Naturopathica Caffeine + Peptide Hydrating Face & Neck Serum

Naturopathica Caffeine + Peptide Hydrating Face & Neck Serum

Efficacy100/100IrritancyMedium

Works for

Anti-aging
Niacinamide, Palmitoyl tetrapeptide-7 + 3 more
Works well
What the product description says
“A tall glass of water for the skin, this powerful hydrating serum combines antioxidant Caffeine with 4 molecular weights of Hyaluronic Acid and a youth-boosting peptide blend for plumped, radiant skin”
Source: Naturopathica

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: copper tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.65%
Copper tripeptide-1Key activeEffect: MediumA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.35–0.65%
Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.15%
Moisturizing
Niacinamide, Palmitoyl tetrapeptide-7 + 23 more
Works well
What the product description says
“Caffeine + Peptide Hydrating Face & Neck Serum”
Source: Naturopathica

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, lactobacillus ferment.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, squalane.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: copper tripeptide-1, niacinamide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.4–0.65%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.35–0.65%
Copper tripeptide-1HeroEffect: HighA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.35–0.65%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~4.2–5.2%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~3.1–3.8%
Coconut alkanesKey active· EmollientEffect: MediumAn emollient that helps soften the skin~1.9–2.3%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1.7–2%
Polyglutamic acidKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin.~0.3–0.55%
Coco-caprylate/caprateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin without creating a greasy texture~0.3–0.55%
Sodium acetylated hyaluronateKey active· HumectantEffect: HighA type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid~0.25–0.45%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%
Cocos nucifera fruit extractKey active· EmollientEffect: HighAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic~0.25–0.5%
Hydrolyzed sodium hyaluronateKey activeEffect: HighAttracts water into the upper layer of the skin~0.25–0.45%
Sodium hyaluronate crosspolymerKey active· HumectantEffect: HighAttracts water into the upper layer of the skin~0.2–0.4%
LactobacillusKey activeEffect: HighA non-living ingredient made by fermentation with the bacteria Lactobacillus. It can help attract water to the upper layer of the skin and might help reduce inflammation~0.2–0.4%
Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.2–0.4%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.05–0.1%
Hydrogenated polydecene· EmollientEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~5.9–7.2%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.1–1.4%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.55–0.8%
Neopentyl glycol diheptanoate· EmollientEffect: LowHelps soften the upper layer of the skin and create a nice product consistency~0.5–0.7%
Portulaca oleracea extract· HumectantEffect: LowA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin~0.2–0.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.15%
Avena sativa kernel extractUnder-dosedAn effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties~0.3–0.55%
Evens skin tone
Side benefit · Niacinamide
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: niacinamide

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%
Anti-blemish
Side benefit · Niacinamide
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~1.4–1.7%

Can it cause trouble?

Irritancy
14 flagged ingredients
Medium risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~3.1–3.8%est.
Polyglyceryl-3 diisostearateHelps oil and water mix togetherMedium~2.2–2.7%est.
Coconut alkanesAn emollient that helps soften the skinMedium~1.9–2.3%est.
Polyhydroxystearic acidUsed to create a thicker product consistency and stabilize the formulationMedium~0.7–1.05%est.
1,2-hexanediolA preservativeMedium~0.55–0.8%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.55–0.8%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.4–0.6%est.
EthylhexylglycerinA preservativeMedium~0.25–0.45%est.
Sodium hyaluronate crosspolymerAttracts water into the upper layer of the skinMedium~0.2–0.4%est.
Portulaca oleracea extractA plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skinMedium~0.2–0.4%est.
Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.2–0.35%est.
Polyglyceryl-2 stearateHelps water and oil mix togetherMedium~0.2–0.4%est.
Polyglyceryl-6 polyricinoleateHelps oil and water mix togetherMedium~0.2–0.35%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.05–0.1%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Polyglyceryl-3 diisostearateHelps oil and water mix together3/5~2.2–2.7%est.
Cocos nucifera fruit extractAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic3/5~0.25–0.5%est.
Coconut alkanesAn emollient that helps soften the skin2/5~1.9–2.3%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Hydrogenated polydecene~5.9–7.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene
Squalane~4.2–5.2%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Caprylic/capric triglyceride~3.1–3.8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Polyglyceryl-3 diisostearate~2.2–2.7%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-3 diisostearate
Coconut alkanes~1.9–2.3%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

An emollient that helps soften the skin

More about Coconut alkanes
Glycerin~1.7–2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Niacinamide~1.4–1.7%
Hero · Moisturizing, Anti-blemish
Irritation risk
Low
Works for
Evens skin toneAnti-agingMoisturizingAnti-blemishReduces irritationAntibacterialAnti-inflammatoryReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide
Butylene glycol~1.1–1.4%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Polyglyceryl-2 oleate~0.95–1.15%
Formula
Irritation risk
Low
Works for
Cleansing
More about Polyglyceryl-2 oleate
Polyhydroxystearic acid~0.7–1.05%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to create a thicker product consistency and stabilize the formulation

More about Polyhydroxystearic acid
1,2-hexanediol~0.55–0.8%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Pentylene glycol~0.55–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Neopentyl glycol diheptanoate~0.5–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin and create a nice product consistency

More about Neopentyl glycol diheptanoate
Sodium chloride~0.45–0.65%
Formula
Irritation risk
Low

Used to stabilize mixtures of oil and water, and create thicker, gel-like product textures

More about Sodium chloride
Caffeine~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Copper tripeptide-1~0.35–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.

More about Copper tripeptide-1
Palmitoyl tetrapeptide-7~0.4–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Palmitoyl tripeptide-1~0.35–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Polyglutamic acid~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin.

More about Polyglutamic acid
Avena sativa kernel extract~0.3–0.55%
Under-dosed
Irritation risk
Low
Works for
Reduces irritationMoisturizingAnti-inflammatoryReduces rednessAnti-oxidation

An effective moisturizing and skin barrier repair ingredient. Helps calm down inflammation and has some anti-oxidant properties

More about Avena sativa kernel extract
Coco-caprylate/caprate~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin without creating a greasy texture

More about Coco-caprylate/caprate
Cocos nucifera fruit extract~0.25–0.5%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic

More about Cocos nucifera fruit extract
Ethylhexylglycerin~0.25–0.45%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Hydrolyzed sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Hydrolyzed sodium hyaluronate
Sodium acetylated hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of hyaluronic acid that works as an excellent moisturizer by attracting water into the upper layer of the skin. Is typically feels less sticky on the skin compared to the usual hyaluronic acid

More about Sodium acetylated hyaluronate
Sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Sodium hyaluronate crosspolymer~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Sodium hyaluronate crosspolymer
Lactobacillus ferment~0.2–0.4%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-inflammatoryReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment
Lactobacillus~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

A non-living ingredient made by fermentation with the bacteria Lactobacillus. It can help attract water to the upper layer of the skin and might help reduce inflammation

More about Lactobacillus
Portulaca oleracea extract~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizing

A plant extract that has some anti-oxidant activity, but solid research is lacking. Can help attract water to the upper layer of the skin

More about Portulaca oleracea extract
Leuconostoc/radish root ferment filtrate~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate
Polyglyceryl-2 stearate~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Polyglyceryl-2 stearate
Polyglyceryl-6 polyricinoleate~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-6 polyricinoleate
Polysorbate 20~0.15–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Silica~0.25–0.45%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Caramel~0.1–0.2%
Formula
Irritation risk
Low
More about Caramel
Tocopherol~0.1–0.15%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Carbomer~0.05–0.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Sodium lactate~0.05–0.1%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Ingredient list view

Water, Hydrogenated polydecene, Squalane, Caprylic/capric triglyceride, Polyglyceryl-3 diisostearate, Coconut alkanes, Glycerin, Niacinamide, Butylene glycol, Polyglyceryl-2 oleate, Polyhydroxystearic acid, 1,2-hexanediol, Pentylene glycol, Neopentyl glycol diheptanoate, Sodium chloride, Caffeine, Copper tripeptide-1, Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Polyglutamic acid, Avena sativa kernel extract, Coco-caprylate/caprate, Cocos nucifera fruit extract, Ethylhexylglycerin, Hydrolyzed sodium hyaluronate, Sodium acetylated hyaluronate, Sodium hyaluronate, Sodium hyaluronate crosspolymer, Lactobacillus ferment, Lactobacillus, Portulaca oleracea extract, Leuconostoc/radish root ferment filtrate, Polyglyceryl-2 stearate, Polyglyceryl-6 polyricinoleate, Polysorbate 20, Silica, Caramel, Tocopherol, Carbomer, Sodium lactate

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
NaturopathicaCaffeine + Peptide Hydrating Face & Neck SerumYOUR PRODUCTNIDASalmon PDRN Peptide SerumMedicubeHyaluronic Multi Peptide SerumArenciaDeep Water Surge Serum 30
Match—86%85%85%
Price$94.00$13.32−$80.68$18.90−$75.10$16.03−$77.97
Shared key ingredients—7 of 1710 of 1711 of 17
Key difference—AdenosineTripeptide-1Oligopeptide-1
Irritancy Medium Low Medium Medium
Drying alcohol————
View product Shop Shop Shop

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

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Naturopathica Caffeine + Peptide Hydrating Face & Neck Serum
NaturopathicaCaffeine + Peptide Hydrating Face & Neck Serum

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.