Manyo

Manyo Bifida Biome Ampoule Mask

Name: Manyo - Bifida Biome Ampoule Mask
Brand: Manyo

Efficacy100/100IrritancyMedium

See all ingredients

Works for

Anti-aging

Niacinamide, Aspartic acid + 7 more

Works well

What the product description says

“They help fortify the skin barrier and prevent moisture loss while brightening, evening out skin, and reducing the appearance of fine lines.”

Source: Soko Glam

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine, niacinamide.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: aspartic acid, lysine, madecassoside, serine, threonine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

NiacinamideKey activeEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.3–0.55%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%

ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.5%

LysineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%

MadecassosideKey activeEffect: MediumAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.3–0.55%

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

Lactococcus ferment lysateEffect: LowConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin~1.1–1.4%

Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.5–0.7%

Moisturizing

Niacinamide, Ceramide np + 30 more

Works well

What the product description says

“Nourish, brighten, and strengthen the skin’s barrier in one easy step!”

Source: Soko Glam

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, madecassoside, niacinamide, panthenol

NiacinamideHeroEffect: HighIs proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production~2.3–2.8%

Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.45–0.65%

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.35–0.6%

MadecassosideHeroEffect: HighAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.3–0.55%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.7%

Bifida ferment lysateKey activeEffect: HighConsists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect~1.6–2%

Lactobacillus ferment lysateKey activeEffect: MediumA "broth" with parts of dead cells of lactobacteria. Might be helpful supporting diverse microbiome in skin, but evidence is lacking~1.4–1.7%

Lactococcus ferment lysateKey activeEffect: HighConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin~1.1–1.4%

Saccharomyces ferment filtrateKey active· HumectantEffect: HighA product of yeast fermentation. Helps attract water to the upper layer of the skin~0.95–1.15%

Lactobacillus fermentKey active· HumectantEffect: HighA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.7–1%

Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.5–0.7%

Hydrolyzed hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. A version of it is naturally present in skin~0.45–0.65%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.4–0.6%

Hydroxyethyl ureaKey active· HumectantEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~0.3–0.55%

IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.3–0.55%

LysineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.55%

ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.3–0.5%

TyrosineKey activeEffect: High~0.3–0.55%

AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.3–0.55%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.3–0.55%

Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.3–0.55%

CysteineKey activeEffect: HighMight help neutralize free radicals in skin and might be helpful against hyperpigmentation~0.3–0.55%

Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.3–0.55%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.3–0.55%

HistidineKey active· HumectantEffect: High~0.3–0.55%

ProlineKey activeEffect: Medium~0.3–0.55%

Ulmus davidiana root extractKey activeEffect: MediumA plant root extract that helps attract water to the upper layer of the skin. It might have an anti-inflammatory effect and could help neturalize free radicals in skin~0.25–0.4%

AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.9–2.3%

Dextrin· HumectantEffect: LowA sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin~0.35–0.6%

AllantoinUnder-dosedHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.3–0.5%

Exfoliation

Side benefit · Hydroxyethyl urea, Allantoin

Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: hydroxyethyl urea.

Hydroxyethyl ureaKey activeEffect: HighA derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients~0.3–0.55%

AllantoinEffect: Low, below effective doseHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.3–0.5%

Anti-oxidation

Side benefit · Bifida ferment lysate, Madecassoside + 6 more

Works well

This product contains antioxidants (madecassoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - bifida ferment lysate, cysteine also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Bifida ferment lysateKey activeEffect: MediumConsists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect~1.6–2%

MadecassosideKey activeEffect: HighAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.3–0.55%

CysteineKey activeEffect: MediumMight help neutralize free radicals in skin and might be helpful against hyperpigmentation~0.3–0.55%

Lactobacillus fermentEffect: LowA fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative~0.7–1%

Ulmus davidiana root extractEffect: LowA plant root extract that helps attract water to the upper layer of the skin. It might have an anti-inflammatory effect and could help neturalize free radicals in skin~0.25–0.4%

AdenosineEffect: LowMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.15–0.3%

CaffeineEffect: LowMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes~0.15–0.25%

Anti-blemish

Side benefit · Niacinamide, Allantoin

Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: niacinamide. This ingredient is used for treating acne and can have a noticeable effect.

AllantoinEffect: Low, below effective doseHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.3–0.5%

Evens skin tone

Side benefit the brand mentions · Niacinamide, Bifida ferment lysate + 4 more

Works well

What the product description says

“They help fortify the skin barrier and prevent moisture loss while brightening, evening out skin, and reducing the appearance of fine lines.”

Source: Soko Glam

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: hydroxyethyl urea, niacinamide

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine, bifida ferment lysate, cysteine, glycyrrhiza uralensis root extract, madecassoside.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Bifida ferment lysateEffect: LowConsists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect~1.6–2%

Glycyrrhiza uralensis root extractEffect: LowLicorice root extract. Might be helpful in reducing hyperpigmentation~0.5–0.8%

CysteineEffect: LowMight help neutralize free radicals in skin and might be helpful against hyperpigmentation~0.3–0.55%

AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.3–0.55%

MadecassosideEffect: LowAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations~0.3–0.55%

Can it cause trouble?

Irritancy

2 strong irritants: Hamamelis virginiana water, Oenothera biennis flower extract

Medium risk

We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Hamamelis virginiana waterA plant extract that can help calm down inflammation in skin. Can, however, itself be irritatingHigh~0.45–0.7%est.

Oenothera biennis flower extractUsed as a fragranceHigh~0.3–0.55%est.

Ulmus davidiana root extractA plant root extract that helps attract water to the upper layer of the skin. It might have an anti-inflammatory effect and could help neturalize free radicals in skinHigh~0.25–0.4%est.

MethylpropanediolHelps dissolve other ingredients in a formulationMedium~5.6–6.9%est.

1,2-hexanediolA preservativeMedium~2–2.4%est.

Glycyrrhiza uralensis root extractLicorice root extract. Might be helpful in reducing hyperpigmentationMedium~0.5–0.8%est.

MadecassosideAn antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulationsMedium~0.3–0.55%est.

EthylhexylglycerinA preservativeMedium~0.3–0.55%est.

Polyglyceryl-10 laurateHelps water and oil mix togetherMedium~0.3–0.6%est.

CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.15–0.25%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Theobroma cacao seed extract—3/5~0.3–0.6%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Methylpropanediol~5.6–6.9%

Irritant · medium

Irritation risk: Medium

Helps dissolve other ingredients in a formulation

More about Methylpropanediol

1,2-hexanediol~2–2.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Glycerin~3–3.7%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Niacinamide~2.3–2.8%

Hero · Moisturizing, Anti-blemish

Irritation risk: Low

Works for

Anti-agingAnti-blemishEvens skin toneMoisturizingReduces irritationAnti-inflammatoryAntibacterialReduces redness

Is proven to be effective in reducing blemishes, evening out skin tone and helping to improve lines and wrinkles. It helps the skin to repair sun damage, calm down inflammation and keep maintain good levels of moisture. The concentration of about 2% is effective for supporting the skin barrier and evening out the skin tone. Concentration of 4-6% is better for helping with acne and balancing the sebum production

More about Niacinamide

Butylene glycol~1.9–2.3%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Bifida ferment lysate~1.6–2%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationEvens skin tone

Consists of remains of dead yeast bacteria cells. Helps to hydrate the skin and reduce irritation. Might has some anti-oxidant effect

More about Bifida ferment lysate

Lactobacillus ferment lysate~1.4–1.7%

Key active

Irritation risk: Low

Works for

Moisturizing

A "broth" with parts of dead cells of lactobacteria. Might be helpful supporting diverse microbiome in skin, but evidence is lacking

More about Lactobacillus ferment lysate

Lactococcus ferment lysate~1.1–1.4%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-agingAnti-inflammatoryAnti-oxidation

Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin

More about Lactococcus ferment lysate

Saccharomyces ferment filtrate~0.95–1.15%

Key active

Irritation risk: Low

Works for

Moisturizing

A product of yeast fermentation. Helps attract water to the upper layer of the skin

More about Saccharomyces ferment filtrate

Lactobacillus ferment~0.7–1%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-inflammatoryReduces irritation

A fermentation product created by bacteria Lactobacillus. The fermented product has anti-bacterial properties and might be helpful in calming down inflammation, but studies are lacking. Helps attract water to the upper layer of the skin. Can be used as a preservative

More about Lactobacillus ferment

Chrysanthemum zawadskii extract~0.55–0.85%

Formula

Irritation risk: Low

More about Chrysanthemum zawadskii extract

Glycyrrhiza uralensis root extract~0.5–0.8%

Irritant · medium

Irritation risk: Medium

Works for

Evens skin tone

Licorice root extract. Might be helpful in reducing hyperpigmentation

More about Glycyrrhiza uralensis root extract

Anastatica hierochuntica extract~0.5–0.8%

Formula

Irritation risk: Low

More about Anastatica hierochuntica extract

Artemisia capillaris extract~0.5–0.75%

Formula

Irritation risk: Low

More about Artemisia capillaris extract

Hamamelis virginiana water~0.45–0.7%

Irritant · high

Irritation risk: High

Works for

Anti-inflammatory

A plant extract that can help calm down inflammation in skin. Can, however, itself be irritating

More about Hamamelis virginiana water

Hyaluronic acid~0.5–0.7%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid

Hydrolyzed hyaluronic acid~0.45–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. A version of it is naturally present in skin

More about Hydrolyzed hyaluronic acid

Sodium hyaluronate~0.4–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Ceramide np~0.45–0.65%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces irritationAnti-inflammatory

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np

Panthenol~0.35–0.6%

Hero · Moisturizing

Irritation risk: Low

Works for

Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Leonurus sibiricus extract~0.3–0.6%

Formula

Irritation risk: Low

More about Leonurus sibiricus extract

Paeonia albiflora flower extract~0.3–0.55%

Formula

Irritation risk: Low

More about Paeonia albiflora flower extract

Hydroxyethyl urea~0.3–0.55%

Key active

Irritation risk: Low

Works for

ExfoliationMoisturizing

A derivative of urea, a compound that is naturally present in skin. Attracts water to the upper layer of the skin. Can enhance penetration of other ingredients

More about Hydroxyethyl urea

Tromethamine~0.3–0.55%

Formula

Irritation risk: Low

Helps adjust pH in products

More about Tromethamine

Cynanchum atratum extract~0.25–0.5%

Formula

Irritation risk: Low

More about Cynanchum atratum extract

Oenothera biennis flower extract~0.3–0.55%

Irritant · high

Irritation risk: High

Used as a fragrance

More about Oenothera biennis flower extract

Madecassoside~0.3–0.55%

Hero · MoisturizingIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidationAnti-agingEvens skin tone

An antioxidant that is typically derived from plant Centella Asiatica. It can help neutralize free radicals in skin and support skin barrier function. It could, however, itself be irritating. It is often unstable in formulations

More about Madecassoside

Isoleucine~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine

Histidine~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Histidine

Cysteine~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationEvens skin tone

Might help neutralize free radicals in skin and might be helpful against hyperpigmentation

More about Cysteine

Cyperus rotundus root extract~0.3–0.55%

Formula

Irritation risk: Low

More about Cyperus rotundus root extract

Aspartic acid~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid

Allantoin~0.3–0.5%

Under-dosed

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryReduces irritationReduces rednessAnti-blemishExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin

Dextrin~0.35–0.6%

Formula

Irritation risk: Low

Works for

Moisturizing

A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin

More about Dextrin

Sodium phytate~0.3–0.55%

Formula

Irritation risk: Low

Used to stabilize product formulations

More about Sodium phytate

Propanediol~0.3–0.6%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Glycine~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Serine~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Glutamic acid~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid

Theobroma cacao seed extract~0.3–0.6%

Comedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

More about Theobroma cacao seed extract

Althaea rosea flower extract~0.3–0.55%

Formula

Irritation risk: Low

More about Althaea rosea flower extract

Ethylhexylglycerin~0.3–0.55%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Polyglyceryl-10 laurate~0.3–0.6%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps water and oil mix together

More about Polyglyceryl-10 laurate

Polyglyceryl-10 myristate~0.3–0.55%

Formula

Irritation risk: Low

More about Polyglyceryl-10 myristate

Leucine~0.3–0.55%

Formula

Irritation risk: Low

More about Leucine

Alanine~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Lysine~0.3–0.55%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Lysine

Arginine~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Tyrosine~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Tyrosine

Phenylalanine~0.3–0.55%

Formula

Irritation risk: Low

More about Phenylalanine

Proline~0.3–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Threonine~0.3–0.5%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine

Valine~0.25–0.5%

Formula

Irritation risk: Low

More about Valine

Pinus palustris leaf extract~0.25–0.5%

Formula

Irritation risk: Low

More about Pinus palustris leaf extract

Pueraria thunbergiana root extract~0.25–0.45%

Formula

Irritation risk: Low

More about Pueraria thunbergiana root extract

Ulmus davidiana root extract~0.25–0.4%

Key activeIrritant · high

Irritation risk: High

Works for

MoisturizingAnti-oxidation

A plant root extract that helps attract water to the upper layer of the skin. It might have an anti-inflammatory effect and could help neturalize free radicals in skin

More about Ulmus davidiana root extract

Methionine~0.2–0.35%

Formula

Irritation risk: Low

More about Methionine

Carbomer~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Caffeine~0.15–0.25%

Irritant · medium

Irritation risk: Medium

Works for

De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine

Xanthan gum~0.15–0.3%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Adenosine~0.15–0.3%

Key active

Irritation risk: Low

Works for

Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine

Cutibacterium granulosum ferment extract filtrate~0.1–0.25%

Formula

Irritation risk: Low

More about Cutibacterium granulosum ferment extract filtrate

Bifida ferment filtrate~0.1–0.15%

Formula

Irritation risk: Low

More about Bifida ferment filtrate

Ingredient list view

Water, Methylpropanediol, 1,2-hexanediol, Glycerin, Niacinamide, Butylene glycol, Bifida ferment lysate, Lactobacillus ferment lysate, Lactococcus ferment lysate, Saccharomyces ferment filtrate, Lactobacillus ferment, Chrysanthemum zawadskii extract, Glycyrrhiza uralensis root extract, Anastatica hierochuntica extract, Artemisia capillaris extract, Hamamelis virginiana water, Hyaluronic acid, Hydrolyzed hyaluronic acid, Sodium hyaluronate, Ceramide np, Panthenol, Leonurus sibiricus extract, Paeonia albiflora flower extract, Hydroxyethyl urea, Tromethamine, Cynanchum atratum extract, Oenothera biennis flower extract, Madecassoside, Isoleucine, Histidine, Cysteine, Cyperus rotundus root extract, Aspartic acid, Allantoin, Dextrin, Sodium phytate, Propanediol, Glycine, Serine, Glutamic acid, Theobroma cacao seed extract, Althaea rosea flower extract, Ethylhexylglycerin, Polyglyceryl-10 laurate, Polyglyceryl-10 myristate, Leucine, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Proline, Threonine, Valine, Pinus palustris leaf extract, Pueraria thunbergiana root extract, Ulmus davidiana root extract, Methionine, Carbomer, Caffeine, Xanthan gum, Adenosine, Cutibacterium granulosum ferment extract filtrate, Bifida ferment filtrate

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	ManyoBifida Biome Ampoule MaskYOUR PRODUCT	VENN SkincareVENN Collagen Intensive Phyto-Retinol Renewal Mask	RejuranMoisture Treatment Mask	MEDIHEALD.N.A Hydrating Protein Sheet Mask
Match	—	91%	90%	88%
Price	$4.77	$39.34+$34.57	$18.00+$13.23	—
Shared key ingredients	—	23 of 28	20 of 28	21 of 28
Key difference	—	Acetyl Tetrapeptide-5	Phytosphingosine	Copper Tripeptide-1
Irritancy	Medium	Medium	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"Manyo - Bifida Biome Ampoule Mask" is effective for: Anti-aging, Evens skin tone, Exfoliation, Anti-blemish and Moisturizing

Ingredient callouts

A good concentration of Niacinamide (2.30% - 2.80%). Niacinamide is a well-studied multi-tasking active. It is stable, and can work well in almost any hydrating formulation. There is solid evidence that Niacinamide can help support skin barrier, regulate oil production and reduce acne and clogged pores. It also helps to fight photodamage and improve the skin tone, reducing pigmentation marks.
Ceramides (ceramide np 0.45% - 0.65%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
Adenosine 0.15% - 0.30%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - madecassoside 0.30% - 0.55% The Centella Asiatica Actives help strengthen and restore the skin barrier, decrease inflammation in skin and neutralize free radicals. They also can help to reduce scarring. The good news is that these actives work even in low concentrations.
Humectants (sodium hyaluronate 0.40% - 0.60%, saccharomyces ferment filtrate 0.95% - 1.15%, panthenol 0.35% - 0.60%, lactobacillus ferment 0.70% - 1.00%, hydroxyethyl urea 0.30% - 0.55%, hydrolyzed hyaluronic acid 0.45% - 0.65%, hyaluronic acid 0.50% - 0.70%, histidine 0.30% - 0.55%, glycerin 3.00% - 3.70%, glutamic acid 0.30% - 0.55%, alanine 0.30% - 0.55%, glycine 0.30% - 0.55%, aspartic acid 0.30% - 0.55% and arginine 0.30% - 0.55%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails from 3.00$ up to 7.40$ in the United States and for 44.86A$ in Australia.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 42 studies and safety reviews.

1
The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
2
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
3
Niacinamide - mechanisms of action and its topical use in dermatologyncbi.nlm.nih.gov
4
Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology, 3(2), 88–93. doi:10.1111/j.1473-2130.2004.00115.x ncbi.nlm.nih.gov
5
Bifidobacterium longumlysate, a new ingredient forreactive skinonlinelibrary.wiley.com
6
Use of Probiotics for Dermal Applicationsresearchgate.net
7
The effect of probiotics on immune regulation, acne, and photoagingncbi.nlm.nih.gov
8
Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face studyncbi.nlm.nih.gov
9
Efficacy of a New Topical Nano-hyaluronic Acid in Humansncbi.nlm.nih.gov
10
Physiochemical properties and application of hyaluronic acid: a systematic reviewonlinelibrary.wiley.com
11
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
12
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
13
Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systemsncbi.nlm.nih.gov
14
Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skinncbi.nlm.nih.gov
15
Skin moisturizing effects of panthenol-based formulationspdfs.semanticscholar.org
16
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmeticscir-safety.org
17
Safety Assessment of Hydroxyethyl Urea As Used in Cosmeticscir-safety.org
18
Safety Assessment of Tromethamine as Used in Cosmeticscir-safety.org
19
Centella asiatica in Dermatology: An Overviewonlinelibrary.wiley.com
20
Protective effect of madecassoside on H2O2-induced oxidative stress and autophagy activation in human melanocytesncbi.nlm.nih.gov
21
Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stressonlinelibrary.wiley.com
22
Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammationmdpi.com
23
Contact dermatitis due to Madecassolonlinelibrary.wiley.com
24
The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trialliebertpub.com
25
Stability Study of the Active Constituents in the Centella asiatica Extract Formulationstandfonline.com
26
Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trialonlinelibrary.wiley.com
27
Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseasespatents.google.com
28
Safety Assessment of α-Amino Acids as Used in Cosmeticsciteseerx.ist.psu.edu
29
The Potential Uses of N-acetylcysteine in Dermatology: A Reviewncbi.nlm.nih.gov
30
Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proofncbi.nlm.nih.gov
31
In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmnessncbi.nlm.nih.gov
32
Profile of wound healing process induced by allantoinscielo.br
33
Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiencyjamanetwork.com
34
Functional glycine receptor in cultured human keratinocytesonlinelibrary.wiley.com
35
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinonlinelibrary.wiley.com
36
In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Responseresearchgate.net
37
Combination of amino acids reduces pigmentation in B16F0 melanoma cellsncbi.nlm.nih.gov
38
Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activitiespubmed.ncbi.nlm.nih.gov
39
Cosmeceutical properties of polysaccharides from the root bark of Ulmus davidiana var. japonicapubmed.ncbi.nlm.nih.gov
40
Anti-Wrinkle Effect of Ulmus davidiana Extractsdbpia.co.kr
41
Development and characterization of a superabsorbing hydrogel film containing Ulmus davidiana var. Japonica root bark and pullulan for skin wound healingsciencedirect.com
42
Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS techniquencbi.nlm.nih.gov

ManyoBifida Biome Ampoule Mask

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