Medium
Drying alcohol	—	—
	View product	Shop

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skinncbi.nlm.nih.gov
3
Glucosamine: an ingredient with skin and other benefitsncbi.nlm.nih.gov
4
Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitroonlinelibrary.wiley.com
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Incorporation of D-(^H)glucosamine into normal and psoriatic epidermal glycoconjugatesonlinelibrary.wiley.com
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Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamineonlinelibrary.wiley.com
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A high-strength AHA/bionic acid skincare regimen in combination with a daily AHA home peel containing N-acetyl tyrosinamide (Aminofil) significantly improves signs of aging on the facejaad.org
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A Novel, Volumizing Cosmetic Formulation Significantly Improves the Appearance of Target Glabellar Lines, Nasolabial Folds, and Crow's Feet in a Double-Blind, Vehicle-Controlled Clinical Trialjddonline.com
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Safety Assessment of Vitis Vinifera (Grape)-Derived Ingredients as Used in Cosmetics cir-safety.org
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The Topical Effect of Grape Seed Extract 2% Cream on Surgery Wound Healingncbi.nlm.nih.gov
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Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinonlinelibrary.wiley.com
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Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiencyjamanetwork.com
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Functional glycine receptor in cultured human keratinocytesonlinelibrary.wiley.com
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Combination of amino acids reduces pigmentation in B16F0 melanoma cellsncbi.nlm.nih.gov
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Surfactants and experimental irritant contact dermatitisncbi.nlm.nih.gov
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Propylene Glycolpubmed.ncbi.nlm.nih.gov
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Skin-sensitizing and irritant properties of propylene glycolonlinelibrary.wiley.com
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Analysis of Dyes in Cosmetics: Challenges and Recent Developmentsmdpi.com

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